Cited by 80Pneumonia and Respiratory InfectionsBacterial Infections and VaccinesMicrobial infections and disease research

The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly

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van Werkhoven, Cornelis H., Huijts, Susanne M., Bolkenbaas, Marieke, Grobbee, Diederick E., Bonten, Marc J. M.·2015·Clinical Infectious Diseases

Abstract

In a post hoc analysis of the Community-Acquired Pneumonia (CAP) immunization Trial in Adults the model-predicted 13-valent pneumococcal conjugate vaccine efficacy for preventing vaccine-type specific CAP and Invasive Pneumococcal Disease declined from 65% to 40% for subjects being 65 and 75 year olds at the time of vaccination, respectively.

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Crossref · 10.1093/cid/civ686

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  • Lower vaccine efficacy and lower vaccine coverage might explain why, despite having a pneumococcal vaccine available for older adults, there was not a decline in AMR burden due to S pneumoniae.

    “This lower efficacy, as well as the lower vaccine coverage, might be why, despite having a pneumococcal vaccine available for older adults,43 there was not a decline in AMR burden due to S pneumoniae.”
  • Vaccine efficacy for vaccine-type community-acquired pneumonia and invasive disease decreases from 65% in 65-year-old subjects to 40% in 75-year-old subjects.

    “Data from this study were used to analyze the effect of age on vaccine efficacy using a statistical model, and a decrease of vaccine efficacy for vaccine-type community acquired pneumonia and invasive disease from 65% (95% CI 38–81) in 65-year old subjects, to 40% (95% CI: 17–56) in 75-year old subjects was determined [169].”

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Authors
van Werkhoven, C. H., Huijts, S. M., Bolkenbaas, M., Grobbee, D. E., & Bonten, M. J. M.
Affiliations
University Medical Center Utrecht (NL)
Venue
Clinical Infectious Diseases
Published
2015-08-11
Volume
61
Issue
12
Pages
1835-1838
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W1931272211
Cited by
80
References
12
Citations by year
2026: 2 · 2025: 8 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 10 · 2015: 1
FWCI
6.29
Type
journal article
Language
en
Open access
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
Funders
Pfizer, Inc.
Topics
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords
13-valent pneumococcal conjugate vaccine, vaccine efficacy, age, older adults, community-acquired pneumonia, invasive pneumococcal disease, Streptococcus pneumoniae
MeSH terms
Age Factors, Aged, Aged, 80 and over, Double-Blind Method, Female, Humans, Male, Pneumococcal Infections, Treatment Outcome, Pneumococcal Vaccines

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