Maternal Consumption of Seafood in Pregnancy and Child Neuropsychological Development: A Longitudinal Study Based on a Population With High Consumption Levels
Open accessAbstract
Seafood consumption during pregnancy is thought to be beneficial for child neuropsychological development, but to our knowledge no large cohort studies with high fatty fish consumption have analyzed the association by seafood subtype. We evaluated 1,892 and 1,589 mother-child pairs at the ages of 14 months and 5 years, respectively, in a population-based Spanish birth cohort established during 2004-2008. Bayley and McCarthy scales and the Childhood Asperger Syndrome Test were used to assess neuropsychological development. Results from multivariate linear regression models were adjusted for sociodemographic characteristics and further adjusted for umbilical cord blood mercury or long-chain polyunsaturated fatty acid concentrations. Overall, consumption of seafood above the recommended limit of 340 g/week was associated with 10-g/week increments in neuropsychological scores. By subtype, in addition to lean fish, consumption of large fatty fish showed a positive association; offspring of persons within the highest quantile (>238 g/week) had an adjusted increase of 2.29 points in McCarthy general cognitive score (95% confidence interval: 0.42, 4.16). Similar findings were observed for the Childhood Asperger Syndrome Test. Beta coefficients diminished 15%-30% after adjustment for mercury or long-chain polyunsaturated fatty acid concentrations. Consumption of large fatty fish during pregnancy presents moderate child neuropsychological benefits, including improvements in cognitive functioning and some protection from autism-spectrum traits.
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This research is equally counterbalanced, with two studies each both identifying and failing to identify an association between maternal omega 3/omega 6 intake or status and autism related outcomes.
“This research is equally counterbalanced, with two studies each both identifying and failing to identify an association between maternal omega 3/omega 6 intake or status and autism related outcomes [240–242].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [242]
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- Hospital San Agustín, Avilés, Asturias, Spain (Isolina 180 Julvez et al. Am J Epidemiol. 2016;183(3):169-182 REFERENCES
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- Authors
- Julvez, J., Méndez, M., Fernandez-Barres, S., Romaguera, D., Vioque, J., Llop, S., Ibarluzea, J., Guxens, M., Avella-Garcia, C., Tardón, A., Riaño, I., Andiarena, A., Robinson, O., Arija, V., Esnaola, M., Ballester, F., & Sunyer, J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Barcelona Biomedical Research Park (ES)
- Universitat de València (ES)
- Universidad de Oviedo (ES)
- University of the Basque Country (ES)
- Universitat Pompeu Fabra (ES)
- ORCID
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01-05
- Volume
- 183
- Issue
- 3
- Pages
- 169-182
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2264936145
- Cited by
- 124
- References
- 27
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 13 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 15 · 2019: 17 · 2018: 20 · 2017: 13 · 2016: 6
- FWCI
- 19.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion, other-oa)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Rovira & Virgili repository (submittedVersion, cc-by)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- HighWire Press Open Archive (submittedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- UNC Libraries
- Funders
- Spanish Institute of Health Carlos III (Ministry of Economy and Competitiveness)
- Infancia y Medio Ambiente (INMA) Network (G03/176, CB06/02/0041)
- Fondo de Investigación Sanitaria (FIS)
- FIS- (PI041436, FIS-PI081151, FIS-PI042018, FIS-PI09/02311, FIS-PI06/0867, FIS-PS09/00090, FIS-PI03/1615, FIS-PI04/1509, FIS-PI04/1112, FIS-PI04/1931, FIS-PI05/1079, FIS-PI05/1052, FIS-PI06/1213, FIS-PI07/0314, FIS-PI09/02647, FIS-13/02429, FIS-PI13/1944, FIS-PI13/2032, CP14/00108)
- Fondo de Investigación Sanitaria-Fondo Europeo de Desarrollo Regional
- Generalitat de Catalunya-Consejo Interdepartamental de Investigación e Innovación Tecnológica (1999SGR 00241)
- Juan de la Cierva (2011-09771-MICINN)
- Conselleria de Sanitat Generalitat Valenciana 1 (048/2010, 060/2010)
- Universidad de Oviedo, Obra Social Cajastur, Department of Health of the Basque Government (2005111093, 2009111069)
- Provincial Government of Gipuzkoa (DFG06/004, DFG08/001)
- Fundación Roger Torné
- Miguel Servet (MS13/00054, MS14/00108)
- Spanish Institute of Health Carlos III
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Mercury impact and mitigation studies
- Keywords
- seafood consumption, pregnancy, child neurodevelopment, fatty fish, lean fish, mercury, long-chain polyunsaturated fatty acids, autistic traits, cognitive development, maternal diet, birth cohort
- MeSH terms
- Adult, Child Development, Child, Preschool, Cognition, Fatty Acids, Unsaturated, Female, Humans, Infant, Longitudinal Studies, Male, Mercury, Neuropsychological Tests, Pregnancy, Prenatal Exposure Delayed Effects, Spain, Seafood, Prenatal Nutritional Physiological Phenomena, Neurodevelopmental Disorders
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