The intense world syndrome-an alternative hypothesis for autism
Open accessAbstract
Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the neuronal structures and cells affected, a unifying theory that could explain the manifold autistic symptoms has still not emerged. Based on recent synaptic, cellular, molecular, microcircuit, and behavioral results obtained with the valproic acid (VPA) rat model of autism, we propose here a unifying hypothesis where the core pathology of the autistic brain is hyper-reactivity and hyper-plasticity of local neuronal circuits. Such excessive neuronal processing in circumscribed circuits is suggested to lead to hyper-perception, hyper-attention, and hyper-memory, which may lie at the heart of most autistic symptoms. In this view, the autistic spectrum are disorders of hyper-functionality, which turns debilitating, as opposed to disorders of hypo-functionality, as is often assumed. We discuss how excessive neuronal processing may render the world painfully intense when the neocortex is affected and even aversive when the amygdala is affected, leading to social and environmental withdrawal. Excessive neuronal learning is also hypothesized to rapidly lock down the individual into a small repertoire of secure behavioral routines that are obsessively repeated. We further discuss the key autistic neuropathologies and several of the main theories of autism and re-interpret them in the light of the hypothesized Intense World Syndrome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The Intense World Theory proposes that there is excessive functioning of neural circuits, such that the neural circuits are hyper-reactive, hyper-plastic, and generally up-regulated.
“This neurobiologically-informed theory proposes that there is excessive functioning of neural circuits, such that the neural circuits are hyper-reactive, hyper-plastic, and generally up-regulated.”
From The impact of atypical sensory processing on social impairments in autism spectrum disorder (2018) · cites this paper as Markram et al., 2007
The Intense World Theory proposes that this creates an intense world, a fragmented world, and an aversive world.
“This creates an intense world, a fragmented world (with focus on individual components of the environment), and an aversive world.”
From The impact of atypical sensory processing on social impairments in autism spectrum disorder (2018) · cites this paper as Markram et al., 2007
The Intense World Theory proposes that low-level sensory perception is enhanced, coupled with deficits in sensory integration.
“Low-level sensory perception is enhanced (intense world), coupled with deficits in sensory integration (fragmented world).”
From The impact of atypical sensory processing on social impairments in autism spectrum disorder (2018) · cites this paper as Markram et al., 2007
The Intense World Theory proposes that perceptual up-regulation results in avoidance of highly emotional and unpredictable cues, such as eyes, faces, and social interactions.
“Such perceptual up-regulation results in an avoidance of highly emotional and unpredictable cues, such as eyes, faces, and social interactions.”
From The impact of atypical sensory processing on social impairments in autism spectrum disorder (2018) · cites this paper as Markram et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The Proceedings of the National Academy of Sciences
Richards, J. W. (1915) · Science · doi:10.1126/science.42.1074.161 · Cited by 13,941 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Does the autistic child have a “theory of mind” ?
Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985) · Cognition · doi:10.1016/0010-0277(85)90022-8 · Cited by 8,599 · cited 1× · see citing works
“Autistic people are thought to be severely impaired in empathising with other people and ‘‘reading their mind’’, which is captured in the ‘‘theory of mind’’ or ‘‘mind-blindness theory’’ of autism (Baron-Cohen et al., 1985; Frith and Happe, 1994).”
Diagnostic and Statistical Manual of Mental Disorders
Siegel, L. J., & Fletcher‐Janzen, E. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0655 · Cited by 8,468 · see citing works
Frith, C., & Frith, U. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.041 · Cited by 3,494 · see citing works
An Experimental Study of Apparent Behavior
Heider, F., & Simmel, M. (1944) · The American Journal of Psychology · doi:10.2307/1416950 · Cited by 3,340 · see citing works
The weak coherence account: detail-focused cognitive style in autism spectrum disorders
Happé, F., & Frith, U. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0039-0 · Cited by 2,884 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
(1989) · UCL Discovery (University College London) · Cited by 2,724 · see citing works
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663 · see citing works
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360 · see citing works
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296 · see citing works
Die „Autistischen Psychopathen” im Kindesalter
Asperger, H. (1944) · Archiv für Psychiatrie und Nervenkrankheiten · doi:10.1007/bf01837709 · Cited by 2,163 · see citing works
Baron‐Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01599.x · Cited by 1,970 · see citing works
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818 · see citing works
Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind
Ozonoff, S., Pennington, B. F., & Rogers, S. J. (1991) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1991.tb00351.x · Cited by 1,766 · see citing works
Just, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589 · see citing works
Why faces are and are not special: An effect of expertise.
Diamond, R., & Carey, S. E. (1986) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.115.2.107 · Cited by 1,584 · see citing works
Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.245 · Cited by 1,487 · see citing works
Autism: beyond “theory of mind”
Frith, U., & Happé, F. (1994) · Cognition · doi:10.1016/0010-0277(94)90024-8 · Cited by 1,450 · see citing works
Neural Mechanisms of Visual Working Memory in Prefrontal Cortex of the Macaque
Miller, E. K., Erickson, C. A., & Desimone, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05154.1996 · Cited by 1,441 · see citing works
Castelli, F. (2002) · Brain · doi:10.1093/brain/awf189 · Cited by 1,377 · see citing works
A mechanism for impaired fear recognition after amygdala damage
Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005) · Nature · doi:10.1038/nature03086 · Cited by 1,331 · see citing works
Social intelligence in the normal and autistic brain: An fMRI study
Baron‐Cohen, S., Ring, H. A., Wheelwright, S., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. C. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00621.x · Cited by 1,320 · see citing works
Why faces are and are not special: An effect of expertise.
Diamond, R., & Carey, S. E. (1986) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.115.2.107 · Cited by 1,309 · see citing works
Visual Following and Pattern Discrimination of Face-like Stimuli by Newborn Infants
Goren, C. C., Sarty, M., & Wu, P. Y. K. (1975) · Pediatrics · doi:10.1542/peds.56.4.544 · Cited by 1,158 · cited 1× · see citing works
“Already newborns show a natural tendency to preferentially attend to faces over other stimuli (Goren et al., 1975; Simion et al., 1998).”
BackgroundBaron-Cohen, S., Ring, H. A., Bullmore, E. T., Wheelwright, S., Ashwin, C., & Williams, S. C. R. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00011-7 · Cited by 1,130 · see citing works
The human amygdala in social judgment
Adolphs, R., Tranel, D., & Damasio, A. R. (1998) · Nature · doi:10.1038/30982 · Cited by 1,125 · see citing works
Evidence of Brain Overgrowth in the First Year of Life in Autism
Courchesne, E. (2003) · JAMA · doi:10.1001/jama.290.3.337 · Cited by 1,120 · see citing works
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083 · see citing works
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071 · see citing works
The human amygdala and the emotional evaluation of sensory stimuli
Zald, D. H. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00248-5 · Cited by 1,062 · see citing works
Social Intelligence in the Normal and Autistic Brain: An fMRI Study
Baron‐Cohen, S., RING, H. A., Wheelwright, S. J., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0028 · Cited by 1,044 · see citing works
Schultz, R. T., Gauthier, I., Klin, A., Fulbright, R. K., Anderson, A. W., Volkmar, F., Skudlarski, P., Lacadie, C., Cohen, D. J., & Gore, J. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.331 · Cited by 1,000 · see citing works
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997 · see citing works
Histoanatomic observations of the brain in early infantile autism
Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964 · see citing works
Brain structural abnormalities in young children with autism spectrum disorder
Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., et al. (2002) · Neurology · doi:10.1212/wnl.59.2.184 · Cited by 961 · see citing works
Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism
Schneider, T., & Przewłocki, R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300518 · Cited by 959 · see citing works
Why Do Autistic Individuals Show Superior Performance on the Block Design Task?
Shah, A., & Uta Frith, A. (1993) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1993.tb02095.x · Cited by 941 · see citing works
The columnar organization of the neocortex.
Mountcastle, V. B. (1997) · Brain : a journal of neurology · doi:10.1093/brain/120.4.701 · Cited by 941 · see citing works
Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI
Pierce, K. (2001) · Brain · doi:10.1093/brain/124.10.2059 · Cited by 898 · see citing works
An islet of ability in autistic children: a research note
Shah, A., & Frith, U. (1983) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1983.tb00137.x · Cited by 888 · see citing works
The Human Amygdala in Social Judgment
Adolphs, R., Tranel, D., & Damásio, A. R. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0027 · Cited by 882 · see citing works
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846 · see citing works
Schumann, C. M., Hamstra, J., Goodlin-Jones, B. L., Lotspeich, L. J., Kwon, H., Buonocore, M. H., Lammers, C. R., Reiss, A. L., & Amaral, D. G. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1297-04.2004 · Cited by 840 · see citing works
Behavioral changes associated with ablation of the amygdaloid complex in monkeys.
Weiskrantz, L. (1956) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0088009 · Cited by 837 · see citing works
The functional neuroanatomy of social behaviour
Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C. R., Van Amelsvoort, T., Robertson, D. M., Rowe, A., Phillips, M., McAlonan, G., Howlin, P., et al. (2000) · Brain · doi:10.1093/brain/123.11.2203 · Cited by 816 · see citing works
Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells
Silberberg, G., & Markram, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.012 · Cited by 768 · see citing works
Self-citationVagaries of Visual Perception in Autism
Dakin, S. C., & Frith, U. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.018 · Cited by 763 · see citing works
Recognition of facial emotion in nine individuals with bilateral amygdala damage
Adolphs, R., Tranel, D., Hamann, S. B., Young, A. W., Calder, A. J., Phelps, E. A., Anderson, A. K., Lee, G. P., & Damásio, A. R. (1999) · Neuropsychologia · doi:10.1016/s0028-3932(99)00039-1 · Cited by 751 · see citing works
Prefrontal involvement in the regulation of emotion: convergence of rat and human studies
Quirk, G. J., & Beer, J. S. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.07.004 · Cited by 701 · see citing works
Autism as an executive disorder
Jarrold, C. (1997) · Oxford University Press eBooks · Cited by 662 · see citing works
THE AUTISTIC CHILD'S APPRAISAL OF EXPRESSIONS OF EMOTION
Hobson, R. P. (1986) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1986.tb01836.x · Cited by 633 · see citing works
When Is the Brain Enlarged in Autism? A Meta-Analysis of All Brain Size Reports
Redcay, E., & Courchesne, E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.026 · Cited by 604 · see citing works
Abnormal Processing of Social Information from Faces in Autism
Adolphs, R., Sears, L. L., & Piven, J. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/089892901564289 · Cited by 590 · see citing works
(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.862 · Cited by 590 · see citing works
Neuropathology of Infantile Autism
Kemper, T. L., & Bauman, M. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199807000-00001 · Cited by 585 · see citing works
Increased Amygdala Activation to Angry and Contemptuous Faces in Generalized Social Phobia
Stein, M. B., Goldin, P. R., Sareen, J., Zorrilla, L. T. E., & Brown, G. G. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1027 · Cited by 582 · see citing works
Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children
Schain, R. J., & Freedman, D. X. (1961) · The Journal of Pediatrics · doi:10.1016/s0022-3476(61)80261-8 · Cited by 579 · see citing works
Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
Persico, A. M., & Bourgeron, T. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.010 · Cited by 575 · see citing works
Neuropsychologic functioning in autism: Profile of a complex information processing disorder.
MINSHEW, N. J., GOLDSTEIN, G., & SIEGEL, D. J. (1997) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617797003032 · Cited by 572 · see citing works
Abnormal cortical voice processing in autism
Gervais, H., Belin, P., Boddaert, N., Leboyer, M., Coez, A., Sfaello, I., Barthélémy, C., Brunelle, F., Samson, Y., & Zilbovicius, M. (2004) · Nature Neuroscience · doi:10.1038/nn1291 · Cited by 568 · see citing works
Cerebral Lobes in Autism: Early Hyperplasia and Abnormal Age Effects
Carper, R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1099 · Cited by 566 · see citing works
Anxiety in High-Functioning Children with Autism
Gillott, A., Furniss, F., & Walter, A. (2001) · Autism · doi:10.1177/1362361301005003005 · Cited by 562 · see citing works
A clinical study of 57 children with fetal anticonvulsant syndromes
Moore, S. J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D. J., Montgomery, T., & Dean, J. C. S. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.7.489 · Cited by 562 · see citing works
Klin, A. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00671 · Cited by 549 · see citing works
"Psychic blindness" and other symptoms following bilateral temporal lobectomy in Rhesus monkeys.
Klüver, H., & Bucy, P. C. (1937) · American Journal of Physiology-Legacy Content · Cited by 549 · see citing works
Neuropathological findings in autism
Palmen, S. J. M. C. (2004) · Brain · doi:10.1093/brain/awh287 · Cited by 527 · see citing works
Designing mouse behavioral tasks relevant to autistic‐like behaviors
Crawley, J. N. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20039 · Cited by 520 · see citing works
Cases, O., Vitalis, T., Seif, I., Maeyer, E. D., Sotelo, C., & Gaspar, P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80048-3 · Cited by 514 · see citing works
British Journal of Developmental Psychology
(2010) · British Journal of Developmental Psychology · doi:10.1111/(issn)2044-835x · Cited by 513 · see citing works
Impaired Recognition of Social Emotions following Amygdala Damage
Adolphs, R., Baron-Cohen, S., & Tranel, D. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807258 · Cited by 510 · see citing works
Heterogeneity in the pyramidal network of the medial prefrontal cortex
Wang, Y., Markram, H., Goodman, P. H., Berger, T. K., Ma, J., & Goldman-Rakic, P. S. (2006) · Nature Neuroscience · doi:10.1038/nn1670 · Cited by 503 · see citing works
Self-citationCONCEPTS OF AUTISM: A REVIEW OF RESEARCH*
Rutter, M. L. (1968) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1968.tb02204.x · Cited by 491 · see citing works
The development of psychopathy
Blair, J., Peschardt, K. S., Budhani, S., Mitchell, D. G. V., & Pine, D. S. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01596.x · Cited by 486 · see citing works
Autism as an executive disorder
Russell, J. A. (1997) · Cited by 483 · see citing works
The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans
Abell, F., Krams, M., Ashburner, J., Passingham, R., Friston, K., Frackowiak, R., Happé, F., Frith, C., & Frith, U. (1999) · NeuroReport · doi:10.1097/00001756-199906030-00005 · Cited by 480 · see citing works
Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism
Howard, M. A., Cowell, P. E., Boucher, J., Broks, P., Mayes, A. R., Farrant, A., & Roberts, N. P. (2000) · Neuroreport · doi:10.1097/00001756-200009110-00020 · Cited by 479 · see citing works
Recognition of faces: an approach to the study of autism
Langdell, T. (1978) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1978.tb00468.x · Cited by 478 · see citing works
BETTELHEI, M., & Gelfand, D. M. (1967) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-196704000-00012 · Cited by 477 · see citing works
The role of the fusiform face area in social cognition: implications for the pathobiology of autism
Schultz, R. T., Grelotti, D. J., Klin, A., Kleinman, J., Van der Gaag, C., Marois, R., & Skudlarski, P. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1208 · Cited by 469 · see citing works
Autism in children with congenital rubella
Chess, S. (1971) · Journal of Autism and Childhood Schizophrenia · doi:10.1007/bf01537741 · Cited by 457 · see citing works
Characteristics of fetal anticonvulsant syndrome associated autistic disorder
Rasalam, A., Hailey, H., Williams, J., Moore, S., Turnpenny, P., Lloyd, D., & Dean, J. (2005) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162205001076 · Cited by 456 · see citing works
AUTISM IN THALIDOMIDE EMBRYOPATHY: A POPULATION STUDY
Strömland, K., Nordin, V., Miller, M. T., Åkerström, B., & Gillberg, C. (1994) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1994.tb11856.x · Cited by 453 · see citing works
What's in a face? The case of autism
Hobson, R. P., Ouston, J., & Lee, A. L. (1988) · British Journal of Psychology · doi:10.1111/j.2044-8295.1988.tb02745.x · Cited by 452 · see citing works
Brain anatomy and sensorimotor gating in Asperger's syndrome
McAlonan, G. M. (2002) · Brain · doi:10.1093/brain/awf150 · Cited by 447 · see citing works
A Broader Phenotype of Autism: The Clinical Spectrum in Twins
Couteur, A. S. L., Bailey, A. J., Goode, S., Pickles, A. R., Gottesman, I. I., Robertson, S., & Rutter, M. L. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01475.x · Cited by 442 · see citing works
Macrocephaly in children and adults with autism
LAINHART, J. E., PIVEN, J., WZOREK, M., LANDA, R., SANTANGELO, S. L., COON, H., & FOLSTEIN, S. E. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199702000-00019 · Cited by 439 · see citing works
Emotional perseveration: an update on prefrontal-amygdala interactions in fear extinction.Preprint
Sotres-Bayon, F., Bush, D. E. A., & LeDoux, J. E. (2004) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.79504 · Cited by 437 · see citing works
(1964) · Andalas University Repository (Andalas University) · Cited by 436 · see citing works
Central coherence and theory of mind in autism: Reading homographs in context
Happe, F. G. E. (1997) · British Journal of Developmental Psychology · doi:10.1111/j.2044-835x.1997.tb00721.x · Cited by 434 · see citing works
Sotres-Bayon, F., Cain, C. K., & LeDoux, J. E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.012 · Cited by 433 · see citing works
The brain response to personally familiar faces in autism: Findings of fusiform activity and beyond
Pierce, K. (2004) · Brain · doi:10.1093/brain/awh289 · Cited by 432 · see citing works
Fetal valproate syndrome and autism: additional evidence of an association
Williams, G., King, J. O., Cunningham, M. L., Stephan, M., Kerr, B. A., & Hersh, J. H. (2001) · Developmental Medicine & Child Neurology · doi:10.1017/s001216220100038x · Cited by 422 · see citing works
Haznedar, M. M., Buchsbaum, M. S., Wei, T.-C., Hof, P. R., Cartwright, C., Bienstock, C. A., & Hollander, E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.12.1994 · Cited by 420 · see citing works
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Bissière, S., Humeau, Y., & Lüthi, A. (2003) · Nature Neuroscience · doi:10.1038/nn1058 · Cited by 415 · see citing works
Stereological Analysis of Amygdala Neuron Number in Autism
Schumann, C. M., & Amaral, D. G. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1285-06.2006 · Cited by 413 · see citing works
A Normed Study of Face Recognition in Autism and Related Disorders
Klin, A., Sparrow, S. S., de Bildt, A. A., Cicchetti, D. V., Cohen, D. J., & Volkmar, F. R. (1999) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1022299920240 · Cited by 408 · see citing works
Sandson, J. R., & Albert, M. L. (1984) · Neuropsychologia · doi:10.1016/0028-3932(84)90098-8 · Cited by 402 · see citing works
The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism
Bachevalier, J., & Loveland, K. A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.07.002 · Cited by 402 · see citing works
Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys
Chugani, D. C., Muzik, O., Rothermel, R., Behen, M. E., Chakraborty, P. K., Mangner, T. J., Silva, E. A. D., & Chugani, H. T. (1997) · Annals of Neurology · doi:10.1002/ana.410420420 · Cited by 399 · see citing works
Hippocampus in autism: a Golgi analysis
Raymond, G. V., Bauman, M. L., & Kemper, T. L. (1995) · Acta Neuropathologica · doi:10.1007/s004010050401 · Cited by 387 · see citing works
Abnormal Fear Conditioning and Amygdala Processing in an Animal Model of Autism
Markram, H., Barkat, T. R., Mendola, D. L., Sandi, C., & Markram, H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301453 · Cited by 382 · see citing works
Self-citationIngram, J. L., Peckham, S. M., Tisdale, B., & Rodier, P. M. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00083-5 · Cited by 381 · see citing works
The Empty Fortress: Infantile Autism and the Birth of the Self.
Deslauriers, N. (1967) · Archives of General Psychiatry · doi:10.1001/archpsyc.1967.01730280126018 · Cited by 380 · see citing works
Rescorla, R. A. (2004) · Learning & Memory · doi:10.1101/lm.77504 · Cited by 380 · see citing works
Follow-up report on autism in congenital rubella
Chess, S. (1977) · Journal of Autism and Childhood Schizophrenia · doi:10.1007/bf01531116 · Cited by 378 · see citing works
Arndt, T. L., Stodgell, C., & Rodier, P. M. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.11.001 · Cited by 369 · see citing works
Comorbid anxiety symptoms in children with pervasive developmental disorders
Muris, P., Steerneman, P., Merckelbach, H., Holdrinet, I., & Meesters, C. (1998) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(98)00022-x · Cited by 368 · see citing works
Allen, G., & Courchesne, E. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.262 · Cited by 366 · see citing works
The Empty Fortress: Infantile Autism and the Birth of the Self
Bettelheim, B. (1972) · Medical Entomology and Zoology · Cited by 365 · see citing works
Unfamiliar Face Recognition in Relatively Able Autistic Children
Boucher, J., & LEWIS, V. A. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb01960.x · Cited by 363 · see citing works
Quirk, G. J. (2002) · Learning & Memory · doi:10.1101/lm.49602 · Cited by 360 · cited 2× · see citing works
“xtinction is usually defined as a learning process in which a new (probbly inhibitory) association is built, namely that the conditioned stimulus o longer predicts danger (Quirk, 2002; Rescorla, 2004).”
BackgroundNeural correlates of genetically abnormal social cognition in Williams syndrome
Meyer-Lindenberg, A., Hariri, A. R., Munoz, K. E., Mervis, C. B., Mattay, V. S., Morris, C. A., & Berman, K. F. (2005) · Nature Neuroscience · doi:10.1038/nn1494 · Cited by 357 · see citing works
Sensorimotor gating deficits in adults with autism
Perry, W., Minassian, A., Lopez, B., Maron, L., & Lincoln, A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.025 · Cited by 352 · see citing works
Fetal Valproate Syndrome: Clinical and Neuro‐developmental Features in Two Sibling Pairs
Christianson, A. L., Chester, N., & Kromberg, J. G. R. (1994) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1994.tb11858.x · Cited by 340 · see citing works
Attentional skills during the first 6 months of age in autism spectrum disorder
MAESTRO, S., MURATORI, F., CAVALLARO, M. C., PEI, F., STERN, D., GOLSE, B., & PALACIO-ESPASA, F. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200210000-00014 · Cited by 336 · see citing works
Neocortical system abnormalities in autism
Luna, B., Minshew, N. J., Garver, K. E., Lazar, N. A., Thulborn, K. R., Eddy, W. F., & Sweeney, J. A. (2002) · Neurology · doi:10.1212/wnl.59.6.834 · Cited by 335 · see citing works
The Cerebral Metabolic Landscape in Autism: Intercorrelations of Regional Glucose Utilization
Horwitz, B. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520310055018 · Cited by 331 · see citing works
Influence of amygdalectomy on social behavior in monkeys.
Rosvold, H. E., Mirsky, A. F., & Pribram, K. H. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058870 · Cited by 331 · see citing works
Carey, S. E. (1992) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1992.0012 · Cited by 330 · see citing works
Face Perception in Children with Autism and Asperger's Syndrome
Davies, S., Bishop, D., Manstead, A. S. R., & Tantam, D. (1994) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1994.tb01808.x · Cited by 325 · see citing works
Medial temporal lobe structures and autism: A review of clinical and experimental findings
Bachevalier, J. (1994) · Neuropsychologia · doi:10.1016/0028-3932(94)90025-6 · Cited by 322 · see citing works
Williams, R. S. (1980) · Archives of Neurology · doi:10.1001/archneur.1980.00500610029003 · Cited by 318 · see citing works
Neurochemical correlates of autistic disorder: a review of the literature
Lam, K. S. L., Aman, M. G., & Arnold, L. E. (2006) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2005.03.003 · Cited by 318 · see citing works
THE AUTISTIC CHILD'S APPRAISAL OF EXPRESSIONS OF EMOTION: A FURTHER STUDY
Hobson, R. P. (1986) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1986.tb00191.x · Cited by 313 · see citing works
Whole blood serotonin in autistic and normal subjects
Anderson, G. M., Freedman, D. X., Cohen, D. J., Volkmar, F. R., Hoder, E. L., McPhedran, P., Minderaa, R. B., Hansen, C. R., & Young, J. G. (1987) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1987.tb00677.x · Cited by 313 · see citing works
The social deficits of the oxytocin knockout mouse
Winslow, J. T., & Insel, T. R. (2002) · Neuropeptides · doi:10.1054/npep.2002.0909 · Cited by 307 · see citing works
Cerebral correlates of preserved cognitive skills in autism
RING, H. A., Baron‐Cohen, S., Wheelwright, S. J., Williams, S., Brammer, M. J., Andrew, C., & Bullmore, E. T. (1999) · Brain · doi:10.1093/brain/122.7.1305 · Cited by 306 · see citing works
Verification of the fetal valproate syndrome phenotype
Ardinger, H. H., Atkin, J., Blackston, R. D., Elsas, L. J., Clarren, S. K., Livingstone, S., Flannery, D. B., Pellock, J. M., Harrod, M. J., Lammer, E. J., et al. (1988) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320290123 · Cited by 301 · see citing works
Effects of tryptophan depletion in drug-free adults with autistic disorder
McDougle, C. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830110029004 · Cited by 301 · see citing works
Autistic Children's Ability to Interpret Faces: A Research Note
Tantam, D., Monaghan, L., Nicholson, H., & Stirling, J. (1989) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1989.tb00274.x · Cited by 298 · see citing works
Schneider, T., Turczak, J., & Przewłocki, R. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300767 · Cited by 298 · see citing works
Autonomic responses of autistic children to people and objects
Hirstein, W., Iversen, P., & Ramachandran, V. S. (2001) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2001.1724 · Cited by 297 · see citing works
Brain development in autism: Early overgrowth followed by premature arrest of growth
Courchesne, E. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20020 · Cited by 295 · see citing works
Subcortical Discrimination of Unperceived Objects during Binocular Rivalry
Pasley, B. N., Mayes, L. C., & Schultz, R. T. (2004) · Neuron · doi:10.1016/s0896-6273(04)00155-2 · Cited by 294 · see citing works
Rinaldi, T., Kulangara, K., Antoniello, K., & Markram, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704391104 · Cited by 290 · see citing works
Self-citationFetal valproate syndrome and autism: additional evidence of an association
Williams, G. M., King, J. O., Cunningham, M. L., et al. (2001) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2001.tb00188.x · Cited by 290 · see citing works
Genetic Studies of Autism: From the 1970s into the Millennium
Rutter, M. L. (2000) · Research on Child and Adolescent Psychopathology · doi:10.1023/a:1005113900068 · Cited by 288 · see citing works
Autism and Known Medical Conditions: Myth and Substance
Rutter, M. L., Bailey, A. J., Bolton, P., & Couteur, A. S. L. (1994) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1994.tb01164.x · Cited by 287 · see citing works
Functional imbalance of visual pathways indicates alternative face processing strategies in autism
Hubl, D., Bölte, S., Feineis–Matthews, S., Lanfermann, H., Federspiel, A., Strik, W., Poustka, F., & Dierks, T. (2003) · Neurology · doi:10.1212/01.wnl.0000091862.22033.1a · Cited by 283 · see citing works
Emotion recognition in autism: coordinating faces and voices
Hobson, R. P., Ouston, J., & Lee, A. (1988) · Psychological Medicine · doi:10.1017/s0033291700009843 · Cited by 283 · see citing works
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice
Hayashi, M. L., Rao, B. S. S., Seo, J.-S., Choi, H.-S., Dolan, B. M., Choi, S.-Y., Chattarji, S., & Tonegawa, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705003104 · Cited by 281 · see citing works
A New Neurobehavioral Model of Autism in Mice: Pre- and Postnatal Exposure to Sodium Valproate
Wagner, G. C., Reuhl, K. R., Cheh, M. A., McRae, P. A., & Halladay, A. K. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0117-y · Cited by 278 · see citing works
Emery, N. J., Capitanio, J. P., Mason, W. A., Machado, C. J., Mendoza, S. P., & Amaral, D. G. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.3.515 · Cited by 273 · see citing works
Spatial attention deficits in patients with acquired or developmental cerebellar abnormality
Townsend, J., Courchesne, E., Covington, J., Westerfield, M., Harris, N. S., Lyden, P., Lowry, T. P., & Press, G. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05632.1999 · Cited by 272 · see citing works
THE SALIENCE OF FACIAL EXPRESSION FOR AUTISTIC CHILDREN
Weeks, S. J., & Hobson, R. P. (1987) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1987.tb00658.x · Cited by 272 · see citing works
Evans, D. W., Canavera, K. E., Kleinpeter., F. L., Maccubbin, E. M., & Taga, K. (2005) · Child Psychiatry & Human Development · doi:10.1007/s10578-004-3619-x · Cited by 271 · see citing works
Functional anatomy of impaired selective attention and compensatory processing in autism
Belmonte, M. K., & Yurgelun-Todd, D. A. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00189-7 · Cited by 266 · see citing works
Zola‐Morgan, S., Squire, L. R., Clower, R. P., & Alvarez‐Royo, P. (1991) · Hippocampus · doi:10.1002/hipo.450010208 · Cited by 265 · see citing works
Hussman, J. P. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010715619091 · Cited by 263 · see citing works
Manzanares, P. A. R., Isoardi, N. A., Carrer, H. F., & Molina, V. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2260-05.2005 · Cited by 262 · see citing works
Cortisol circadian rhythms and response to stress in children with autism
Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.011 · Cited by 258 · see citing works
Linking etiologies in humans and animal models: Studies of autism
Rodier, P. M., Ingram, J. L., Tisdale, B., & Croog, V. J. (1997) · Reproductive Toxicology · doi:10.1016/s0890-6238(97)80001-u · Cited by 248 · see citing works
Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions
Prather, M. D., Lavenex, P., Mauldin-Jourdain, M. L., Mason, W. A., Capitanio, J. P., Mendoza, S. P., & Amaral, D. G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00445-6 · Cited by 248 · see citing works
Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta).
Aggleton, J., & Passingham, R. (1981) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077848 · Cited by 236 · see citing works
AUTISM AND MEDICAL DISORDERS: A REVIEW OF THE LITERATURE
Gillberg, C., & Coleman, M. (1996) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1996.tb15081.x · Cited by 235 · see citing works
Autism: Processing of novel auditory information assessed by event-related brain potentials
Courchesne, E., Kilman, B. A., Galambos, R., & Lincoln, A. J. (1984) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(84)90063-7 · Cited by 222 · see citing works
Allen, G., Müller, R., & Courchesne, E. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.005 · Cited by 219 · see citing works
Perception of Complex Sounds: Abnormal Pattern of Cortical Activation in Autism
Boddaert, N., Belin, P., Chabane, N., Poline, J., Barthélémy, C., Mouren, M., Brunelle, F., Samson, Y., & Zilbovicius, M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.2057 · Cited by 217 · see citing works
Parietal lobe abnormalities detected with MR in patients with infantile autism.
Courchesne, E., Press, G. A., & Yeung-Courchesne, R. (1993) · American Journal of Roentgenology · doi:10.2214/ajr.160.2.8424359 · Cited by 214 · see citing works
The Hyperserotonemia of Autisma
Anderson, G. M., Horne, W. C., Chatterjee, D., & Cohen, D. J. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16893.x · Cited by 210 · see citing works
The impact of early and late damage to the human amygdala on 'theory of mind' reasoning.
Shaw, P., Lawrence, E., Radbourne, C., Bramham, J., Polkey, C., & David, A. (2004) · Brain : a journal of neurology · doi:10.1093/brain/awh168 · Cited by 210 · see citing works
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
Shaban, H., Humeau, Y., Herry, C., Casassus, G., Shigemoto, R., Ciocchi, S., Barbieri, S., van der Putten, H., Kaupmann, K., Bettler, B., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1732 · Cited by 208 · see citing works
Serotonergic Responsivity in Male Young Adults With Autistic Disorder
McBride, P. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810030019003 · Cited by 206 · see citing works
Narita, N., Kato, M., Tazoe, M., Miyazaki, K., Narita, M., & Okado, N. (2002) · Pediatric Research · doi:10.1203/00006450-200210000-00018 · Cited by 205 · see citing works
Brain Mapping of Language and Auditory Perception in High-Functioning Autistic Adults: A PET Study
Müller, R., Behen, M. E., Rothermel, R. D., Chugani, D. C., Muzik, O., Mangner, T. J., & Chugani, H. T. (1999) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025914515203 · Cited by 200 · see citing works
Accelerated head growth in early development of individuals with autism
Dementieva, Y. A., Vance, D. D., Donnelly, S. L., Elston, L. A., Wolpert, C. M., Ravan, S. A., DeLong, G. R., Abramson, R. K., Wright, H. H., & Cuccaro, M. L. (2004) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2004.08.005 · Cited by 198 · see citing works
Miyazaki, K., Narita, N., & Narita, M. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.05.004 · Cited by 195 · see citing works
COURCHESNE, E., REDCAY, E., MORGAN, J. T., & KENNEDY, D. P. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050285 · Cited by 192 · see citing works
Micali, N., Chakrabarti, S., & Fombonne, E. J. (2004) · Autism · doi:10.1177/1362361304040636 · Cited by 187 · see citing works
Atypical patterns of cerebral motor activation in autism: a functional magnetic resonance study
Müller, R.-A., Pierce, K., Ambrose, J. B., Allen, G., & Courchesne, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01004-0 · Cited by 186 · see citing works
The amygdala and autism: implications from non-human primate studies
Amaral, D. G., Bauman, M. D., & Mills Schumann, C. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00043.x · Cited by 184 · see citing works
Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid
Rinaldi, T., Silberberg, G., & Markram, H. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm117 · Cited by 184 · see citing works
Self-citationAffect comprehension in children with pervasive developmental disorders
Braverman, M., Fein, D., Lucci, D., & Waterhouse, L. (1989) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02211848 · Cited by 183 · see citing works
A male with fetal valproate syndrome and autism
Williams, P. G., & Hersh, J. H. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07500.x · Cited by 182 · see citing works
Altman, J., & Bayer, S. A. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901940102 · Cited by 177 · see citing works
Ciesielski, K. T., Courchesne, E., & Elmasian, R. (1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90174-i · Cited by 175 · see citing works
Neuropsychological divergence of high-level autism and severe dyslexia
Rumsey, J. M., & Hamburger, S. D. (1990) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02284715 · Cited by 175 · see citing works
How do we know the minds of others? Domain-specificity, simulation, and enactive social cognition
Adolphs, R. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.127 · Cited by 170 · see citing works
Evidence of altered energy metabolism in autistic children
Chugani, D. C., Sundram, B. S., Behen, M. E., Lee, M.-L., & Moore, G. J. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00022-6 · Cited by 169 · see citing works
Abnormal classical eye-blink conditioning in autism
Sears, L. L., Finn, P., & Steinmetz, J. E. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172283 · Cited by 166 · see citing works
Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
Cook, E. H., Arora, R. C., Anderson, G. M., Berry‐Kravis, E., Yan, S., Yeoh, H. C., Sklena, P. J., Charak, D., & LEVENTHAL, B. L. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90685-v · Cited by 166 · see citing works
Role of altered brain serotonin mechanisms in autism
Chugani, D. C. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001167 · Cited by 166 · see citing works
Bennett-Clarke, C., Leslie, M. J., Lane, R. D., & Rhoades, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07594.1994 · Cited by 165 · see citing works
Autism: recent molecular genetic advances
Lamb, J. A. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.6.861 · Cited by 163 · see citing works
Amygdala damage impairs emotion recognition from scenes only when they contain facial expressions
Adolphs, R., & Tranel, D. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00064-2 · Cited by 163 · see citing works
Neuroanatomical abnormalities as risk factors for bipolar disorder
Hájek, T., CARREY, N. J., & Alda, M. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00238.x · Cited by 155 · see citing works
Impaired spontaneous anthropomorphizing despite intact perception and social knowledge
Heberlein, A. S., & Adolphs, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308220101 · Cited by 153 · see citing works
Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism
Tordjman, S., McBride, P., Hertzig, M. E., Snow, M. E., Anderson, G. M., Hall, L. M., Thompson, S., Ferrari, P., & Cohen, D. J. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01697.x · Cited by 152 · see citing works
Autism Spectrum Traits in Children with Mood and Anxiety Disorders
Towbin, K. E., Pradella, A., Gorrindo, T., Pine, D. S., & Leibenluft, E. (2005) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2005.15.452 · Cited by 152 · cited 1× · see citing works
“A recent study screening for autism-like sympoms in children with mood and anxiety disorders, found that up to 62% f these kids fall into the autistic spectrum and might qualify for a possile ASD diagnosis (Towbin et al., 2005).”
BackgroundStevenson, R. E., Schroer, R. J., Skinner, C. D., Fender, D., & Simensen, R. J. (1997) · The Lancet · doi:10.1016/s0140-6736(05)62956-x · Cited by 148 · see citing works
Aronson, M., Hagberg, B. S., & Gillberg, C. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07493.x · Cited by 147 · see citing works
Autism in Fetal Alcohol Syndrome: A Report of Six Cases
Nanson, J. L. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01417.x · Cited by 147 · see citing works
Teratogenicity and developmental toxicity of valproic acid in rats
Vorhees, C. V. (1987) · Teratology · doi:10.1002/tera.1420350205 · Cited by 146 · see citing works
Preferential orienting to faces in newborns: A temporal-nasal asymmetry.
Simion, F., Valenza, E., Umiltà, C. A., & Barba, B. D. (1998) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.24.5.1399 · Cited by 140 · see citing works
Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats
Binkerd, P. E. (1988) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(88)90112-1 · Cited by 140 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Kling A. Brothers L. (1992) The amygdala and social behavior. In Aggleton J. P., ed. Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction (New York, Wiley).
- Lord C. Spence S. (2006) Autism sepctrum disorder: phenotype and diagnosis. In Understanding Autism: From Basic Neuroscience to Treatment, Moldin S.O. Rubenstein J. L., eds., (Boca Raton, CRC Press, Taylor & Francis Group) pp 1– 23
Cited by
Sorted by citations
Salience processing and insular cortical function and dysfunction
Uddin, L. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3857 · Cited by 2,083 · see citing works
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939 · see citing works
Robertson, C. E., & Baron-Cohen, S. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.112 · Cited by 1,157 · see citing works
From the genetic architecture to synaptic plasticity in autism spectrum disorder
Bourgeron, T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3992 · Cited by 975 · see citing works
A behavioral comparison of male and female adults with high functioning autism spectrum conditions
Lai, M.-C., Lombardo, M. V., Pasco, G., Ruigrok, A. N. V., Wheelwright, S. J., Sadek, S. A., Chakrabarti, B., MRC AIMS Consortium, & Baron-Cohen, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020835 · Cited by 650 · see citing works
The Functional Benefits of Criticality in the Cortex
Shew, W. L., & Plenz, D. (2013) · The Neuroscientist · doi:10.1177/1073858412445487 · Cited by 607 · see citing works
The Intense World Theory – A Unifying Theory of the Neurobiology of Autism
Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 521 · see citing works
Self-citationThe impact of atypical sensory processing on social impairments in autism spectrum disorder
Thye, M. D., Bednarz, H. M., Herringshaw, A. J., Sartin, E. B., & Kana, R. K. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.04.010 · Cited by 513 · see citing works
“The Intense World Theory offers another mechanism for how the sensory and social features of ASD may be related (Markram et al., 2007; Markram and Markram, 2010).”
Clinical assessment of social cognitive function in neurological disorders
Henry, J. D., von Hippel, W., Molenberghs, P., Lee, T., & Sachdev, P. S. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.229 · Cited by 488 · see citing works
The idiosyncratic brain: distortion of spontaneous connectivity patterns in autism spectrum disorder
Hahamy, A., Behrmann, M., & Malach, R. (2015) · Nature Neuroscience · doi:10.1038/nn.3919 · Cited by 416 · see citing works
Cannistraci, C. V., Alanis‐Lobato, G., & Ravasi, T. (2013) · Scientific Reports · doi:10.1038/srep01613 · Cited by 404 · see citing works
Embodiment and sense-making in autism
Jaegher, H. D. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00015 · Cited by 396 · see citing works
Buzsáki, G. (2019) · doi:10.1093/oso/9780190905385.001.0001 · Cited by 358 · see citing works
Alterations of GABAergic Signaling in Autism Spectrum Disorders
Pizzarelli, R., & Cherubini, E. (2011) · Neural Plasticity · doi:10.1155/2011/297153 · Cited by 323 · see citing works
Unreliable evoked responses in autism
Dinstein, I., Heeger, D. J., Lorenzi, L., Minshew, N. J., Malach, R., & Behrmann, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.026 · Cited by 318 · see citing works
Validating γ oscillations and delayed auditory responses as translational biomarkers of autism
Gandal, M. J., Edgar, J. C., Ehrlichman, R. S., Mehta, M., Roberts, T. P. L., & Siegel, S. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.031 · Cited by 314 · see citing works
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., & Sigman, M. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.11.024 · Cited by 311 · see citing works
Autism: A “Critical Period” Disorder?
LeBlanc, J. J., & Fagiolini, M. (2011) · Neural Plasticity · doi:10.1155/2011/921680 · Cited by 301 · see citing works
Comparative genomics of autism and schizophrenia
Crespi, B., Stead, P., & Elliot, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906080106 · Cited by 262 · see citing works
Neural variability: friend or foe?
Dinstein, I., Heeger, D. J., & Behrmann, M. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.04.005 · Cited by 254 · see citing works
Rethinking autism: implications of sensory and movement differences for understanding and support
Donnellan, A. M., Hill, D. A., & Leary, M. R. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00124 · Cited by 219 · see citing works
High intelligence: A risk factor for psychological and physiological overexcitabilities
Karpinski, R. I., Kinase Kolb, A. M., Tetreault, N. A., & Borowski, T. B. (2018) · Intelligence · doi:10.1016/j.intell.2017.09.001 · Cited by 217 · see citing works
Smith, A. (2009) · The Psychological Record · doi:10.1007/bf03395675 · Cited by 216 · see citing works
Mouse model of Timothy syndrome recapitulates triad of autistic traits
Bader, P. L., Faizi, M., Kim, L. H., Owen, S. F., Tadross, M. R., Alfa, R. W., Bett, G. C. L., Tsien, R. W., Rasmusson, R. L., & Shamloo, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112667108 · Cited by 212 · see citing works
Rinaldi, T. (2008) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.004.2008 · Cited by 210 · see citing works
Hasson, U., Avidan, G., Gelbard, H., Vallines, I., Harel, M., Minshew, N. J., & Behrmann, M. (2009) · Autism Research · doi:10.1002/aur.89 · Cited by 189 · see citing works
Network Plasticity in Adaptive Filtering and Behavioral Habituation
Ramaswami, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.035 · Cited by 194 · see citing works
Duffy, F. H., & Als, H. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-64 · Cited by 208 · see citing works
A challenging, unpredictable world for people with Autism Spectrum Disorder
Gomot, M., & Wicker, B. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.09.017 · Cited by 194 · see citing works
Mehta, M. V., Gandal, M. J., & Siegel, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026077 · Cited by 182 · see citing works
Sensory abnormalities in children with autism spectrum disorder
Posar, A., & Visconti, P. (2017) · Jornal de Pediatria · doi:10.1016/j.jped.2017.08.008 · Cited by 195 · see citing works
Balasco, L., Provenzano, G., & Bozzi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01016 · Cited by 183 · see citing works
Modeling Autistic Features in Animals
Patterson, P. H. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212b80f · Cited by 169 · see citing works
Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism
Piochon, C., Kloth, A. D., Grasselli, G., Titley, H. K., Nakayama, H., Hashimoto, K., Wan, V., Simmons, D. H., Eissa, T. L., Nakatani, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6586 · Cited by 157 · see citing works
Smith, A. (2009) · The Psychological Record · doi:10.1007/bf03395663 · Cited by 154 · see citing works
Normal Movement Selectivity in Autism
Dinstein, I., Thomas, C., Humphreys, K., Minshew, N. J., Behrmann, M., & Heeger, D. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.034 · Cited by 149 · see citing works
Inhibitory engrams in perception and memory
Barron, H. C., Vogels, T. P., Behrens, T. E., & Ramaswami, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701812114 · Cited by 147 · see citing works
Brenes, J. C., Lackinger, M., Höglinger, G. U., Schratt, G., Schwarting, R. K. W., & Wöhr, M. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.23842 · Cited by 155 · see citing works
General developmental health in the VPA-rat model of autism
Favre, M., Barkat, T. R., Mendola, D. L., Khazen, G., Markram, H., & Markram, H. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00088 · Cited by 139 · see citing works
Self-citationHadjikhani, N. K., Johnels, J. Å., Zürcher, N. R., Lassalle, A., Guillon, Q., Hippolyte, L., Billstedt, E., Ward, N., Lemonnier, É., & Gillberg, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-03378-5 · Cited by 133 · see citing works
Sleep disturbances are associated with specific sensory sensitivities in children with autism
Tzischinsky, O., Meiri, G., Manelis, L., Bar‐Sinai, A., Flusser, H., Michaelovski, A., Zivan, O., Ilan, M., Faroy, M., Menashe, I., et al. (2018) · Molecular Autism · doi:10.1186/s13229-018-0206-8 · Cited by 135 · see citing works
Kas, M. J., Glennon, J. C., Buitelaar, J., Ey, E., Biemans, B., Crawley, J., Ring, R. H., Lajonchere, C., Esclassan, F., Talpos, J., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3268-5 · Cited by 132 · see citing works
Dickinson, A. H., Jones, M., & Milne, E. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.011 · Cited by 128 · see citing works
Cortical variability in the sensory-evoked response in autism
Haigh, S. M., Heeger, D. J., Dinstein, I., Minshew, N., & Behrmann, M. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2276-6 · Cited by 113 · see citing works
McDiarmid, T. A., Bernardos, A. C., & Rankin, C. H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.028 · Cited by 119 · see citing works
Amatachaya, A., Auvichayapat, N., Patjanasoontorn, N., Suphakunpinyo, C., Ngernyam, N., Aree-uea, B., Keeratitanont, K., & Auvichayapat, P. (2014) · Behavioural Neurology · doi:10.1155/2014/173073 · Cited by 122 · see citing works
Dani, V. S., & Nelson, S. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-09.2009 · Cited by 121 · see citing works
Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism
Banerjee, A., García‐Oscos, F., Roychowdhury, S., Galindo, L. C., Hall, S., Kilgard, M. P., & Atzori, M. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001216 · Cited by 120 · see citing works
What We Have Learned about Autism Spectrum Disorder from Valproic Acid
Chomiak, T., Turner, N. R., & Hu, B. (2013) · Pathology Research International · doi:10.1155/2013/712758 · Cited by 121 · see citing works
Kim, J., Seung, H., Kwon, K. J., Ko, M. J., Lee, E. J., Oh, H. A., Choi, C. S., Kim, K. C., Gonzales, E. L., You, J. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104927 · Cited by 117 · see citing works
D’Souza, D., D’Souza, H., & Karmiloff‐Smith, A. (2017) · Journal of Child Language · doi:10.1017/s030500091700006x · Cited by 113 · see citing works
Sartorato, F., Przybylowski, L. F., & Sarko, D. K. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.02.004 · Cited by 112 · see citing works
Stevenson, R. A., Segers, M., Ferber, S., Barense, M. D., & Wallace, M. T. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00379 · Cited by 110 · see citing works
LTD-like molecular pathways in developmental synaptic pruning
Piochon, C., Kano, M., & Hansel, C. (2016) · Nature Neuroscience · doi:10.1038/nn.4389 · Cited by 108 · see citing works
Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid
Nicolini, C., Ahn, Y., Michalski, B., Rho, J. M., & Fahnestock, M. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0184-4 · Cited by 109 · see citing works
Immune system gene dysregulation in autism and schizophrenia
Michel, M., Schmidt, M. J., & Mirnics, K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22044 · Cited by 107 · see citing works
The reality of autism: On the metaphysics of disorder and diversity
Chapman, R. (2020) · Philosophical Psychology · doi:10.1080/09515089.2020.1751103 · Cited by 109 · see citing works
Qiu, S., Anderson, C. T., Levitt, P., & Shepherd, G. M. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6569-10.2011 · Cited by 106 · see citing works
RDoC-based categorization of amygdala functions and its implications in autism
Hennessey, T., Andari, E., & Rainnie, D. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.007 · Cited by 105 · see citing works
Garcia-Oscos, F., Salgado, H., Hall, S., Thomas, F., Farmer, G. E., Bermeo, J., Galindo, L. C., Ramirez, R. D., D'Mello, S., Rose-John, S., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.018 · Cited by 105 · see citing works
Lam, P. P. Y., Du, R. Y., Peng, S., McGrath, C. P. J., & Yiu, C. K. Y. (2020) · Autism · doi:10.1177/1362361319877337 · Cited by 109 · see citing works
Sandhya, T., Sowjanya, J., & Veeresh, B. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0717-1 · Cited by 103 · see citing works
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism
Kim, J.-W., Seung, H., Kim, K. C., Gonzales, E. L. T., Oh, H. A., Yang, S. M., Ko, M. J., Han, S.-H., Banerjee, S., & Shin, C. Y. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.014 · Cited by 102 · see citing works
Noise from the periphery in autism
Brincker, M., & Torres, E. B. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00034 · Cited by 100 · see citing works
Oberman, L. M. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00026 · Cited by 99 · see citing works
Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders
Oberman, L. M., Rotenberg, A., & Pascual‐Leone, Á. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1960-2 · Cited by 98 · see citing works
Increased BDNF expression in fetal brain in the valproic acid model of autism
Almeida, L. E. F., Roby, C. D., & Krueger, B. K. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.01.007 · Cited by 95 · see citing works
Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism
Mottron, L., Duret, P., Mueller, S., Moore, R. D., d’Arc, B. F., Jacquemont, S., & Xiong, L. (2015) · Molecular Autism · doi:10.1186/s13229-015-0024-1 · Cited by 97 · see citing works
Zimmermann, F. F., Gaspary, K. V., Leite, C. E., Cognato, G. D. P., & Bonan, C. D. (2015) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.10.002 · Cited by 92 · see citing works
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia
Devor, A., Andreassen, O. A., Wang, Y., Mäki‐Marttunen, T., Smeland, O. B., Fan, C.-C., Schork, A. J., Holland, D., Thompson, W. K., Witoelar, A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.33 · Cited by 89 · see citing works
Scherf, K. S. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00026 · Cited by 91 · see citing works
Altered tactile processing in children with autism spectrum disorder
Tavassoli, T., Bellesheim, K., Tommerdahl, M., Holden, J. M., Kolevzon, A., & Buxbaum, J. D. (2016) · Autism Research · doi:10.1002/aur.1563 · Cited by 88 · see citing works
Children with autism spectrum disorder have unstable neural responses to sound
Otto‐Meyer, S., Krizman, J., White‐Schwoch, T., & Kraus, N. (2018) · Experimental Brain Research · doi:10.1007/s00221-017-5164-4 · Cited by 88 · see citing works
Deregulation of synaptic plasticity in autism
Hansel, C. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.02.003 · Cited by 83 · see citing works
Kang, J., & Kim, E. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00017 · Cited by 81 · see citing works
The amygdala and the relevance detection theory of autism: an evolutionary perspective
Zalla, T., & Sperduti, M. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00894 · Cited by 85 · see citing works
Does mindfulness meditation increase empathy? An experiment
Ridderinkhof, A., de Bruin, E. I., Brummelman, E., & Bögels, S. M. (2017) · Self and Identity · doi:10.1080/15298868.2016.1269667 · Cited by 80 · see citing works
A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse
Keum, S., Kim, A., Shin, J. J., Kim, J., Park, J., & Shin, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.041 · Cited by 77 · see citing works
Hens, K., Robeyns, I., & Schaubroeck, K. (2018) · Philosophy Compass · doi:10.1111/phc3.12559 · Cited by 80 · see citing works
Normal binocular rivalry in autism: Implications for the excitation/inhibition imbalance hypothesis
Said, C. P., Egan, R. D., Minshew, N. J., Behrmann, M., & Heeger, D. J. (2012) · Vision Research · doi:10.1016/j.visres.2012.11.002 · Cited by 73 · see citing works
Abnormal modulation of corticospinal excitability in adults with Asperger’s syndrome
Oberman, L. M., Eldaief, M. C., Fecteau, S., Ifert‐Miller, F., Tormos, J. M., & Pascual‐Leone, Á. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08172.x · Cited by 72 · see citing works
Singletary, W. M. (2015) · Neuropsychoanalysis · doi:10.1080/15294145.2015.1092334 · Cited by 71 · see citing works
Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder
Nagode, D. A., Meng, X., Winkowski, D. E., Smith, E., Khan-Tareen, H., Kareddy, V., Kao, J. P. Y., & Kanold, P. O. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.006 · Cited by 70 · see citing works
Kessler, K., Seymour, R. A., & Rippon, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.002 · Cited by 69 · see citing works
Late onset deficits in synaptic plasticity in the valproic acid rat model of autism
Martin, H. G. S., & Manzoni, O. J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00023 · Cited by 69 · see citing works
Sensory abnormalities in children with autism spectrum disorder
Posar, A., & Visconti, P. (2018) · Jornal de Pediatria (Versão em Português) · doi:10.1016/j.jpedp.2017.11.009 · Cited by 81 · see citing works
Prolonged auditory brainstem responses in infants with autism
Miron, O., Roth, D. A., Gabis, L. V., Henkin, Y., Shefer, S., Dinstein, I., & Geva, R. (2015) · Autism Research · doi:10.1002/aur.1561 · Cited by 68 · see citing works
Blomqvist, M., Bejerot, S., & Dahllöf, G. (2015) · BMC Oral Health · doi:10.1186/s12903-015-0065-z · Cited by 67 · see citing works
Update on autism: A review of 1300 reports published in 2008
Hughes, J. R. (2009) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2009.09.023 · Cited by 67 · see citing works
Go, H. S., Seo, J. E., Kim, K. C., Han, S. M., Kim, P., Kang, Y. S., Han, S. H., Shin, C. Y., & Ko, K. H. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-48 · Cited by 65 · see citing works
Radwan, B., Dvorak, D., & Fenton, A. A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.01.003 · Cited by 63 · see citing works
“This is Your Brain on Rhetoric”: Research Directions for Neurorhetorics
Jack, J., & Appelbaum, L. G. (2010) · Rhetoric Society Quarterly · doi:10.1080/02773945.2010.516303 · Cited by 62 · see citing works
Hens, K. (2021) · Open Book Publishers · doi:10.11647/obp.0261 · Cited by 66 · see citing works
Neurodevelopmental Hypothesis about the Etiology of Autism Spectrum Disorders
Inui, T., Kumagaya, S., & Myowa‐Yamakoshi, M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00354 · Cited by 59 · see citing works
Observational fear behavior in rodents as a model for empathy
Kim, A., Keum, S., & Shin, H. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12521 · Cited by 60 · see citing works
Emotional Empathy in Autism Spectrum Conditions: Weak, Intact, or Heightened?
Smith, A. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0799-z · Cited by 59 · see citing works
Meeking, M. M., MacFabe, D. F., Mepham, J. R., Foley, K. A., Tichenoff, L. J., Boon, F. H., Kavaliers, M., & Ossenkopp, K. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109794 · Cited by 58 · see citing works
Search superiority in autism within, but not outside the crowding regime
Baldassi, S., Pei, F., Megna, N., Recupero, G., Viespoli, M., Igliozzi, R., Tancredi, R., Muratori, F., & Cioni, G. (2009) · Vision Research · doi:10.1016/j.visres.2009.06.007 · Cited by 58 · see citing works
Kinast, K., Peeters, D., Kolk, S. M., Schubert, D., & Homberg, J. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00072 · Cited by 57 · see citing works
The Emperor's new clothes: Eclecticism in autism treatment
Dillenburger, K. (2011) · Research in Autism · doi:10.1016/j.rasd.2010.12.008 · Cited by 57 · see citing works
- Authors
- Markram, H.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Markram, Henry
- ORCID
- Markram, Henry
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2007-11-01
- Volume
- 1
- Issue
- 1
- Pages
- 77-96
- ISSN
- 1662-453X (ISSN-L)
- 1662-4548
- PMC
- PMC2518049
- OpenAlex
- W2128332414
- Cited by
- 394
- References
- 258
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 10 · 2023: 21 · 2022: 17 · 2021: 32 · 2020: 19 · 2019: 35 · 2018: 25 · 2017: 37 · 2016: 22 · 2015: 34 · 2014: 28 · 2013: 26 · 2012: 18
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, neural circuits, neocortex, amygdala, social withdrawal, repetitive behavior, autism theory, neuropathology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
