A spatiotemporal profile of visual system activation revealed by current source density analysis in the awake macaque
Abstract
We investigated the spatiotemporal activation pattern, produced by one visual stimulus, across cerebral cortical regions in awake monkeys. Laminar profiles of postsynaptic potentials and action potentials were indexed with current source density (CSD) and multiunit activity profiles respectively. Locally, we found contrasting activation profiles in dorsal and ventral stream areas. The former, like V1 and V2, exhibit a 'feedforward' profile, with excitation beginning at the depth of Lamina 4, followed by activation of the extragranular laminae. The latter often displayed a multilaminar/columnar profile, with initial responses distributed across the laminae and reflecting modulation rather than excitation; CSD components were accompanied by either no changes or by suppression of action potentials. System-wide, response latencies indicated a large dorsal/ventral stream latency advantage, which generalizes across a wide range of methods. This predicts a specific temporal ordering of dorsal and ventral stream components of visual analysis, as well as specific patterns of dorsal-ventral stream interaction. Our findings support a hierarchical model of cortical organization that combines serial and parallel elements. Critical in such a model is the recognition that processing within a location typically entails multiple temporal components or 'waves' of activity, driven by input conveyed over heterogeneous pathways from the retina.
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Processing is substantially faster via the dorsal stream, which would permit it to prime ventral stream areas.
“Processing is substantially faster via the dorsal stream, which would permit it to prime ventral stream areas (72–74).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [74]
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- Authors
- Schroeder, C.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Schroeder, C.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-10-01
- Volume
- 8
- Issue
- 7
- Pages
- 575-592
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2143051737
- Cited by
- 464
- References
- 78
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 16 · 2023: 14 · 2022: 16 · 2021: 18 · 2020: 21 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 31 · 2014: 22 · 2013: 23 · 2012: 27
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh047939-03, 5r01mh055620-08)
- National Institute of Mental Health (MH-47939, MH55620)
- National Institute of General Medical Sciences (T32 GM 7288, T32GM007288)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- visual cortex, current source density, dorsal stream, ventral stream, response latency, multi-unit activity, action potential, primary visual cortex, macaque
- MeSH terms
- Animals, Evoked Potentials, Visual, Macaca fascicularis, Male, Photic Stimulation, Reaction Time, Space Perception, Visual Pathways, Magnetoencephalography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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