The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Physical Activity, Sedentary Behavior, and Leukocyte Telomere Length in Women
Open accessAbstract
Leukocyte telomere length (LTL) is a potential indicator of cellular aging; however, its relation to physical activity and sedentary behavior is unclear. The authors examined cross-sectionally associations among activity, sedentary behavior, and LTL among 7,813 women aged 43-70 years in the Nurses' Health Study. Participants self-reported activity by questionnaire in 1988 and 1992 and sedentary behavior in 1992. Telomere length in peripheral blood leukocytes, collected in 1989-1990, was measured by quantitative polymerase chain reaction. The least-squares mean telomere length (z-score) was calculated after adjustment for age and other potential confounders. For total activity, moderately or highly active women had a 0.07-standard deviation (SD) increase in LTL (2-sided P(trend) = 0.02) compared with those least active. Greater moderate- or vigorous-intensity activity was also associated with increased LTL (SD = 0.11 for 2-4 vs. <1 hour/week and 0.04 for ≥7 vs. <1 hour/week; 2-sided P(trend) = 0.02). Specifically, calisthenics or aerobics was associated with increased LTL (SD = 0.10 for ≥2.5 vs. 0 hours/week; 2-sided P(trend) = 0.04). Associations remained after adjustment for body mass index. Other specific activities and sitting were unassociated with LTL. Although associations were modest, these findings suggest that even moderate amounts of activity may be associated with longer telomeres, warranting further investigation in large prospective studies.
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Cites
Compendium of Physical Activities: Classification of energy costs of human physical activities
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Accelerated telomere shortening in response to life stress
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“The reproducibility and validity of these questions have been described elsewhere (27).”
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“In the NHS, physical activity was significantly associated with decreased risk of breast (28) and colorectal (29) cancers, coronary heart disease (30), and type 2 diabetes (31), while sedentary behaviors increased risk of type 2 diabetes and obesity (21).”
BackgroundLeukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
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The rate of telomere sequence loss in human leukocytes varies with age
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Cited by
Social determinants and health behaviors: conceptual frames and empirical advances
Short, S. E., & Mollborn, S. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2015.05.002 · Cited by 566
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Duggal, N. A., Niemiro, G., Harridge, S. D. R., Simpson, R. J., & Lord, J. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0177-9 · Cited by 436
Ornish, D., Lin, J., Chan, J. M., Epel, E., Kemp, C., Weidner, G., Marlin, R., Frenda, S. J., Magbanua, M. J. M., Daubenmier, J., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70366-8 · Cited by 390
Chronic Kidney Disease: A Clinical Model of Premature Aging
Stenvinkel, P., & Larsson, T. E. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.11.051 · Cited by 296
Physical activity and telomere length: Impact of aging and potential mechanisms of action
Arsenis, N. C., You, T., Ogawa, E. F., Tinsley, G. M., & Zuo, L. (2017) · Oncotarget · doi:10.18632/oncotarget.16726 · Cited by 288
Metadata
- Authors
- Du, M., Prescott, J., Kraft, P., Han, J., Giovannucci, E., Hankinson, S. E., & De Vivo, I.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-01
- Volume
- 175
- Issue
- 5
- Pages
- 414-422
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2162224061
- Cited by
- 183
- References
- 18
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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