Statins and sepsis.

Early goal-directed therapy in the treatment of severe sepsis and septic shock

Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743 · see citing works

Intensive insulin therapy in critically ill patients.

Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977 · see citing works

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503 · see citing works

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124 · see citing works

Nonalcoholic Fatty Liver Disease

Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228 · see citing works

Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock

Annane, D. (2002) · JAMA · doi:10.1001/jama.288.7.862 · Cited by 3,055 · see citing works

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

Conference, F. T. I. S. D., Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E. H., Angus, D. C., Cook, D., Cohen, J., Opal, S. M., Vincent, J., et al. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1662-x · Cited by 2,877 · see citing works

The immunopathogenesis of sepsis

Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742 · see citing works

Endothelial cells in physiology and in the pathophysiology of vascular disorders.

Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., et al. (1998) · PubMed · doi:10.1182/blood.v91.10.3527 · Cited by 2,244 · see citing works

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

Laufs, U., Fata, V. L., Plutzky, J., & Liao, J. K. (1998) · Circulation · doi:10.1161/01.cir.97.12.1129 · Cited by 1,837 · see citing works

Effect of Statin Therapy on C-Reactive Protein Levels

Albert, M. A., Danielson, E., Rifai, N., Ridker, P. M., & for the PRINCE Investigators (2001) · JAMA · doi:10.1001/jama.286.1.64 · Cited by 1,642 · see citing works

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557 · see citing works

Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., & D, E. B. M. (1999) · Circulation · doi:10.1161/01.cir.100.3.230 · Cited by 1,479 · see citing works

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438 · see citing works

Current Perspectives on Statins

Maron, D. J., Fazio, S., & Linton, M. F. (2000) · Circulation · doi:10.1161/01.cir.101.2.207 · Cited by 1,217 · see citing works

Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update

Schächter, M. (2004) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2004.00299.x · Cited by 1,216 · see citing works

The Pathogenesis of Vasodilatory Shock

Landry, D. W., & Oliver, J. A. (2001) · New England Journal of Medicine · doi:10.1056/nejmra002709 · Cited by 1,142 · see citing works

ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins

Writing Committee Members:, Pasternak, R. C., Smith, S. C., Bairey-Merz, C. N., Grundy, S. M., Cleeman, J. I., & Lenfant, C. (2002) · Circulation · doi:10.1161/01.cir.0000032466.44170.44 · Cited by 1,088 · see citing works

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Weitz‐Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J. A., Bruns, C., Cottens, S., Takada, Y., & Hommel, U. (2001) · Nature Medicine · doi:10.1038/89058 · Cited by 1,041 · see citing works

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

Laufs, U., & Liao, J. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.24266 · Cited by 1,035 · see citing works

Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial

McCarey, D. W., McInnes, I. B., Madhok, R., Hampson, R., Scherbakova, O., Ford, I., Capell, H. A., & Sattar, N. A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16449-0 · Cited by 818 · see citing works

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

Ridker, P. M., Rifai, N., & Clearfield, M. B. (2001) · ACC Current Journal Review · doi:10.1016/s1062-1458(01)00460-3 · Cited by 762 · see citing works

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

van Amersfoort, E. S., van Berkel, T. J. C., & Kuiper, J. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.379-414.2003 · Cited by 750 · see citing works

HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells

Llevadot, J., Murasawa, S., Kureishi, Y., Uchida, S., Masuda, H., Kawamoto, A., Walsh, K., Isner, J. M., & Asahara, T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13131 · Cited by 701 · see citing works

Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

Greenwood, J., Steinman, L., & Zamvil, S. S. (2006) · Nature reviews. Immunology · doi:10.1038/nri1839 · Cited by 685 · see citing works

HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells

Llevadot, J., Murasawa, S., Kureishi, Y., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113131 · Cited by 611 · see citing works

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions

Shitara, Y., & Sugiyama, Y. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.03.003 · Cited by 574 · see citing works

The evolving role of statins in the management of atherosclerosis

Vaughan, C. J., Gotto, A. M., & Basson, C. T. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00525-2 · Cited by 573 · see citing works

Pathophysiology of Sepsis

Remick, D. G. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060872 · Cited by 500 · see citing works

Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction.

Lacoste, L., Lam, J., Hung, J., Letchacovski, G., Solymoss, C., & Waters, D. (1995) · Circulation · doi:10.1161/01.cir.92.11.3172 · Cited by 490 · see citing works

Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia

Bradford, R. H. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.1.43 · Cited by 479 · see citing works

Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland

Padkin, A., Goldfrad, C. H., Brady, T., Young, D., Black, N. A., & Rowan, K. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000085141.75513.2b · Cited by 453 · see citing works

Myopathy and Rhabdomyolysis Associated With Lovastatin-Gemfibrozil Combination Therapy

Pierce, L. R. (1990) · JAMA · doi:10.1001/jama.1990.03450010075034 · Cited by 425 · see citing works

Rapid Reduction in C-Reactive Protein With Cerivastatin Among 785 Patients With Primary Hypercholesterolemia

Ridker, P. M., Rifai, N., & Lowenthal, S. P. (2001) · Circulation · doi:10.1161/01.cir.103.9.1191 · Cited by 415 · see citing works

HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia

Weber, C., Erl, W., Weber, K. S. C., & Weber, P. C. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00324-0 · Cited by 409 · see citing works

Withdrawal of Cerivastatin from the World Market

Furberg, C. D., & Pitt, B. (2001) · Trials · doi:10.1186/cvm-2-5-205 · Cited by 400 · see citing works

Prior Statin Therapy Is Associated With a Decreased Rate of Severe Sepsis

Almog, Y., Shefer, A., Novack, V., Maimon, N., Barski, L., Eizinger, M., Friger, M. D., Zeller, L., & Danon, A. (2004) · Circulation · doi:10.1161/01.cir.0000138932.17956.f1 · Cited by 399 · see citing works

Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice

Laufs, U., Gertz, K. R., Huang, P. L., Nickenig, G., Böhm, M., Dirnagl, U., & Endres, M. (2000) · Stroke · doi:10.1161/01.str.31.10.2442 · Cited by 387 · see citing works

Inhibition of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Blocks Hypoxia-mediated Down-regulation of Endothelial Nitric Oxide Synthase

Laufs, U., Fata, V. L., & Liao, J. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31725 · Cited by 384 · see citing works

Expanded Clinical Evaluation of Lovastatin (EXCEL) Study Results

Bradford, R. H. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400010067008 · Cited by 374 · see citing works

Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS)

Matute‐Bello, G., Liles, W. C., Steinberg, K. P., Kiener, P. A., Mongovin, S. M., Chi, E. Y., Jonas, M., & Martin, T. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2217 · Cited by 347 · see citing works

HMG-CoA Reductase Inhibitors Regulate Inflammatory Transcription Factors in Human Endothelial and Vascular Smooth Muscle Cells

Dichtl, W., Dulak, J., Frick, M., Alber, H., Schwarzacher, S., Ares, M., Nilsson, J., Pachinger, O., & Weidinger, F. (2003) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000043456.48735.20 · Cited by 345 · see citing works

Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions

Kaesemeyer, W. H., Caldwell, R. B., Huang, J., & Caldwell, R. W. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00514-2 · Cited by 343 · see citing works

The molecular pathogenesis of endotoxic shock and organ failure

Karima, R., Matsumoto, S., Higashi, H., & Matsushima, K. (1999) · Molecular Medicine Today · doi:10.1016/s1357-4310(98)01430-0 · Cited by 340 · see citing works

Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis

Hackam, D. G., Mamdani, M., Li, P., & Redelmeier, D. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68041-0 · Cited by 317 · see citing works

Influenza and COPD Mortality Protection as Pleiotropic, Dose-Dependent Effects of Statins

Frost, F. J., Petersen, H. V., Tollestrup, K., & SKIPPER, B. J. (2007) · CHEST Journal · doi:10.1378/chest.06-1997 · Cited by 301 · see citing works

Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect

Inoue, I., Goto, S.-I., Mizotani, K., Awata, T., Mastunaga, T., Kawai, S.-I., Nakajima, T., Hokari, S., Komoda, T., & Katayama, S. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00680-9 · Cited by 298 · see citing works

Inhibition of Monocyte Chemotactic Protein-1 Synthesis by Statins

Romano, M., Diomede, L., Sironi, M., Massimiliano, L., Sottocorno, M., Polentarutti, N., Guglielmotti, A., Albani, D., Bruno, A., Fruscella, P., et al. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780115 · Cited by 296 · see citing works

Statin treatment after onset of sepsis in a murine model improves survival.

Merx, M. W., Liehn, E. A., Graf, J., van de Sandt, A., Schaltenbrand, M., Schrader, J., Hanrath, P., & Weber, C. (2005) · Circulation · doi:10.1161/circulationaha.104.502195 · Cited by 287 · see citing works

Neuroprotection mediated by changes in the endothelial actin cytoskeleton

Laufs, U., Endres, M., Stagliano, N. E., Amin‐Hanjani, S., Chui, D.-S., Yang, S.-X., Simoncini, T., Yamada, M., Aïkawa, E., Allen, P. G., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9639 · Cited by 279 · see citing works

HMG-CoA Reductase Inhibitor Simvastatin Profoundly Improves Survival in a Murine Model of Sepsis

Merx, M. W., Liehn, E. A., Janssens, U., Lütticken, R., Schrader, J., Hanrath, P., & Weber, C. (2004) · Circulation · doi:10.1161/01.cir.0000129774.09737.5b · Cited by 277 · see citing works

Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study

Majumdar, S. R., McAlister, F. A., Eurich, D. T., Padwal, R. S., & Marrie, T. J. (2006) · BMJ · doi:10.1136/bmj.38992.565972.7c · Cited by 270 · see citing works

Such stuff as dreams are made on: mediator-directed therapy in sepsis

Marshall, J. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1084 · Cited by 263 · see citing works

Statins and the vascular endothelial inflammatory response

Greenwood, J., & Mason, J. C. (2007) · Trends in Immunology · doi:10.1016/j.it.2006.12.003 · Cited by 262 · see citing works

Suppression of Endothelial Nitric Oxide Production After Withdrawal of Statin Treatment Is Mediated by Negative Feedback Regulation of Rho GTPase Gene Transcription

Laufs, U., Endres, M., Custodis, F., Gertz, K. R., Nickenig, G., Liao, J. K., & Böhm, M. (2000) · Circulation · doi:10.1161/01.cir.102.25.3104 · Cited by 261 · see citing works

Inhibition of Thromboxane Biosynthesis and Platelet Function by Simvastatin in Type IIa Hypercholesterolemia

Notarbartolo, A., Davı̀, G., Averna, M. R., Barbagallo, C. M., Ganci, A., Giammarresi, C., Placa, F. L., & Patrono, C. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.2.247 · Cited by 259 · see citing works

Severe Invasive Group A Streptococcal Infections In Ontario, Canada: 1987-1991

Demers, B., Simor, A. E., Vellend, H., Schlievert, P. M., Byrne, S., Jamieson, F. B., Walmsley, S. L., & Low, D. E. (1993) · Clinical Infectious Diseases · doi:10.1093/clind/16.6.792 · Cited by 250 · see citing works

Statins Reduce Interleukin-6–Induced C-Reactive Protein in Human Hepatocytes: New Evidence for Direct Antiinflammatory Effects of Statins

Arnaud, C., Burger, F., Steffens, S., Veillard, N. R., Nguyen, T. H., Trono, D., & Mach, F. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000163840.63685.0c · Cited by 247 · see citing works

In Vivo Anti-Inflammatory Effect of Statins Is Mediated by Nonsterol Mevalonate Products

Diomede, L., Albani, D., Sottocorno, M., Donati, M. B., Bianchi, M., Fruscella, P., & Salmona, M. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0801.094222 · Cited by 246 · see citing works

HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells

Bourcier, T., & Libby, P. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.556 · Cited by 233 · see citing works

HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells

ToddBourcier, & PeterLibby (2000) · Arteriosclerosis Thrombosis and Vascular Biology · Cited by 233 · see citing works

Vascular Endothelial Growth Factor May Contribute to Increased Vascular Permeability in Acute Respiratory Distress Syndrome

THICKETT, D. R., Armstrong, L., Christie, S. J., & Millar, A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.9.2011071 · Cited by 232 · see citing works

Circulating Endothelial Cells in Patients with Septic Shock

Mutunga, M. P., FULTON, B., Bullock, R., Batchelor, A. M., GASCOIGNE, A., Gillespie, J. I., & Baudouin, S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.9912036 · Cited by 227 · see citing works

Update on Statins: 2003

Vaughan, C. J., & Gotto, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000139312.10076.ba · Cited by 218 · see citing works

Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery

Chello, M., Patti, G., Candura, D., Mastrobuoni, S., Sciascio, G. D., Agrò, F. E., Carassiti, M., & Covino, E. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000201407.89977.ea · Cited by 213 · see citing works

Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo

Luo, Z., Fujio, Y., Kureishi, Y., Rudic, R. D., Daumerie, G., Fulton, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9419 · Cited by 210 · see citing works

Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects.

Yasuda, H., Yuen, P. S. T., Hu, X., Zhou, H., & Star, R. A. (2006) · Kidney International · doi:10.1038/sj.ki.5000300 · Cited by 209 · see citing works

HMG CoA reductase inhibitors

Hunninghake, D. B. (1992) · Current Opinion in Lipidology · doi:10.1097/00041433-199202000-00005 · Cited by 196 · see citing works

Cerivastatin Improves Survival of Mice with Lipopolysaccharide-Induced Sepsis

Ando, H., Takamura, T., Ota, T., Nagai, Y., & Kobayashi, K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39169-4 · Cited by 192 · see citing works

HMG-CoA Reductase Inhibitor Modulates Monocyte–Endothelial Cell Interaction Under Physiological Flow Conditions In Vitro

Yoshida, M., Sawada, T., Ishii, H., Gerszten, R. E., Rosenzweig, A., Gimbrone, M. A., Yasukochi, Y., & Numano, F. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0701.092143 · Cited by 187 · see citing works

Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro

Kleemann, R., Verschuren, L., de Rooij, B. F., Lindeman, J. H. N., de Maat, M. P. M., Szalai, A. J., Princen, H. M. G., & Kooistra, T. (2004) · Blood · doi:10.1182/blood-2003-11-3791 · Cited by 180 · see citing works

Pharmacokinetics of Fluvastatin After Single and Multiple Doses in Normal Volunteers

Tse, F. L. S., Jaffe, J. M., & Troendle, A. J. (1992) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1992.tb05773.x · Cited by 176 · see citing works

Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia

Musiał, J., Undas, A., Gajewski, P., Jankowski, M., Sydor, W., & Szczeklik, A. (2001) · International Journal of Cardiology · doi:10.1016/s0167-5273(00)00439-3 · Cited by 175 · see citing works

Effect of () variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers

Chung, J., Cho, J., YU, K., Kim, J., Oh, D., JUNG, H., Lim, K. S., MOON, K., SHIN, S., & Jang, I. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.07.003 · Cited by 170 · see citing works

Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureus α-Toxin

Pruefer, D., Makowski, J., Schnell, M. G. O., Buerke, U., Dahm, M., Oelert, H., Sibelius, U., Grandel, U., Grimminger, F., Seeger, W., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034048.38910.91 · Cited by 168 · see citing works

Effects of HMG-CoA Reductase Inhibitors on Coagulation and Fibrinolysis Processes

Krysiak, R. G., Okopie, B., & Herman, Z. S. (2003) · Drugs · doi:10.2165/00003495-200363170-00005 · Cited by 165 · see citing works

Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo

Niessner, A., Steiner, S., Speidl, W. S., Pleiner, J., Seidinger, D., Maurer, G., Goronzy, J. J., Weyand, C. M., Kopp, C. W., Huber, K., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.12.022 · Cited by 154 · see citing works

Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors Modify the Inflammatory Response of Human Macrophages and Endothelial Cells Infected With Chlamydia pneumoniae

Kothe, H., Dalhoff, K., Rupp, J., Müller, A., Kreuzer, J., Maass, M., & Katus, H. A. (2000) · Circulation · doi:10.1161/01.cir.101.15.1760 · Cited by 151 · see citing works

Statins and the Risk of Pneumonia: A Population‐Based, Nested Case‐Control Study

Schlienger, R. G., Fedson, D. S., Jick, S. S., Jick, H., & Meier, C. R. (2007) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.3.325 · Cited by 147 · see citing works

Comparative Pharmacokinetics and Pharmacodynamics of Pravastatin and Lovastatin

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Simvastatin Blunts Endotoxin-Induced Tissue Factor In Vivo

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Comparative Evaluation of the Safety and Efficacy of HMG-CoA Reductase Inhibitor Monotherapy in the Treatment of Primary Hypercholesterolemia

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Effect of Interferon Gamma on Infection-Related Death in Patients With Severe Injuries

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Statin treatment and reduced risk of pneumonia in patients with diabetes

van de Garde, E. M. W., Hak, E., Souverein, P. C., Hoes, A. W., van den Bosch, J. M. M., & Leufkens, H. G. M. (2006) · Thorax · doi:10.1136/thx.2006.062885 · Cited by 132 · see citing works

Endothelial cell apoptosis in sepsis

Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., & Karl, I. E. (2002) · Critical Care Medicine · doi:10.1097/00003246-200205001-00009 · Cited by 123 · see citing works

Reduction of Platelet Activity Markers in Type II Hypercholesterolemic Patients by a HMG-CoA-Reductase Inhibitor

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Simvastatin attenuates leukocyte recruitment in experimental bacterial meningitis

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Integrating Outcome Benefit Into Anesthetic Design: The Promise of Steroids and Statins

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Effect of statins on outcomes in immunosuppressed patients with bloodstream infection

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Progress in Perioperative Medicine: Focus on Statins

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Chronic Statin Use and Long-Term Rates of Sepsis

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Effects of prior treatment with simvastatin on skeletal muscle structure and mitochondrial enzyme activities during early phases of sepsis.

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A case report of systemic capillary leak syndrome (Clarkson's disease)

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Neue Aspekte der perioperativen Statintherapie

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Statins and sepsis

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Core Topics in Critical Care Medicine

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Established Statin Use Reduces Mortality From Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis

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The anti-inflammatory effects of atorvastatin upon the outcome of traumatic brain injury patients: A randomized-controlled double-blind clinical trial

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On the Use of Graphical Models to Study ICU Outcome Prediction in Septic Patients Treated with Statins

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The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

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Can statins improve outcome in colorectal surgery?: Part I

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Perioperative protective effects of statins

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Moderation of Immunopathological Parameters by Pravastatin in Pasteurella multocida (Pm52) Induced Septicaemic Mice

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Statins Downregulate the Constitutive Expression of HLA-DR and Reduce Intracellular CD74 in the Monocyte Cell Line Mono Mac 6

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Efecto de la administración de las estatinas en la patología crítica no cardiológica

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Mitigation of Septic Signs by Pravastatin during LPS Co-Administered Hen-Egg White Lysozyme Immunization in Mice

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Protection from pulmonary apoptosis: a new therapeutic choice for septic acute lung injury

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Statins in Portal Hypertension

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Comparison of the effects of dietary flavonoids and statins on lipopolysaccharide-induced vascular inflammation

Alshalmani, S. (2011) · Nottingham ePrints (University of Nottingham) · Cited by 1 · see citing works

Statins-More Than Just Plaque Stabilisation

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Alternative Therapies for Septic Shock: Beyond Early Goal-Directed Therapy

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On the Intelligent Management of Sepsis in the Intensive Care Unit

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Statins and sepsis letter: Author reply

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Comparing the anti-inflammatory effects of Simvastatin and Rosuvastatin by measuring IL-1β, IL-6 and TNF-α levels using a murinic caecal ligation and puncture induced sepsis model / Compararea efectelor anti-inflamatoare ale Simvastatinei și Rosuvastatinei măsurând nivelele serice ale IL-1β, IL-6 si TNF-α folosind un model de sepsis la șobolan indus prin ligatură și puncție cecală

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Efecto antiinflamatorio de las estatinas en la sepsis

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Over expression of the RhoGAP domain to assess inhibition of staphylococcus aureus infection : senior honors thesis (HONRS 499)

Willis, J. A. (2009) · Cardinal Scholar (Ball State University)

in the lung streptococcal M1 protein-induced neutrophil infiltration Simvastatin regulates CXC chemokine formation in

Zhang, S., Qi, Z., & Herwald, H. (2016)

Exaggerated neutrophil immunosenescence in sepsis and its potential modification with simvastatin

Patel, J. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)

Sepsis in adults: Recognition and treatment in clinical guidelines

Sevillano-Barbero, M. (2018) · Practice Nursing · doi:10.12968/pnur.2018.29.11.544

Simvastatin improves survival and reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury

Nežić, L., Amidžić, L., Jacevic, V. M., Dobrić, S., Škrbić, R., Stojiljković, M. P., Komic, J., & Stoisavljević-Šatara, S. (2011) · Scripta Medica · doi:10.5937/scrimed1101007n

Association between statins use and mortality in critically ill patients with sepsis included myocardial injury: a retrospective cohort study

Wei, S.-X., Dong, Y.-M., Su, Y., Chen, Y., Wang, X.-Y., Dong, H., Weng, D., Hu, Y., Guo, S., Mei, X., et al. (2025) · European Journal of Medical Research · doi:10.1186/s40001-025-02711-3

Rosuvastatin Attenuates Pulmonary Damage in Rats with Cecal Ligation and Puncture-Induced Sepsis

Yıldız, S. İ., Saydam, F., Topçu, A., Tümkaya, L., Kutlu, E. Y., & Uydu, H. A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15114112

Are There Any Benefits from Statin Treatment for the Septic Patient?

Krüger, P., & Venkatesh, B. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0378-9 · Cited by 11 · see citing works

Statins: the next step in adjuvant therapy for sepsis?

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A new role for statins in sepsis

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Rationale of Statin Therapy in Septic Patients

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Y a-t-il une place pour un traitement par statines chez les patients présentant un sepsis sévère ?

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