The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Alterations in Cerebral Metabolic Rate and Blood Supply across the Adult Lifespan
Open accessAbstract
With age, the brain undergoes comprehensive changes in its function and physiology. Cerebral metabolism and blood supply are among the key physiologic processes supporting the daily function of the brain and may play an important role in age-related cognitive decline. Using MRI, it is now possible to make quantitative assessment of these parameters in a noninvasive manner. In the present study, we concurrently measured cerebral metabolic rate of oxygen (CMRO(2)), cerebral blood flow (CBF), and venous blood oxygenation in a well-characterized healthy adult cohort from 20 to 89 years old (N = 232). Our data showed that CMRO(2) increased significantly with age, while CBF decreased with age. This combination of higher demand and diminished supply resulted in a reduction of venous blood oxygenation with age. Regional CBF was also determined, and it was found that the spatial pattern of CBF decline was heterogeneous across the brain with prefrontal cortex, insular cortex, and caudate being the most affected regions. Aside from the resting state parameters, the blood vessels' ability to dilate, measured by cerebrovascular reactivity to 5% CO(2) inhalation, was assessed and was reduced with age, the extent of which was more prominent than that of the resting state CBF.
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Cites
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Self-citationNeurovascular regulation in the normal brain and in Alzheimer's disease
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“Global CMRO2 in units of micromoles per minute was calculated from the Yv and CBF measures using the Fick principle (Kety and Schmidt 1948): CMRO2=CBF ðYa –YvÞ Ca ½1 where Ca is the amount of oxygen molecules that a unit volume of blood can carry, assumed to be 833.7 lmol O2/100 ml blood based on…”
BackgroundMethodInfluentialDisruption of Large-Scale Brain Systems in Advanced Aging
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Zimmerman, B., Rypma, B., Gratton, G., & Fabiani, M. (2021) · Psychophysiology · doi:10.1111/psyp.13796 · Cited by 179
Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain
Graves, S. I., & Baker, D. J. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13403 · Cited by 118
Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia
Jordan, L. C., Gindville, M. C., Scott, A. O., Juttukonda, M. R., Strother, M. K., Kassim, A. A., Chen, S.-C., Lu, H., Pruthi, S., Shyr, Y., et al. (2016) · Brain · doi:10.1093/brain/awv397 · Cited by 104
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Metadata
- Authors
- Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-04
- Volume
- 21
- Issue
- 6
- Pages
- 1426-1434
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2129932089
- Cited by
- 399
- References
- 12
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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