Functional anatomy and interaction of fast and slow visual pathways in macaque monkeys
Abstract
We measured the timing, areal distribution, and laminar profile of fast, wavelength-insensitive and slower, wavelength-sensitive responses in V1 and extrastriate areas, using laminar current-source density analysis in awake macaque monkeys. There were 3 main findings. 1) We confirmed previously reported significant ventral-dorsal stream latency lags at the level of V4 (V4 mean = 38.7 ms vs. middle temporal mean = 26.9 ms) and inferotemporal cortex (IT mean = 43.4 ms vs. dorsal bank of the superior temporal sulcus mean = 33.9 ms). 2) We found that wavelength-sensitive inputs in areas V1, V4, and IT lagged the wavelength-insensitive responses by significant margins; this lag increased over successive levels of the system. 3) We found that laminar activation profiles in V4 and IT were inconsistent with "feedforward" input through the ascending ventral cortical pathway; the likely alternative input routes include both lateral inputs from the dorsal stream and direct inputs from nonspecific thalamic neurons. These findings support a "Framing" Model of ventral stream visual processing in which rapidly conducted inputs, mediated by one or more accessory pathways, modulate the processing of more slowly conducted feedforward inputs.
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A fundamental role of the M system/dorsal stream might be to produce a low-resolution template of the visual scene that influences perceptual processes in ventral occipito-temporal cortex by allowing P pathway fine-detailed input to be used more effectively.
“A fundamental role of the M system/dorsal stream might be to produce a low-resolution template of the visual scene that influences perceptual processes, such as categorization of natural images, object recognition, and perceptual grouping in the ventral occipito-temporal cortex, by allowing P pathway fine-detailed input to be used more effectively (3,75–80).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [75]
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Self-citation
- Authors
- Chen, C.-M., Lakatos, P., Shah, A. S., Mehta, A. D., Givre, S. J., Javitt, D. C., & Schroeder, C. E.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- Albert Einstein College of Medicine (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-01
- Volume
- 17
- Issue
- 7
- Pages
- 1561-1569
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2145055552
- Cited by
- 155
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 13 · 2012: 11
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (T32M072288)
- National Institute of Mental Health (R01MH060358, MH 060358)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- ventral stream, dorsal stream, color vision, primary visual cortex, V4, inferotemporal cortex, thalamic input, macaque visual cortex
- MeSH terms
- Animals, Brain Mapping, Evoked Potentials, Visual, Macaca fascicularis, Male, Nerve Net, Neurons, Afferent, Photic Stimulation, Reaction Time, Visual Pathways
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