Brain microbleeds and Alzheimer’s disease: innocent observation or key player?
Abstract
Brain microbleeds are small dot-like lesions appearing as hyposignals on gradient echo magnetic resonance sequences. In Alzheimer's disease, brain microbleeds are of special interest as they may play a crucial role in the pathophysiology. They may be a missing link between two important theories on the neuropathogenesis of Alzheimer's disease-the amyloid cascade hypothesis and the vascular hypothesis. Moreover, they may affect the clinical course of the disease and may have therapeutic consequences. The aim of this article is to review available data to understand the meaning of brain microbleeds in clinical terms and underlying pathology in the context of Alzheimer's disease. We also review the available evidence and highlight the pitfalls of our current knowledge on brain microbleeds in the setting of clinical trials design.
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Cerebral microbleeds are common in people with AD, DLB, stroke and trauma.
“Cerebral microbleeds are common in people with AD, DLB, stroke and trauma [34].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [34]
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- Authors
- Cordonnier, C., & van der Flier, W. M.
- Affiliations
- Université de Lille (FR)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-21
- Volume
- 134
- Issue
- 2
- Pages
- 335-344
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2145396188
- Cited by
- 310
- References
- 12
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 11 · 2021: 11 · 2020: 12 · 2019: 14 · 2018: 28 · 2017: 21 · 2016: 28 · 2015: 28 · 2014: 39 · 2013: 29 · 2012: 24
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- cerebral microbleeds, Alzheimer's disease, amyloid hypothesis, vascular hypothesis, neuropathogenesis, clinical course, therapeutic target, clinical trial design, gradient echo MRI, cerebral small vessel disease
- MeSH terms
- Alzheimer Disease, Brain, Cerebral Hemorrhage, Clinical Trials as Topic, Humans, Magnetic Resonance Imaging, Platelet Aggregation Inhibitors, Risk Factors, Prevalence, Positron-Emission Tomography
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