Stress, Food, and Inflammation: Psychoneuroimmunology and Nutrition at the Cutting Edge
Open accessAbstract
Inflammation is the common link among the leading causes of death. Mechanistic studies have shown how various dietary components can modulate key pathways to inflammation, including sympathetic activity, oxidative stress, transcription factor nuclear factor-kappaB activation, and proinflammatory cytokine production. Behavioral studies have demonstrated that stressful events and depression can also influence inflammation through these same processes. If the joint contributions of diet and behavior to inflammation were simply additive, they would be important. However, several far more intriguing interactive possibilities are discussed: stress influences food choices; stress can enhance maladaptive metabolic responses to unhealthy meals; and diet can affect mood as well as proinflammatory responses to stressors. Furthermore, because the vagus nerve innervates tissues involved in the digestion, absorption, and metabolism of nutrients, vagal activation can directly and profoundly influence metabolic responses to food, as well as inflammation; in turn, both depression and stress have well-documented negative effects on vagal activation, contributing to the lively interplay between the brain and the gut. As one example, omega-3 fatty acid intake can boost mood and vagal tone, dampen nuclear factor-kappaB activation and responses to endotoxin, and modulate the magnitude of inflammatory responses to stressors. A better understanding of how stressors, negative emotions, and unhealthy meals work together to enhance inflammation will benefit behavioral and nutritional research, as well as the broader biomedical community.
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- Premisecitation
Stress and depression can directly provoke proinflammatory cytokine production without infection or injury.
“stress and depression can also directly provoke proinflammatory cytokine production in the absence of infection or injury (17-18).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [17] Kiecolt-Glaser JK McGuire L Robles TR Glaser R Emotions, morbidity, and mortality: New perspectives from psychoneuroimmunology Annu Rev Psychol 2002 53 83 107 11752480 source
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- Premisecitation
Stress can worsen maladaptive metabolic responses to unhealthy meals.
“stress can enhance maladaptive metabolic responses to unhealthy meals”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [50] Le Fur C Romon M Lebel P Devos P Lancry A Guedon-Moreau L Fruchart JC Dallongeville J Influence of mental stress and circadian cycle on pastprandial lipemia Am J Clin Nutr 1999 70 213 20 10426697 source
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- Premisecitation
NF-κB is a key bridge for stress-induced increases in proinflammatory cytokines and their genes.
“NF-κB appears to be a prime bridge for stress-induced increases in proinflammatory cytokines and the genes that control their expression (5).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [5] Bierhaus A Wolf J Andrassy M Rohleder N Humpert PM Petrov D Ferstl R von Eynatten M Wendt T Rudofsky G Joswig M Morcos M Schwaninger M McEwen B Kirschbaum C Nawroth PP A mechanism converting psychosocial stress into mononuclear cell activation Proc Natl Acad Sci U S A 2003 100 1920 5 12578963 PMC149934 source
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- Premisecitation
Inflammation is implicated in the pathophysiology of depression.
“Several lines of research have implicated inflammation in the pathophysiology of depression (13-14).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [13] Miller GE Backwell E Turning up the heat: Inflammation as a mechanism linking chronic stress, depression, and heart disease Curr Dir Psychol Sci 2006 15 269 72 source
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- cites [14] Raison CL Capuron L Miller AH Cytokines sing the blues: Inflammation and the pathogenesis of depression Trends Immunol 2006 27 24 31 16316783 PMC3392963 source
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- Premisecitation
Stressful events and depression can influence inflammation through the same pathways as diet.
“Behavioral studies have demonstrated that stressful events and depression can also influence inflammation through these same processes.”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [5] Bierhaus A Wolf J Andrassy M Rohleder N Humpert PM Petrov D Ferstl R von Eynatten M Wendt T Rudofsky G Joswig M Morcos M Schwaninger M McEwen B Kirschbaum C Nawroth PP A mechanism converting psychosocial stress into mononuclear cell activation Proc Natl Acad Sci U S A 2003 100 1920 5 12578963 PMC149934 source
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- cites [6] Epel ES Blackburn EH Lin J Dhabhar FS Adler NE Morrow JD Cawthon RM Accelerated telomere shortening in response to life stress see comment Proc Natl Acad Sci U S A 2004 101 17312 5 15574496 PMC534658
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- cites [7] Steptoe A Hamer M Chida Y The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis Brain Behavior and Immunity 2007 21 901 12 17475444 source
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- Premisecitation
Inflammation is a shared link among the main causes of death.
“Inflammation is the common link among the leading causes of death.”
- Also stated in: § Abstract · plain
“these diseases share inflammation as a common link (1-2)”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [1] Giugliano D Ceriello A Esposito K The effects of diet on inflammation - Emphasis on the metabolic syndrome J Am Coll Cardiol 2006 48 677 85 16904534 source
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- cites [2] Aggarwal BB Shishodia S Sandur SK Pandey MK Sethi G Inflammation and cancer: How hot is the link? Biochem Pharmacol 2006 72 1605 21 16889756 source
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- Also stated in: § Abstract · plain
- Premisecitation
Trans-fat consumption is linked to higher inflammation, with higher CRP and IL-6 in top consumers.
“CRP was 73% higher in women in the highest quintile of consumption compared with those in the lowest quintile, and IL-6 levels were 17% higher in the highest compared to the lowest quintiles (9).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [9] Lopez-Garcia E Schulze MB Meigs JB Manson JE Rifai N Stampfer MJ Willett WC Hu FB Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction J Nutr 2005 135 562 6 15735094 source
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- Premisecitation
Stress and depression motivate less healthy food choices.
“Both laboratory and epidemiological studies suggest that depression and stressful events motivate less healthy food choices”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [42] Adam TC Epel ES Stress, eating and the reward system Physiology & Behavior 2007 91 449 58 17543357 source
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- cites [43] Wardle J Steptoe A Oliver G Lipsey Z Stress, dietary restraint and food intake J Psychosom Res 2000 48 195 202 10719137 source
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- Premisecitation
Dietary components can alter inflammation pathways such as sympathetic activity, oxidative stress, NF-κB activation, and proinflammatory cytokine production.
“Mechanistic studies have shown how various dietary components can modulate key pathways to inflammation including sympathetic activity, oxidative stress, transcription factor nuclear factor kappa B (NF-κB) activation, and proinflammatory cytokine production.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [4] Calder PC Albers R Antoine JM Blum S Bourdet-Sicard R Ferns GA Folkerts G Friedmann PS Frost GS Guarner F Lovik M Macfarlane S Meyer PD M'Rabet L Serafini M van Eden W van Loo J Vas Dias W Vidry S Winklhofer-Roob BM Zhao J Inflammatory disease processes and interactions with nutrition Br J Nutr 2009 101 1 S1 45 19586558
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- Premisecitation
Vagal activation directly influences metabolic responses to food and inflammation.
“vagal activation can directly and profoundly influence metabolic responses to food, as well as inflammation”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [53] Teff KL Visceral nerves: Vagal and sympathetic innervation Journal of Parenteral and Enteral Nutrition 2008 32 569 71 18753395 source
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- Interpretationcitation
Prolonged intermittent fasting substantially reduces inflammation.
“These provocative data suggest that prolonged intermittent fasting substantially decreases inflammation.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [56] Aksungar FB Topkaya AE Akyildiz M Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting Ann Nutr Metab 2007 51 88 95 17374948 source
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- Premisecitation
Omega-3 PUFAs diminish endotoxin-induced inflammatory and neuroendocrine responses.
“data from endotoxin challenges show that the n-3 PUFAs can diminish these responses while simultaneously modulating changes in the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medullary (SAM) axes.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [39] Michaeli B Berger MM Revelly JP Tappy L Chiolero R Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers Clinical Nutrition (Edinburgh, Scotland) 2007 26 70 7 17055120 source
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- cites [40] Pluess TT Hayoz D Berger MM Tappy L Revelly JP Michaeli B Carpentier YA Chiolero RL Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects Intensive Care Med 2007 33 789 97 17377770 source
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- May combine two claims. 10
May combine two claims.
InterpretationcitationDiet can affect mood and the magnitude of inflammatory responses to stressors.
“diet can impact mood as well as proinflammatory responses to stressors”
- Also stated in: § Dietary Influences on Mood and Proinflammatory Stress Responses: Omega-3 and Omega-6 · hedged
“these studies (26, 28) suggest that diet can influence the magnitude of inflammatory responses to stress and depression as well as mood.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [26] Maes M Christophe A Bosmans E Lin AH Neels H In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stress Biol Psychiatry 2000 47 910 20 10807964 source
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- cites [28] Kiecolt-Glaser JK Belury MA Porter K Beversdorf D Lemeshow S Glaser R Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults Psychosom Med 2007 69 217 24 17401057 PMC2856352 source
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- Also stated in: § Dietary Influences on Mood and Proinflammatory Stress Responses: Omega-3 and Omega-6 · hedged
May combine two claims.
PremisecitationDepression and stress reduce vagal activation.
“both depression and stress have well-documented negative effects on vagal activation”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [52] Yin J Levanon D Chen JDZ Inhibitory effects of stress on postprandial gastric myoelectrical activity and vagal tone in healthy subjects Neurogastroenterol Motil 2004 16 737 44 15601423 source
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- cites [54] Pieper S Brosschot JF van der Leeden R Thayer JF Cardiac effects of momentary assessed worry episodes and stressful events Psychosom Med 2007 69 901 9 17991822 source
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May combine two claims.
PremisecitationOmega-3 fatty acid intake dampens NF-κB activation and endotoxin responses.
“dampen NF-κB activation and responses to endotoxin”
Quote in the paperSubstantial claim0 of 4 sources checked- cites [32] Zhao Y Joshi-Barve S Barve S Chen LH Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation J Am Coll Nutr 2004 23 71 8 14963056 source
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- cites [33] Jolly CA Muthukumar A Avula CP Troyer D Fernandes G Life span is prolonged in food-restricted autoimmune-prone (NZB × NZW)F(1) mice fed a diet enriched with (n-3) fatty acids J Nutr 2001 131 2753 60 11584100 source
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- cites [39] Michaeli B Berger MM Revelly JP Tappy L Chiolero R Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers Clinical Nutrition (Edinburgh, Scotland) 2007 26 70 7 17055120 source
Not checked in the free run.
- cites [40] Pluess TT Hayoz D Berger MM Tappy L Revelly JP Michaeli B Carpentier YA Chiolero RL Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects Intensive Care Med 2007 33 789 97 17377770 source
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May combine two claims.
PremisecitationDiets that promote inflammation are high in refined starches, sugar, saturated and trans fats, and low in omega-3 fatty acids, antioxidants, and fiber.
“Diets that promote inflammation are high in refined starches, sugar, saturated and trans-fats, and low in omega-3 fatty acids, natural antioxidants and fiber from fruits, vegetables, and whole grains (1).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [1] Giugliano D Ceriello A Esposito K The effects of diet on inflammation - Emphasis on the metabolic syndrome J Am Coll Cardiol 2006 48 677 85 16904534 source
Not checked in the free run.
May combine two claims.
PremisecitationChronic stressors increase IL-6 and oxidative stress.
“the average annual rate of increase in serum IL-6 was about four times as large in men and women who were chronically stressed by caregiving for a spouse with dementia compared to similar individuals with no caregiving responsibilities (23).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [23] Kiecolt-Glaser JK Preacher KJ MacCallum RC Atkinson C Malarkey WB Glaser R Chronic stress and age-related increases in the proinflammatory cytokine IL-6 Proc Natl Acad Sci U S A 2003 100 9090 5 12840146 PMC166443 source
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- cites [6] Epel ES Blackburn EH Lin J Dhabhar FS Adler NE Morrow JD Cawthon RM Accelerated telomere shortening in response to life stress see comment Proc Natl Acad Sci U S A 2004 101 17312 5 15574496 PMC534658
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May combine two claims.
PremisecitationStress increases postprandial lipemia and delays triglyceride clearance.
“Importantly, stress both enhances post-meal peaks and delays clearance.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [50] Le Fur C Romon M Lebel P Devos P Lancry A Guedon-Moreau L Fruchart JC Dallongeville J Influence of mental stress and circadian cycle on pastprandial lipemia Am J Clin Nutr 1999 70 213 20 10426697 source
Not checked in the free run.
- cites [51] Stoney CM West SG Hughes JW Lentino LM Finney ML Falko J Bausserman L Acute psychological stress reduces plasma triglyceride clearance Psychophysiology 2002 39 80 5 12206298 source
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May combine two claims.
PremisecitationHigh-fat meals can cause low-grade endotoxemia and NF-κB activation in PBMCs.
“High-fat meals can stimulate low-grade endotoxemia”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [36] Erridge C Attina T Spickett CM Webb DJ A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation Am J Clin Nutr 2007 86 1286 92 17991637 source
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May combine two claims.
PremisecitationFasting protects normal cells but not tumor cells from high-dose chemotherapy.
“in normal cells, fasting slows the cell cycle and thus is protective. However, tumor cells do not respond to starvation by slowing cell division, and their continued high replicative rate makes them more vulnerable to chemotherapy (57).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [57] Raffaghello L Lee C Safdie FM Wei M Madia F Bianchi G Longo VD Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy Proceedings of the National Academy of Sciences 2008 105 8215 20 PMC2448817 18378900 source
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May combine two claims.
PremisecitationOmega-3 PUFAs reduce proinflammatory cytokine production and oxidative stress.
“higher levels of n-3 PUFAs as well as lower n-6:n-3 ratios are associated with lower proinflammatory cytokine production (29).”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [29] Ferrucci L Cherubini A Bandinelli S Bartali B Corsi A Lauretani F Martin A Andres-Lacueva C Senin U Guralnik JM Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers J Clin Endocrinol Metab 2006 91 439 46 16234304 source
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- cites [34] Mori TA Puddey IB Burke V Croft KD Dunstan DW Rivera JH Beilin LJ Effect of omega 3 fatty acids on oxidative stress in humans: GC-MS measurement of urinary F-2-isoprostane excretion Redox Report 2000 5 45 6 10905544 source
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May combine two claims.
InterpretationcitationStress and depression promote less healthy food choices that can increase inflammation.
“Thus, in general, stress and depression promote less healthy food choices that can boost inflammation.”
Quote in the paperSubstantial claim0 of 5 sources checked- cites [42] Adam TC Epel ES Stress, eating and the reward system Physiology & Behavior 2007 91 449 58 17543357 source
Not checked in the free run.
- cites [43] Wardle J Steptoe A Oliver G Lipsey Z Stress, dietary restraint and food intake J Psychosom Res 2000 48 195 202 10719137 source
Not checked in the free run.
- cites [44] Liu C Xie B Chou CP Koprowski C Zhou D Palmer P Sun P Guo Q Duan L Sun X Anderson Johnson C Perceived stress, depression and food consumption frequency in the college students of China Seven Cities Physiol Behav 2007 92 748 54 17585967 source
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- cites [45] Mikolajczyk RT El Ansari W Maxwell AE Food consumption frequency and perceived stress and depressive symptoms among students in three European countries Nutr J 2009 8 31 19604384 PMC2716364 source
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- cites [46] Eng PM Kawachi I Fitzmaurice G Rimm EB Effects of marital transitions on changes in dietary and other health behaviours in US male health professionals J Epidemiol Community Health 2005 59 56 62 15598728 PMC1763358 source
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Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dietary intake and the microbiome are potent modulators of inflammatory pathways.
“Finally, it is important to note that dietary intake and the microbiome are potent modulators of inflammatory pathways (Kiecolt-Glaser, 2010;Petra et al, 2015)”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Kiecolt-Glaser, 2010
The Abstract and ‘Diet and Inflammation’ section state that dietary components and dietary patterns influence inflammatory pathways. The discussion of bacterial endotoxins after high-fat meals does not establish that the microbiome itself modulates those pathways; the microbiome part of the claim is not supported by this paper. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPhysical activity bolsters mediating immune proteins and gene expression and more distal biological aging endpoints, such as mitochondrial health and telomerase levels, which are related to telomere maintenance.
“Physical activity also bolsters mediating immune proteins and gene expression (74,75) and more distal biological aging endpoints, such as mitochondrial health and telomerase levels (76–79), which are intimately related to telomere maintenance (20,80,81).”
From Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter (2015) · cites this paper as [81]
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Can Fasting Blunt Chemotherapy's Debilitating Side Effects?
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“Ghanim et al. (2004); Handschin and Spiegelman (2008); Hotamisligil (2006); Kiecolt-Glaser (2010); O’Connor et al. (2009); Yanbaeva et al. (2007); Yudkin et al. (2000)”
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“Marriage is a natural context to study how psychological stress and diet work additively and interactively to influence health, through effects on eating behavior and biological mediators like inflammation (Kiecolt-Glaser, 2010).”
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“…has been a dramatic shift toward a greater representation of n-6 (or omega 6) polyunsaturated fatty acids (PUFAs) in relation to n-3 fatty acids (Kiecolt-Glaser, 2010). n-3 fatty acids are found in large quantities in fish and fish oil extracts, and there is evidence that increased consumption…”
BackgroundInfluentialInflammation: The Common Pathway of Stress-Related Diseases
Liu, Y.-Z., Wang, Y.-X., & Jiang, C.-L. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00316 · Cited by 800 · see citing works
“Stress enhances both post-meal peaks of triglycerides and delays lipids clearance (Kiecolt-Glaser, 2010).”
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“The antiinflammatory properties of foods in the Healthy diet were shown to influence concentrations of monoamines, which are thought to play a role in the regulation of emotions and cognition (45).”
BackgroundInflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
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“Indeed, smoking promotes inflammation (101), as does consumption of high-fat and high-sugar foods (102) and sedentary behavior (103).”
BackgroundDietary patterns and depression risk: a meta-analysis
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“In contrast, it is suggested that a high intake of fruits, vegetables, fish, and whole grains provides less risk for the occurrence of depression [66] because the anti-inflammatory properties may reduce oxidative stress and neuronal damage [67].”
BackgroundSmith, K. J., Gavey, S., Riddell, N. E., Kontari, P., & Victor, C. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.002 · Cited by 341 · see citing works
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“Studies showed that inflammation is associated with a wide range of progressive diseases, such as metabolic disorder, cancer, Alzheimer’s and cardiovascular disease (Libby, 2007; Kiecolt-Glaser, 2010).”
BackgroundEffects of childhood abuse on adult obesity: a systematic review and meta‐analysis
Hemmingsson, E., Johansson, K., & Reynisdottir, S. (2014) · Obesity Reviews · doi:10.1111/obr.12216 · Cited by 265 · see citing works
“Upbringing conditions such as these can lead to psychological effects such as eating to suppress negative emotions, decreased executive function and cognitive flexibility, a disturbed sleeping pattern and unhealthy lifestyle choices in terms of diet and exercise (3,14,20,53).”
BackgroundThe theory of resilience and relational load
Afifi, T. D., Merrill, A. F., & Davis, S. M. (2016) · Personal Relationships · doi:10.1111/pere.12159 · Cited by 259 · see citing works
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
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“In terms of physiology, adipose tissue is a major source of pro-inflammatory cytokines, which fuels pre-existing inflammation even further (106), leading to multiple knock-on effects such as cognitive impairment and depression (87).”
BackgroundMatricon, J., Méleine, M., Gelot, A., Piche, T., Dapoigny, M. C., Muller, E., & Ardid, D. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12080 · Cited by 216 · see citing works
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“providing fluidity to neurons cell membrane) [27].”
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“In particular, stress can lead to a prolonged release of cortisol and subsequent activation of immune cells, especially neutrophils, followed by the production of free radicals (17, 18).”
BackgroundA family-oriented psychosocial intervention reduces inflammation in low-SES African American youth
Miller, G. E., Brody, G. H., Yu, T., & Chen, E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406578111 · Cited by 180 · see citing works
“Also of interest would be SAAF’s effects on other lifestyle factors, like dietary composition and physical activity, as well as deep abdominal fat, which is a major reservoir of inflammatory activity (24, 37, 40).”
BackgroundOddy, W. H., Allen, K. L., Trapp, G., Ambrosini, G. L., Black, L. J., Huang, R., Rzehak, P., Runions, K., Pan, F., Beilin, L. J., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.002 · Cited by 183 · see citing works
“2008) and postprandial hyperglycaemia can increase free radical production and pro-inflammatory cytokines, accelerating and stimulating depressive symptoms (Kiecolt-Glaser 2010), and potentially increasing irritability and aggression (Zalcman, Siegel.”
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“Increases of these inflammatory cytokines and the transcription factor NF-κβ have been associated with the development of mental health disorders and inhibition of these cytokines and NF-κβ has been suggested as a method of treatment [79–82].”
MethodPuterman, E., Lin, J., Krauss, J., Blackburn, E. H., & Epel, E. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.70 · Cited by 150 · see citing works
“19,20,78 There are suggestions of quite similar mechanistic bene fi ts of sleep 43,79,80 and nutrition 42,81 on stress-responsive systems.”
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“On one hand, stress typically induces a preference for a high-fat and high-sucrose (HFS) diet, which can dampen the cortisol stress response, giving rise to a state of emotional eating (46,47) as well as susceptibility for weight gain and metabolic dysfunction (40,47).”
BackgroundJaremka, L. M., Lindgren, M. E., & Kiecolt‐Glaser, J. K. (2013) · Depression and Anxiety · doi:10.1002/da.22078 · Cited by 137 · see citing works
“For example, people often eat poorly and stop exercising when they are stressed or depressed;[71, 144] both food and exercise influence inflammation.[133, 145] Researchers in these areas can investigate multiple hypotheses about the relationships among distress, health behaviors, and inflammation.”
BackgroundSelf-citationObesity, Dietary Factors, Nutrition, and Breast Cancer Risk
Seiler, A., Chen, M. A., Brown, R. L., & Fagundes, C. P. (2018) · Current Breast Cancer Reports · doi:10.1007/s12609-018-0264-0 · Cited by 131 · see citing works
“Meanwhile, diet can impact mood, as well as pro-inflammatory responses to stressors [68].”
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“Among these are cigarette smoking, heavy alcohol drinking, drug use, excessive eating of sugar and fat, lack of sleep, and physical inactivity (Burini et al., 2020; Hosseinzadeh et al., 2016; Kiecolt-Glaser, 2010; Loprinzi, 2016; Mullington et al., 2010; Raposa et al., 2014; Shields et al., 2017).”
BackgroundRosano, C., Marsland, A. L., & Gianaros, P. J. (2012) · Europe PMC (PubMed Central) · Cited by 109 · see citing works
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“In addition, recent studies report that a short term supplementation of nonstressed students with EPA/DHA triggers decreased anxiety symptoms and reduced LPS-induced IL-6 production by blood cells (Kiecolt-Glaser, 2010).”
Racial Disparities in the Health Benefits of Educational Attainment
Fuller‐Rowell, T. E., Curtis, D. S., Doan, S. N., & Coe, C. L. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000128 · Cited by 106 · see citing works
“Chronic stress exposure can result in low-grade systemic inflammation (2,4,5) and a dysregulated state of immune functioning associated with increased morbidity and cardiovascular disease mortality (6Y8).”
BackgroundKnight, E. L., Jiang, Y., Rodriguez-Stanley, J., Almeida, D. M., Engeland, C. G., & Zilioli, S. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.015 · Cited by 107 · see citing works
“…which result in increased exposure to endotoxin and pro-inflammatory signaling (de Punder & Pruimboom, 2015; Knight et al., 2020); and behavioral responses to stress, including consumption of high-fat diets, alcohol, and tobacco (Khan et al., 2019; Kiecolt-Glaser, 2010; Raposa et al., 2014).”
BackgroundHostinar, C. E., & Miller, G. E. (2019) · American Psychologist · doi:10.1037/amp0000520 · Cited by 99 · see citing works
“For instance, there is some emerging evidence that the negative effects of stress activation on the body can be contained and minimized after the fact by physical exercise and dietary factors such as antioxidants in fruits and vegetables (Kiecolt-Glaser, 2010).”
BackgroundThe Interplay between Maternal Nutrition and Stress during Pregnancy: Issues and Considerations
Lindsay, K. L., Buß, C., Wadhwa, P. D., & Entringer, S. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000457136 · Cited by 93 · see citing works
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“Chronic stress affects not only the quantity and timing of food intake but also the choice of foods, which may even lead to depression and inflammation and influence metabolic responses a human body undergoes in stress [22].”
BackgroundBreymeyer, K. L., Lampe, J. W., McGregor, B. A., & Neuhouser, M. L. (2016) · Appetite · doi:10.1016/j.appet.2016.08.008 · Cited by 85 · see citing works
“…symptom studies suggest that increased systemic inflammation and oxidative processes resulting from the western and processed foods diet patterns are major contributors to poor mood and depression symptoms (Akbaraly et al., 2009; Jacka et al., 2010; Kiecolt-Glaser, 2010; Shelton & Miller, 2010).”
BackgroundInfluentialChronic tonsillitis and biofilms: a brief overview of treatment modalities
Bakar, M. A., McKimm, J., Haque, S. Z., Majumder, M. A. A., & Haque, M. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s162486 · Cited by 90 · see citing works
Interleukin-6 in Schizophrenia—Is There a Therapeutic Relevance?
Borovčanin, M., Jovanović, I., Radosavljevic, G. D., Pantic, J. M., Janicijevic, S. M., Arsenijević, N., & Lukić, M. L. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00221 · Cited by 91 · see citing works
Basiouni, S., Téllez‐Isaías, G., Latorre, J. D., Graham, D. B., Petrone-García, V. M., El-Seedi, H. R., Yalçın, S., El‐Wahab, A. A., Visscher, C., May‐Simera, H., et al. (2023) · Veterinary Sciences · doi:10.3390/vetsci10010055 · Cited by 90 · see citing works
The Nature and Treatment of Pandemic-Related Psychological Distress
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“However, consequences of eating such foods include inflammation in the body, which has been linked to various health conditions such as depression (Kiecolt-Glaser 2010).”
BackgroundStress pathways to health inequalities: Embedding ACEs within social and behavioral contexts.
Nurius, P. S., Green, S., Logan‐Greene, P., Longhi, D., & Song, C. (2016) · PubMed · Cited by 87 · see citing works
The human biology – saturated with experience
Getz, L., Kirkengen, A. L., & Ulvestad, E. (2011) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.10.0874 · Cited by 82 · see citing works
Influence of Physical Exercise on Neuroimmunological Functioning and Health: Aging and Stress
Archer, T., Fredriksson, A., Schϋtz, E., & Kostrzewa, R. M. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9224-9 · Cited by 81 · see citing works
“Psychosocial stress–distress and self-destructive affect are associated with inflammatory biomarkers, including IL-6 and C-reactive protein (Huffman et al. 2010; Kiecolt-Glaser 2010; Kop et al. 2008; Slavich et al. 2010).”
BackgroundThe association between diet and mood: A systematic review of current literature
Arab, A., Mehrabani, S., Moradi, S., & Amani, R. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.014 · Cited by 80 · see citing works
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Salehin, S., Rasmussen, P., mai, S., Mushtaq, M., Agarwal, M., Hasan, S. M., Salehin, S., Raja, M. W., Gilani, S. A., & Khalife, W. I. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043337 · Cited by 83 · see citing works
“In recent years, it has come to light that processed sugars, refined starches and high concentrations of saturated fat can induce low-grade systemic inflammation [31].”
BackgroundWulsin, L. R., Herman, J. P., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.12.010 · Cited by 73 · see citing works
“, 2010), low-grade chronic inflammation (Kiecolt-Glaser, 2010; Tracey, 2002), and insulin resistance (Reaven, 1988).”
BackgroundWang, C.-J., Yang, T.-F., Wang, G., Zhao, Y., Yang, L., & Bi, B.-N. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.11.052 · Cited by 75 · see citing works
Relationships and Inflammation across the Lifespan: Social Developmental Pathways to Disease
Fagundes, C. P., Bennett, J. M., Derry, H. M., & Kiecolt‐Glaser, J. K. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00392.x · Cited by 76 · see citing works
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“Moreover, the above studies were conducted in the free-living environment, whichmeans that there was no control to determine the influence of potential confounders related to lifestyle changes during Ramadan month that may affect the measured biomarkers, such as energy consumption (78), sleep duration (79), and physic…”
BackgroundCOVID-19 and ethnicity: A novel pathophysiological role for inflammation
Vepa, A., Bae, J. P., Ahmed, F., Pareek, M., & Khunti, K. K. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.06.056 · Cited by 60 · see citing works
Effects and associations of nutrition in patients with venous leg ulcers: A systematic review
Barber, G. A., Weller, C. D., & Gibson, S. (2017) · Journal of Advanced Nursing · doi:10.1111/jan.13474 · Cited by 65 · see citing works
The Cambridge Handbook of Substance and Behavioral Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591 · Cited by 63 · see citing works
Suhett, L. G., Hermsdorff, H. H. M., Cota, B. C., Ribeiro, S. A. V., Shivappa, N., Hébert, J. R., Franceschini, S. D. C. C., & de Novaes, J. F. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1734911 · Cited by 58 · see citing works
“Another likely explanation involves the generation of oxidant compounds such as hydrogen peroxide and superoxide radicals during food metabolism, which, in turn, activate the NF-kB pathway, promoting inflammation (Kiecolt-Glaser 2010).”
BackgroundKiecolt-Glaser, J. K., Fagundes, C. P., Andridge, R., Peng, J., Malarkey, W. B., Habash, D., & Belury, M. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.149 · Cited by 54 · see citing works
“Correspondence: Professor JK Kiecolt-Glaser, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, 460 Medical Center Drive, Columbus, OH 43210, USA. E-mail: Janice.Kiecolt-Glaser@osumc.edu Received 15 February 2016; revised 27 May 2016; accepted 18 July 2016 Molecular Psychiatry (…”
BackgroundSelf-citationHow lifestyle factors and their associated pathogenetic mechanisms impact psoriasis
Madden, S. K., Flanagan, K. L., & Jones, G. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.05.006 · Cited by 54 · see citing works
Jiang, W., Mo, M., Li, M., Wang, S., Muyiduli, X., Shao, B., Jiang, S. S., & Yu, Y. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13728 · Cited by 52 · see citing works
“Evidence from studies supports the fact that there is a recursive, bidirectional relationship between mental health and nutrition of nonpregnant humans.(31,32) The possible reverse association that depression and anxiety can interfere in dietary diversity cannot be neglected.”
ResultHolland, T. M., Agarwal, P., Wang, Y., Dhana, K., Leurgans, S. E., Shea, K., Booth, S. L., Rajan, K. B., Schneider, J. A., & Barnes, L. L. (2022) · Neurology · doi:10.1212/wnl.0000000000201541 · Cited by 54 · see citing works
López-Olivares, M., Mohatar-Barba, M., Fernández-Gómez, E., & Enrique-Mirón, C. (2020) · Nutrients · doi:10.3390/nu12061826 · Cited by 55 · see citing works
Arouca, A. B., Michels, N., Moreno, L. A., González‐Gil, E. M., Marcos, A., Gómez‐Martínez, S., Díaz, L. E., Widhalm, K., Molnár, D., Μanios, Y., et al. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1457-4 · Cited by 55 · see citing works
Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2013
Maraldi, T., Vauzour, D., & Angeloni, C. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/576363 · Cited by 53 · see citing works
“Caffeic acid has been reported to have neuroprotective effects against Aβ-induced neurotoxicity in vitro and to inhibit peroxynitrite-induced neuronal injury [78–80].”
BackgroundInfluentialIntake of Mediterranean foods associated with positive affect and low negative affect
Ford, P. A., Jaceldo‐Siegl, K., Lee, J. W., Youngberg, W. S., & Tonstad, S. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.11.002 · Cited by 50 · see citing works
Milaneschi, Y., Bandinelli, S., Penninx, B. W. J. H., Vogelzangs, N., Corsi, A. M., Lauretani, F., Kisialiou, A., Vazzana, R., Terracciano, A., Guralnik, J. M., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.113 · Cited by 51 · see citing works
Graham, A. M., Doyle, O. J., Tilden, E. L., Sullivan, E. L., Gustafsson, H., Marr, M. C., Allen, M. C., & Seghete, K. L. M. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.10.012 · Cited by 54 · see citing works
“Psychological stress is purported to be related to dietary intake via alterations in food choices, in hormones that regulate hunger and satiety, and in digestive processes (see 142 for a more thorough discussion of these points).”
Karabatsiakis, A., & Schönfeldt‐Lecuona, C. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00901-7 · Cited by 52 · see citing works
Restorative Biological Processes and Health
Robles, T. F., & Carroll, J. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00368.x · Cited by 51 · see citing works
“In addition, the essential building blocks that are provided by diet and nutrition to promote growth are key mediators (Kiecolt-Glaser, 2010).”
BackgroundAlmeneessier, A. S., BaHammam, A. A., Alzoghaibi, M. A., Olaish, A. H., Nashwan, S. Z., & BaHammam, A. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226034 · Cited by 51 · see citing works
“Additionally, all previous studies did not control for factors shown to affect the levels of the measured biomarkers, such as caloric intake [7], sleep duration [8], and energy expenditure [11].”
BackgroundReed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48 · see citing works
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
Derevensky, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.024 · Cited by 45 · see citing works
Considering the Overlap and Nonoverlap of Compulsivity, Impulsivity, and Addiction
Blum, A. W., & Grant, J. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.038 · Cited by 44 · see citing works
Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45 · see citing works
Mindfulness-Based Interventions Applied to Addiction Treatments
Kechter, A., & Black, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.040 · Cited by 43 · see citing works
Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
Stacy, A. W., Pike, J. R., & Lee, A. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.017 · Cited by 43 · see citing works
Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44 · see citing works
Sensitization of Incentive Salience and the Transition to Addiction
Warlow, S. M., Baumgartner, H. M., Freeland, C. M., Naffziger, E. E., Olney, J. J., Berridge, K. C., & Robinson, M. J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.006 · Cited by 45 · see citing works
Tanning as an Addiction: The State of the Research and Implications for Intervention
Miller, K. A., & Mays, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.037 · Cited by 43 · see citing works
Schulte, E. M., Schiestl, E. T., & Gearhardt, A. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.035 · Cited by 43 · see citing works
Johnson, C. S. C., Shively, C. A., Michalson, K. T., Lea, A. J., DeBo, R. J., Howard, T. D., Hawkins, G. A., Appt, S. E., Liu, Y., McCall, C. E., et al. (2021) · eLife · doi:10.7554/elife.68293 · Cited by 46 · see citing works
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42 · see citing works
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42 · see citing works
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42 · see citing works
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42 · see citing works
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42 · see citing works
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
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Unveiling stress markers: A systematic review investigating psychological stress biomarkers
Shah, K., Kumari, R., & Jain, M. (2024) · Developmental Psychobiology · doi:10.1002/dev.22490 · Cited by 51 · see citing works
Allostatic load and systemic comorbidities in psychiatric disorders
Finlay, S., Rudd, D., McDERMOTT, B. M., & Sarnyai, Z. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105726 · Cited by 41 · see citing works
Omega-3 fatty acids and stress-induced changes to mood and cognition in healthy individuals
Giles, G. E., Mahoney, C. R., Urry, H. L., Brunyé, T. T., Taylor, H. A., & Kanarek, R. B. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.02.018 · Cited by 38 · see citing works
“Stress and depression, as well as dietary composition akin to the Western diet with high n-6 to n-3 PUFA ratio, have been shown to influence inflammation through the same pathways (Kiecolt-Glaser, 2010).”
BackgroundInfluentialCan we vaccinate against depression?
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Neuro-, Cardio-, and Immunoplasticity: Effects of Early Adversity
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Focus on disability-free life expectancy: implications for health-related quality of life
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Omega-3 fatty acids influence mood in healthy and depressed individuals
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Individual and Neighborhood Socioeconomic Status and Inflammation in Mexican American Women
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Implications of altered iron homeostasis for age-related macular degeneration
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- Authors
- Kiecolt-Glaser, J. K.
- Venue
- Psychosomatic Medicine
- Published
- 2010-05
- Volume
- 72
- Issue
- 4
- Pages
- 365-369
- ISSN
- 0033-3174 (ISSN-L)
- PMC
- PMC2868080
- OpenAlex
- W1988667864
- Cited by
- 310
- References
- 62
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 17 · 2023: 18 · 2022: 23 · 2021: 15 · 2020: 65 · 2019: 16 · 2018: 22 · 2017: 18 · 2016: 13 · 2015: 9 · 2014: 13 · 2013: 19 · 2012: 23
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG029562, AG029562)
- National Cancer Institute (CA126857, R01CA126857, CA131029, R01CA131029)
- National Center for Research Resources (UL1RR025755)
- National Center for Complementary and Integrative Health (R21AT003912, AT003912)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- psychoneuroimmunology, inflammation, stress, diet, depression, vagus nerve, vagal tone, omega-3 fatty acids, NF-κB, oxidative stress, inflammatory cytokines, lipopolysaccharide response, gut-brain axis, food choice, mood
- MeSH terms
- C-Reactive Protein, Cause of Death, Diet, Eating, Fatty Acids, Unsaturated, Humans, Inflammation, Nutritional Physiological Phenomena, Psychoneuroimmunology, Stress, Psychological, Tumor Necrosis Factor-alpha, Fatty Acids, Omega-3
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