The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer’s disease
Open accessAbstract
Synaptic dysfunction is an early mechanism in Alzheimer’s disease that involves progressively larger areas of the brain over time. However, how it starts and propagates is unknown. Here we show that amyloid-β released by microglia in association with large extracellular vesicles (Aβ-EVs) alters dendritic spine morphology in vitro, at the site of neuron interaction, and impairs synaptic plasticity both in vitro and in vivo in the entorhinal cortex–dentate gyrus circuitry. One hour after Aβ-EV injection into the mouse entorhinal cortex, long-term potentiation was impaired in the entorhinal cortex but not in the dentate gyrus, its main target region, while 24 h later it was also impaired in the dentate gyrus, revealing a spreading of long-term potentiation deficit between the two regions. Similar results were obtained upon injection of extracellular vesicles carrying Aβ naturally secreted by CHO7PA2 cells, while neither Aβ42 alone nor inflammatory extracellular vesicles devoid of Aβ were able to propagate long-term potentiation impairment. Using optical tweezers combined to time-lapse imaging to study Aβ-EV–neuron interaction, we show that Aβ-EVs move anterogradely at the axon surface and that their motion can be blocked through annexin-V coating. Importantly, when Aβ-EV motility was inhibited, no propagation of long-term potentiation deficit occurred along the entorhinal–hippocampal circuit, implicating large extracellular vesicle motion at the neuron surface in the spreading of long-term potentiation impairment. Our data indicate the involvement of large microglial extracellular vesicles in the rise and propagation of early synaptic dysfunction in Alzheimer’s disease and suggest a new mechanism controlling the diffusion of large extracellular vesicles and their pathogenic signals in the brain parenchyma, paving the way for novel therapeutic strategies to delay the disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Microglia could also lead to synaptic dysfunction in vivo and in vitro by releasing Aβ-containing EVs.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [198]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Self-citationAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
The amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Flagged first, then by citations
Cited by
Sorted by citations
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616
Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier
Schiera, G., Liegro, C. M. D., Schirò, G., Sorbello, G., & Liegro, I. D. (2024) · Cells · doi:10.3390/cells13020150 · Cited by 128
Neuropathogenesis-on-chips for neurodegenerative diseases
Amartumur, S., Nguyen, H. M., Huynh, T., Kim, T. S., Woo, R., Oh, E., Kim, K. K., Lee, L. P., & Heo, C. (2024) · Nature Communications · doi:10.1038/s41467-024-46554-8 · Cited by 131
Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling
Hermann, D. M., Peruzzotti‐Jametti, L., Giebel, B., & Pluchino, S. (2023) · Brain · doi:10.1093/brain/awad332 · Cited by 79
Research progress on the role of extracellular vesicles in neurodegenerative diseases
Li, Z., Wang, X., Wang, X., Yi, X., Wong, Y. K., Wu, J., Xie, F., Hu, D., Wang, Q., Wang, J., et al. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00375-9 · Cited by 67
The Yin and Yang of Microglia-Derived Extracellular Vesicles in CNS Injury and Diseases
Ghosh, M., & Pearse, D. D. (2024) · Cells · doi:10.3390/cells13221834 · Cited by 69
Research progress in Alzheimer's disease and bone-brain axis
Zhang, F., & Zhang, W. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102341 · Cited by 62
Extracellular Vesicles as Mediators of Neuroinflammation in Intercellular and Inter-Organ Crosstalk
Cabrera‐Pastor, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137041 · Cited by 60
Wang, L., Zhang, X., Yang, Z., Wang, B., Gong, H., Zhang, K., Lin, Y., & Sun, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00453-6 · Cited by 55
Neuroinflammation of traumatic brain injury: Roles of extracellular vesicles
Liu, X., Zhang, L., Cao, Y., Jia, H., Li, X., Li, F., Zhang, S., & Zhang, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1088827 · Cited by 56
The multiple faces of extracellular vesicles released by microglia: Where are we 10 years after?
Gabrielli, M., Raffaele, S., Fumagalli, M., & Verderio, C. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.984690 · Cited by 55
Self-citationHu, M., Han, Y., Zhang, X., Tian, S., Shang, Z., Yuan, Z., & He, L. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07077-y · Cited by 58
Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles
D’Egidio, F., Castelli, V., d’Angelo, M., Ammannito, F., Quintiliani, M., & Cimini, A. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106663 · Cited by 41
Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles
Zhou, W., Zhao, L., Mao, Z., Wang, Z., Zhang, Z., & Li, M. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01345-5 · Cited by 42
The emerging role of extracellular vesicles in fungi: a double-edged sword
Lai, Y., Jiang, B., Hou, F., Huang, X.-H., Ling, B., Lü, H., Zhong, T., & Huang, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1216895 · Cited by 38
Extracellular Vesicle-Mediated Neuron–Glia Communications in the Central Nervous System
Ikezu, T., Yang, Y., Verderio, C., & Krämer‐Albers, E. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1170-24.2024 · Cited by 50
Self-citationRaffaele, S., & Fumagalli, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.950819 · Cited by 40
Polini, B., Ricardi, C., Bertolini, A., Carnicelli, V., Rutigliano, G., Saponaro, F., Zucchi, R., & Chiellini, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411569 · Cited by 37
Self-citationVisconte, C., Golia, M. T., Fenoglio, C., Serpente, M., Gabrielli, M., Arcaro, M., Sorrentino, F., Busnelli, M., Arighi, A., Fumagalli, G., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00746-0 · Cited by 36
Self-citationLipid and lipoprotein metabolism in microglia: Alzheimer’s disease mechanisms and interventions
Sprenger, K. G., Lietzke, E. E., Melchior, J. T., & Bruce, K. D. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100872 · Cited by 42
Extracellular Vesicles as “Very Important Particles” (VIPs) in Aging
Mas‐Bargues, C., & Alique, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044250 · Cited by 34
Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
Oshchepkova, A. L., Аркадьевна, З. М., & Vlassov, V. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087287 · Cited by 35
Singh, R., Rai, S., Bharti, P. S., Zehra, S., Gorai, P. K., Modi, G. P., Rani, N., Dev, K., Inampudi, K. K., Y., V. V., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03475-z · Cited by 28
Gabrielli, M., Tozzi, F., Verderio, C., & Origlia, N. (2022) · Cells · doi:10.3390/cells12010063 · Cited by 34
Self-citationChemparathy, D. T., Ray, S., Ochs, C., Ferguson, N., Gawande, D. Y., Dravid, S. M., Callen, S. E., Sil, S., & Buch, S. J. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12439 · Cited by 24
Zhou, L., Wang, Y., Xu, Y., Zhang, Y., & Zhu, C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03232-2 · Cited by 26
Pini, L., Salvalaggio, A., Wennberg, A. M. V., Dimakou, A., Matteoli, M., & Corbetta, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101867 · Cited by 26
Wang, D., Guan, S., Lu, P., Li, Y., & Xu, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114354 · Cited by 24
Extracellular Vesicles in Pathophysiology: A Prudent Target That Requires Careful Consideration
Shahi, S. K., Kang, T., & Fonseka, P. (2024) · Cells · doi:10.3390/cells13090754 · Cited by 26
Zhu, Z., Liao, L., & Qiao, H. (2022) · Acupuncture and Herbal Medicine · doi:10.1097/hm9.0000000000000039 · Cited by 22
Gómez-Pascual, A., Naccache, T., Xu, J., Hooshmand, K., Wretlind, A., Gabrielli, M., Lombardo, M. T., Shi, L., Buckley, N. J., Tijms, B. M., et al. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108588 · Cited by 23
Self-citationInvolvement of a lateral entorhinal cortex engram in episodic-like memory recall
Tozzi, F., Guglielmo, S., Paraciani, C., van den Oever, M. C., Mainardi, M., Cattaneo, A., & Origlia, N. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114795 · Cited by 24
Self-citationNeuron-derived extracellular vesicle-based diagnostics for Tau and Alzheimer’s disease
Chinnathambi, S., Kumarappan, M., Malik, S., Velmurugan, G., & Chandrashekar, M. (2025) · Brain Network Disorders · doi:10.1016/j.bnd.2024.12.006 · Cited by 21
Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases
Haghighitalab, A., Dominici, M., Matin, M. M., Shekari, F., Warkiani, M. E., Lim, R., Ahmadiankia, N., Mirahmadi, M., Bahrami, A. R., & Bidkhori, H. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1090416 · Cited by 21
Exosomes in multiple sclerosis and Alzheimer's disease – Adversary and ally
Tang, N. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100665 · Cited by 21
Intercellular communication is crucial in the regulation of healthy aging via exosomes
Sun, H., Xia, T., Ma, S., Lv, T., & Li, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107591 · Cited by 25
P2X7 Receptor and Extracellular Vesicle Release
Golia, M. T., Gabrielli, M., & Verderio, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129805 · Cited by 19
Self-citationShukla, S., Currim, F., Singh, J., Goyani, S., Saranga, M. V., Shinde, A., Mane, M., Chandak, N., Kishore, S., & Singh, R. K. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106439 · Cited by 21
Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids
Torrini, F., Gil-García, M., Cardellini, J., Frigerio, R., Basso, M., Gori, A., & Arosio, P. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.03.006 · Cited by 18
Gonul, C. P., Karaçiçek, B., & Genç, Ş. (2025) · Developmental Neurobiology · doi:10.1002/dneu.22984 · Cited by 17
Liu, X., Wang, H., Tian, X., Luo, Y., Ma, M., Zheng, Z., Wang, Y., Shi, F., Wang, Q., Xu, Z. F., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03488-2 · Cited by 17
Gao, X., Liu, D., Yue, K., Zhang, Z., Jiang, X., & Luo, P. (2024) · Biomolecules · doi:10.3390/biom14030378 · Cited by 17
Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?
Sharma, A., Parekh, B. K., Patil, V., Renuka Jyothi, S., Nayak, P. P., Janney, J. B., Singh, G., & Al-Hasnaawei, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23015 · Cited by 17
Falcicchia, C., Tozzi, F., Gabrielli, M., Amoretti, S., Masini, G., Nardi, G., Guglielmo, S., Ratto, G. M., Arancio, O., Verderio, C., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad170 · Cited by 15
Self-citationHalipi, V., Sasanian, N., Feng, J., Hu, J., Lubart, Q., Bernson, D., van Leeuwen, D., Ahmadpour, D., Sparr, E., & Esbjörner, E. K. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00655 · Cited by 15
Microglial Modulation in Alzheimer’s Disease: Central Players in Neuroinflammation and Pathogenesis
Hussain, M. S., Khan, Y., Fatima, R., Maqbool, M., Ramalingam, P. S., Khan, M. G., & Bisht, A. S. (2025) · Current Alzheimer Research · doi:10.2174/0115672050364292250113063513 · Cited by 15
Yousefizadeh, A., Piccioni, G., Saidi, A., Triaca, V., Mango, D., & Nisticò, R. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106404 · Cited by 15
Arbaciauskaite, S., Silvestri, S., Luo, P., Krüger, C., Mossmann, Z. J., Allelein, S., Scholz, A., Löffler, D., Fiorenza, S., Menale, A., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05719-w · Cited by 13
Hermann, D. M., Wang, C., Yusuf, A. M., Herz, J., Doeppner, T. R., & Giebel, B. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251325039 · Cited by 15
Balbi, M., Bonanno, G., Bonifacino, T., & Milanese, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065240 · Cited by 14
Batabyal, R., Bansal, A., Cechinel, L. R., Authelet, K. J., Goldberg, M., Nadler, E. P., Keene, C. D., Jayadev, S., Domoto‐Reilly, K., Li, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814024 · Cited by 13
Kanuri, S. H., & Sirrkay, P. J. (2024) · Brain Circulation · doi:10.4103/bc.bc_113_23 · Cited by 13
Arif, S., Qazi, T. J., Quan, Z., Ni, J., Li, Z., Qiu, Y., & Qing, H. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102614 · Cited by 13
Shahlaei, M., Afkhami, H., Ahmadieh-Yazdi, A., Mirmazloumi, S. H., Sahraei, S. S., Akbari, M., Yang, P., Manoochehri, H., Tanzadehpanah, H., Mahaki, H., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118548 · Cited by 11
Counil, H., Silva, R. O., Rabanel, J., Zaouter, C., Haddad, M., Khedher, M. R. B., Brambilla, D., Fülöp, T., Patten, S. A., & Ramassamy, C. (2025) · Journal of Extracellular Biology · doi:10.1002/jex2.70027 · Cited by 12
Zhang, C., Tan, R., Zhou, X., Wang, R., Wang, X., Ma, R., Chu, F., Li, Y., Yin, T., & Liu, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094651 · Cited by 9
Almalki, W. H., & Almujri, S. S. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155614 · Cited by 9
Cambria, C., Ingegnoli, F., Borzi, E., Cantone, L., Coletto, L. A., Rizzuto, A. S., Lucia, O. D., Briguglio, S., Ruscica, M., Caporali, R. F., et al. (2022) · Cells · doi:10.3390/cells11152276 · Cited by 9
The role of microglia in neurological diseases with involvement of extracellular vesicles
Xie, H., Wu, F., Mao, J., Wang, Y., Zhu, J., Zhou, X., Hong, K., Li, B., Qiu, X., & Wen, C. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106700 · Cited by 9
D’Arrigo, G., Cutugno, G., Golia, M. T., Sironi, F. M., Lombardi, M., Colombo, S. F., Frigerio, R., Cretich, M., Gagni, P., Battocchio, E., et al. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70173 · Cited by 10
Self-citationExtracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?
Romero-García, N., Huete-Acevedo, J., Mas‐Bargues, C., Sanz‐Ros, J., Dromant, M., Badenes, R., & Borrás, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065102 · Cited by 8
Raffaele, S., Lombardi, M., Marangon, D., Abbracchio, M. P., Lecca, D., Verderio, C., & Fumagalli, M. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01612-7 · Cited by 10
Self-citationHuman Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia
Lombardo, M. T., Gabrielli, M., Julien‐Marsollier, F., Faivre, V., Charpentier, T. L., Bokobza, C., D’Aliberti, D., Pelizzi, N., Halimi, C., Spinelli, S., et al. (2024) · Cells · doi:10.3390/cells13191665 · Cited by 6
Self-citationImmuno‐Regulation of Brain Region‐Specific Organoids Containing Isogenic Microglia‐Like Cells
Liu, C., Ene, J., Lü, W., Syed, F., Sun, L. J., Raulin, A., Ren, Y., Wang, X. S., Kanekiyo, T., & Li, Y. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503579 · Cited by 5
Wang, T., Guo, M., Wu, H., Liu, S., Ji, Y., Wang, P., & Xu, G. (2025) · GeroScience · doi:10.1007/s11357-025-01888-z · Cited by 4
Jimenez-Harrison, D., Butler, M. J., Ijaz, H., Alsabbagh, R., Bettes, M. N., DeMarsh, J. W., Mackey-Alfonso, S. E., Muscat, S. M., Alvarez, B. D., Blackwell, J. A., et al. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100969 · Cited by 4
Liu, C., Ding, X., Zhao, M., Chen, C., Zhang, X., Zhao, R., Chen, Y., & Xie, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116661 · Cited by 4
Zhang, Q., Lo, H., Song, Y., Feng, L., You, H., Chen, X., Wang, Y., & Pan, X. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03598-8 · Cited by 4
Sever, M., Cakir-Aktas, C., Güler, Ü., Onat, B., Solgun, B., Şahin, M., Belder, N., Erdener, Ş. E., Salih, B., & Dalkara, T. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02213-x · Cited by 3
Marques, B. L., Lirio, P. H. C., Vicente, M. A., Unzueta‐Larrinaga, P., Urigüen, L., & Campos, A. C. (2025) · Pharmaceuticals · doi:10.3390/ph18121817 · Cited by 3
Ren, J., Wang, Y., Wang, Y., Zhang, Y., Xing, M., Deng, S., Tong, S., Wang, L., Zheng, C., Yang, J., et al. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115266 · Cited by 3
Microglia-derived sEV: Friend or foe in the pathogenesis of cognitive impairment
Chen, L., & Wang, W. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111287 · Cited by 3
Zebardast, F., Riethmueller, M. P. S., & Nowick, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-30392-9 · Cited by 2
Autophagy–exosome crosstalk in neurodegeneration: Mechanisms and therapeutic opportunities
Sedighi, S., Guan, T., Michetti, F., Cordani, M., Behrooz, A. B., Sabouni, F., Eshraghi, M., Saleem, A., Ghavami, S., & Aghanoori, M. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109025 · Cited by 3
Cui, D., Wang, X., & Shang, X. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s606362 · Cited by 2
Quach, B., Salehi, S. N., Roufegarinejad, R., Guleria, V. S., Mante, M., Florio, J. B., Rissman, R. A., & Winston, C. N. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115893 · Cited by 2
Zare, H., Kasdorf, M., & Nik, A. B. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103982 · Cited by 2
MicroRNAs Fine-Tune Brain and Body Communication in Health and Disease
Henshall, D. C. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_12 · Cited by 1
Myers, S. J., Medapati, M. R., Allman, B. L., Pasternak, S., Whitehead, S. N., & Roseborough, A. D. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101261 · Cited by 1
Xin, J., Liu, J., Dong, H.-M., Yu, H., Xiao, Z., Hu, J.-N., Jiang, Q., Zhu, Y.-P., Feng, L., Feng, Y., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3243-2 · Cited by 2
Dong, X., Tan, H., Song, L., Jiang, B., Wu, Y., Duan, L., Yang, S., Zhang, H., Zou, Z., Zhang, W., et al. (2026) · Physics of Life Reviews · doi:10.1016/j.plrev.2026.07.004 · Cited by 1
Neurodegenerative Disorder and Fine Particulate Matter
Kawahara, H., & Hanayama, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-7067-0_14 · Cited by 1
Bong, S., Choi, H., Song, H., Kim, D. K., Mook‐Jung, I., & Lee, D. Y. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70030 · Cited by 1
Liu, F.-W., Zhang, X.-R., Cong, Y.-F., Liu, Y., Zhang, H., & Hou, X. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0143 · Cited by 1
Gómez-Pascual, A., Naccache, T., Xu, J., Hooshmand, K., Wretlind, A., Gabrielli, M., Lombardo, M. T., Shi, L., Buckley, N. J., Tijms, B. M., et al. (2023) · doi:10.1101/2023.03.02.23286674 · Cited by 1
Self-citationVasilopoulou, F., Yaman, Ü., Salih, D. A. M., Hardy, J., Wray, S., & Pocock, J. M. (2025) · Research Square · doi:10.21203/rs.3.rs-7487794/v1 · Cited by 1
Fagiani, F., Fülöp, T., Govoni, S. M., & Lanni, C. (2023) · Biomedicines · doi:10.3390/biomedicines11020484
Pociūtė, A., & Pivoriūnas, A. (2025) · BioEssays · doi:10.1002/bies.70040
Singh, R., Rai, S., Bharti, P. S., Zehra, S., Gorai, P. K., Modi, G. P., Rani, N., Dev, K., Inampudi, K. K., Y., V. V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26736822
Lin, B., Chai, L., Zuo, S., Dai, Y., Chen, L., & Huang, J. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00606
Voorbraeck, L., Alarcón-Gil, J., Giraud, R., Pozzobon, F., Pereira, M. J., Guo, S., Cao, Z., Distefano, K., Forouzanfar, M. H., Wiklander, O. P. B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.09.710050 · Cited by 1
Adhish, M., Dey, S., & Mitra, P. (2026) · Neuroinformatics · doi:10.1007/s12021-026-09774-5
Shuaibu, C., Anderson, M., Far, M. A. A., Shakil, A., Beaupre, C., Donkers, S., & Adebiyi, O. E. (2026) · Research Square · doi:10.21203/rs.3.rs-9398108/v1
Glycolysis: The Bridge Between Cellular Interaction and Alzheimer’s Disease
Lei, Q., He, Y., & Fang, B. (2026) · Biomolecules · doi:10.3390/biom16060796
Shuaibu, C., Anderson, M., Far, M. A. A., Shakil, A., Beaupre, C., Donkers, S., & Adebiyi, O. E. (2026) · Research Square · doi:10.21203/rs.3.rs-9852062/v1
Wang, Y., Wu, W., Yan, L., Zhang, B., Li, Q., & Zhou, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1849218
Extracellular vesicles in neurodegenerative diseases: A new frontier in diagnosis and therapy
Mohammad, S. I., Vasudevan, A., Oriquat, G., Gajjar, T. B., Hanumanthayya, M., Shukla, S. K., Tailor, N. K., Baig, M. R., Fadaam, O., & Abdul, A. S. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116455
Extracellular vesicles in Alzheimer’s disease: New perspectives on diagnosis and therapy
Klepe, A., Mi, J., Neuhaus, W., & Burek, M. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.08.024
Metadata
- Authors
- Gabrielli, M., Prada, I., Joshi, P., Falcicchia, C., D’Arrigo, G., Rutigliano, G., Battocchio, E., Zenatelli, R., Tozzi, F., Radeghieri, A., Arancio, O., Origlia, N., & Verderio, C.
- Affiliations
- CNR Institute of Neuroscience , Vedano al Lambro, MB 20854 , Italy
- Neuroscience Institute (IT)
- Scuola Superiore Sant'Anna (IT)
- University of Milano-Bicocca (IT)
- University of Brescia (IT)
- Scuola Normale Superiore (IT)
- Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (IT)
- Columbia University (US)
- Corresponding author
- Origlia, Nicola
- Verderio, Claudia
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-03-03
- Volume
- 145
- Issue
- 8
- Pages
- 2849-2868
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC9420022
- OpenAlex
- W4214920994
- Cited by
- 106
- References
- 105
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 27 · 2023: 22 · 2022: 6
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion, cc-by-nc)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, cc-by-nc)
- Scuola Normale Superiore di Pisa (submittedVersion, cc-by-nc)
- Funders
- American National Institutes of Health (1R56AG056108-01)
- Alzheimer’s Association Research Fellowship (2018-AARF-588984)
- Italian Multiple Sclerosis Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, microglia, large extracellular vesicles, amyloid-beta, synaptic dysfunction, long-term potentiation, dendritic spine morphology, synaptic plasticity, vesicle motility, annexin V, amyloid-beta 42, disease propagation
- MeSH terms
- Extracellular Vesicles, Alzheimer Disease, Animals, Hippocampus, Amyloid beta-Peptides, Microglia, Long-Term Potentiation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
