Clinical Importance of Streptococcus gallolyticus infection among colorectal cancer patients: systematic review and meta-analysis
Abstract
Background Streptococcus bovis has long been associated with colorectal cancer (CRC). However, not all genospecies are as closely related to CRC. With this systematic review, we aim to increase the awareness of the association between S. bovis biotype I (Streptococcus gallolyticus) and CRC and urge for uniform molecular microbiological classification. Methods In January 2011, the PubMed database was searched for all studies that investigated the association between S. bovis, infective endocarditis (IE), and CRC. A total of 191 studies were screened for eligibility and yielded 52 case reports and 31 case series, of which 11 were used for meta-analysis on the association between S. bovis biotype, IE, and adenomas/carcinomas (CRC). Results Among the S. bovis-infected patients who underwent colonic evaluation, the median percentage of patients who had concomitant adenomas/carcinomas was 60% (interquartile range, 22%), which largely exceeds the disease rate reported in the general asymptomatic population. Meta-analysis showed that patients with S. bovis biotype I infection had a strongly increased risk of having CRC (pooled odds ratio [OR], 7.26; 95% confidence interval [CI], 3.94-13.36) and IE (pooled OR, 16.61; 95% CI, 8.85-31.16), compared with S. bovis biotype II-infected patients. Notably, CRC occurred more often among patients with S. bovis IE than among patients with S. bovis infection at other sites (pooled OR, 3.72; 95% CI, 2.03-6.81). Conclusions Our meta-analysis clearl…
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Streptococcus gallolyticus is potentially associated with disease, including colorectal cancer (11% prevalence vs. 3% in healthy controls).
“Streptococcus gallolyticus is similarly potentially associated with disease, including colorectal cancer 112-114 (11% prevalence vs. 3% in healthy controls; Table S4), and was also prevalent in food.”
From Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome. (2024) · cites this paper as [113]
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- Authors
- Boleij, A., van Gelder, M. M. H. J., Swinkels, D. W., & Tjalsma, H.
- Affiliations
- Radboud University Medical Center (NL)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-01
- Volume
- 53
- Issue
- 9
- Pages
- 870-878
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2121395658
- Cited by
- 377
- References
- 66
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 23 · 2023: 37 · 2022: 34 · 2021: 27 · 2020: 30 · 2019: 31 · 2018: 36 · 2017: 20 · 2016: 21 · 2015: 29 · 2014: 17 · 2013: 24 · 2012: 14
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Streptococcus bovis, colorectal cancer, infective endocarditis, colorectal adenoma, biotype classification, cancer risk
- MeSH terms
- Aged, Endocarditis, Female, Humans, Male, Middle Aged, Streptococcal Infections, Colorectal Neoplasms, Streptococcus bovis
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