Regulation of Copper and Iron Homeostasis by Metal Chelators: A Possible Chemotherapy for Alzheimer’s Disease
Abstract
With the increase of life expectancy of humans in more than two-thirds of the countries in the World, aging diseases are becoming the frontline health problems. Alzheimer's disease (AD) is now one of the major challenges in drug discovery, since, with the exception of memantine in 2003, all clinical trials with drug candidates failed over the past decade. If we consider that the loss of neurons is due to a high level of oxidative stress produced by nonregulated redox active metal ions like copper linked to amyloids of different sizes, regulation of metal homeostasis is a key target. The difficulty for large copper-carrier proteins to directly extract copper ions from metalated amyloids might be considered as being at the origin of the rupture of the copper homeostasis regulation in AD brains. So, there is an urgent need for new specific metal chelators that should be able to regulate the homeostasis of metal ions, specially copper and iron, in AD brains. As a consequence of that concept, chelators promoting metal excretion from brain are not desired. One should favor ligands able to extract copper ions from sinks (amyloids being the major one) and to transfer these redox-active metal ions to copper-carrier proteins or copper-containing enzymes. Obviously, the affinity of these chelators for the metal ion should not be a sufficient criterion, but the metal specificity and the ability of the chelators to release the metal under specific biological conditions should be considered. Such an approach is still largely unexplored. The requirements for the chelators are very high (ability to cross the brain-blood barrier, lack of toxicity, etc.), few chemical series were proposed, and, among them, biochemical or biological data are scarce. As a matter of fact, the bioinorganic pharmacology of AD represents less than 1% of all articles dedicated to AD drug research. The major part of these articles deals with an old and rather toxic drug, clioquinol and related analogs, that do not efficiently extract copper from soluble amyloids. We have designed and developed new tetradendate ligands such as 21 and PA1637 based on bis(8-aminoquinolines) that are specific for copper chelation and are able to extract copper(II) from amyloids and then can release copper ion upon reduction with a biological reducing agent. These studies contribute to the understanding of the physicochemical properties of the tetradentate copper ligands compared with bidentate ligands like clioquinol. One of these copper ligands, PA1637, after selection with a nontransgenic mouse model that is able to efficiently monitor the loss of episodic memory, is currently under preclinical development.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Alzheimer's disease, brain levels of copper, iron and zinc increase almost three times normal.
“In AD the level of metal ions in the brain mainly copper, iron, zinc increases almost 3 times the normal.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [126]
Clioquinol has shown better results in treating neurodegenerative disease.
“Clioquinol from class 8-hydroxyquinoline has shown better results in treating neurodegenerative disease.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [126]
Clioquinol is a bi-dentate ligand with 2:1 activity against copper and zinc ions.
“It is a bi-dentate ligand which has 2:1 activity against copper and zinc ions.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [126]
Clioquinol transfers metal ions from extracellular to intracellular environment to maintain metal ion balance and dissolves Aβ-Cu2+/Zn2+ aggregates.
“It is known to transfer metal ions from extracellular environment to intra cellular environment of the cell to maintain metal ion balance and also dissolves Ab-Cu2+/Zn2+aggregates [125, 126].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [126]
Deferoxamine and Deferiprone are main metal chelators for iron; they treat memory impairment due to iron and prevent ROS production and metal-induced toxicity.
“Deferoxamine (DFO) and Deferiprone are main metal chelators for iron. They treat memory impairment due to iron and also prevent ROS production as well as metal induced toxicity.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [126]
Cites
2013 Alzheimer's disease facts and figures
Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works
The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
Alzheimer’s disease drug-development pipeline: Few candidates, frequent failures
Cummings, J. L., Morstorf, T., & Zhong, K. (2014) · Alzheimer's Research & Therapy · doi:10.1186/alzrt269 · Cited by 1,744 · see citing works
Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y.-S., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00317-8 · Cited by 1,447 · see citing works
Alzheimer’s disease: Clinical trials and drug development
Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217 · see citing works
Duce, J. A., Tsatsanis, A., Cater, M. A., James, S., Robb, E. L., Wikhe, K., Leong, S. L., Perez, K. A., Johanssen, T., Greenough, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.08.014 · Cited by 682 · see citing works
Adlard, P. A., Cherny, R. A., Finkelstein, D. I., Gautier, E., Robb, E., Cortes, M., Volitakis, I., Liu, X., Smith, J. P., Perez, K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.018 · Cited by 672 · see citing works
Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells
Park, E., Choi, J., Park, Y., & Park, K. (2008) · Toxicology · doi:10.1016/j.tox.2007.12.022 · Cited by 565 · see citing works
Dong, J., Atwood, C., Anderson, V. E., Siedlak, S. L., Smith, M. A., Perry, G. L., & CAREY, P. R. (2003) · Biochemistry · doi:10.1021/bi0272151 · Cited by 560 · see citing works
Biological metals and metal-targeting compounds in major neurodegenerative diseases
Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497 · see citing works
PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses
Faux, N. G., Ritchie, C. W., Gunn, A. P., Rembach, A., Tsatsanis, A., Bedő, J., Harrison, J., Lannfelt, L., Blennow, K., Zetterberg, H., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1390 · Cited by 406 · see citing works
Tomiyama, T., Matsuyama, S., Iso, H., Umeda, T., Takuma, H., Ohnishi, K., Ishibashi, K., Teraoka, R., Sakama, N., Yamashita, T., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5825-09.2010 · Cited by 396 · see citing works
Metallostasis in Alzheimer's disease
Ayton, S., Lei, P., & Bush, A. I. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.558 · Cited by 354 · see citing works
Bayer, T. A., Schäfer, S., Simons, A., Kemmling, A., Kamer, T., Tepest, R., Eckert, A., Schüssel, K., Eikenberg, O., Sturchler, C., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2332818100 · Cited by 325 · see citing works
Brain microbleeds and Alzheimer’s disease: innocent observation or key player?
Cordonnier, C., & van der Flier, W. M. (2011) · Brain · doi:10.1093/brain/awq321 · Cited by 310 · see citing works
NMDA Receptor Activation Mediates Copper Homeostasis in Hippocampal Neurons
Schlief, M. L., Craig, A. M., & Gitlin, J. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3699-04.2005 · Cited by 296 · see citing works
Di Vaira, M., Bazzicalupi, C., Orioli, P., Messori, L., Bruni, B., & Zatta, P. (2004) · Inorganic Chemistry · doi:10.1021/ic0494051 · Cited by 292 · see citing works
Guilloreau, L., Combalbert, S., Sournia‐Saquet, A., Mazarguil, H., & Faller, P. (2007) · ChemBioChem · doi:10.1002/cbic.200700111 · Cited by 273 · see citing works
Choi, J.-S., Braymer, J. J., Nanga, R. P. R., Ramamoorthy, A., & Lim, M. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006091107 · Cited by 264 · see citing works
Brain iron metabolism and its perturbation in neurological diseases
Crichton, R. R., Dexter, D. T., & Ward, R. J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0470-z · Cited by 246 · see citing works
Phillips, J. P. (1956) · Chemical Reviews · doi:10.1021/cr50008a003 · Cited by 240 · see citing works
Chaudière, J., Wilhelmsen, E. C., & Tappel, A. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43563-0 · Cited by 220 · see citing works
Jiang, D., Men, L., Wang, J., Zhang, Y., Chickenyen, S., Wang, Y., & Zhou, F. (2007) · Biochemistry · doi:10.1021/bi700508n · Cited by 202 · see citing works
Guo, C., Wang, T., Zheng, W. H., Shan, Z., Teng, W., & Wang, Z. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.009 · Cited by 200 · see citing works
Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide
Garah, F. E., Bijani, C., Coppel, Y., Faller, P., & Hureau, C. (2011) · Inorganic Chemistry · doi:10.1021/ic201233b · Cited by 199 · see citing works
Donnelly, P. S., Caragounis, A., Du, T., Laughton, K. M., Volitakis, I., Cherny, R. A., Sharples, R. A., Hill, A. F., Li, Q., Masters, C. L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705957200 · Cited by 196 · see citing works
Liu, G., Men, P., Harris, P. L. R., Rolston, R. K., Perry, G. L., & Smith, M. A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.020 · Cited by 177 · see citing works
Li, M., Shi, P., Xu, C., Ren, J., & Qu, X. (2013) · Chemical Science · doi:10.1039/c3sc50697e · Cited by 166 · see citing works
Matlack, K. E. S., Tardiff, D. F., Narayan, P. S., Hamamichi, S., Caldwell, K. A., Caldwell, G. A., & Lindquist, S. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402228111 · Cited by 166 · see citing works
Storr, T., Merkel, M., Song-Zhao, G. X., Scott, L. E., Green, D. E., Bowen, M. L., Thompson, K. H., Patrick, B. O., Schugar, H. J., & Orvig, C. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068965r · Cited by 156 · see citing works
Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease
Perez, L. R., & Franz, K. J. (2010) · Dalton Trans. · doi:10.1039/b919237a · Cited by 156 · see citing works
Malm, T., Iivonen, H., Goldsteins, G., Keksa-Goldsteine, V., Ahtoniemi, T., Kanninen, K. M., Salminen, A., Auriola, S. O. K., van Groen, T., Tanila, H., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0059-07.2007 · Cited by 154 · see citing works
Huang, L., Lu, C., Sun, Y., Mao, F., Luo, Z., Su, T., Jiang, H., Shan, W., & Li, X. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300978h · Cited by 153 · see citing works
Geng, J., Li, M. C., Wu, L. J., Ren, J., & Qu, X. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm3003813 · Cited by 152 · see citing works
Treiber, C., Simons, A., Strauß, M., Hafner, M., Cappai, R., Bayer, T. A., & Multhaup, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407410200 · Cited by 147 · see citing works
† (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70262-5 · Cited by 144 · see citing works
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn 2+
Andersson, D. A., Gentry, C., Moss, S., & Bevan, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812675106 · Cited by 136 · see citing works
Preparation and Study of New Poly‐8‐Hydroxyquinoline Chelators for an anti‐Alzheimer Strategy
Deraeve, C., Boldron, C., Maraval, A., Mazarguil, H., Gornitzka, H., Vendier, L., Pitié, M., & Meunier, B. (2007) · Chemistry - A European Journal · doi:10.1002/chem.200701024 · Cited by 128 · see citing works
Self-citationBarone, E., Di Domenico, F., Mancuso, C., & Butterfield, D. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.09.018 · Cited by 127 · see citing works
Xiong, Y., Jing, X.-P., Zhou, X.-W., Wang, X.-L., Yang, Y., Sun, X.-Y., Qiu, M., Cao, F.-Y., Lu, Y.-M., Liu, R., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.07.003 · Cited by 122 · see citing works
Zussy, C., Brureau, A., Keller, E., Marchal, S., Blayo, C., Delair, B., IXART, G., Maurice, T., & Givalois, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053117 · Cited by 116 · see citing works
Wang, Z., Wang, Y., Li, W., Mao, F., Sun, Y., Huang, L., & Li, X. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500119g · Cited by 116 · see citing works
Werner coordination chemistry and neurodegeneration
Telpoukhovskaia, M. A., & Orvig, C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35236b · Cited by 112 · see citing works
Youdim, M. B. H. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.1.1 · Cited by 110 · see citing works
Faller, P., & Hureau, C. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201202697 · Cited by 107 · see citing works
Li, S., Jiang, N., Xie, S., Wang, K. D. G., Wang, X., & Kong, L. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob42010h · Cited by 96 · see citing works
Ceccom, J., Cosledan, F., Halley, H., Francès, B., Lassalle, J. M., & Meunier, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043105 · Cited by 88 · see citing works
Self-citationRestored degradation of the Alzheimer’s amyloid‐β peptide by targeting amyloid formation
Crouch, P. J., Tew, D. J., Du, T., Nguyen, D., Caragounis, A., Filiz, G., Blake, R. E., Trounce, I. A., Soon, C. P. W., Laughton, K. M., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05870.x · Cited by 88 · see citing works
Clioquinol-Zinc Chelate: A Candidate Causative Agent of Subacute Myelo-Optic Neuropathy
Arbiser, J. L., Kraeft, S.-K., van Leeuwen, R., Hurwitz, S. J., Selig, M., Dickersin, G. R., Flint, A., Byers, H. R., & Chen, L. B. (1998) · Molecular Medicine · doi:10.1007/bf03401927 · Cited by 85 · see citing works
Folk, D. S., & Franz, K. J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja100943r · Cited by 85 · see citing works
Shi, P., Li, M., Ren, J., & Qu, X. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201301015 · Cited by 82 · see citing works
Ferrada, E., Arancibia, V., Bárbara Loeb, L., Norambuena, E., Olea‐Azar, C., & Huidobro-Toro, J. P. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.02.004 · Cited by 81 · see citing works
Kamalinia, G., Khodagholi, F., Atyabi, F., Amini, M., Shaerzadeh, F., Sharifzadeh, M. S., & Dinarvand, R. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4002014 · Cited by 73 · see citing works
Beck, M. W., Oh, S. B., Kerr, R. A., Lee, H. J., Kim, S., Kim, S., Jang, M., Ruotolo, B. T., Lee, J., & Lim, M. H. (2015) · Chemical Science · doi:10.1039/c4sc03239j · Cited by 71 · see citing works
Liu, Z. D., Kayyali, R., Hider, R. C., Porter, J. B., & Theobald, A. E. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010817i · Cited by 70 · see citing works
Amijee, H., Bate, C., Williams, A., Virdee, J. K., Jeggo, R., Spanswick, D. C., Scopes, D. I. C., Treherne, J. M., Mazzitelli, S., Chawner, R., et al. (2012) · Biochemistry · doi:10.1021/bi300415v · Cited by 70 · see citing works
Aliès, B., Sasaki, I., Proux, O., Sayen, S., Guillon, E., Faller, P., & Hureau, C. (2013) · Chemical Communications · doi:10.1039/c2cc38236a · Cited by 68 · see citing works
Nguyen, M., Robert, A., Sournia‐Saquet, A., Vendier, L., & Meunier, B. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201402143 · Cited by 65 · see citing works
Self-citationKenche, V. B., Zawisza, I., Masters, C. L., Bal, W., Barnham, K. J., & Drew, S. C. (2013) · Inorganic Chemistry · doi:10.1021/ic302289r · Cited by 59 · see citing works
Huang, W., Lv, D., Yu, H., Sheng, R., Kim, S. C., Wu, P., Luo, K., Li, J. X., & Hu, Y. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.06.042 · Cited by 58 · see citing works
Green, D. E., Bowen, M. L., Scott, L. E., Storr, T., Merkel, M., Böhmerle, K., Thompson, K. H., Patrick, B. O., Schugar, H. J., & Orvig, C. (2009) · Dalton Transactions · doi:10.1039/b918439b · Cited by 56 · see citing works
Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents
Deraeve, C., Piti, M., Mazarguil, H., & Meunier, B. (2007) · New Journal of Chemistry · doi:10.1039/b616085a · Cited by 53 · see citing works
Self-citationZheng, H., Youdim, M. B. H., & Fridkin, M. (2010) · ACS Chemical Neuroscience · doi:10.1021/cn100069c · Cited by 50 · see citing works
Takeda, A., Takada, S., Ando, M., Itagaki, K., Tamano, H., Suzuki, M., Iwaki, H., & Oku, N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.017 · Cited by 47 · see citing works
Lakatos, A., Zsigó, É., Hollender, D., May, N. V., Fülöp, L., Simon, D., Bozsó, Z., & Kiss, T. (2009) · Dalton Transactions · doi:10.1039/b916366b · Cited by 46 · see citing works
Noël, S., Rodriguez, S. B., Sayen, S., Guillon, E., Faller, P., & Hureau, C. (2014) · Metallomics · doi:10.1039/c4mt00016a · Cited by 44 · see citing works
Jammal, A. E., Howell, P. L., Turner, M. A., Li, N., & Templeton, D. M. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00030a005 · Cited by 43 · see citing works
Scott, L. E., Page, B. D. G., Patrick, B. O., & Orvig, C. (2008) · Dalton Transactions · doi:10.1039/b815404j · Cited by 38 · see citing works
Noël, S., Perez, F., Pedersen, J. T., Aliès, B., Mallet‐Ladeira, S., Sayen, S., Guillon, E., Gras, E., & Hureau, C. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2012.05.016 · Cited by 37 · see citing works
Oliveri, V., Attanasio, F., Puglisi, A., Spencer, J., Sgarlata, C., & Vecchio, G. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201402690 · Cited by 33 · see citing works
Deraeve, C., Maraval, A., Vendier, L., Faugeroux, V., Pitié, M., & Meunier, B. (2008) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.200800924 · Cited by 32 · see citing works
Self-citationOliveri, V., Attanasio, F., Puglisi, A., et al. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201490121 · Cited by 26 · see citing works
The Necessity of Having a Tetradentate Ligand to Extract Copper(II) Ions from Amyloids
Nguyen, M., Rechignat, L., Robert, A., & Meunier, B. (2014) · ChemistryOpen · doi:10.1002/open.201402075 · Cited by 24 · see citing works
Self-citationSheppard, L. N., & Kontoghiorghes, G. J. (1991) · Inorganica Chimica Acta · doi:10.1016/s0020-1693(00)80369-2 · Cited by 19 · see citing works
Iron(III)-selective dendritic chelators
Zhou, T., Hider, R. C., Liu, Z. D., & Neubert, H. (2004) · Tetrahedron Letters · doi:10.1016/j.tetlet.2004.10.110 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
“They include pyrrolidine dithiocarbonate (PDTC), pyridine derivatives, reduced Schiff base derivatives, Bis(hydrazide), bis(thiosemicarbazones) (BTSC), peptides and multifunctional ligands [126].”
BackgroundMetal Ions in Alzheimer’s Disease: A Key Role or Not?
Liu, Y., Nguyen, M., Robert, A., & Meunier, B. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00248 · Cited by 353 · see citing works
Self-citationCurrent Research Therapeutic Strategies for Alzheimer’s Disease Treatment
Folch, J., Petrov, D., Ettcheto, M., Abad, S., Sánchez-López, E., García, M. L., Olloquequi, J., Beas-Zarate, C., Auladell, C., & Camins, A. (2016) · Neural Plasticity · doi:10.1155/2016/8501693 · Cited by 270 · see citing works
Chen, L.-L., Fan, Y.-G., Zhao, L.-X., Zhang, Q., & Wang, Z.-Y. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106301 · Cited by 200 · see citing works
Rajasekhar, K., & Govindaraju, T. (2018) · RSC Advances · doi:10.1039/c8ra03620a · Cited by 150 · see citing works
Wang, Z., Hu, J., Yang, X., Feng, X., Li, X., Huang, L., & Chan, A. S. C. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01417 · Cited by 91 · see citing works
Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage
Rajasekhar, K., Mehta, K., & Govindaraju, T. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00033 · Cited by 69 · see citing works
Iron Pathophysiology in Alzheimer’s Diseases
Wang, T., Xu, S.-F., Fan, Y.-G., Li, L.-B., & Guo, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_5 · Cited by 64 · see citing works
D'Acunto, C. W., Kaplánek, R., Gbelcová, H., Kejík, Z., Bříza, T., Vasina, L., Havlík, M., Ruml, T., & Král, V. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.02.084 · Cited by 26 · see citing works
Wang, X.-X., Xie, F., Jia, C.-C., Yan, N., Zeng, Y.-L., Wu, J.-D., & Liu, Z.-P. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113821 · Cited by 23 · see citing works
Gonzalez, P., Sabater, L., Mathieu, E., Faller, P., & Hureau, C. (2022) · Biomolecules · doi:10.3390/biom12101327 · Cited by 13 · see citing works
- Authors
- Robert, A., Liu, Y., Nguyen, M., & Meunier, B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Guangdong University of Technology (CN)
- Corresponding author
- Robert, Anne
- Meunier, Bernard
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-05-06
- Volume
- 48
- Issue
- 5
- Pages
- 1332-1339
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2404450481
- Cited by
- 212
- References
- 75
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 10 · 2023: 23 · 2022: 17 · 2021: 25 · 2020: 26 · 2019: 25 · 2018: 26 · 2017: 18 · 2016: 16 · 2015: 4
- FWCI
- 15.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Accounts of Chemical Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Keywords
- Alzheimer's disease, copper homeostasis, iron homeostasis, metal chelators, copper chelation, amyloid, oxidative stress, tetradentate ligands, clioquinol, redox-active metal ions, drug discovery
- MeSH terms
- Alzheimer Disease, Chelating Agents, Copper, Homeostasis, Humans, Iron, Organometallic Compounds, Molecular Structure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
