Association of Antepartum and Postpartum Depression in Ghanaian and Ivorian Women With Febrile Illness in Their Offspring: A Prospective Birth Cohort Study
Abstract
In low-income countries, perinatal depression is common, but longitudinal data on its influence on child health are rare. We examined the association between maternal depression and febrile illness in children. There were 654 mother/child dyads in Ghana and Côte d'Ivoire that were enrolled in a prospective birth cohort in 2010-2011 and underwent 2-years of follow up. Mothers were examined for depression using the Patient Health Questionnaire depression module antepartum and 3 and 12 months postpartum. The hazard of febrile illness in children of depressed and nondepressed mothers was estimated using a recurrent event Cox proportional hazards model. The prevalences of antepartum depression in mothers from Côte d'Ivoire and Ghana were 28.3% and 26.3%, respectively. The prevalences of depression at 3 and 12 months postpartum were 11.8% and 16.1% (Côte d'Ivoire) and 8.9% and 7.2% (Ghana). The crude and adjusted (for country and socioeconomic status) hazard ratios of febrile illness in children of depressed mothers compared with those in children of nondepressed mothers were 1.57 (95% confidence interval: 1.20, 2.07) and 1.32 (95% confidence interval: 1.01, 1.74) respectively. Perinatal depression was frequent and associated with febrile illness in the offspring. Our results showed that a high prevalence of depression in sub-Saharan Africa may pose a serious public health threat to women and their offspring.
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Maternal postpartum depression was robustly and predictively associated with febrile disease in children.
“One study indicated a robust and predictive association between maternal PPD and febrile disease in children.135”
From Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes (2019) · cites this paper as [135]
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Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes
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- Authors
- Guo, N., Bindt, C., Te Bonle, M., Appiah-Poku, J., Hinz, R., Barthel, D., Koffi, M., Posdzich, S., Deymann, S., Barkmann, C., Schlüter, L., Jaeger, A., Blay Nguah, S., Eberhardt, K. A., N'Goran, E., Tagbor, H., Ehrhardt, S., for the International CDS Study Group, Baum, J., Burchard, G. D., Claussen, L., Ewert, H., Feldt, T., Fordjour, D., Hahn, A., Koffi, J. E., Kra, E., Loag, W., May, J., Mohammed, Y., Osei, Y., Reime, B., Schoppen, S., & Tannich, E.
- Affiliations
- Johns Hopkins University (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
- Université Jean Lorougnon Guédé (CI)
- Université Félix Houphouët-Boigny (CI)
- Kwame Nkrumah University of Science and Technology (GH)
- Corresponding author
- Ehrhardt, Stephan
- ORCID
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09-07
- Volume
- 178
- Issue
- 9
- Pages
- 1394-1402
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2117089929
- Cited by
- 72
- References
- 44
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 6 · 2014: 5 · 2013: 1
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Repository of Futwangen University of Applied Sciences (Furtwangen University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- perinatal depression, antenatal depression, postpartum depression, maternal depression, childhood febrile illness, child health, mother-child dyads, sub-Saharan Africa, Ghana, Côte d'Ivoire, socioeconomic status
- MeSH terms
- Adult, Age Factors, Breast Feeding, Depression, Depressive Disorder, Female, Fever, Ghana, Health Status, Humans, Infant, Infant, Newborn, Cote d'Ivoire, Mothers, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Prospective Studies, Residence Characteristics, Risk Factors, Social Class, Prevalence, Depression, Postpartum
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