The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Probiotics as Antifungals in Mucosal Candidiasis
Open accessAbstract
Candidais an opportunistic pathogen that causes mucosal and deep systemic candidiasis. The emergence of drug resistance and the side effects of currently available antifungals have restricted their use as long-term prophylactic agents for candidal infections. Given this scenario, probiotics have been suggested as a useful alternative for the management of candidiasis. We analyzed the available data on the efficacy of probiotics in candidal colonization of host surfaces. A number of well-controlled studies indicate that probiotics, particularly lactobacilli, suppressCandidagrowth and biofilm development in vitro.A few clinical trials have also shown the beneficial effects of probiotics in reducing oral, vaginal, and enteric colonization byCandida; alleviation of clinical signs and symptoms; and, in some cases, reducing the incidence of invasive fungal infection in critically ill patients. Probiotics may serve in the future as a worthy ally in the battle against chronic mucosal candidal infections.
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“Probiotic Lactobacillus strains have been reported in vitro and in vivo to be beneficial for candidiasis management, including oral candidiasis.1,2”
From Aggregation and adhesion ability of various probiotic strains and Candida species: An in vitro study (2024) · cites this paper as [1]
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Cites
Probiotic bacteria: safety, functional and technological properties
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Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments
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Probiotics Reduce the Prevalence of Oral Candida in the Elderly—a Randomized Controlled Trial
Hatakka, K., Ahola, A. J., Yli‐Knuuttila, H., Richardson, M. D., Poussa, T. A., Meurman, J. H., & Korpela, R. (2007) · Journal of Dental Research · doi:10.1177/154405910708600204 · Cited by 306
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Effect of oral bacteria on growth and survival of Candida albicans biofilms
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Cited by
Sorted by citations
Matsubara, V. H., Wang, Y., Bandara, H. M. H. N., Mayer, M. P. A., & Samaranayake, L. P. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7527-3 · Cited by 206
“Due to these concerns, the use of probiotic bacteria has been proposed as an alternative prophylactic and therapeutic mode of treatment against human Candida infections (Matsubara et al. 2016; Meurman 2005).”
BackgroundSelf-citationMaurer, M., Gresnigt, M. S., Last, A., Wollny, T., Berlinghof, F., Pospich, R., Cseresnyés, Z., Medyukhina, A., Graf, K., Gröger, M., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119396 · Cited by 209
“Our observations are in agreement with reports from in vivo studies [38] and demonstrate the usefulness of the intestine-on-chip model as a platform for functional studies on microbial communication and host-microbe interaction in vitro .”
BackgroundResultInfluentialNormal Oral Flora and the Oral Ecosystem
Samaranayake, L. P., & Matsubara, V. H. (2017) · Dental Clinics of North America · doi:10.1016/j.cden.2016.11.002 · Cited by 191
Early gut mycobiota and mother-offspring transfer
Schei, K., Avershina, E., Øien, T., Rudi, K., Follestad, T., Salamati, S., & Ødegård, R. A. (2017) · Microbiome · doi:10.1186/s40168-017-0319-x · Cited by 179
The role of probiotic bacteria in managing periodontal disease: a systematic review
Matsubara, V. H., Bandara, N., Ishikawa, K., Mayer, M. P. A., & Samaranayake, L. P. (2016) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2016.1194198 · Cited by 147
“Consequently, there has been an increasing interest in the use of probiotics for oral infections [39], including periodontal diseases.”
Background
Metadata
- Authors
- Matsubara, V. H., Bandara, H. M. H. N., Mayer, M. P. A., & Samaranayake, L. P.
- Affiliations
- The University of Queensland (AU)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01-29
- Volume
- 62
- Issue
- 9
- Pages
- 1143-1153
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2325976755
- Cited by
- 151
- References
- 40
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 16 · 2023: 13 · 2022: 18 · 2021: 15 · 2020: 20 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 6
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (acceptedVersion, other-oa)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- probiotics, antifungal activity, mucosal candidiasis, Candida, lactobacilli, candidal colonization, biofilm formation, oral candidiasis, vaginal candidiasis, invasive fungal infections, critically ill patients, antifungal resistance, candidiasis prophylaxis
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Candidiasis, Female, Humans, Infant, Infant, Newborn, Lactobacillus, Middle Aged, Probiotics, Young Adult
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