Cited by 15,582Genomics and Phylogenetic StudiesRNA and protein synthesis mechanismsPlant Diversity and Evolution

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models

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Stamatakis, Alexandros·2006·Bioinformatics

Abstract

UNLABELLED: RAxML-VI-HPC (randomized axelerated maximum likelihood for high performance computing) is a sequential and parallel program for inference of large phylogenies with maximum likelihood (ML). Low-level technical optimizations, a modification of the search algorithm, and the use of the GTR+CAT approximation as replacement for GTR+Gamma yield a program that is between 2.7 and 52 times faster than the previous version of RAxML. A large-scale performance comparison with GARLI, PHYML, IQPNNI and MrBayes on real data containing 1000 up to 6722 taxa shows that RAxML requires at least 5.6 times less main memory and yields better trees in similar times than the best competing program (GARLI) on datasets up to 2500 taxa. On datasets > or =4000 taxa it also runs 2-3 times faster than GARLI. RAxML has been parallelized with MPI to conduct parallel multiple bootstraps and inferences on distinct starting trees. The program has been used to compute ML trees on two of the largest alignments to date containing 25,057 (1463 bp) and 2182 (51,089 bp) taxa, respectively. AVAILABILITY: icwww.epfl.ch/~stamatak

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Metadata

Authors
Stamatakis, A.
Affiliations
École Polytechnique Fédérale de Lausanne (CH)
Corresponding author
Stamatakis, Alexandros
Venue
Bioinformatics
Published
2006-08-23
Volume
22
Issue
21
Pages
2688-2690
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2168696662
Cited by
15,582
References
12
Citations by year
2026: 198 · 2025: 337 · 2024: 418 · 2023: 480 · 2022: 628 · 2021: 841 · 2020: 918 · 2019: 993 · 2018: 1019 · 2017: 1078 · 2016: 1245 · 2015: 1338 · 2014: 1714 · 2013: 1292 · 2012: 1075
FWCI
82.83
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Bioinformatics (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • reroDoc Digital Library (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant Diversity and Evolution
Keywords
maximum likelihood phylogenetic inference, large phylogenies, parallel computing, MPI, bootstrapping, software performance comparison, phylogenetics software
MeSH terms
Algorithms, Models, Genetic, Phylogeny, Sequence Homology, Nucleic Acid, Software, Species Specificity, Models, Statistical, Sequence Alignment, Conserved Sequence, Sequence Analysis, DNA, Evolution, Molecular

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