The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cortical Change in Alzheimer's Disease Detected with a Disease-specific Population-based Brain Atlas
Abstract
We report the first detailed population-based maps of cortical gray matter loss in Alzheimer's disease (AD), revealing prominent features of early structural change. New computational approaches were used to: (i) distinguish variations in gray matter distribution from variations in gyral patterns; (ii) encode these variations in a brain atlas (n = 46); (iii) create detailed maps localizing gray matter differences across groups. High resolution 3D magnetic resonance imaging (MRI) volumes were acquired from 26 subjects with mild to moderate AD (age 75.8+/-1.7 years, MMSE score 20.0+/-0.9) and 20 normal elderly controls (72.4+/-1.3 years) matched for age, sex, handedness and educational level. Image data were aligned into a standardized coordinate space specifically developed for an elderly population. Eighty-four anatomical models per brain, based on parametric surface meshes, were created for all 46 subjects. Structures modeled included: cortical surfaces, all major superficial and deep cortical sulci, callosal and hippocampal surfaces, 14 ventricular regions and 36 gyral boundaries. An elastic warping approach, driven by anatomical features, was then used to measure gyral pattern variations. Measures of gray matter distribution were made in corresponding regions of cortex across all 46 subjects. Statistical variations in cortical patterning, asymmetry, gray matter distribution and average gray matter loss were then encoded locally across the cortex. Maps of group differences were generated. Average maps revealed complex profiles of gray matter loss in disease. Greatest deficits (20-30% loss, P<0.001-0.0001) were mapped in the temporo-parietal cortices. The sensorimotor and occipital cortices were comparatively spared (0-5% loss, P>0.05). Gray matter loss was greater in the left hemisphere, with different patterns in the heteromodal and idiotypic cortex. Gyral pattern variability also differed in cortical regions appearing at different embryonic phases. 3D mapping revealed profiles of structural deficits consistent with the cognitive, metabolic and histological changes in early AD. These deficits can therefore be (i) charted in a living population and (ii) compared across individuals and groups, facilitating longitudinal, genetic and interventional studies of dementia.
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Cites
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Growth patterns in the developing brain detected by using continuum mechanical tensor maps
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Self-citationRate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
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Self-citationPreclinical prediction of Alzheimer's disease using SPECT
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“Greatest gray matter loss in the temporoparietal cortex may underlie the prominent temporal-parietal hypometabolism that is consistently found at this stage of AD, often asymmetrically (Friedland and Luxenberg, 1988; Johnson et al., 1998).”
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Cited by
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Mapping cortical change across the human life span
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Self-citationLongitudinal Mapping of Cortical Thickness and Brain Growth in Normal Children
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A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex
Van Essen, D. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.058 · Cited by 1,151
Metadata
- Authors
- Thompson, P. M., Mega, M. S., Woods, R. P., Zoumalan, C. I., Lindshield, C. J., Blanton, R. E., Moussai, J., Holmes, C. J., Cummings, J. L., & Toga, A. W.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01-01
- Volume
- 11
- Issue
- 1
- Pages
- 1-16
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2132458496
- Cited by
- 443
- References
- 9
- FWCI
- 20.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thompson, P. M., Mega, M. S., Woods, R. P., Zoumalan, C. I., Lindshield, C. J., Blanton, R. E., Moussai, J., Holmes, C. J., Cummings, J. L., & Toga, A. W. (2001). Cortical Change in Alzheimer's Disease Detected with a Disease-specific Population-based Brain Atlas. Cerebral Cortex. https://doi.org/10.1093/cercor/11.1.1
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