Effect of soy protein varying in isoflavone content on serum lipids in healthy young men

McVeigh, Brianne L; Dillingham, Barbara L; Lampe, Johanna W; Duncan, Alison M

doi:10.1093/ajcn/83.2.244

Cited by 88Phytoestrogen effects and researchLipoproteins and Cardiovascular HealthPhytochemicals and Antioxidant Activities

Effect of soy protein varying in isoflavone content on serum lipids in healthy young men

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McVeigh, Brianne L, Dillingham, Barbara L, Lampe, Johanna W, Duncan, Alison M·2006·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/83.2.244

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Abstract

Background Previous research supports a role for soy protein in reducing serum lipids; however, few studies involved healthy male subjects or focused on soy isoflavones (or did both).Objective The objective was to ascertain the effects of soy protein varying in isoflavone content on serum lipids in healthy young men.Design Thirty-five males (x +/- SD age: 27.9 +/- 5.7 y) consumed milk protein isolate (MPI), low-isoflavone soy protein isolate (low-iso SPI; 1.64 +/- 0.19 mg aglycone isoflavones/d), and high-isoflavone SPI (high-iso SPI; 61.7 +/- 7.4 mg aglycone isoflavones/d) for 57 d each, separated by 4-wk washout periods, in a randomized crossover design. Blood samples were collected at the beginning and end of each treatment period, and total, LDL, and HDL cholesterol; triacylglycerols; apolipoprotein (apo) B; apo A-I; and C-reactive protein (CRP) were measured in serum. Twenty-four-hour urine samples were collected for 3 consecutive days at the end of each treatment period and analyzed for isoflavones.Results Urinary isoflavones were significantly greater with consumption of the high-iso SPI than with that of the low-iso SPI or MPI. The differences between the 3 treatments with respect to individual serum lipids were not significant, but the ratios of total to HDL cholesterol, LDL to HDL cholesterol, and apo B to apo A-I were significantly lower with both SPI treatments than with MPI treatment.Conclusion Soy protein, regardless of isoflavone content, modulates serum lipid ratios in a direction beneficial for cardiovascular disease risk in healthy young men.

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In a large Swedish study, linoleic acid in cholesteryl esters is inversely associated with CRP concentration.
“although a large Swedish study reported an inverse association between linoleic acid in cholesteryl esters and CRP concentration (582)”
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“The concentration of a-linolenic acid in blood lipids (578,579,582) or granulocytes (374) was not associated with CRP or IL-6 concentration.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [582]

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Authors: McVeigh, B. L., Dillingham, B. L., Lampe, J. W., & Duncan, A. M.
Affiliations: Fred Hutch Cancer Center (US)
Corresponding author: Duncan, Alison M
ORCID: Lampe, Johanna W
Duncan, Alison M
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2006-02
Volume: 83
Issue: 2
Pages: 244-251
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/83.2.244
OpenAlex: W2106002029
Cited by: 88
References: 51
Citations by year: 2026: 2 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 6 · 2013: 5 · 2012: 7
FWCI: 6.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6238 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: soy protein, soy isoflavones, serum lipids, soy protein isolate, milk protein isolate, cardiovascular risk, healthy young men
MeSH terms: Adult, Apolipoproteins B, C-Reactive Protein, Cardiovascular Diseases, Cholesterol, Dose-Response Relationship, Drug, Humans, Isoflavones, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Risk Factors, Triglycerides, Apolipoprotein A-I, Cross-Over Studies, Soybean Proteins

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Effect of soy protein varying in isoflavone content on serum lipids in healthy young men

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