Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,776 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

B lymphocytes secrete antigen-presenting vesicles.

Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · cited 1× · see citing works

Rab27a and Rab27b control different steps of the exosome secretion pathway

Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works

Current knowledge on exosome biogenesis and release

Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223 · see citing works

Membrane Fusion: Grappling with SNARE and SM Proteins

Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027 · see citing works

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Perez-Hernandez, D., Vázquez, J., Martín-Cófreces, N., Martínez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,907 · see citing works

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works

The Mechanisms of Vesicle Budding and Fusion

Bonifacino, J. S., & Glick, B. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01079-1 · Cited by 1,863 · see citing works

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works

Endocytic recycling

Maxfield, F. R., & McGraw, T. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1315 · Cited by 1,716 · see citing works

Rab Conversion as a Mechanism of Progression from Early to Late Endosomes

Rink, J. C., Ghigo, É., Kalaidzidis, Y. L., & Zerial, M. (2005) · Cell · doi:10.1016/j.cell.2005.06.043 · Cited by 1,680 · see citing works

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643 · see citing works

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Zhang, H., Freitas, D. P., Kim, H. S., Fabijanic, K. I., Li, Z., Chen, H., Mark, M. T., Molina, H., Benito‐Martín, A., Bojmar, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0040-4 · Cited by 1,623 · see citing works

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Colombo, M., Moita, C. F., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L. F., Théry, C., & Raposo, G. (2013) · Journal of Cell Science · doi:10.1242/jcs.128868 · Cited by 1,472 · see citing works

Pathways and mechanisms of endocytic recycling

Grant, B. D., & Donaldson, J. G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2755 · Cited by 1,468 · see citing works

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,430 · see citing works

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

Maas, S. L. N., Breakefield, X. O., & Weaver, A. M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.003 · Cited by 1,419 · see citing works

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369 · see citing works

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Escudier, B. J., Dorval, T., Chaput, N., André, F., Caby, M.-P., Novault, S., Flament, C., Leboulaire, C., Borg, C., Amigorena, S., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-10 · Cited by 1,285 · see citing works

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242 · see citing works

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

Morse, M. A., Garst, J. L., Osada, T., Khan, S., Hobeika, A. C., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A. X., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-9 · Cited by 1,123 · see citing works

Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics

Yang, D., Zhang, W., Zhang, H., Zhang, F., Chen, L., Ma, L., Larcher, L. M., Chen, S., Liu, N., Zhao, Q., et al. (2020) · Theranostics · doi:10.7150/thno.41580 · Cited by 1,048 · see citing works

VESICLES ASSOCIATED WITH CALCIFICATION IN THE MATRIX OF EPIPHYSEAL CARTILAGE

Anderson, H. C. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.41.1.59 · Cited by 1,046 · see citing works

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

Zhang, H., Deng, T., Liu, R., Ning, T., Yang, H., Liu, D., Zhang, Q., Lin, D., Ge, S., Bai, M., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01168-8 · Cited by 1,025 · see citing works

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Säftig, P., Marks, M. S., Rubinstein, E., & Raposo, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.019 · Cited by 955 · see citing works

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration

Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2018) · Theranostics · doi:10.7150/thno.29766 · Cited by 914 · see citing works

Escrt-III

Babst, M., Katzmann, D. J., Estepa, E. J., Meerloo, T., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00220-4 · Cited by 875 · see citing works

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

Record, M., Carayon, K., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.004 · Cited by 853 · see citing works

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., et al. (2010) · Science · doi:10.1126/science.1190809 · Cited by 836 · see citing works

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Besse, B., Charrier, M., Lapierre, V., Dansin, É., Lantz, O. J., Planchard, D., Chevalier, T. L., Livartoski, A., Barlési, F., Laplanche, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1071008 · Cited by 802 · see citing works

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

Kosaka, N., Iguchi, H., Hagiwara, K., Yoshioka, Y., Takeshita, F., & Ochiya, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446831 · Cited by 772 · see citing works

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

Sengupta, V., Sengupta, S., Lazo, A., Woods, P., Nolan, A., & Bremer, N. J. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0080 · Cited by 751 · see citing works

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

Katakowski, M., Buller, B., Zheng, X., Lü, Y., Rogers, T., Osobamiro, O. O., Shu, W., Jiang, F., & Chopp, M. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.019 · Cited by 748 · see citing works

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Kojima, R., Bojar, D., Rizzi, G., Hamri, G. C.-E., El-Baba, M. D., Saxena, P., Ausländer, S., Tan, K. R., & Fussenegger, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03733-8 · Cited by 748 · see citing works

Sorting it out: Regulation of exosome loading

Villarroya‐Beltri, C., Baixauli, F., Gutiérrez‐Vázquez, C., Sánchez‐Madrid, F., & Mittelbrunn, M. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.04.009 · Cited by 745 · see citing works

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

Stuffers, S., Wegner, C. S., Stenmark, H., & Brech, A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00920.x · Cited by 731 · see citing works

Intestinal epithelial cells secrete exosome–like vesicles

van Niel, G., Raposo, G., Candalh, C., Boussac, M., Hershberg, R. M., Cerf–Bensussan, N., & Heyman, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.26263 · Cited by 698 · see citing works

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Kooijmans, S. A. A., Stremersch, S., Braeckmans, K., de Smedt, S. C., Hendrix, A., Wood, M. J. A., Schiffelers, R. M., Raemdonck, K., & Vader, P. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.014 · Cited by 663 · see citing works

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

Babst, M., Katzmann, D. J., Snyder, W. B., Wendland, B., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00219-8 · Cited by 662 · see citing works

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

Shurtleff, M. J., Karfilis, K. V., Temoche-Diaz, M. M., Ri, S., & Schekman, R. W. (2016) · eLife · doi:10.7554/elife.19276 · Cited by 648 · see citing works

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

Bobrie, A., Krumeich, S., Reyal, F., Recchi, C., Moita, L. F., Seabra, M. C., Ostrowski, M., & Théry, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0925 · Cited by 647 · see citing works

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

Pankiv, S., Alemu, E. A., Brech, A., Bruun, J., Lamark, T., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200907015 · Cited by 645 · see citing works

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

Frank, F., Sonenberg, N., & Nagar, B. (2010) · Nature · doi:10.1038/nature09039 · Cited by 625 · see citing works

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

Yáñez‐Mó, M., Barreiro, O., Gordón‐Alonso, M., Sala-Valdés, M., & Sánchez‐Madrid, F. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.06.004 · Cited by 617 · see citing works

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

Okoye, I., Coomes, S. M., Pelly, V. S., Czieso, S., Papayannopoulos, V., Tolmachova, T., Seabra, M. C., & Wilson, M. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.019 · Cited by 604 · see citing works

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

Ghossoub, R., Lembo, F., Rubio, A., Baron, C. L., Bouchet, J., Vitale, N., Slavík, J., Machala, M., & Zimmermann, P. (2014) · Nature Communications · doi:10.1038/ncomms4477 · Cited by 601 · see citing works

Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles’ characteristics compared to precipitating agents

Gámez‐Valero, A., Tortajada, M., Carreras‐Planella, L., Franquesa, M., Beyer, K., & Borràs, F. E. (2016) · Scientific Reports · doi:10.1038/srep33641 · Cited by 601 · see citing works

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

Santangelo, L., Giurato, G., Cicchini, C., Montaldo, C., Mancone, C., Tarallo, R., Battistelli, C., Alonzi, T., Weisz, A., & Tripodi, M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.031 · Cited by 600 · see citing works

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

Koppers‐Lalic, D., Hackenberg, M., Bijnsdorp, I. V., van Eijndhoven, M. A. J., Sadek, P., Sie, D., Zini, N., Middeldorp, J. M., Ylstra, B., de Menezes, R. X., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.027 · Cited by 589 · see citing works

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

Ohshima, K., Inoue, K., Fujiwara, A., Hatakeyama, K., Kanto, K., Watanabe, Y., Muramatsu, K., Fukuda, Y., Ogura, S., Yamaguchi, K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013247 · Cited by 577 · see citing works

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

Hoshino, D., Kirkbride, K. C., Costello, K., Clark, E. S., Sinha, S., Grega‐Larson, N. E., Tyska, M. J., & Weaver, A. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.050 · Cited by 561 · see citing works

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

Guduric‐Fuchs, J., O’Connor, A., Camp, B., O’Neill, C. L., Medina, R. J., & Simpson, D. A. C. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-357 · Cited by 554 · see citing works

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

Fader, C. M., Sánchez, D. G., Mestre, M. B., & Colombo, M. I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.09.011 · Cited by 544 · see citing works

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

Zarovni, N., Corrado, A., Guazzi, P., Zocco, D., Lari, E., Radano, G., Muhhina, J., Fondelli, C., Gavrilova, J., & Chiesi, A. (2015) · Methods · doi:10.1016/j.ymeth.2015.05.028 · Cited by 535 · see citing works

Clathrin-independent pathways of endocytosis

Mayor, S., Parton, R. G., & Donaldson, J. G. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016758 · Cited by 525 · see citing works

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M., & Caplan, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201002049 · Cited by 514 · see citing works

Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium‐Dependent Manner

Savina, A., Fader, C. M., Damiani, M. T., & Colombo, M. I. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00257.x · Cited by 512 · see citing works

RAB31 marks and controls an ESCRT-independent exosome pathway

Wei, D., Zhan, W., Gao, Y., Huang, L., Gong, R., Wang, W., Zhang, R., Wu, Y., Gao, S., & Kang, T. (2020) · Cell Research · doi:10.1038/s41422-020-00409-1 · Cited by 498 · see citing works

Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry

Tian, Y., Ma, L., Gong, M., Su, G., Zhu, S., Zhang, W., Wang, S., Li, Z., Chen, C., Li, L., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b07782 · Cited by 492 · see citing works

Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1β-Primed Mesenchymal Stem Cells Against Sepsis

Song, Y., Dou, H., Li, X., Zhao, X., Li, Y., Liu, D., Ji, J., Liu, F., Ding, L., Ni, Y., et al. (2017) · Stem Cells · doi:10.1002/stem.2564 · Cited by 490 · see citing works

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

Villarroya‐Beltri, C., Baixauli, F., Mittelbrunn, M., Fernández‐Delgado, I., Torralba, D., Moreno-Gonzalo, O., Baldanta, S., Enrich, C., Guerra, S., & Sánchez‐Madrid, F. (2016) · Nature Communications · doi:10.1038/ncomms13588 · Cited by 489 · see citing works

The exosome pathway in K562 cells is regulated by Rab11

Savina, A., Vidal, M., & Colombo, M. I. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.12.2505 · Cited by 487 · see citing works

A novel affinity-based method for the isolation of highly purified extracellular vesicles

Nakai, W., Yoshida, T., Díez, D., Miyatake, Y., Nishibu, T., Imawaka, N., Naruse, K., Sadamura, Y., & Hanayama, R. (2016) · Scientific Reports · doi:10.1038/srep33935 · Cited by 486 · see citing works

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

Zhang, H., & Lyden, D. C. (2019) · Nature Protocols · doi:10.1038/s41596-019-0126-x · Cited by 482 · see citing works

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

Teng, Y., Ren, Y., Hu, X., Mu, J., Samykutty, A. K., Zhuang, X., Deng, Z., Kumar, A., Zhang, L., Merchant, M. L., et al. (2017) · Nature Communications · doi:10.1038/ncomms14448 · Cited by 479 · see citing works

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

Rojas, R., van Vlijmen, T., Mardones, G. A., Prabhu, Y., Rojas, A. L., Mohammed, S., Heck, A. J. R., Raposo, G., van der Sluijs, P., & Bonifacino, J. S. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804048 · Cited by 458 · see citing works

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

Tauro, B. J., Greening, D. W., Mathias, R. A., Mathivanan, S., Ji, H. L., & Simpson, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021303 · Cited by 446 · see citing works

The biology of extracellular vesicles: The known unknowns

Margolis, L. B., & Sadovsky, Y. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000363 · Cited by 443 · see citing works

Rab7 Associates with Early Endosomes to Mediate Sorting and Transport of Semliki Forest Virus to Late Endosomes

Vonderheit, A., & Helenius, A. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030233 · Cited by 437 · see citing works

Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Kooijmans, S. A. A., Gomez‐Aleza, C., Roffler, S. R., van Solinge, W. W., Vader, P., & Schiffelers, R. M. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31053 · Cited by 429 · see citing works

Endosomes

Helenius, A., Mellman, I., Wall, D. A., & Hubbard, A. L. (1983) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(83)90350-x · Cited by 428 · see citing works

Endosomal transport function in yeast requires a novel AAA‐type ATPase, Vps4p

Babst, M., Sato, T. K., Banta, L. M., & Emr, S. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1820 · Cited by 424 · see citing works

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

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ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

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