Evidence and perspectives of cell senescence in neurodegenerative diseases
Open accessAbstract
Increased life expectancies have significantly increased the number of individuals suffering from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). The financial cost for current and future patients with these diseases is overwhelming, resulting in substantial economic and societal costs. Unfortunately, most recent high-profile clinical trials for neurodegenerative diseases have failed to obtain efficacious results, indicating that novel approaches are desperately needed to treat these pathologies. Cell senescence, characterized by permanent cell cycle arrest, resistance to apoptosis, mitochondrial alterations, and secretion of senescence-associated secretory phenotype (SASP) components, has been extensively studied in mitotic cells such as fibroblasts, which is considered a hallmark of aging. Furthermore, multiple cell types in the senescent state in the brain, including neurons, microglia, astrocytes, and neural stem cells, have recently been observed in the context of neurodegenerative diseases, suggesting that these senescent cells may play an essential role in the pathological processes of neurodegenerative diseases. Therefore, this review begins by outlining key aspects of cell senescence constitution followed by examining the evidence implicating senescent cells in neurodegenerative diseases. In the final section, we review how cell senescence may be targeted as novel therapeutics to treat pathologies associated with neurodegenerative diseases.
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Cell senescence is involved in the occurrence or progression of neurodegenerative diseases.
“Cell senescence is involved in the occurrence or progression of neurodegenerative diseases.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [404]
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- Authors
- Si, Z., Sun, L., & Wang, X.
- Affiliations
- Ningbo University (CN)
- Harbin Medical University (CN)
- Corresponding author
- Wang, Xidi
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 137
- Pages
- 111327
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3126345928
- Cited by
- 105
- References
- 56
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 27 · 2023: 29 · 2022: 13 · 2021: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Harbin Medical University (2017JCZX38)
- Natural Science Foundation of Heilongjiang Province (QC2017018)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- cellular senescence, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, senescence-associated secretory phenotype, microglia, astrocytes, neural stem cells, neurons, senolytics, aging, mitochondrial changes, apoptosis resistance
- MeSH terms
- Alzheimer Disease, Animals, Humans, Parkinson Disease, Phenotype, Cellular Senescence, Neurodegenerative Diseases
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