Cited by 151Antifungal resistance and susceptibilityProbiotics and Fermented FoodsReproductive tract infections research

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Probiotics as Antifungals in Mucosal Candidiasis

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Matsubara, Victor H., Bandara, H. M. H. N., Mayer, Marcia P. A., Samaranayake, Lakshman P.·2016·Clinical Infectious Diseases

DOI 10.1093/cid/ciw038

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Abstract

Candidais an opportunistic pathogen that causes mucosal and deep systemic candidiasis. The emergence of drug resistance and the side effects of currently available antifungals have restricted their use as long-term prophylactic agents for candidal infections. Given this scenario, probiotics have been suggested as a useful alternative for the management of candidiasis. We analyzed the available data on the efficacy of probiotics in candidal colonization of host surfaces. A number of well-controlled studies indicate that probiotics, particularly lactobacilli, suppressCandidagrowth and biofilm development in vitro.A few clinical trials have also shown the beneficial effects of probiotics in reducing oral, vaginal, and enteric colonization byCandida; alleviation of clinical signs and symptoms; and, in some cases, reducing the incidence of invasive fungal infection in critically ill patients. Probiotics may serve in the future as a worthy ally in the battle against chronic mucosal candidal infections.

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Probiotic Lactobacilli Inhibit Early Stages of Candida Albicans Biofilm Development by Reducing Their Growth, Cell Adhesion, and Filamentation
Matsubara, V. H., Wang, Y., Bandara, H. M. H. N., Mayer, M. P. A., & Samaranayake, L. P. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7527-3 · Cited by 206
“Due to these concerns, the use of probiotic bacteria has been proposed as an alternative prophylactic and therapeutic mode of treatment against human Candida infections (Matsubara et al. 2016; Meurman 2005).”
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A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies
Maurer, M., Gresnigt, M. S., Last, A., Wollny, T., Berlinghof, F., Pospich, R., Cseresnyés, Z., Medyukhina, A., Graf, K., Gröger, M., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119396 · Cited by 209
“Our observations are in agreement with reports from in vivo studies [38] and demonstrate the usefulness of the intestine-on-chip model as a platform for functional studies on microbial communication and host-microbe interaction in vitro .”
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Normal Oral Flora and the Oral Ecosystem
Samaranayake, L. P., & Matsubara, V. H. (2017) · Dental Clinics of North America · doi:10.1016/j.cden.2016.11.002 · Cited by 191
Early gut mycobiota and mother-offspring transfer
Schei, K., Avershina, E., Øien, T., Rudi, K., Follestad, T., Salamati, S., & Ødegård, R. A. (2017) · Microbiome · doi:10.1186/s40168-017-0319-x · Cited by 179
The role of probiotic bacteria in managing periodontal disease: a systematic review
Matsubara, V. H., Bandara, N., Ishikawa, K., Mayer, M. P. A., & Samaranayake, L. P. (2016) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2016.1194198 · Cited by 147
“Consequently, there has been an increasing interest in the use of probiotics for oral infections [39], including periodontal diseases.”
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Authors: Matsubara, V. H., Bandara, H. M. H. N., Mayer, M. P. A., & Samaranayake, L. P.
Affiliations: The University of Queensland (AU)
ORCID: Matsubara, Victor H.
Samaranayake, Lakshman P.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2016-01-29
Volume: 62
Issue: 9
Pages: 1143-1153
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/ciw038
OpenAlex: W2325976755
Cited by: 151
References: 40
Citations by year: 2026: 12 · 2025: 15 · 2024: 16 · 2023: 13 · 2022: 18 · 2021: 15 · 2020: 20 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 6
FWCI: 2.16
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (acceptedVersion, other-oa)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: probiotics, antifungal activity, mucosal candidiasis, Candida, lactobacilli, candidal colonization, biofilm formation, oral candidiasis, vaginal candidiasis, invasive fungal infections, critically ill patients, antifungal resistance, candidiasis prophylaxis
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Candidiasis, Female, Humans, Infant, Infant, Newborn, Lactobacillus, Middle Aged, Probiotics, Young Adult

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Probiotics as Antifungals in Mucosal Candidiasis

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