Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528

Immunology of multiple sclerosis

Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149

The many faces of macrophage activation

Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902

MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1

Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07519.x · Cited by 1,413

Prostaglandins as modulators of immunity

Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., & Tontonoz, P. (2003) · Nature Medicine · doi:10.1038/nm820 · Cited by 1,158

Anti-inflammatory lipid mediators and insights into the resolution of inflammation

Lawrence, T., Willoughby, D. A., & Gilroy, D. W. (2002) · Nature reviews. Immunology · doi:10.1038/nri915 · Cited by 879

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis

Greter, M., Heppner, F. L., Lemos, M. P., Odermatt, B. M., Goebels, N., Laufer, T., Noelle, R. J., & Becher, B. (2005) · Nature Medicine · doi:10.1038/nm1197 · Cited by 862

Restoring immune suppression in the multiple sclerosis brain

Koning, N., Uitdehaag, B. M. J., Huitinga, I., & Hoek, R. M. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.09.005 · Cited by 28

Cannabis use by individuals with multiple sclerosis: effects on specific immune parameters

Sexton, M., Cudaback, E., Abdullah, R. A., Finnell, J. S., Mischley, L. K., Rozga, M., Lichtman, A. H., & Stella, N. (2014) · Inflammopharmacology · doi:10.1007/s10787-014-0214-z · Cited by 28

Myelin Debris Impairs Tight Junctions and Promotes the Migration of Microvascular Endothelial Cells in the Injured Spinal Cord

Yao, F., Luo, Y., Chen, Y., Li, Y., Hu, X., You, X., Li, Z., Yu, S., Tian, D., Zheng, M., et al. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01203-w · Cited by 27

Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated Astrocytes in Experimental Autoimmune Encephalomyelitis

Bozic, I. D., Tesovic, K., Laketa, D., Adžić, M., Jakovljevic, M., Bjelobaba, I. M., Savić, D. Z., Nedeljković, N., Peković, S., & Lavrnja, I. C. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2509-8 · Cited by 27

Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury

Zhang, C., Zhao, S., Huang, Z., Ao, X., Liu, H., Dai, S., Zheng, Z., Li, Y., Guo, X., Gu, J., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103469 · Cited by 28

T cell recognition of self-antigen presenting cells by protein transfer assay reveals a high frequency of anti-myelin T cells in multiple sclerosis

Bahbouhi, B., Pettré, S., Berthelot, L., Garcia, A., Ngono, A. E., Degauque, N., Michel, L., Wiertlewski, S., Lefrère, F., Meyniel, C., et al. (2010) · Brain · doi:10.1093/brain/awq074 · Cited by 25

Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease

van Eijk, M., Aust, G., Brouwer, M. S. M., van Meurs, M., Voerman, J. S. A., Dijke, E., Pouwels, W., Sändig, I., Wandel, E., Aerts, J. M. F. G., et al. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.02.004 · Cited by 25

Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity

Kamermans, A., Rijnsburger, M., Chakraborty, A., van der Pol, S., de Vries, H. E., & van Horssen, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00950 · Cited by 25

High-density lipoprotein cholesterol is associated with multiple sclerosis fatigue: A fatigue-metabolism nexus?

Browne, R. W., Jakimovski, D., Ziliotto, N., Kühle, J., Bernardi, F., Weinstock‐Guttman, B., Zivadinov, R., & Ramanathan, M. K. (2019) · Journal of clinical lipidology · doi:10.1016/j.jacl.2019.06.003 · Cited by 24

Type 3 Deiodinase Expression in Inflammatory Spinal Cord Lesions in Rat Experimental Autoimmune Encephalomyelitis

Boelen, A., Mikita, J., Boiziau, C., Chassande, O., Fliers, E., & Petry, K. G. (2009) · Thyroid · doi:10.1089/thy.2009.0228 · Cited by 24

Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis

Ferret-Sena, V., Capela, C., & Sena, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061639 · Cited by 24

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

Schnaars, M. (2011) · doi:10.53846/goediss-919 · Cited by 25

Distinct origins, gene expression and function of microglia and monocyte-derived macrophages in CNS myelin injury and regeneration

Davies, C. L., & Miron, V. E. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.06.016 · Cited by 24

Decreased Neuro‐Axonal Proteins in CSF at First Attack of Suspected Multiple Sclerosis

Stoop, M. P., Runia, T. F., Stingl, C., de Vries, R. M. V. D. V., Luider, T. M., & Hintzen, R. Q. (2017) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201700005 · Cited by 23

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

Zhang, G., Yao, Q., Long, C., Yi, P., Song, J., Wu, L., Wan, W., Rao, X., Lin, Y., Wei, G., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01508 · Cited by 25

Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination

Standiford, M. M., Grund, E. M., & Howe, C. L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02360-3 · Cited by 23

CC-chemokine ligand 18/pulmonary activation-regulated chemokine expression in the CNS with special reference to traumatic brain injuries and neoplastic disorders

Chang, C., Lee, Y., Leu, S., Wang, C.-Y., Wei, C., Hung, K.-S., Pai, M.-H., Tsai, M., & Wu, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.050 · Cited by 22

Connecting Immune Cell Infiltration to the Multitasking Microglia Response and TNF Receptor 2 Induction in the Multiple Sclerosis Brain

Veroni, C., Serafini, B., Rosicarelli, B., Fagnani, C., Aloisi, F., & Agresti, C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00190 · Cited by 21

Quantitative analysis of lipid debris accumulation caused by cuprizone induced myelin degradation in different CNS areas

Ozsvár, A., Szipöcs, R., Ozsvár, Z., Baka, J., Barzó, P., Tamás, G., & Molnár, G. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.01.003 · Cited by 24

Demyelinating diseases

Sobel, R. A., & Moore, G. W. (2008) · CRC Press eBooks · doi:10.1201/b13319-21 · Cited by 22

Differential transcriptional response profiles in human myeloid cell populations

Healy, L. M., Perron, G., Won, S., Rao, V. T. S., Guiot, M., Moore, C. S., Bar‐Or, A., & Antel, J. P. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.04.006 · Cited by 22

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals

Raji, C. A., Meysami, S., Hashemi, S., Garg, S., Akbari, N., Gouda, A., Chodakiewitz, Y. G., Nguyen, T. D., Niotis, K., Merrill, D. A., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0820 · Cited by 22

Long‐term impact of neonatal inflammation on demyelination and remyelination in the central nervous system

Bénardais, K., Gudi, V., Gai, L., Nessler, J. N., Singh, V., Prajeeth, C. K., Skripuletz, T., & Stangel, M. (2014) · Glia · doi:10.1002/glia.22706 · Cited by 19

miRNAs in Microglia: Important Players in Multiple Sclerosis Pathology

Walsh, A. D., Nguyen, L., & Binder, M. D. (2021) · ASN NEURO · doi:10.1177/1759091420981182 · Cited by 23

Increased CCL18 plasma levels are associated with neurodegenerative MRI outcomes in multiple sclerosis patients

Ziliotto, N., Bernardi, F., Jakimovski, D., Baroni, M., Bergsland, N., Ramasamy, D. P., Weinstock‐Guttman, B., Zamboni, P., Marchetti, G., Zivadinov, R., et al. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.07.009 · Cited by 20

Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord

Wang, X., Cheng, Z., Tai, W., Shi, M., Ayazi, M., Liu, Y., Sun, L. J., Yu, C., Fan, Z., Bin, G., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.013 · Cited by 19

VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology

Borggrewe, M., Kooistra, S. M., Wesseling, E. M., Gierschek, F. L., Brummer, M. L., Nowak, E. C., Medeiros-Furquim, T., Otto, T. A., Lee, S. W., Noelle, R. J., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01186-7 · Cited by 20

Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection

Venkatasubramanian, S., Tripathi, D., Tucker, T. A., Paidipally, P., Cheekatla, S. S., Welch, E., Raghunath, A., Jeffers, A., Tvinnereim, A., Schechter, M., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545817 · Cited by 19

Myelin ingestion alters macrophage antigen-presenting function in vitro and in vivo

van Zwam, M., Samsom, J. N., Nieuwenhuis, E. E. S., Melief, M., Wierenga‐Wolf, A. F., Dijke, E., Talens, S., van Meurs, M., Voerman, J. S. A., Boven, L. A., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1209813 · Cited by 19

Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era

Borst, K., & Prinz, M. (2020) · Brain Pathology · doi:10.1111/bpa.12910 · Cited by 17

The “window of susceptibility” for inflammation in the immature central nervous system is characterized by a leaky blood–brain barrier and the local expression of inflammatory chemokines

Schoderboeck, L., Adzemovic, M. Z., Nicolussi, E.-M., Crupinschi, C., Hochmeister, S., Fischer, M.-T., Lassmann, H., & Bradl, M. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.026 · Cited by 19

Multiple sclerosis severity variant in DYSF-ZNF638 locus associates with neuronal loss and inflammation

Engelenburg, H. J., van den Bosch, A. M. R., Chen, J. Q. A., Hsiao, C., Melief, M., Harroud, A., Huitinga, I., Hamann, J., & Smolders, J. (2025) · iScience · doi:10.1016/j.isci.2025.112430 · Cited by 18

Neuro-immune crosstalk in depressive symptoms of multiple sclerosis

Wang, C., Zhou, Y., & Feinstein, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106005 · Cited by 20

TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids

Goldberg, G., Coelho, L. B. V., Mo, G., Adang, L. A., Patne, M., Chen, Z., García-Bassets, I., Mesci, P., & Muotri, A. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02348-w · Cited by 20

The Plasticity of Immune Cell Response Complicates Dissecting the Underlying Pathology of Multiple Sclerosis

Sarkar, S. K., Willson, A. M. L., & Jordan, M. A. (2024) · Journal of Immunology Research · doi:10.1155/2024/5383099 · Cited by 19

Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions

Große-Veldmann, R., Becker, B., Amor, S., van der Valk, P., Beyer, C., & Kipp, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9420-y · Cited by 18

Interleukin-1 receptor antagonist: An exploratory plasma biomarker that correlates with disability and provides pathophysiological insights in relapsing-remitting multiple sclerosis

Blandford, S. N., Galloway, D. A., Williams, J. B., Arsenault, S. T., Brown, J. E., MacLean, G., Moore, G. R. W., Barron, J., Ploughman, M., Clift, F., et al. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103006 · Cited by 16

Pathological Heterogeneity of Idiopathic Central Nervous System Inflammatory Demyelinating Disorders

Lucchinetti, C. F. (2007) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-73677-6_2 · Cited by 18

Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis

Chen, J. Q. A., McNamara, N. B., Engelenburg, H. J., Jongejan, A., Wever, D. D., Hopman, K., van Rixel, E., Nijhuis, P. J. H., de Winter, F., Moerland, P. D., et al. (2025) · Brain · doi:10.1093/brain/awae414 · Cited by 17

Inflammation-related alterations of lipids after spinal cord injury revealed by Raman spectroscopy

Tamošaitytė, S., Galli, R., Uckermann, O., Sitoci-Ficici, K. H., Koch, M. K., Later, R., Schackert, G., Koch, E., Steiner, G. R., & Kirsch, M. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.21.6.061008 · Cited by 17

Meningeal Foam Cells and Ependymal Cells in Axolotl Spinal Cord Regeneration

Enos, N., Takenaka, H., Scott, S., Salfity, H., Kirk, M. P., Egar, M., Sarria, D. A., Slayback, D. L., Belecky‐Adams, T. L., & Chernoff, E. A. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02558 · Cited by 17

CD44 variant isoforms control experimental autoimmune encephalomyelitis by affecting the lifespan of the pathogenic T cells

Ghazi‐Visser, L., Laman, J. D., Nagel, S., van Meurs, M., van Riel, D. A. J., Tzankov, A., Frank, S., Adams, H., Wolk, K., Terracciano, L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-228809 · Cited by 17

Fascin-1 is Highly Expressed Specifically in Microglia After Spinal Cord Injury and Regulates Microglial Migration

Yu, S., Cheng, L., Tian, D., Li, Z., Yao, F., Luo, Y., Liu, Y., Zhu, Z., Zheng, M., & Jing, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.729524 · Cited by 16

Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Elo, P., Li, X., Liljenbäck, H., Gardberg, M., Moisio, O., Miner, M. W. G., Virta, J., Saraste, A., Srinivasarao, M., Pugh, M. R., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02073-7 · Cited by 17

Immune Regulatory Cell Bias Following Alemtuzumab Treatment in Relapsing-Remitting Multiple Sclerosis

Kashani, N., Kelland, E. E., Vajdi, B., Anderson, L. M., Gilmore, W., & Lund, B. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706278 · Cited by 16

Deciphering glial contributions to CSF1R-related disorder via single-nuclear transcriptomic profiling: a case study

Pan, J., Forés-Martos, J., Nouh, C. D., Jensen, T. D., Vallejo, K., Cayrol, R., Ahmadian, S. S., Ashley, E. A., Greicius, M. D., & Cobos, I. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01853-5 · Cited by 16

Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?

Sestito, C., Brevé, J. J. P., van Eggermond, M. C. J. A., Killestein, J., Teunissen, C. E., van Rossum, J., Wilhelmus, M. M. M., Drukarch, B., van den Elsen, P. J., & van Dam, A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1035-y · Cited by 16

Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain

Picone, P., Palumbo, F. S., Federico, S., Pitarresi, G. L., Adamo, G., Bongiovanni, A., Chaves-Sanjuán, A., Cancemi, P., Muccilli, V., Giglio, V., et al. (2021) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100146 · Cited by 15

Neuroinflammation responses and neurodegeneration in multiple sclerosis

Nataf, S. (2009) · Revue Neurologique · doi:10.1016/j.neurol.2009.09.012 · Cited by 15

UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation

Loix, M., Vanherle, S., Bolkaerts, L., Verberk, S. G. S., Punt, M., Wouters, F., Moonen, B., Verhagen, R. F. M., van Wouw, S. A. E., Jongejan, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62053-w · Cited by 16

Role of the Peripheral Nervous System in PD Pathology, Diagnosis, and Treatment

Ma, C., Zhang, W., & Cao, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.598457 · Cited by 15

Induction of Encephalitis in Rhesus Monkeys Infused with Lymphocryptovirus-Infected B-Cells Presenting MOG34–56 Peptide

Haanstra, K. G., Wubben, J. A. M., Jonker, M., & Hart, B. A. ‘. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071549 · Cited by 14

CNS macrophage contributions to myelin health

Hoffmann, A., & Miron, V. E. (2024) · Immunological Reviews · doi:10.1111/imr.13416 · Cited by 13

Viscoelastic properties of white and gray matter-derived microglia differentiate upon treatment with lipopolysaccharide but not upon treatment with myelin

van Wageningen, T. A., Antonovaité, N., Paardekam, E. J., Brevé, J. J. P., Iannuzzi, D., & van Dam, A. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02134-x · Cited by 12

Defining and Regulating Acute Inflammatory Lesion Formation during the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Bolton, C., & Smith, P. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150716103629 · Cited by 14

Tissue Transglutaminase contributes to myelin phagocytosis in interleukin-4-treated human monocyte-derived macrophages

Sestito, C., Brevé, J. J. P., Bol, J. G. J. M., Wilhelmus, M. M. M., Drukarch, B., & van Dam, A. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155024 · Cited by 15

Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy

Wang, B., Du, A., Chen, X., Huang, T., Mamun, A. A., Li, P., Du, S., Feng, Y.-Z., Jiang, L.-Y., Xu, J., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01463-w · Cited by 13

Inflammation alters myeloid cell and oligodendroglial iron-handling in multiple sclerosis

Riedl, C. J., Bormann, D., Steinmaurer, A., Novak, A., Testa, G., Poldlehner, E., Haider, C., Berger, T., Mildner, M., Höftberger, R., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02020-0 · Cited by 12

Elevated phagocytic capacity directs innate spinal cord repair

Shaw, D. K., Saraswathy, V. M., McAdow, A. R., Zhou, L., Park, D., Mote, R. D., Saini, A., Douthitt, A. J., Stepankova, K., Unverzagt, B., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117482 · Cited by 12

Microglia and Multiple Sclerosis

Hammond, B. P., Panda, S. P., Kaushik, D. K., & Plemel, J. R. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_25 · Cited by 11

The release of cytokines by macrophages is not affected by myelin ingestion

Glim, J. E., Vereyken, E. J. F., Heijnen, D. A. M., García-Vallejo, J. J., & Dijkstra, C. D. (2010) · Glia · doi:10.1002/glia.21062 · Cited by 11

Myelin ingestion by macrophages promotes their motility and capacity to recruit myeloid cells

van Zwam, M., Wierenga‐Wolf, A. F., Melief, M., Schrijver, B., Laman, J. D., & Boven, L. A. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.021 · Cited by 11

A peptide targeting inflammatory CNS lesions in the EAE rat model of multiple sclerosis

Boiziau, C., Nikolski, M., Mordelet, E., Aussudre, J., Vargas-Sanchez, K., & Petry, K. G. (2018) · Inflammation · doi:10.1007/s10753-018-0748-0 · Cited by 10

Macrophage polarization and future perspectives: a comprehensive review

Chowdary, Y. Y., Patil, M. M., & Raghu, A. V. (2024) · Discover Materials · doi:10.1007/s43939-024-00133-2 · Cited by 10

Role of liver X receptor in multiple sclerosis: A long furtive life behind a barrier

Abulaban, A. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Ahmed, E., Fawzy, M. N., Alruwaili, M., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111333 · Cited by 10

Inflammation induced neurological handicap processes in multiple sclerosis: new insights from preclinical studies

Petry, K. G., Brochet, B., Dousset, V., Vignes, J. R., & Boiziau, C. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0432-5 · Cited by 10

Tissue-specific features of microglial innate immune responses

Timmerman, R., Burm, S. M., & Bajramovic, J. J. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104924 · Cited by 10

Tissue Transglutaminase Appears in Monocytes and Macrophages but Not in Lymphocytes in White Matter Multiple Sclerosis Lesions

Chrobok, N. L., Bol, J. G. J. M., Wilhelmus, M. M. M., Drukarch, B., & van Dam, A. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz030 · Cited by 12

Foamy microglia link oxylipins to disease progression in multiple sclerosis

van der Vliet, D., Di, X., Shamorkina, T. M., Coulon-Bainier, C., Pavlovic, A., van der Vliet, I. A. C. M., Zeng, Y., Macnair, W., van Egmond, N., Chen, J. Q. A., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02302-3 · Cited by 9

Plasma Lipoproteins in Brain Inflammatory and Neurodegenerative Diseases

Sena, A., Capela, C., Nóbrega, C., Ferret-Sena, V., Campos, E., & Pedros, R. (2012) · InTech eBooks · doi:10.5772/51268 · Cited by 9

Autoantibodies and their potential roles in diseases of the nervous system

Beasley, S. J., & Greer, J. M. (2015) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12269 · Cited by 10

Impact of human myelin on the maturation and function of human monocyte-derived dendritic cells

Gredler, V., Ebner, S., Schanda, K., Forstner, M., Berger, T. G., Romani, N., & Reindl, M. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.11.003 · Cited by 9

Detection of chitinase activity by 2-aminobenzoic acid labeling of chito-oligosaccharides.

der Vlugt, K. G.-V., Bussink, A. P., Groener, J., Boot, R., & Aerts, J. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2008.09.028 · Cited by 11

Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Ban, Y., Dong, W., Zhang, L., Zhou, T. G., Altiti, A. S., Ali, K., Mootoo, D. R., Blaho, V. A., Hla, T., Ren, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00404 · Cited by 9

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Picone, P., Palumbo, F. S., Cancilla, F., Girgenti, A., Cancemi, P., Muccilli, V., Francesco, A. D., Cimino, M., Cipollina, C., Soligo, M., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.016 · Cited by 8

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Li, J., Zheng, M., Ouyang, F., Ye, J., Huang, J., Zhao, Y., Wang, J., Shan, F., Li, Z., Yu, S., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70181 · Cited by 8

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Yan, P., Deng, Y. M., Su, X., Kong, H., Zhang, Y., Li, W., & Kong, E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18677-6.00007-5 · Cited by 8

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Shafit‐Zagardo, B., Sidoli, S., Goldman, J. E., DuBois, J. C., Corboy, J. R., Strittmatter, S. M., Guzik, H. M., Edema, U., Arackal, A. G., Botbol, Y. M., et al. (2023) · Cells · doi:10.3390/cells12131734 · Cited by 9

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Schreiner, B., Bailey, S. L., & Miller, S. D. (2006) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.3.1.57 · Cited by 7

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Lucchinetti, C. F. (2007) · Springer eBooks · doi:10.1007/978-0-387-36003-4_12 · Cited by 7

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van Rossum, D., Hilbert, S., Straßenburg, S., Hanisch, U., & Brück, W. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.100 · Cited by 8

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Suesca, E., Alejo, J. L. P., Bolaños, N. I., Ocampo, J., Leidy, C., & González, J. M. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22305 · Cited by 7

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Ding, D., Zhang, L., Liu, X., Sun, C., He, J., Li, J., Gao, X., Guan, F., & Zhang, L. (2022) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2021.0123 · Cited by 4

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Kopec, B. M., Ulapane, K. R., Moral, M. E. G., & Siahaan, T. J. (2018) · Neuromethods · doi:10.1007/978-1-4939-8946-1_2 · Cited by 4

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Kuo, R., Carlson, M. L., Reyes, S. T., Nagy, S. C., Kalita, M., Alam, I. S., Malik, N., Jackson, I. M., Acosta, C., Falk, I. N., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-67907-x · Cited by 3

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Mulat, Y., Ren, Z., Nong, C., Fu, C. B., Huo, Y., Zhao, M., Dai, Y., Chen, C., Wang, P., Wang, R., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03756-9 · Cited by 3

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Kulanga, M. (2008) · doi:10.53846/goediss-723

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