Associations of the Mediterranean diet with cognitive and neuroimaging phenotypes of dementia in healthy older adults
Open accessAbstract
Background Accumulating evidence suggests that higher Mediterranean diet (MedDiet) adherence is associated with higher global cognitive performance and brain structural integrity as well as decreased risk of Alzheimer disease (AD) and vascular dementia (VaD). Objectives We directly examined cross-sectional associations between the MedDiet and cognitive and neuroimaging phenotypes associated with AD and VaD (separately) in a cohort of nondemented, nondepressed older adults. Methods Community-dwelling older adults (n = 82; aged ∼68.8 y; 50% female, 50% minority) underwent dietary (Block Food Frequency Questionnaire 2005) and neuropsychological assessments and neuroimaging. MedDiet scores were quantified with the use of published criteria, and participants were divided into High and Low (median split) adherence groups. We focused our neuropsychological investigation on cognitive phenotypes primarily associated with AD [i.e., learning and memory (L&M)] and VaD (i.e., information processing and executive functioning). AD neuroimaging phenotypes consisted of hippocampal and dentate gyrus volumes quantified using T1-weighted images and the FreeSurfer 6.0 segmentation pipeline (http://surfer.nmr.mgh.harvard.edu). The VaD neuroimaging phenotype consisted of total white matter hyperintensity (WMH) volumes quantified using combined T1-weighted and T2-fluid-attenuated inversion recovery images. Neuroimaging metrics were adjusted for total intracranial volume. Separate multivariable linea…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human intervention studies have shown that consumption of a Mediterranean diet can dramatically reduce the incidence of neurodegenerative disorders, psychiatric conditions, cancer, and cardiovascular disease.
“Human intervention studies have shown that the consumption of a Mediterranean diet can dramatically reduce the incidence of neurodegenerative disorders (Karstens et al., 2019;Romagnolo and Selmin, 2017;Scarmeas et al., 2006), psychiatric conditions, cancer (Schwingshackl et al., 2017) and cardiovascular disease (CVD (Bonaccio et al., 2013;Tsivgoulis et al., 2015;Wu and Sun, 2017)).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Karstens et al., 2019
Cites
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324 · see citing works
Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature
Destrieux, C., Fischl, B., Dale, A., & Halgren, E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.010 · Cited by 2,956 · see citing works
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992 · see citing works
Probability of stroke: a risk profile from the Framingham Study.
Wolf, P. A., D'Agostino, R. B., Belanger, A. J., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.3.312 · Cited by 1,782 · cited 1× · see citing works
“To assess stroke risk, a modified Framingham Stroke Risk Profile (mFSRP; age not included) was calculated using information obtained by trained staff in the Center for Clinical and Translational Science’s Clinical Research Center at UIC including systolic blood pressure, hypertension medication, diabetes mellitus, cur…”
MethodValidation of a self-administered diet history questionnaire using multiple diet records
Block, G., Woods, M., Potosky, A., & Clifford, C. (1990) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(90)90099-b · Cited by 1,197 · see citing works
Dinu, M., Pagliai, G., Casini, A., & Sofi, F. (2018) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.58 · Cited by 1,016 · see citing works
Alzheimer's disease drug development pipeline: 2017
Cummings, J., Lee, G., Mortsdorf, T., Ritter, A., & Zhong, K. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.05.002 · Cited by 549 · cited 2× · see citing works
“85), we created High and Low self-reported MedDiet adherence groups based on the median split [dummy-coded high (1) and low (0)].”
BackgroundMethodAdherence to a Mediterranean-type dietary pattern and cognitive decline in a community population
Tangney, C. C., Kwasny, M. J., Li, H., Wilson, R. S., Evans, D. A., & Morris, M. C. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007369 · Cited by 397 · see citing works
Loughrey, D. G., Lavecchia, S., Brennan, S., Lawlor, B. A., & Kelly, M. E. (2017) · Advances in Nutrition · doi:10.3945/an.117.015495 · Cited by 250 · see citing works
Alzheimer’s disease and hippocampal adult neurogenesis; exploring shared mechanisms
Hollands, C., Bartolotti, N., & Lazarov, O. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00178 · Cited by 160 · see citing works
Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
Staubo, S. C., Aakre, J. A., Vemuri, P., Syrjanen, J. A., Mielke, M. M., Geda, Y. E., Kremers, W. K., Machulda, M. M., Knopman, D. S., Petersen, R. C., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.06.2359 · Cited by 147 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline
Rajaram, S., Jones, J., & Lee, G. J. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz081 · Cited by 235 · see citing works
Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age
Ballarini, T., Melo van Lent, D., Brunner, J., Schröder, A., Wolfsgruber, S., Altenstein, S., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012067 · Cited by 153 · see citing works
Sánchez-Sánchez, M. L., García-Vigara, A., Hidalgo-Mora, J. J., García-Pérez, M.-Á., Tarín, J., & Cano, A. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.03.008 · Cited by 137 · see citing works
Dietary Patterns and Alzheimer’s Disease: An Updated Review Linking Nutrition to Neuroscience
Ellouze, I., Sheffler, J., Nagpal, R., & Arjmandi, B. (2023) · Nutrients · doi:10.3390/nu15143204 · Cited by 104 · see citing works
- Authors
- Karstens, A. J., Tussing-Humphreys, L., Zhan, L., Rajendran, N., Cohen, J., Dion, C., Zhou, X. J., & Lamar, M.
- Affiliations
- University of Illinois Chicago (US)
- University of Wisconsin–Stout (US)
- Rush University Medical Center (US)
- University of Pittsburgh (US)
- University of Florida Health (US)
- Corresponding author
- Lamar, Melissa
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 109
- Issue
- 2
- Pages
- 361-368
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC6367961
- OpenAlex
- W2914698268
- Cited by
- 136
- References
- 13
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 17 · 2023: 23 · 2022: 27 · 2021: 23 · 2020: 18 · 2019: 8
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (K01 AG040192, R21 AG048176, 1S10RR028898)
- National Heart, Lung, and Blood Institute (R01 HL129153)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- Mediterranean diet, dietary adherence, Alzheimer's disease, vascular dementia, cognitive phenotypes, hippocampal volume, dentate gyrus, white matter hyperintensities, learning and memory, executive function, information processing, older adults, brain structural integrity
- MeSH terms
- Aged, Alzheimer Disease, Brain, Energy Intake, Cognition, Cognition Disorders, Cross-Sectional Studies, Dementia, Female, Humans, Male, Memory, Mental Processes, Neuropsychological Tests, Phenotype, Cohort Studies, Linear Models, Diet, Mediterranean, Executive Function, Neuroimaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
