The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cytomegalovirus Infection and the Risk of Mortality and Frailty in Older Women: A Prospective Observational Cohort Study
Open accessAbstract
Cytomegalovirus (CMV), a prevalent pathogen, causes severe disease in immunocompromised humans. However, present understanding is limited regarding the long-term clinical effect of persistent CMV infection in immunocompetent adults. The authors conducted a prospective observational cohort study (1992-2002) of 635 community-dwelling women in Baltimore, Maryland, aged 70-79 years in the Women's Health and Aging Studies to examine the effect of CMV infection on the risk of frailty, a common geriatric syndrome, and mortality in older women. The effect of baseline serum CMV antibody (immunoglobulin G) concentration on the risk of 3-year incident frailty, defined by using a 5-component measure, and 5-year mortality was examined with Cox proportional hazards models. Compared with those who were CMV seronegative, women in the highest quartile of CMV antibody concentration had a greater incidence of frailty (hazard ratio = 3.46, 95% confidence interval: 1.45, 8.27) and mortality (hazard ratio = 3.81, 95% confidence interval: 1.64, 8.83). After adjustment for potential confounders, CMV antibody concentration in the highest quartile independently increased the risk of 5-year mortality (hazard ratio = 2.79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Self-citationProportional hazards tests and diagnostics based on weighted residuals
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Self-citationPartial residuals for the proportional hazards regression model
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Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
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Phenotype of frailty: characterization in the women's health and aging studies
Bandeen-Roche, K., Xue, Q.-L., Ferrucci, L., Walston, J., Guralnik, J. M., Chaves, P., Zeger, S. L., & Fried, L. P. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.3.262 · Cited by 1,215
Self-citationChronic infections and coronary heart disease: is there a link?
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Seroprevalence of Cytomegalovirus Infection in the United States, 1988-1994
Staras, S. A. S., Dollard, S. C., Radford, K. W., Flanders, W. D., Pass, R. F., & Cannon, M. J. (2006) · Clinical Infectious Diseases · doi:10.1086/508173 · Cited by 1,007
Associations of Subclinical Cardiovascular Disease With Frailty
Newman, A. B., Gottdiener, J. S., McBurnie, M. A., Hirsch, C. H., Kop, W. J., Tracy, R., Walston, J. D., & Fried, L. P. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m158 · Cited by 809
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Cited by
HIV Infection, Inflammation, Immunosenescence, and Aging
Deeks, S. G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042909-093756 · Cited by 1,349
Leng, S., Chen, X., & Mao, G. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s45300 · Cited by 991
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Collerton, J., Martin-Ruiz, C., Davies, K., Hilkens, C. M., Isaacs, J., Kolenda, C., Parker, C., Dunn, M., Catt, M., Jagger, C., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.005 · Cited by 420
Cytomegalovirus infection enhances the immune response to influenza
Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa2293 · Cited by 332
Metadata
- Authors
- Wang, G. C., Kao, W. H. L., Murakami, P., Xue, Q.-L., Chiou, R. B., Detrick, B., McDyer, J. F., Semba, R. D., Casolaro, V., Walston, J. D., & Fried, L. P.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04-16
- Volume
- 171
- Issue
- 10
- Pages
- 1144-1152
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2154123565
- Cited by
- 265
- References
- 37
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, G. C., Kao, W. H. L., Murakami, P., Xue, Q.-L., Chiou, R. B., Detrick, B., McDyer, J. F., Semba, R. D., Casolaro, V., Walston, J. D., & Fried, L. P. (2010). Cytomegalovirus Infection and the Risk of Mortality and Frailty in Older Women: A Prospective Observational Cohort Study. American Journal of Epidemiology. https://doi.org/10.1093/aje/kwq062
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
