The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Abstract
Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.
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Cites
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BackgroundIKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
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Cited by
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
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Metadata
- Authors
- Colotta, F., Allavena, P., Sica, A., Garlanda, C., & Mantovani, A.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05-25
- Volume
- 30
- Issue
- 7
- Pages
- 1073-1081
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2102144390
- Cited by
- 2,890
- References
- 37
- FWCI
- 45.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Colotta, F., Allavena, P., Sica, A., Garlanda, C., & Mantovani, A. (2009). Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis. https://doi.org/10.1093/carcin/bgp127
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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