Fusobacterium nucleatum and colorectal cancer: A review
Open accessAbstract
Fusobacterium nucleatum (F.nucleatum ) is a Gramnegative obligate anaerobe bacterium in the oral cavity and plays a role in several oral diseases, including periodontitis and gingivitis.Recently, several studies have reported that the level of F. nucleatum is significantly elevated in human colorectal adenomas and carcinomas compared to that in adjacent normal tissue.Several researchers have also demonstrated that F. nucleatum is obviously associated with colorectal cancer and promotes the development of colorectal neoplasms.In this review, we have summarized the recent reports on F. nucleatum and its role in colorectal cancer and have highlighted the methods of detecting F. nucleatum in colorectal cancer, the underlying mechanisms of pathogenesis, immunity status, and colorectal cancer prevention strategies that target F. nucleatum .
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The net result of these changes is the creation of a pro-inflammatory milieu for tumor growth, favored by the FapA-mediated suppression of T cells' cytotoxic activity.
“The net result of these changes is the creation of a pro-inflammatory milieu for tumor growth, favored by the FapA-mediated suppression of T cells’ cytotoxic activity[147,150].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [147]
F. nucleatum is a commensal anaerobic bacterium of the oral cavity associated with periodontal disorders, and it has been found in large quantities in CRC.
“F. nucleatum is a commensal anaerobic bacterium of the oral cavity associated with periodontal disorders, and it has been found in large quantities in CRC[147].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [147]
F. nucleatum has two adhesion proteins, FapA and FadA, the latter of which mediates the invasion of the bacterium into the intestinal epithelium.
“This microorganism has two adhesion proteins, FapA and FadA, the latter of which mediates the invasion of the bacterium into the intestinal epithelium.”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [147]
The consequence of F. nucleatum invasion is the promotion of NF-κB signaling and the expression of several cytokines, such as IL-6, IL-8, IL-10, IL-18 and TNF-α.
“The consequence of this invasion is the promotion of NF-κB signaling and the expression of several cytokines, such as IL-6, IL-8, IL-10, IL-18 and TNF-α.”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [147]
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Streptococcus bovis infection and colorectal neoplasia: a meta‐analysis
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Flagged first, then by citations
Cited by
Sorted by citations
The Oral Microbiome and Cancer
Irfan, M., Delgado, R. Z. R., & Frias-Lopez, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.591088 · Cited by 341 · see citing works
Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
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Gastro-Intestinal and Oral Microbiome Signatures Associated with Healthy Aging
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Chen, W.-D., Zhang, X., Zhang, M.-J., Zhang, Y.-P., Shang, Z.-Q., Xin, Y.-W., & Zhang, Y. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i30.4120 · Cited by 38 · see citing works
- Authors
- Shang, F.-M., & Liu, H.-L.
- Venue
- World Journal of Gastrointestinal Oncology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2018-03-15
- Volume
- 10
- Issue
- 3
- Pages
- 71-81
- ISSN
- 1948-5204 (ISSN-L)
- PMC
- PMC5852398
- OpenAlex
- W2789721957
- Cited by
- 258
- References
- 102
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 30 · 2023: 23 · 2022: 30 · 2021: 45 · 2020: 51 · 2019: 31 · 2018: 8 · 2016: 1
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastrointestinal Oncology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81472707)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- Fusobacterium nucleatum, colorectal cancer, colorectal adenoma, gut microbiota, periodontitis, gingivitis, oral bacteria, colorectal neoplasia, carcinogenesis, host immunity, cancer prevention, bacterial detection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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