Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HL-60
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The apoptosis-inducing effect of fucoxanthin on human leukemic HL-60 cells was investigated. Fucoxanthin, which was obtained from the brown alga Undaria pinnatifida, inhibited the proliferation of HL-60 cells and induced DNA fragmentation on agarose gel electrophoresis, a typical characteristic feature of apoptotic cells. The results of sandwich ELISA using anti-biotin-antibody and anti-DNA-antibody also demonstrated DNA fragmentation in accordance with the increase in fucoxanthin concentration and incubation time. Since the level of DNA fragmentation did not increase after 24 h incubation, fucoxanthin appeared to have some effect on cell cycle. In contrast, β-carotene did not show an apoptosis-inducing effect on HL-60 cells. These results suggested that a carotenoid structure might be crucial for inducing apoptosis.
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Carotenoids are natural antioxidants applied in food products; the most abundant carotenoid of marine macroalgae is fucoxanthin, which possesses antiproliferative activity; carotenoids also possess antioxidant, antimicrobial, and antihypertensive activity.
“Carotenoids are natural antioxidants and they are applied in different food products [18]. The most abundant carotenoid of marine macroalgae is fucoxanthin (Figure 4) and it possess antiproliferative activity [19,20]. Except for antiproliferative properties, carotenoids also possess antioxidant [21], antimicrobial, and antihypertensive activity [22].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [19]
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Jaswir, I., Noviendri, D., Salleh, H. M., Taher, M., Miyashita, K., & Ramli, N. (2013) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2012.691435 · Cited by 55 · see citing works
Fucoxanthin extraction and fatty acid analysis of Sargassum binderi and S. duplicatum
Noviendri, D., Irw, Jaswir, I., Salleh, H. M., Taher, M., Miyashita, K., & Ramli, N. (2011) · The International Islamic University Malaysia Repository (The International Islamic University Malaysia) · doi:10.5897/jmpr.9000658 · Cited by 54 · see citing works
Advantageous characteristics of the diatom Chaetoceros gracilis as a sustainable biofuel producer
Tokushima, H., Inoue‐Kashino, N., Nakazato, Y., Masuda, A., Ifuku, K., & Kashino, Y. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0649-0 · Cited by 54 · see citing works
Antiproliferative effect of neoxanthin and fucoxanthin on cultured cells
Kotake‐Nara, E., Sugawara, T., & Nagao, A. (2005) · Fisheries Science · doi:10.1111/j.1444-2906.2005.00986.x · Cited by 54 · see citing works
Yip, W. H., Lim, S. J., Mustapha, W. A. W., Maskat, M. Y., & Said, M. (2014) · Sains Malaysiana · Cited by 53 · see citing works
Fucoxanthin Extractions of Brown Seaweeds and Analysis of Their Lipid Fraction in Methanol
Jaswir, I., Noviendri, D., Salleh, H. M., & Miyashita, K. (2012) · Food Science and Technology Research · doi:10.3136/fstr.18.251 · Cited by 50 · see citing works
Jaswir, I. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb11.2765 · Cited by 49 · see citing works
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Kanamoto, A., Kato, Y., Yoshida, E., Hasunuma, T., & Kondo, A. (2021) · Marine Biotechnology · doi:10.1007/s10126-021-10028-5 · Cited by 47 · see citing works
Single-step extraction of carotenoids from brown macroalgae using non-ionic surfactants
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Minhas, L. A., Kaleem, M., Farooqi, H. M. U., Kausar, F., Waqar, R., Bhatti, T., Aziz, S., Jung, D. W., & Mumtaz, A. S. (2024) · Algal Research · doi:10.1016/j.algal.2024.103396 · Cited by 43 · see citing works
Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity
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Seaweed Carotenoid, Fucoxanthin, as Functional Food
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Screening for Bioactive Compounds from Algae
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Marine lipids as a source of high-quality fatty acids and antioxidants
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- Authors
- HOSOKAWA, M., WANEZAKI, S., MIYAUCHI, K., KURIHARA, H., KOHNO, H., KAWABATA, J., ODASHIMA, S., & TAKAHASHI, K.
- Affiliations
- Hokkaido University (JP)
- Kanazawa Medical University (JP)
- Venue
- Food Science and Technology Research
- Published
- 1999
- Volume
- 5
- Issue
- 3
- Pages
- 243-246
- ISSN
- 1344-6606 (ISSN-L)
- 1881-3984
- OpenAlex
- W2013418062
- Cited by
- 173
- References
- 14
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 15 · 2019: 8 · 2018: 15 · 2017: 12 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 4
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Food Science and Technology Research (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- fucoxanthin, apoptosis, HL-60 cells, leukemia, Undaria pinnatifida, DNA fragmentation, cell proliferation inhibition, carotenoids, beta-carotene, cell cycle
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