The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly
Open accessAbstract
In a post hoc analysis of the Community-Acquired Pneumonia (CAP) immunization Trial in Adults the model-predicted 13-valent pneumococcal conjugate vaccine efficacy for preventing vaccine-type specific CAP and Invasive Pneumococcal Disease declined from 65% to 40% for subjects being 65 and 75 year olds at the time of vaccination, respectively.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lower vaccine efficacy and lower vaccine coverage might explain why, despite having a pneumococcal vaccine available for older adults, there was not a decline in AMR burden due to S pneumoniae.
“This lower efficacy, as well as the lower vaccine coverage, might be why, despite having a pneumococcal vaccine available for older adults,43 there was not a decline in AMR burden due to S pneumoniae.”
From Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 (2024) · cites this paper as [43]
Vaccine efficacy for vaccine-type community-acquired pneumonia and invasive disease decreases from 65% in 65-year-old subjects to 40% in 75-year-old subjects.
“Data from this study were used to analyze the effect of age on vaccine efficacy using a statistical model, and a decrease of vaccine efficacy for vaccine-type community acquired pneumonia and invasive disease from 65% (95% CI 38–81) in 65-year old subjects, to 40% (95% CI: 17–56) in 75-year old subjects was determined [169].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [169]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults
Bonten, M. J. M., Huijts, S. M., Bolkenbaas, M., Webber, C., Patterson, S., Gault, S., van Werkhoven, C. H., van Deursen, A. M. M., Sanders, E. A. M., Verheij, T. J. M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1408544 · Cited by 1,248 · see citing works
Self-citationThe aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908 · see citing works
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659 · see citing works
Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567 · see citing works
Romero‐Steiner, S., Musher, D. M., Cetron, M. S., Pais, L. B., Groover, J. E., & Carlone, G. M. (1999) · Clinical Infectious Diseases · doi:10.1086/520200 · Cited by 311 · see citing works
Age effects on B cells and humoral immunity in humans
Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.004 · Cited by 271 · see citing works
Roux, A. D., Schmöele-Thoma, B., Siber, G. R., Hackell, J. G., Kuhnke, A., Ahlers, N., BAKER, S. A., Razmpour, A., Emini, E. A., Fernsten, P. D., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/529142 · Cited by 268 · see citing works
Jackson, L. A., Gurtman, A., van Cleeff, M., Jansen, K. U., Jayawardene, D. A., Devlin, C., Scott, D. A., Emini, E. A., Gruber, W. C., & Schmöele-Thoma, B. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.04.085 · Cited by 232 · see citing works
Diagnostic accuracy of a serotype-specific antigen test in community-acquired pneumonia
Huijts, S. M., Pride, M. W., Vos, J. M. I., Jansen, K. U., Webber, C., Gruber, W. C., Boersma, W. G., Snijders, D., Kluytmans, J. A. J. W., van der Lee, I., et al. (2013) · European Respiratory Journal · doi:10.1183/09031936.00137412 · Cited by 72 · see citing works
Self-citationVermeiren, A. P. A., Hoebe, C. J. P. A., & Dukers–Muijrers, N. H. T. M. (2013) · Journal of Clinical Virology · doi:10.1016/j.jcv.2013.07.003 · Cited by 69 · see citing works
MacIntyre, C. R., Ridda, I., Gao, Z., Moa, A., McIntyre, P. B., Sullivan, J. S., Jones, T. R., Hayen, A. D., & Lindley, R. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094578 · Cited by 41 · see citing works
Dbaibo, G. S., El-Ayoubi, N. K., Ghanem, S., Hajar, F., Bianco, V., Miller, J. M., & Mesaros, N. E. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0065-0 · Cited by 37 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Naghavi, M., Vollset, S. E., Ikuta, K. S., Swetschinski, L. R., Gray, A. P., Wool, E. E., Robles Aguilar, G., Mestrovic, T., Smith, G., Han, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01867-1 · Cited by 3,791 · see citing works
Bajaj, V., Gadi, N., Spihlman, A. P., Wu, S. C., Choi, C. H., & Moulton, V. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.571416 · Cited by 476 · see citing works
Aging of the immune system: Focus on inflammation and vaccination
Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439 · see citing works
Influence of immune aging on vaccine responses
Gustafson, C. E., Kim, C., Weyand, C. M., & Goronzy, J. J. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.017 · Cited by 286 · see citing works
Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults
Falsey, A. R., Williams, K. L., Gymnopoulou, E., Bart, S., Ervin, J. E., Bastian, A. R., Menten, J., Paepe, E. D., Vandenberghe, S., Chan, E. K. H., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2207566 · Cited by 154 · see citing works
Overcoming immune dysfunction in the elderly: trained immunity as a novel approach
Bulut, O., Kilic, G., Domínguez-Andrés, J., & Netea, M. G. (2020) · International Immunology · doi:10.1093/intimm/dxaa052 · Cited by 99 · see citing works
Scelfo, C., Menzella, F., Fontana, M. S., Ghidoni, G., Galeone, C., & Facciolongo, N. C. (2021) · Vaccines · doi:10.3390/vaccines9050420 · Cited by 90 · see citing works
Patterson, S., Webber, C., Patton, M., Drews, W., Huijts, S. M., Bolkenbaas, M., Gruber, W. C., Scott, D. A., & Bonten, M. J. M. (2016) · Trials in Vaccinology · doi:10.1016/j.trivac.2016.04.004 · Cited by 78 · see citing works
Self-citationThe full benefits of adult pneumococcal vaccination: A systematic review
Cafiero-Fonseca, E. T., Stawasz, A., Johnson, S. T., Sato, R., & Bloom, D. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186903 · Cited by 60 · see citing works
Wang, J., Zhang, F., Jiang, F., Hu, L., Chen, J., & Wang, Y. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23935 · Cited by 54 · see citing works
van Deursen, A. M. M., van Houten, M. A., Webber, C., Patton, M., Scott, D. A., Patterson, S., Sidhu, M. S., Drews, W., Gruber, W. C., Emini, E. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix419 · Cited by 49 · see citing works
Self-citationPneumococcal vaccination and chronic respiratory diseases
Froes, F., Roche, N., & Blasi, F. (2017) · International Journal of COPD · doi:10.2147/copd.s140378 · Cited by 49 · see citing works
Huguet, E., Maccallini, G., Pardini, P., Hidalgo, M., Obregon, S., Botto, F. O., Koretzky, M., Nilsson, P. M., Ferdinand, K. C., & Kotliar, C. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.04.002 · Cited by 48 · see citing works
Nicoli, F., Clave, E., Wanke, K., von Braun, A., Bondet, V., Alanio, C., Douay, C., Baqué, M., Lependu, C., Marconi, P., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103852 · Cited by 41 · see citing works
de Boer, P. T., van Werkhoven, C. H., van Hoek, A. J., Knol, M. J., Sanders, E. A. M., Wallinga, J., de Melker, H. E., & Steens, A. (2024) · BMC Medicine · doi:10.1186/s12916-024-03277-3 · Cited by 39 · see citing works
Pneumococcal Capsular Polysaccharide Immunity in the Elderly
Adler, H., Ferreira, D. M., Gordon, S. B., & Rylance, J. (2017) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00004-17 · Cited by 39 · see citing works
Thomas, R. E. (2021) · Geriatrics · doi:10.3390/geriatrics6010013 · Cited by 31 · see citing works
Theilacker, C., Fletcher, M. A., Jódar, L., & Gessner, B. D. (2022) · Microorganisms · doi:10.3390/microorganisms10010127 · Cited by 31 · see citing works
Economic evaluation of pneumococcal vaccines for adults aged over 50 years in Belgium
Willem, L., Blommaert, A., Hanquet, G., Thiry, N., Bilcke, J., Theeten, H., Verhaegen, J., Goossens, H., & Beutels, P. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1428507 · Cited by 29 · see citing works
Ceccato, A., Cillóniz, C., Ranzani, O., Menéndez, R., Agustı́, C., Gabarrús, A., Ferrer, M., Sibila, O., Niederman, M. S., & Torres, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178022 · Cited by 29 · see citing works
Williams, G. H., Llewelyn, A., Brandão, R. A. R., Chowdhary, K., Hardisty, K.-M., & Loddo, M. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.101021 · Cited by 26 · see citing works
Treskova, M., Scholz, S. M., & Kuhlmann, A. (2019) · PharmacoEconomics · doi:10.1007/s40273-019-00805-5 · Cited by 26 · see citing works
Musher, D. M., & Rodriguez‐Barradas, M. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1098794 · Cited by 25 · see citing works
Deb, A., Podmore, B., Barnett, R., Beier, D., Galetzka, W., Qizilbash, N., Häckl, D., Mihm, S., Johnson, K. D., & Weiss, T. W. (2022) · Epidemiology and Infection · doi:10.1017/s0950268822001182 · Cited by 25 · see citing works
Grant, L. R., Slack, M., Yan, Q., Trzciński, K., Barratt, J., Sobczyk, E. A., Appleby, J. C., Cane, A. D., Jódar, L., Istúriz, R., et al. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1921579 · Cited by 22 · see citing works
The 20-valent pneumococcal conjugate vaccine (PCV20): expected added value
Janssens, E., Flamaing, J., Vandermeulen, C., Peetermans, W. E., Desmet, S., & Munter, P. D. (2022) · Acta Clinica Belgica · doi:10.1080/17843286.2022.2039865 · Cited by 22 · see citing works
Efficacy and Safety of Vaccinations in Geriatric Patients: A Literature Review
Ciarambino, T., Crispino, P., Buono, P., Giordano, V., Trama, U., Iodice, V., Leoncini, L., & Giordano, M. (2023) · Vaccines · doi:10.3390/vaccines11091412 · Cited by 24 · see citing works
Karlsson, J., Roalfe, L., Hogevik, H., Zancolli, M., Andréasson, B., Goldblatt, D., & Wennerås, C. (2016) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00654-15 · Cited by 22 · see citing works
van der Heiden, M., Shetty, S. A., Bijvank, E., Beckers, L., Çevirgel, A., van Sleen, Y., Tcherniaeva, I., Ollinger, T., Burny, W., van Binnendijk, R. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50760-9 · Cited by 21 · see citing works
Chen, C., Wood, J., Beutels, P., Menzies, R., MacIntyre, C. R., Dirmesropian, S., Reyes, J. F., McIntyre, P. B., & Newall, A. T. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.01.052 · Cited by 21 · see citing works
Cost-effectiveness of pneumococcal vaccination for elderly in Sweden
Wolff, E., Storsæter, J., Örtqvist, Å., Nauclér, P., Larsson, S., Lepp, T., & Roth, A. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.05.072 · Cited by 19 · see citing works
van Werkhoven, C. H., Bolkenbaas, M., Huijts, S. M., Verheij, T. J., & Bonten, M. J. M. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.09.011 · Cited by 19 · see citing works
Self-citationGarnica, M., Aiello, A., Ligotti, M. E., Accardi, G., Arasanz, H., Bocanegra, A., Blanco, E., Calabrò, A., Chocarro, L., Echaide, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179797 · Cited by 19 · see citing works
van der Heiden, M., Boots, A. M. H., Marinović, A. A. B., de Rond, L., van Maurik, M., Tcherniaeva, I., Berbers, G. A. M., & Buisman, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00817 · Cited by 17 · see citing works
Cost-effectiveness analysis of 21-valent pneumococcal conjugated vaccine among adults in Canada
Ximenes, R., Simmons, A. E., Gebretekle, G. B., Nam, A., Wong, E., Salvadori, M. I., Golden, A., Sander, B., Hildebrand, K. J., Tunis, M. C., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.126985 · Cited by 17 · see citing works
Optimal age targeting for pneumococcal vaccination in older adults; a modelling study
Thindwa, D., Clifford, S., Kleynhans, J., von Gottberg, A., Walaza, S., Meiring, S. T., Swarthout, T. D., Miller, E., McIntyre, P. B., Andrews, N. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36624-8 · Cited by 15 · see citing works
Marbaix, S., Peetermans, W. E., Verhaegen, J., Annemans, L., Sato, R., Mignon, A., Atwood, M., & Weycker, D. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199427 · Cited by 14 · see citing works
Cost-effectiveness of 13-valent pneumococcal conjugate vaccine (PCV13) in older Australians
Dirmesropian, S., Wood, J., MacIntyre, C. R., Beutels, P., McIntyre, P. B., Menzies, R., Reyes, J. F., Chen, C., & Newall, A. T. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.06.085 · Cited by 13 · see citing works
Rosenthal, M., Stoecker, C., Leidner, A. J., Cho, B., Pilishvili, T., & Kobayashi, M. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.126567 · Cited by 12 · see citing works
Immunofitness in the elderly: The role of vaccination in promoting healthy aging
Rial, J. G., Redondo, E., Calle, I. R., Mascarós, E., Ocaña, D., Jimeno, I., Gil, A., Linares, M., Onieva-García, M. Á., González‐Romo, F., et al. (2026) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2026.2624234 · Cited by 12 · see citing works
Walkowski, W., Bassett, J., Bhalla, M., Pfeifer, B. A., & Ghanem, E. N. B. (2021) · Vaccines · doi:10.3390/vaccines9060589 · Cited by 10 · see citing works
Rong, Y., Wang, F., Li, X., Liang, X., Zhou, Y., Zhang, D., Liu, J., Zeng, H., Wang, J., & Shi, Y. (2021) · PubMed Central · Cited by 8 · see citing works
Bhalla, M., Nayerhoda, R., Tchalla, E. Y. I., Abamonte, A., Park, D., Simmons, S. R., Pfeifer, B. A., & Ghanem, E. N. B. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.798868 · Cited by 8 · see citing works
Pneumococcal infections in elderly patients attending hospital since PCV-13 authorization in Spain
Payeras, A., Peñaranda, M., Iñigo, A., Garau, M., Pérez, J. L., Gallegos, C., & Riera, M. (2016) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2016.1218044 · Cited by 8 · see citing works
Ecarnot, F., & Maggi, S. (2024) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/a-2500-2121 · Cited by 6 · see citing works
Cost-utility analysis of a universal pneumococcal vaccination programme for older adults in Norway
Nymark, L. S., Berild, J. D., Lyngstad, T. M., Winje, B. A., Vestrheim, D. F., Aaberge, I., Juvet, L. K., & Wolff, E. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2101333 · Cited by 6 · see citing works
Gogoi, H., Mansouri, S., Katikaneni, D. S., & Jin, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01674 · Cited by 5 · see citing works
Kobayashi, M., Stoecker, C., Xing, W., Cho, B., & Pilishvili, T. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1861876 · Cited by 5 · see citing works
Lenzing, E., Rezahosseini, O., Burgdorf, S. K., Nielsen, S. D., & Harboe, Z. B. (2022) · Expert Review of Vaccines · doi:10.1080/14760584.2022.2049250 · Cited by 5 · see citing works
Visser, M., van Beek, J., Tcherniaeva, I., van Rooijen, D. M., Beckers, L., Bijvank, E., de Jonge, M. I., Lockhart, S. P., Pride, M. W., Rots, N. Y., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01152-7 · Cited by 4 · see citing works
Beeslaar, J. F., Peyrani, P., Absalon, J., Maguire, J. D., Eiden, J., Balmer, P., Maansson, R., & Perez, J. L. (2020) · Infectious Diseases and Therapy · doi:10.1007/s40121-020-00322-5 · Cited by 4 · see citing works
Fletcher, M. A., Schmöele-Thoma, B., Vojicic, J., Daigle, D., Paradiso, P. R., & Morales, G. D. C. (2024) · Expert Review of Vaccines · doi:10.1080/14760584.2024.2404636 · Cited by 4 · see citing works
The lung bacterial microbiome in community-acquired and nosocomial pneumonia
Bos, L. D. J., Rylance, J., & Gordon, S. B. (2019) · European Respiratory Society eBooks · doi:10.1183/2312508x.10016418 · Cited by 4 · see citing works
What do we know about the cost-effectiveness of pneumococcal conjugate vaccination in older adults?
Newall, A. T. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2016.1197449 · Cited by 4 · see citing works
Whelan, M., Galipeau, Y., Habeeb, N. W.-A., Konforte, D., Hassan, M. A. E., Booth, R. A., Arnold, C. R., Langlois, M., & Pelchat, M. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad384 · Cited by 3 · see citing works
Lei, H., Zhong, K., Chen, J., Li, P., Chen, J., Li, H., Cheng, B., & Zhou, J. (2025) · Advances in Wound Care · doi:10.1089/wound.2025.0021 · Cited by 3 · see citing works
Pneumococcal conjugate vaccines in older adults and immunocompromised individuals
Luvira, V., Ngamprasertchai, T., & Pitisuttithum, P. (2025) · Expert Review of Vaccines · doi:10.1080/14760584.2025.2602525 · Cited by 2 · see citing works
Gebretekle, G. B., O’Reilly, R., Mac, S., Fadel, S. A., Crowcroft, N. S., & Sander, B. (2025) · Expert Review of Vaccines · doi:10.1080/14760584.2025.2488495 · Cited by 2 · see citing works
Constrained Optimization for Pneumococcal Vaccination in Brazil
Olbrecht, J., Gomez, J. A., Bellinghen, L.-A. V., Vlaenderen, I. V., & Standaert, B. A. (2021) · Value in Health Regional Issues · doi:10.1016/j.vhri.2020.11.011 · Cited by 2 · see citing works
Mamcarz, A., Wełnicki, M. T., Dróżdż, J., Grabowski, M., Jankowski, P., Kuchar, E. P., Leszek, P., Mitkowski, P. P., & Wysocki, J. (2023) · Kardiologia Polska · doi:10.33963/v.kp.96718 · Cited by 2 · see citing works
Tai, J.-H., Lyu, Y.-Y., Zhang, Y., Chu, W.-W., Yang, M. C., Zhou, Q., & Wu, Y. (2025) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107636 · Cited by 1 · see citing works
Nakao, R., Kimura, S., Abe, K., Yamaguchi, T., Kuroda, E., Hamaguchi, S., Tateda, K., Ohki, Y., Narisawa, N., Ohnishi, M., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01345-0 · Cited by 1 · see citing works
Bhalla, M., Herring, S. E., Lenhard, A. P., Wheeler, J., Aswad, F., Klumpp, K., Rebo, J., Wang, Y., Wilhelmsen, K., Fortney, K., et al. (2024) · Infection and Immunity · doi:10.1128/iai.00522-23 · Cited by 1 · see citing works
Resposta imunológica vacinal na população geriátrica: duração e efetividade
Camargo, R. P., Nascimento, T. A., Ferreira, M. V. M., Paz, C. V. D. A., Malacarne, L. P., de Sousa, E. G., Pegoraro, F., & Gomes, S. T. M. (2024) · Brazilian Journal of Health Review · doi:10.34119/bjhrv7n3-301 · Cited by 1 · see citing works
van der Heiden, M., Shetty, S. A., Bijvank, E., Beckers, L., Çevirgel, A., van Sleen, Y., Tcherniaeva, I., Ollinger, T., Burny, W., van Binnendijk, R. S., et al. (2024) · medRxiv · doi:10.1101/2024.01.22.24301601 · Cited by 1 · see citing works
Vacuna neumocócica: «El camino del progreso no es ni rápido ni fácil»
Payeras, A., & Arrizabalaga, M. (2016) · Medicina Clínica · doi:10.1016/j.medcli.2015.12.001
Neumococcal vaccine: “the road to progress is neither fast nor easy”
Payeras, A., & Arrizabalaga, M. (2016) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2016.05.032
Pneumokokkenimpfung mit PCV-13 für Senioren
Heppner, H. J. (2016) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-016-8572-7
Infectious immunity and pneumococcal vaccine responses in multiple myeloma and related disorders
Karlsson, J. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Effects of Ageing on the Vaccination Response
Weinberger, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_5
Pneumococcal disease and the impact of pneumococcal conjugate vaccines
Wagenvoort, G. H. J. (2017) · Utrecht University Repository (Utrecht University)
Promotion of a Lifelong Immunization Program for Healthy Ageing
Flamaing, J. (2018) · Practical issues in geriatrics · doi:10.1007/978-3-319-96529-1_16
Pneumococcal Vaccines in Adults
Nanduri, S. A., Pilishvili, T., & Bennett, N. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-55435-0.00012-4
Vaccination Against Pneumococcal Disease in the European Union, with Particular Focus on Germany
Falkenhorst, G., & Flamaing, J. (2019) · Practical issues in geriatrics · doi:10.1007/978-3-030-05159-4_11
Arguedas, A. G., Gessner, B. D., Williams, S., Fletcher, M. A., Istúriz, R., Reinert, R., & Jódar, L. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.09.107
Optimal age targeting for pneumococcal vaccination in older adults; a modelling studyPreprint
Thindwa, D., Clifford, S., Kleynhans, J., von Gottberg, A., Walaza, S., Meiring, S. T., Swarthout, T. D., Miller, E., McIntyre, P. B., Andrews, N. J., et al. (2022) · medRxiv · doi:10.1101/2022.11.07.22282045
Building on a Strong Foundation to Address a New Era to Help Protect Against Pneumococcal Disease
Science, I. M. A. (2022) · EMJ Microbiology & Infectious Diseases · doi:10.33590/emjmicrobiolinfectdis/10028394
Zhao, J., Li, G., Qiu, Y., Wang, Y., Huang, G., Gong, Y., Liu, J., & Shen, F. (2025) · Research Square · doi:10.21203/rs.3.rs-7950784/v1
de Boer, P. T., van Werkhoven, C. H., Hoek, A. J. V., Knol, M. J., Sanders, E. A. M., Wallinga, J., de Melker, H. E., & Steens, A. (2024) · Figshare · doi:10.6084/m9.figshare.25231181
Bletnitsky, S., Leidner, A. J., Kobayashi, M., Cho, B., & Stoecker, C. (2026) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2026.108412
- Authors
- van Werkhoven, C. H., Huijts, S. M., Bolkenbaas, M., Grobbee, D. E., & Bonten, M. J. M.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-08-11
- Volume
- 61
- Issue
- 12
- Pages
- 1835-1838
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W1931272211
- Cited by
- 80
- References
- 12
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 10 · 2015: 1
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Pfizer, Inc.
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- 13-valent pneumococcal conjugate vaccine, vaccine efficacy, age, older adults, community-acquired pneumonia, invasive pneumococcal disease, Streptococcus pneumoniae
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Double-Blind Method, Female, Humans, Male, Pneumococcal Infections, Treatment Outcome, Pneumococcal Vaccines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review