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Cited by 85Parkinson's Disease Mechanisms and TreatmentsSleep and Work-Related FatigueCircadian rhythm and melatonin

A prospective study of night shift work, sleep duration, and risk of Parkinson's disease

Chen, Honglei, Schernhammer, Eva, Schwarzschild, Michael A., Ascherio, Alberto·2006·American Journal of Epidemiology
DOI 10.1093/aje/kwj096
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Abstract

The authors prospectively investigated whether working rotating night shifts was associated with the risk of Parkinson's disease among 84,794 female nurses who reported years of night shift work in 1988 (the US Nurses' Health Study). After 975,912 person-years of follow-up (1988-2000), 181 incident Parkinson's disease cases were documented. Compared with nurses who never worked rotating night shifts, those with 15 years or more of night shift work had a 50% lower risk of Parkinson's disease after adjustment for age and smoking (95% confidence interval: 0.26, 0.97; p(trend) = 0.01). Sleep duration was positively associated with Parkinson's disease risk: The relative risk was 1.84 (95% confidence interval: 0.99, 3.42) when comparing nurses who reported 9 or more hours of sleep per day with those who slept 6 hours or less (p(trend) = 0.005). These data suggest that working night shifts may be protective against Parkinson's disease or that low tolerance for night shift work is an early marker of Parkinson's disease. Conversely, habitual longer sleep duration may be an earlier marker of Parkinson's disease. Because of the novelty and the exploratory nature of these findings, confirmation is needed.

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  • Shift work makes workers change their bed time frequently, which leads to sleeping problems like poor sleep quality, followed by disturbance of chronobiological rhythms.

    “Second, shift work makes the workers change their bed time frequently, 41 which leads to sleeping problems like poor sleep quality, followed by the disturbance of the chronobiological rhythms.42 43”

    From Shift work and diabetes mellitus: a meta-analysis of observational studies (2015) · cites this paper as [41]

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Authors
Chen, H., Schernhammer, E., Schwarzschild, M. A., & Ascherio, A.
Affiliations
  • National Institutes of Health (US)
  • Brigham and Women's Hospital (US)
  • Massachusetts General Hospital (US)
Corresponding author
Chen, Honglei
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2006-02-22
Volume
163
Issue
8
Pages
726-730
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/kwj096
OpenAlex
W2098260062
Cited by
85
References
30
Citations by year
2026: 2 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA-87969, P01CA087969)
  • National Institute of Neurological Disorders and Stroke (NS48468, K08NS048468, NS 35624, R01NS035624)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
Parkinson's disease, night shift work, rotating night shifts, sleep duration, nurses, occupational risk factors, disease risk markers, shift work
MeSH terms
Alcohol Drinking, Anti-Inflammatory Agents, Non-Steroidal, Circadian Rhythm, Coffee, Female, Humans, Nurses, Parkinson Disease, Prospective Studies, Risk Factors, Sleep Deprivation, Work Schedule Tolerance, Body Mass Index, Incidence, Proportional Hazards Models, Risk Assessment

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