Molecular Pathogenesis of the Tauopathies

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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Alzheimer's disease

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Untitled work

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Cryo-EM structures of tau filaments from Alzheimer’s disease

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Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

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Progressive Supranuclear Palsy

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Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

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Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

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PET Imaging of Tau Deposition in the Aging Human Brain

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Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

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Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

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Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

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Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

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Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)

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A common inversion under selection in Europeans

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APP mouse models for Alzheimer’s disease preclinical studies.

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

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über eigenartige Krankheitsfälle des späteren Alters

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Proteopathic tau seeding predicts tauopathy in vivo

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Aβ Oligomers Cause Localized Ca ²⁺ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

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Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer’s disease

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Tau and tauopathies

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Src protein–tyrosine kinase structure and regulation

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Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

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Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

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Tau promotes neurodegeneration through global chromatin relaxation

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Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms

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In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum

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Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

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Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

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Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome

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Measurement of Phosphorylated Tau Epitopes in the Differential Diagnosisof Alzheimer Disease: A Comparative Cerebrospinal Fluid Study

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Global Hairpin Folding of Tau in Solution

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Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration

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Simultaneous Measurement of β-Amyloid(1–42), Total Tau, and Phosphorylated Tau (Thr181) in Cerebrospinal Fluid by the xMAP Technology

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Nuclear Tau, a Key Player in Neuronal DNA Protection

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Phosphorylation of Tau by Fyn: Implications for Alzheimer's Disease

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Constitutive activation of Src family kinases in mouse embryos that lack Csk

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Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

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Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

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MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum

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Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations

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C-terminal inhibition of tau assembly in vitro and in Alzheimer’s disease

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<scp>F</scp>yn inhibition rescues established memory and synapse loss in <scp>A</scp>lzheimer mice

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Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease

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Antisense Reduction of Tau in Adult Mice Protects against Seizures

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Accelerated filament formation from tau protein with specific FTDP‐17 missense mutations

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Tau‐positive dial Inclusions in Progressive Supranuclear Palsy, Corticobasal Degeneration and Pick's Disease

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CORTICAL AND SUBCORTICAL ARGYROPHILIC GRAINS CHARACTERIZE A DISEASE ASSOCIATED WITH ADULT ONSET DEMENTIA

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CAKβ/Pyk2 Kinase Is a Signaling Link for Induction of Long-Term Potentiation in CA1 Hippocampus

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Tau-based therapies in neurodegeneration: opportunities and challenges

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Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

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Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and <i>Drosophila</i> Genetic Models of Epilepsy

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Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes

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Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

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Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

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c-Src-Mediated Phosphorylation of hnRNP K Drives Translational Activation of Specifically Silenced mRNAs

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Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

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Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

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Glial and Neuronal Tau Pathology in Tauopathies: Characterization of Disease-Specific Phenotypes and Tau Pathology Progression

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Globular glial tauopathies (GGT): consensus recommendations

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Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2–dependent RNA granules

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Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue

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Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment

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Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

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Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn‐mediated local protein translation

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Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

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