The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
Abstract
Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for the prevention of cancer. However, the mechanism of the anti-carcinogenic activity of resveratrol is not well understood. Here we offer a possible explanation of its anti-cancer effect. Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis.
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Cites
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 2×
“It was shown to have an anti-carcinogenic effect in a two-stage mouse skin cancer model ( 21 ).”
BackgroundMice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Dong, Z., Birrer, M. J., Watts, R. G., Matrisian, L. M., & Colburn, N. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.609 · Cited by 386
AP1/ jun Function Is Differentially Induced in Promotion-Sensitive and Resistant JB6 Cells
Bernstein, L. R., & Colburn, N. H. (1989) · Science · doi:10.1126/science.2541502 · Cited by 207
Cited by
Molecular targets of dietary agents for prevention and therapy of cancer
Aggarwal, B. B., & Shishodia, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.02.009 · Cited by 1,754
Post-translational modification of p53 in tumorigenesis
Bode, A. M., & Dong, Z. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1455 · Cited by 1,270
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Perspectives for Cancer Prevention With Natural Compounds
Amin, A. R. M. R., Kucuk, O., Khuri, F. R., & Shin, D. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.6235 · Cited by 572
Biological Effects of Resveratrol
Bhat, K. P. L., Kosmeder, J. W., & Pezzuto, J. M. (2001) · Antioxidants & Redox Signaling · doi:10.1089/152308601317203567 · Cited by 507
Metadata
- Authors
- Huang, C.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02-01
- Volume
- 20
- Issue
- 2
- Pages
- 237-242
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2166185936
- Cited by
- 338
- References
- 4
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, C. (1999). Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis. https://doi.org/10.1093/carcin/20.2.237
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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