Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
Open accessAbstract
Cellular senescence, a state of stable growth arrest, can occur in response to various stress stimuli such as telomere shortening, treatment with chemotherapeutic drugs or the aberrant activation of oncogenes. Senescent cells communicate with their environment by secreting various cytokines and growth factors, and it has become clear that this 'secretory phenotype' can have pro- as well as anti-tumorigenic effects. Recent work from our laboratory showed that premalignant, senescent hepatocytes are recognized and cleared through an antigen-specific immune response and that this immune response, designated as 'senescence surveillance' is crucial for tumor suppression in the liver [(Kang,T.W. et al. (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature, 479, 547-551]. It is an emerging concept that immune responses against senescent cells have a broader biological significance in cancer- as well as non-cancer pathologies and current data suggest that distinct immune responses are engaged to clear senescent cells in different disease settings. In this review article, we will discuss different examples how immune responses against senescent cells are involved to restrict disease progression in cancer- and non-cancer pathologies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Senescent cells can be recognized by T helper cells and cleared by macrophages and natural killer lymphocytes.
“Although senescent cells can be recognized by T helper cells and cleared by macrophages and natural killer lymphocytes [27,34,35], their number has been shown to increase with normal ageing in tissues of humans, primates and rodents [36,37].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [35]
Senescent cells can be eliminated through a SASP-induced immune response involving innate and adaptive immunity.
“Senescent cells can be eliminated through a SASP-induced immune response, which can involve both innate and adaptive immunity.”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [111]
SASP can activate an immune response.
“activating an immune response”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [111]
Senescent cells formed following tissue damage can promote their own clearance by secreting chemo-attractants that recruit and activate immune cells.
“Indeed, senescent cells formed following tissue damage can promote their own clearance by secreting chemo-attractants that recruit and activate immune cells [265].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [265]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474 · see citing works
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works
“Most strikingly, late-life clearance of senescent cells still attenuated progression of already established age-related disorders (40).”
BackgroundSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · see citing works
Self-citationSenescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Senescence of activated stellate cells limits liver fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.06.049 · Cited by 2,029 · see citing works
Self-citationSenescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
Self-citationCrucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works
Self-citationSenescence in premalignant tumours
Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482 · see citing works
Reversal of human cellular senescence: roles of the p53 and p16 pathways
Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457 · see citing works
Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354 · see citing works
Lowe, S. W., Cepero, E., & Evan, G. I. (2004) · Nature · doi:10.1038/nature03098 · Cited by 1,309 · see citing works
Oncogene-induced senescence as an initial barrier in lymphoma development
Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works
Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998 · see citing works
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works
Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M., & Green, M. R. (2008) · Cell · doi:10.1016/j.cell.2007.12.032 · Cited by 903 · see citing works
Senescence of human fibroblasts induced by oncogenic Raf
Zhu, J., Woods, D., McMahon, M., & Bishop, J. M. (1998) · Genes & Development · doi:10.1101/gad.12.19.2997 · Cited by 826 · see citing works
Microarray analysis of replicative senescence
Shelton, D. N., Chang, E., Whittier, P. S., Choi, D., & Funk, W. D. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80420-5 · Cited by 764 · see citing works
Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637 · see citing works
Parrinello, S., Coppe, J.-P., Krtolica, A., & Campisi, J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01635 · Cited by 631 · see citing works
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works
Bavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1716 · Cited by 453 · see citing works
Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
Willimsky, G., & Blankenstein, T. J. F. (2005) · Nature · doi:10.1038/nature03954 · Cited by 439 · see citing works
Putting the stress on senescence
Serrano, M., & Blasco, M. A. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00278-7 · Cited by 413 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
Dirac, A. M. G., & Bernards, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300023200 · Cited by 254 · see citing works
Narita, M., & Lowe, S. W. (2005) · Nature Medicine · doi:10.1038/nm0905-920 · Cited by 150 · see citing works
Pitiyage, G. N., Slijepčević, P., Gabrani, A., Chianea, Y. G., Lim, K. P., Prime, S. S., Tilakaratne, W. M., Fortune, F., & Parkinson, E. K. (2010) · The Journal of Pathology · doi:10.1002/path.2839 · Cited by 100 · see citing works
Kato, D., Miyazawa, K., Ruas, M., Starborg, M., Wada, I., Oka, T., Sakai, T., Peters, G. G., & Hara, E. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00426-8 · Cited by 87 · see citing works
Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy
Speeckaert, R., van Geel, N., Vermaelen, K., Lambert, J., Gele, M. V., Speeckaert, M. M., & Brochez, L. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00799.x · Cited by 57 · see citing works
Mason, D. X., Keppler, D., Zhang, J., Jackson, T. J., Seger, Y. R., Matsui, S., Abreo, F., Cowell, J. K., Hannon, G. J., Lowe, S. W., et al. (2006) · Carcinogenesis · doi:10.1093/carcin/bgi264 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
“In the case of senescent tumor cells, there is good evidence that they are subjected to strict immune surveillance and are efficiently removed by phagocytosis (Hoenicke and Zender, 2012; Kang et al., 2011; Xue et al., 2007).”
BackgroundCellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363 · see citing works
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works
“…secretory phenotype (SASP) can also evoke a local inflammatory response with complex effects, including the elimination of senescent cells by phagocytosis, thus leading to tissue remodeling and damage resolution (Freund et al., 2010; Hoenicke and Zender, 2012; Krizhanovsky et al., 2008).”
InfluentialAge and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works
Cellular senescence and its effector programs
Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855 · see citing works
“Paracrine effects of the SASP also provoke anti-tumor immunity (Serrano 2011; Hoenicke and Zender 2012).”
BackgroundmTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3225 · Cited by 788 · see citing works
“In contrast, the SASP can induce senescence 4,6,7 and activate the immune system to keep neoplastic cells in check 8 .”
Self-citationVascular smooth muscle cell death, autophagy and senescence in atherosclerosis
Grootaert, M. O. J., Moulis, M., Roth, L., Martinet, W., Vindis, C., Bennett, M. R., & De Meyer, G. R. Y. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy007 · Cited by 606 · see citing works
Impaired immune surveillance accelerates accumulation of senescent cells and aging
Ovadya, Y., Landsberger, T., Leins, H., Vadai, E., Gal, H., Biran, A., Yosef, R., Sagiv, A., Agrawal, A., Shapira, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07825-3 · Cited by 578 · see citing works
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
Pereira, B. I., Devine, O. P., Vukmanovic-Stejic, M., Chambers, E. S., Subramanian, P., Patel, N., Virasami, A., Sebire, N. J., Kinsler, V., Valdovinos, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10335-5 · Cited by 556 · see citing works
Inside and out: the activities of senescence in cancer
Pérez-Mancera, P. A., Young, A. R. J., & Narita, M. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3773 · Cited by 462 · see citing works
Ageing, Cellular Senescence and Neurodegenerative Disease
Kritsilis, M., V. Rizou, S., Koutsoudaki, P. N., Evangelou, K., Gorgoulis, V. G., & Papadopoulos, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102937 · Cited by 448 · see citing works
“Although senescent cells can be recognized by T helper cells and cleared by macrophages and natural killer lymphocytes [27,34,35], their number has been shown to increase with normal ageing in tissues of humans, primates and rodents [36,37].”
BackgroundA multidimensional systems biology analysis of cellular senescence in aging and disease
Avelar, R. A., Ortega, J. G., Tacutu, R., Tyler, E. J., Bennett, D., Binetti, P., Budovsky, A., Chatsirisupachai, K., Johnson, E., Murray, A., et al. (2020) · Genome Biology · doi:10.1186/s13059-020-01990-9 · Cited by 399 · see citing works
“A visual inspection showed a number of bottleneck genes between Module 1 and Module 16, consistent with the role of the immune system in clearance and surveillance of senescence cells and the secretion of immunomodulators by senescent cells [69] (Additional file 1: Table S35).”
BackgroundFocus on the Contribution of Oxidative Stress in Skin Aging
Papaccio, F., D’Arino, A., Caputo, S., & Bellei, B. (2022) · Antioxidants · doi:10.3390/antiox11061121 · Cited by 431 · see citing works
“In the complicated context of organismal aging, it is not known to what extent continuous proliferation contributes to regulating the number of senescent cells, and whether age-related impairment of the immune system function contributes to the accumulation of senescent cells in old individuals [75].”
BackgroundMechanisms and Regulation of Cellular Senescence
Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395 · see citing works
“Indeed, senescent cells formed following tissue damage can promote their own clearance by secreting chemo-attractants that recruit and activate immune cells [265].”
BackgroundContribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 427 · see citing works
Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J., Grune, T., & Castro, J. P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.001 · Cited by 368 · see citing works
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357 · see citing works
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Prasanna, P. G. S., Citrin, D. E., Hildesheim, J., Ahmed, M. M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., van Deursen, J., Goronzy, J. J., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab064 · Cited by 351 · see citing works
Cellular senescence in renal ageing and disease
Sturmlechner, I., Durik, M., Sieben, C. J., Baker, D. J., & van Deursen, J. M. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.183 · Cited by 345 · see citing works
NKG2D ligands mediate immunosurveillance of senescent cells
Sagiv, A., Burton, D. G. A., Moshayev, Z., Vadai, E., Wensveen, F., Ben-Dor, S., Golani, O., Polic, B., & Krizhanovsky, V. (2016) · Aging · doi:10.18632/aging.100897 · Cited by 345 · see citing works
“The secretion of chemoattractants and the up-regulation of adhesion molecules also forms part of an immunogenic phenotype often attributed to senescent cells [14, 15].”
BackgroundMolecular and biological hallmarks of ageing
Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 322 · see citing works
The role of cellular senescence in cardiac disease: basic biology and clinical relevance
Mehdizadeh, M., Aguilar, M., Thorin, É., Ferbeyre, G., & Nattel, S. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00624-2 · Cited by 316 · see citing works
Neutrophil Extracellular Traps (NETs) in Cancer Invasion, Evasion and Metastasis
Demkow, U. A. (2021) · Cancers · doi:10.3390/cancers13174495 · Cited by 261 · see citing works
“Whatever the mechanistic basis, it appears that immunosurveillance of tumors is canonically dependent on the presence of the major histocompatibility complex 1 (MHC1) antigens on cancer cells enabling lymphocytes T (both CD4+ and CD8+) to discriminate tumor cells from normal cells, as well as to control the tumor cell…”
BackgroundKim, J. W., Nam, K. H., Ahn, S.-H., Park, D. J., Kim, H., Kim, S. H., Chang, H. K., Lee, J., Kim, Y. J., Lee, H. S., et al. (2014) · Gastric Cancer · doi:10.1007/s10120-014-0440-5 · Cited by 249 · see citing works
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246 · see citing works
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Procopio, M.-G., Laszlo, C., Al Labban, D., Kim, D. E., Bordignon, P., Jo, S.-H., Goruppi, S., Menietti, E., Ostano, P., Ala, U., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3228 · Cited by 223 · see citing works
“Senescent cells can be cleared by mechanisms like macrophage activation 10 , and there can be selective pressure for stromal fibroblasts with CAF properties to escape senescence 1,8,9,11–14 .”
Pilkington, S. M., Bulfone‐Paus, S., Griffiths, C. E. M., & Watson, R. E. B. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.006 · Cited by 229 · see citing works
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works
“Alternatively, it is possible that senescent cell elimination can be achieved by the promotion of their natural mechanism of destruction, which consists of elimination through immunesurveillance [206].”
BackgroundMechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases
Pyo, I. S., Yun, S., Yoon, Y. E., Choi, J. W., & Lee, S. (2020) · Molecules · doi:10.3390/molecules25204649 · Cited by 213 · see citing works
“Cellular senescence has some physiological benefits, such as repressing tumorigenesis; however, excessive accumulation of senescent cells exacerbates the negative effects of aging [4].”
BackgroundPapatheodoridi, A., Chrysavgis, L., Koutsilieris, M., & Chatzigeorgiou, A. (2019) · Hepatology · doi:10.1002/hep.30834 · Cited by 206 · see citing works
“The secretion of chemokines and cytokines such as IL-1b, IL-8, and MCP-1 through SASP attracts immune cells, leading to immunological clearance of the senescent cells.(14,15) Consistently, aging and chronic stress induce telomere attrition and excessive SASP, leading to accumulation of senescent cells and insufficient…”
BackgroundIonizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases
Wang, Y., Boerma, M., & Zhou, D. (2016) · Radiation Research · doi:10.1667/rr14445.1 · Cited by 204 · see citing works
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Song, P., An, J., & Zou, M.-H. (2020) · Cells · doi:10.3390/cells9030671 · Cited by 198 · see citing works
Hallmarks of aging and immunosenescence: Connecting the dots
Rodrigues, L. P., Teixeira, V. R., Alencar‐Silva, T., Simonassi-Paiva, B., Pereira, R. W., Pogue, R. E., & Carvalho, J. L. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.006 · Cited by 187 · see citing works
Spatial and Temporal Control of Senescence
Ito, Y., Hoare, M., & Narita, M. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.07.004 · Cited by 178 · see citing works
Aneuploidy as a promoter and suppressor of malignant growth
Vasudevan, A., Schukken, K. M., Sausville, E. L., Girish, V., Adebambo, O. A., & Sheltzer, J. M. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00321-1 · Cited by 176 · see citing works
Merelli, B., Massi, D., Cattaneo, L., & Mandalà, M. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.08.002 · Cited by 169 · see citing works
Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal
Erenpreisa, J. A., & Cragg, M. S. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-92 · Cited by 170 · see citing works
“This process appears important for tumour control as if the immune response is suppressed, cancer develops [9,10].”
BackgroundDNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
Olivieri, F., Albertini, M. C., Orciani, M., Ceka, A., Cricca, M., Procopio, A. D., & Bonafè, M. (2015) · Oncotarget · doi:10.18632/oncotarget.5899 · Cited by 163 · see citing works
“Emerging role of miRNAs and their shuttles in ARDs MiR-21, miR-146a, and miR-155 are among the miRNAs being reported as biomarkers for a number of distinct human diseases, suggesting that they are involved in the modulation of non-specific pathogenic mechanisms [132].”
BackgroundInfluentialHTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ
Giam, C., & Semmes, O. J. (2016) · Viruses · doi:10.3390/v8060161 · Cited by 162 · see citing works
“cells, neutrophils, and macrophages, for their clearance (reviewed in [81]).”
BackgroundCellular senescence impact on immune cell fate and function
Vicente, R., Mausset-Bonnefont, A.-L., Jorgensen, C., Louis-Plence, P., & Brondello, J.-M. (2016) · Aging Cell · doi:10.1111/acel.12455 · Cited by 151 · see citing works
The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
Wagner, K., & Wagner, N. (2022) · Cells · doi:10.3390/cells11121966 · Cited by 156 · see citing works
Multifocal epithelial tumors and field cancerization: stroma as a primary determinant
Dotto, G. P. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72589 · Cited by 169 · see citing works
Biological basis and treatment of frailty and sarcopenia
Sato, R., Vatic, M., da Fonseca, G. W. P., Anker, S. D., & von Haehling, S. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae073 · Cited by 128 · see citing works
Lunyak, V. V., Amaro-Ortiz, A., & Gaur, M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00220 · Cited by 114 · see citing works
“The recruitment of the inflammatory cells has shown to result in senescent cells removal leading to tissue remodeling as well as regeneration (Krizhanovsky et al., 2008; Freund et al., 2010; Kang et al., 2011; Hoenicke and Zender, 2012).”
BackgroundIgarashi, K., & Watanabe‐Matsui, M. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.232.229 · Cited by 113 · see citing works
“Senescent cells are believed to induce local inflammation and immune responses (Hoenicke and Zender 2012).”
Cangi, M. G., Biavasco, R., Cavalli, G., Grassini, G., Dal-Cin, E., Campochiaro, C., Guglielmi, B., Berti, A., Lampasona, V., von Deimling, A., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204924 · Cited by 112 · see citing works
The Aging Lung and Idiopathic Pulmonary Fibrosis
Gulati, S., & Thannickal, V. J. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.02.008 · Cited by 111 · see citing works
Senescence of Primary Amniotic Cells via Oxidative DNA Damage
Menon, R., Boldogh, I. R., Urrabaz‐Garza, R., Polettini, J., Syed, T. A., Saade, G. R., Papaconstantinou, J., & Taylor, R. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083416 · Cited by 112 · see citing works
Evidence and perspectives of cell senescence in neurodegenerative diseases
Si, Z., Sun, L., & Wang, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111327 · Cited by 105 · see citing works
Combinatorial approach to cancer immunotherapy: strength in numbers
Vilgelm, A. E., Johnson, D. B., & Richmond, A. J. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.5ri0116-013rr · Cited by 106 · see citing works
“Based on these findings, it was proposed that senescence and SASP are essential steps in the process of immunosurveillance and elimination of premalignant cells in the body [178].”
BackgroundCellular senescence and tumor promotion: Is aging the key?
Loaiza, N., & Demaria, M. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.01.007 · Cited by 101 · see citing works
Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders
Bellei, B., & Picardo, M. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100981 · Cited by 93 · see citing works
Suppression of p16 alleviates the senescence-associated secretory phenotype
(2021) · doi:10.18632/aging.202640 · Cited by 84 · see citing works
“senescence surveillance by immune cells [47, 95], thereby promoting tumorigenesis.”
BackgroundShahbandi, A., Chiu, F.-Y., Ungerleider, N., Kvadas, R. M., Mheidly, Z., Sun, M. J. S., Tian, D., Waizman, D. A., Anderson, A. Y., Machado, H. L., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00466-y · Cited by 85 · see citing works
Mariñó, Z., Darnell, A., Lens, S., Sapena, V., Díaz, A., Belmonte, E., Perelló, C., Calleja, J. L., Varela, M., Rodríguez, M., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.005 · Cited by 83 · see citing works
Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools
Knoppert, S. N., Valentijn, F. A., Nguyen, T. Q., Goldschmeding, R., & Falke, L. L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00770 · Cited by 88 · see citing works
Menon, R., Mesiano, S. A., & Taylor, R. N. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00196 · Cited by 81 · see citing works
Lansu, K., & Gentile, S. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.174 · Cited by 80 · see citing works
Aging, Cellular Senescence, and Progressive Multiple Sclerosis
Papadopoulos, D., Magliozzi, R., Mitsikostas, D. D., Gorgoulis, V. G., & Nicholas, R. S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00178 · Cited by 83 · see citing works
“Both apoptotic and senescent cells are cleared by the immune system in a highly regulatedmanner andmay contribute to age-related brain volume loss (Hoenicke and Zender, 2012; Ovadya et al., 2018).”
BackgroundMetronomic chemotherapy from rationale to clinical studies: A dream or reality?
Gnoni, A., Silvestris, N., Licchetta, A., Santini, D., Scartozzi, M., Ria, R., Pisconti, S., Petrelli, F., Vacca, A., & Lorusso, V. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.01.008 · Cited by 78 · see citing works
“Several authors have proposed that tumor escape from mmuno-surveillance could be the most important hallmark f cancer development [33–35], and that the immunosuppresion caused by chemotherapy, may contribute to the tumor ell growth, because of the reduction of the white blood cell ount [36–38].”
BackgroundMalavolta, M., Bracci, M., Santarelli, L., Sayeed, M. A., Pierpaoli, E., Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Cardelli, M., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/4159013 · Cited by 77 · see citing works
“In addition, it is an emerging concept that immune responses against senescent cells are crucial to restrict disease progression in cancer pathologies [17].”
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells
Menter, T., & Tzankov, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00054 · Cited by 76 · see citing works
Targeting senescent cells to attenuate cardiovascular disease progression
Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 76 · see citing works
“At present, senescence immunotherapy is an emerging research field (Burton and Stolzing, 2018; Hoenicke and Zender, 2012; Krizhanovsky et al., 2008; Sagiv et al., 2013).”
BackgroundTherapeutic targeting of replicative immortality
Yaswen, P., MacKenzie, K. L., Keith, W. N., Hentosh, P., Rodier, F., Zhu, J., Firestone, G. L., Matheu, A., Carnero, A., Bilsland, A. E., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.007 · Cited by 74 · see citing works
Cellular senescence is a promising target for chronic wounds: a comprehensive review
Wang, Z., & Shi, C. (2020) · Burns & Trauma · doi:10.1093/burnst/tkaa021 · Cited by 71 · see citing works
Premature aging/senescence in cancer cells facing therapy: good or bad?
Calvo, L., Ghadaouia, S., Martinez, A., & Rodier, F. (2015) · Biogerontology · doi:10.1007/s10522-015-9593-9 · Cited by 71 · see citing works
Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential
Adnot, S., Amsellem, V., Boyer, L., Marcos, É., Saker, M., Houssaini, A., Kebe, K., Dagouassat, M., Lipskaia, L., & Boczkowski, J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.007 · Cited by 69 · see citing works
Zhang, Y., Yang, B., Wang, J., Cheng, F., Shi, K., Ying, L., Wang, C., Xia, K., Huang, X., Gong, Z., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9503562 · Cited by 68 · see citing works
Telomeric aging: mitotic clock or stress indicator?
Koliada, A. K., Krasnienkov, D. S., & Vaiserman, A. M. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00082 · Cited by 67 · see citing works
“In this process, senescent cells interact with their environment by secreting various growth factors and cytokines, being thereby recognized and eliminated by an antigen-specific immune response (Hoenicke and Zender, 2012; Sagiv and Krizhanovsky, 2013).”
BackgroundContribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00055.x · Cited by 65 · see citing works
Khalil, R., Diab‐Assaf, M., & Lemaı̂tre, J.-M. (2023) · Cells · doi:10.3390/cells12060915 · Cited by 66 · see citing works
“The intricacy of senescence and SASP regulation is illustrated by the lncRNA MIR31HG, which, depending on its cellular localization, can both induce and delay senescence [104].”
BackgroundNatural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
Antonangeli, F., Soriani, A., Ricci, B., Ponzetta, A., Benigni, G., Morrone, S., Bernardini, G., & Santoni, A. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1218105 · Cited by 64 · see citing works
“and senescent cells can be recognized by the immune system, senescence is thought to be a major barrier to tumor formation.(12) This finding has attracted the attention of the scientific”
BackgroundZheng, J., Jiang, L., Zhang, L., Yang, L., Deng, J., You, Y., Li, N., Wu, H., Li, W., Lü, J., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs307 · Cited by 63 · see citing works
The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis
Guicciardi, M. E., Trussoni, C. E., LaRusso, N. F., & Gores, G. J. (2019) · Hepatology · doi:10.1002/hep.31067 · Cited by 62 · see citing works
“(33) Indeed, SASP modulates the immune surveillance of senescent cells and can attract immune cells, especially macrophages, to senescent cells for their elimination.(38,39) Although the involvement of other cell types cannot be ruled out, in vitro coculture”
BackgroundSenescent T cells: Beneficial and detrimental roles
Laphanuwat, P., Gomes, D. C. O., & Akbar, A. N. (2023) · Immunological Reviews · doi:10.1111/imr.13206 · Cited by 61 · see citing works
da Silva, B. D. O., Ramos, L. F., & Moraes, K. C. M. (2017) · Cell Biology International · doi:10.1002/cbin.10790 · Cited by 61 · see citing works
“In addition, a remarkable characteristic of senescent cells is the senescence-associated secretory phenotype (SASP) generated as a consequence of the increased expression and secretion of interleukins, chemokines, growth factors, and proteases (Hoenicke and Zender, 2012), mediated by the activity of transcription fact…”
BackgroundOxidative Stress and Cellular Senescence Are Involved in the Aging Kidney
Márquez‐Expósito, L., Tejedor-Santamaria, L., Valentijn, F. A., Tejera‐Muñoz, A., Rayego‐Mateos, S., Marchant, V. A., Rodrigues-Díez, R. R., Rubio-Soto, I., Knoppert, S. N., Ortíz, A., et al. (2022) · Antioxidants · doi:10.3390/antiox11020301 · Cited by 59 · see citing works
A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation
Soen, Y., Knafo, M., & Elgart, M. (2015) · Biology Direct · doi:10.1186/s13062-015-0097-y · Cited by 53 · see citing works
PIM ‐1 modulates cellular senescence and links IL ‐6 signaling to heterochromatin formation
Jin, B., Wang, Y., Wu, C., Liu, K. Y., Chen, H., & Mao, Z. B. (2014) · Aging Cell · doi:10.1111/acel.12249 · Cited by 55 · see citing works
“Increasing evidences have shown that cellular senescence acts as a protective mechanism against carcinogenesis (Lanigan et al., 2011; Hoenicke & Zender, 2012; Vargas et al., 2012).”
BackgroundSuccess after failure: the role of endometrial stem cells in recurrent miscarriage
Lucas, E. S., Dyer, N. P., Fishwick, K. J., Ott, S., & Brosens, J. J. (2016) · Reproduction · doi:10.1530/rep-16-0306 · Cited by 55 · see citing works
“An alternative scenario is that influx of immune cells, and specifically uterine natural killer cells, during the luteal phase plays a key role in homeostatic balancing of the stromal subpopulations through selective clearance of senescent cells (Hoenicke & Zender 2012).”
Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem?
Aquino-Martínez, R., Khosla, S., Farr, J. N., & Monroe, D. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207441 · Cited by 54 · see citing works
“This process is called senescent cell immune surveillance, in which the release of senescence-associated proinflammatory signals play essential roles in attracting neutrophils, macrophages, lymphocytes and natural killer cells [67,83,85].”
BackgroundInfluentialMerkt, W., Zhou, Y., Han, H., & Lagares, D. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12952 · Cited by 56 · see citing works
“59,62,63 In the context of wound healing, NK cells expressing TRAIL have been involved in the resolution of the tissue repair programme by promoting apoptosis of senescent myofibroblasts and other cell types.”
The Janus Face of Death Receptor Signaling during Tumor Immunoediting
Reilly, E. O., Tirincsi, A., Logue, S. E., & Szegezdi, É. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00446 · Cited by 53 · see citing works
Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential
Maleki, M., Khelghati, N., Alemi, F., Bazdar, M., Asemi, Z., Majidinia, M., Sadeghpoor, A., Mahmoodpoor, A., Jadidi‐Niaragh, F., Targhazeh, N., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118341 · Cited by 52 · see citing works
Cellular Senescence and Periodontitis: Mechanisms and Therapeutics
Chen, S., Zhou, D., Liu, O., Chen, H., Wang, Y., & Zhou, Y. (2022) · Biology · doi:10.3390/biology11101419 · Cited by 49 · see citing works
“The SASP promotes the migration of immune cells that help remove senescent cells [88].”
BackgroundBrauer, E., Lange, T., Keller, D., Görlitz, S., Cho, S., Keye, J., Gossen, M., Petersen, A., & Kornak, U. (2022) · Aging Cell · doi:10.1111/acel.13744 · Cited by 47 · see citing works
“Senescent cells secrete a variety of pro- inflammatory cytokines as part of the senescence- associated secretory phenotype (SASP) (Coppé et al., 2010) that lead to the recruitment of the immune system and subsequent cell clearance (Hoenicke & Zender, 2012; Kang et al., 2011).”
BackgroundNovoa, B., Pereiro, P., López‐Muñoz, A., Varela, M., Forn‐Cuní, G., Anchelin, M., Dios, S., Romero, A., Martinez‐López, A., Medina‐Gali, R. M., et al. (2019) · Aging Cell · doi:10.1111/acel.13020 · Cited by 41 · see citing works
“Indeed, it has been reported that these cell types, together with macrophages, play a pivotal role in the clearance of senescent cells (Hoenicke & Zender, 2012).”
BackgroundAlexander, E., Hildebrand, D. G., Kriebs, A., Obermayer, K., Manz, M., Rothfuss, O. C., Eßmann, F., & Schulze‐Osthoff, K. (2013) · Journal of Cell Science · doi:10.1242/jcs.128835 · Cited by 45 · see citing works
“Finally, these cytokines or other secreted factors have been shown to attract immune cells in an inflammatory response, leading to the elimination of senescent tumor cells (Kang et al., 2011; Xue et al., 2007; Hoenicke and Zender, 2012).”
BackgroundA tale of the good and bad: Cell senescence in bone homeostasis and disease
Liu, X., & Wan, M. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.03.005 · Cited by 44 · see citing works
Feng, M., Kim, J., Field, K. P., Reid, C., Chatzistamou, I., & Shim, M. (2019) · FASEB BioAdvances · doi:10.1096/fba.2019-00041 · Cited by 42 · see citing works
Neutrophil extracellular traps and long COVID
Shafqat, A., Omer, M. H., Albalkhi, I., Razzak, G. A., Abdulkader, H. S., Rab, S. A., Sabbah, B. N., AlKattan, K. M., & Yaqinuddin, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1254310 · Cited by 46 · see citing works
Cellular senescence in tissue repair: every cloud has a silver lining.
Yun, M. (2018) · International Journal of Developmental Biology · doi:10.1387/ijdb.180081my · Cited by 37 · see citing works
“Furthermore, due to its capacity to alter the microenvironment and promote inflammation (Hoenicke and Zender, 2012), the SASP has been proposed to contribute to tissue malfunction and degeneration.”
BackgroundModulation of therapy-induced senescence by reactive lipid aldehydes
Flor, A. C., Doshi, A. P., & Kron, S. J. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.45 · Cited by 40 · see citing works
Lee, Y., Chen, Y.-Y., Yeh, Y.-L., Wang, Y., & Chen, R.-J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112716 · Cited by 39 · see citing works
“If the senescent cancer cells in treated tumor tissue cannot be completely eliminated by a proper senescence immune surveillance response, the treatment is failing [9,10].”
BackgroundNovel PET Imaging Probe for Quantitative Detection of Senescence In Vivo
Xiang, X., Dong, C., Zhou, L., Liu, J., Rabinowitz, Z. M., Zhang, Y., Guo, H., He, F., Chen, X., Wang, Y., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00179 · Cited by 39 · see citing works
Rajesh, K., Papadakis, A. I., Kazimierczak, U., Peidis, P., Wang, S., Ferbeyre, G., Kaufman, R. J., & Koromilas, A. E. (2013) · Aging · doi:10.18632/aging.100620 · Cited by 38 · see citing works
Al-Rajhi, N., Soudy, H., Ahmed, S. A., Elhassan, T. A. M., Mohammed, S. F., Khoja, H. A., & Ghebeh, H. (2020) · BMC Cancer · doi:10.1186/s12885-020-06757-w · Cited by 38 · see citing works
“A recent trial has shown that multiple immunotherapeutic agents can synergize to enhance endogenous antitumor immunity [6].”
Role of Senescent Renal Cells in Pathophysiology of Diabetic Kidney Disease
Wiley, C. D. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01314-y · Cited by 38 · see citing works
- Authors
- Hoenicke, L., & Zender, L.
- Affiliations
- Helmholtz Centre for Infection Research (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Zender, L.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-02
- Volume
- 33
- Issue
- 6
- Pages
- 1123-1126
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2121022075
- Cited by
- 248
- References
- 40
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 11 · 2023: 15 · 2022: 26 · 2021: 21 · 2020: 31 · 2019: 24 · 2018: 24 · 2017: 14 · 2016: 22 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- cellular senescence, senescence-associated secretory phenotype, tumor suppression, liver cancer, antigen-specific immune response, tumor immunology, telomere shortening, chemotherapy-induced senescence, oncogene activation
- MeSH terms
- Humans, Immunologic Surveillance, Liver, Neoplasms, Precancerous Conditions, Cytokines, Cellular Senescence, Disease Progression, Chemokines, Hepatocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
