Cited by 464Visual perception and processing mechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

A spatiotemporal profile of visual system activation revealed by current source density analysis in the awake macaque

Schroeder, C.·1998·Cerebral Cortex

Abstract

We investigated the spatiotemporal activation pattern, produced by one visual stimulus, across cerebral cortical regions in awake monkeys. Laminar profiles of postsynaptic potentials and action potentials were indexed with current source density (CSD) and multiunit activity profiles respectively. Locally, we found contrasting activation profiles in dorsal and ventral stream areas. The former, like V1 and V2, exhibit a 'feedforward' profile, with excitation beginning at the depth of Lamina 4, followed by activation of the extragranular laminae. The latter often displayed a multilaminar/columnar profile, with initial responses distributed across the laminae and reflecting modulation rather than excitation; CSD components were accompanied by either no changes or by suppression of action potentials. System-wide, response latencies indicated a large dorsal/ventral stream latency advantage, which generalizes across a wide range of methods. This predicts a specific temporal ordering of dorsal and ventral stream components of visual analysis, as well as specific patterns of dorsal-ventral stream interaction. Our findings support a hierarchical model of cortical organization that combines serial and parallel elements. Critical in such a model is the recognition that processing within a location typically entails multiple temporal components or 'waves' of activity, driven by input conveyed over heterogeneous pathways from the retina.

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Crossref · 10.1093/cercor/8.7.575

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  • Processing is substantially faster via the dorsal stream, which would permit it to prime ventral stream areas.

    “Processing is substantially faster via the dorsal stream, which would permit it to prime ventral stream areas (72–74).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [74]

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Authors
Schroeder, C.
Affiliations
Nathan Kline Institute for Psychiatric Research (US)
Corresponding author
Schroeder, C.
Venue
Cerebral Cortex
Published
1998-10-01
Volume
8
Issue
7
Pages
575-592
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2143051737
Cited by
464
References
78
Citations by year
2026: 6 · 2025: 17 · 2024: 16 · 2023: 14 · 2022: 16 · 2021: 18 · 2020: 21 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 31 · 2014: 22 · 2013: 23 · 2012: 27
FWCI
6.58
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh047939-03, 5r01mh055620-08)
  • National Institute of Mental Health (MH-47939, MH55620)
  • National Institute of General Medical Sciences (T32 GM 7288, T32GM007288)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
visual cortex, current source density, dorsal stream, ventral stream, response latency, multi-unit activity, action potential, primary visual cortex, macaque
MeSH terms
Animals, Evoked Potentials, Visual, Macaca fascicularis, Male, Photic Stimulation, Reaction Time, Space Perception, Visual Pathways, Magnetoencephalography

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