The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Thyroid Hormone Action in Neural Development
Abstract
Effects of thyroid hormone on development of the brain have been documented for over a century. Although in many respects the hypothyroid brain appears morphologically normal, functional impairments include mental retardation, ataxia and spasticity. Keyed by the discovery of nuclear receptors for thyroid hormone that function as transcription factors, recent work has examined the mechanism of thyroid hormone action in brain development. The prediction that gene expression regulated by thyroid hormone is important for mediating brain development has spurred the search for thyroid hormone-responsive genes. Here we review some of the identified genes whose expression patterns correlate with the functional deficits observed in the hypothyroid brain. Recently identified thyroid hormone-responsive genes include synaptotagmin-related gene 1 (Srg1), a putative mediator of synaptic structure and/or activity, and hairless, a transcriptional cofactor that may influence the expression of other thyroid hormone-responsive genes.
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Cites
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Cited by
Thyroid hormone receptors in brain development and function
Bernal, J. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0424 · Cited by 706
Zoeller, R. T., & Rovet, J. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01243.x · Cited by 605
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Ramakers, G. J. A. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02118-4 · Cited by 374
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Metadata
- Authors
- Thompson, C. C.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-10-01
- Volume
- 10
- Issue
- 10
- Pages
- 939-945
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2130631987
- Cited by
- 264
- References
- 66
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
