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Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase
Open accessAbstract
The modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) during the postinitiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks and then they were fed the diets containing AX or CX at concentrations of 100 and 500 p.p.m. for 34 weeks. The others contained the groups of rats treated with AX or CX alone and untreated. At the end of the study (week 37), the incidence and multiplicity of neoplasms (adenoma and adenocarcinoma) in the large intestine of rats initiated with AOM and followed by AX or CX containing diet at a high dose (500 p.p.m.) were significantly smaller than those of rats given AOM alone (P < 0.001). In addition, AX or CX feeding significantly inhibited the development of aberrant crypt foci induced by AOM. Dietary exposure to AX or CX also decreased cell proliferation activity as revealed by measuring 5'-bromodeoxyuridine-labeling index as crypt cells, colonic mucosal ornithine decarboxylase activity and blood polyamine levels. These results indicate that AX and CX are possible chemopreventers for carcinogenesis of colon in addition to urinary bladder and oral cavity and such effects may be partly due to suppression of cell proliferation.
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“Astaxanthin enhances in vitro immunoglobulin antibody production by mouse spleen cells stimulated with sheep red blood cells, at least in part by exerting actions on T-cells, especially T-helper cells (Tanaka et al., 1995, Jyonouchi et al., 1993, Park et al., 2010).”
From Microalgae Metabolites: A Rich Source for Food and Medicine (2019) · cites this paper as Tanaka et al., 1995
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Metadata
- Authors
- Tanaka, T., Kawamori, T., Ohnishi, M., Makita, H., Mori, H., Satoh, K., & Hara, A.
- Affiliations
- Gifu University (JP)
- Gifu Pharmaceutical University (JP)
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1995
- Volume
- 16
- Issue
- 12
- Pages
- 2957-2963
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W1964960880
- Cited by
- 134
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 12 · 2018: 3 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- colon carcinogenesis, azoxymethane, astaxanthin, canthaxanthin, xanthophylls, chemoprevention, aberrant crypt foci, cell proliferation, ornithine decarboxylase, polyamines, colonic adenoma, adenocarcinoma, dietary carotenoids
- MeSH terms
- Animals, Azoxymethane, Bromodeoxyuridine, Carcinogens, Carotenoids, Colon, Colonic Neoplasms, Diet, Intestinal Mucosa, Male, Ornithine Decarboxylase, Polyamines, Rats, Inbred F344, Incidence, Canthaxanthin, beta Carotene, Xanthophylls, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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