Cited by 83Fluoride Effects and RemovalHeavy Metal Exposure and ToxicityAluminum toxicity and tolerance in plants and animals

Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride

Banji, David, Banji, Otilia J.F., Pratusha, N. Gouri, Annamalai, A.R.·2013·Food Chemistry

Abstract

The study investigated the role of Spirulina platensis in reversing sodium fluoride-induced thyroid, neurodevelopment and oxidative alterations in offspring of pregnant rats. The total antioxidant activity, phycocyanins, and β carotene content were quantified in Spirulina. Thirty female pregnant rats were allocated to six groups and treatment initiated orally from embryonic day (ED) 6 to postnatal day (PND) 15. Treatment groups included control, Spirulina alone, sodium fluoride (20 mg/kg) alone, and sodium fluoride along with Spirulina (250 and 500 mg/kg). Serum fluoride levels were determined on ED 20 and PND 11. Offspring were subjected to behavioural testing, estimation of thyroid levels, oxidative measurements in brain mitochondrial fraction and histological evaluation of the cerebellum. Fluoride-induced alterations in thyroid hormones, behaviour and increased oxidative stress. Spirulina augmented the displacement of fluoride, facilitated antioxidant formation, improved behaviour and protected Purkinje cells. Supplementing Spirulina during pregnancy could reduce the risk of fluoride toxicity in offspring.

Integrity signals

Registry

Crossref · 10.1016/j.foodchem.2013.02.076

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Banji, D., Banji, O. J. F., Pratusha, N. G., & Annamalai, A. R.
Affiliations
Annamalai University (IN)
Corresponding author
Banji, David
Venue
Food Chemistry
Publisher
Elsevier BV
Published
2013-09
Volume
140
Issue
1-2
Pages
321-331
ISSN
0308-8146 (ISSN-L)
OpenAlex
W1966852919
Cited by
83
References
72
Citations by year
2026: 7 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 2 · 2013: 2
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Locations
  • Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universidad Nacional de Colombia
Topics
  • Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Keywords
Spirulina platensis, sodium fluoride, fluoride toxicity, prenatal exposure, offspring neurodevelopment, thyroid dysfunction, oxidative stress, behavior change, phycocyanin, beta-carotene, antioxidant activity, Purkinje cells, cerebellum, mitochondrial oxidative stress
MeSH terms
Animals, Antioxidants, Behavior, Brain, Female, Humans, Male, Phycocyanin, Pregnancy, Prenatal Exposure Delayed Effects, Sodium Fluoride, Thyroid Gland, Thyroid Hormones, Rats, Wistar, Oxidative Stress, Maternal Exposure, beta Carotene, Dietary Supplements, Rats, Spirulina

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review