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Prospective study of abdominal adiposity and gallstone disease in US men
Abstract
Background Obesity is an established risk factor for gallstones, but whether abdominal adiposity contributes independently to the risk, particularly in men, remains unclear. Objective The purpose of the study was to examine the associations of abdominal circumference and waist-to-hip ratio, as measures of abdominal adiposity, with the risk of symptomatic gallstone disease in men. Design We prospectively studied measures of abdominal obesity in relation to the incidence of symptomatic gallstone disease in a cohort of 29 847 men who were free of prior gallstone disease and who provided complete data on waist and hip circumferences. Data on weight, height, and waist and hip circumferences were collected in 1986 and in 1987 through self-administered questionnaires. As part of the Health Professionals Follow-Up Study, men reported newly diagnosed symptomatic gallstone disease on questionnaires mailed to them every 2 y. Results We documented 1117 new cases of symptomatic gallstone disease during 264 185 person-years of follow-up. After adjustment for body mass index and other known or suspected risk factors for gallstones, men with a height-adjusted waist circumference > or = 102.6 cm (40.4 in) had a relative risk of 2.29 (95% CI: 1.69, 3.11; P for trend or = 0.99 had a multivariate relative risk of 1.78 (1.38, 2.28; P for trend Conclusions Our data suggest the presence of a significant association between abdominal adiposity and the incidence of symptomatic gallstone disease. As m…
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Increased risk associated with abdominal adiposity can occur independently of BMI.
“The increased risk associated with abdominal adiposity can occur independently of BMI, as illustrated in 2 cohorts from the USA [10,11].”
From Excess Body Weight and Gallstone Disease (2021) · cites this paper as [11]
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Excess Body Weight and Gallstone Disease
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Metadata
- Authors
- Tsai, C.-J., Leitzmann, M. F., Willett, W. C., & Giovannucci, E. L.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 80
- Issue
- 1
- Pages
- 38-44
- ISSN
- 0002-9165
- Cited by
- 145
- References
- 3
- Language
- en
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