The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Probiotics as Antifungals in Mucosal Candidiasis
Open accessAbstract
Candidais an opportunistic pathogen that causes mucosal and deep systemic candidiasis. The emergence of drug resistance and the side effects of currently available antifungals have restricted their use as long-term prophylactic agents for candidal infections. Given this scenario, probiotics have been suggested as a useful alternative for the management of candidiasis. We analyzed the available data on the efficacy of probiotics in candidal colonization of host surfaces. A number of well-controlled studies indicate that probiotics, particularly lactobacilli, suppressCandidagrowth and biofilm development in vitro.A few clinical trials have also shown the beneficial effects of probiotics in reducing oral, vaginal, and enteric colonization byCandida; alleviation of clinical signs and symptoms; and, in some cases, reducing the incidence of invasive fungal infection in critically ill patients. Probiotics may serve in the future as a worthy ally in the battle against chronic mucosal candidal infections.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Probiotic Lactobacillus strains have been reported in vitro and in vivo to be beneficial for candidiasis management, including oral candidiasis.1,2”
From Aggregation and adhesion ability of various probiotic strains and Candida species: An in vitro study (2024) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Probiotic bacteria: safety, functional and technological properties
Saarela, M., Mogensen, G., Fondén, R., Mättö, J., & Mattila-Sandholm, T. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00375-8 · Cited by 1,202
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184
Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments
Gantner, B. N., Simmons, R. M., & Underhill, D. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600594 · Cited by 686
Khalesi, S., Sun, J., Buys, N., & Jayasinghe, R. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03469 · Cited by 516
Probiotics Reduce the Prevalence of Oral Candida in the Elderly—a Randomized Controlled Trial
Hatakka, K., Ahola, A. J., Yli‐Knuuttila, H., Richardson, M. D., Poussa, T. A., Meurman, J. H., & Korpela, R. (2007) · Journal of Dental Research · doi:10.1177/154405910708600204 · Cited by 306
Manzoni, P., Mostert, M., Leonessa, M., Priolo, C., Farina, D., Monetti, C., Latino, M. A., & Gomirato, G. (2006) · Clinical Infectious Diseases · doi:10.1086/504324 · Cited by 305
Jones, M. L., Tomaro-Duchesneau, C., Martoni, C. J., & Prakash, S. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.758706 · Cited by 190
Martinez, R. C. R., Franceschini, S. A., Patta, M. C., Quintana, S. M., Candido, R. C., Ferreira, J. C., Martinis, E. C. P. D., & Reid, G. (2009) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02477.x · Cited by 187
Effect of oral bacteria on growth and survival of Candida albicans biofilms
Thein, Z. M., Samaranayake, Y. H., & Samaranayake, L. P. (2006) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2006.02.005 · Cited by 185
Romeo, M. G., Romeo, D. M., Trovato, L., Oliveri, S. M., Palermo, F., Cota, F., & Betta, P. (2010) · Journal of Perinatology · doi:10.1038/jp.2010.57 · Cited by 183
Cited by
Sorted by citations
Matsubara, V. H., Wang, Y., Bandara, H. M. H. N., Mayer, M. P. A., & Samaranayake, L. P. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7527-3 · Cited by 206
“Due to these concerns, the use of probiotic bacteria has been proposed as an alternative prophylactic and therapeutic mode of treatment against human Candida infections (Matsubara et al. 2016; Meurman 2005).”
BackgroundSelf-citationMaurer, M., Gresnigt, M. S., Last, A., Wollny, T., Berlinghof, F., Pospich, R., Cseresnyés, Z., Medyukhina, A., Graf, K., Gröger, M., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119396 · Cited by 209
“Our observations are in agreement with reports from in vivo studies [38] and demonstrate the usefulness of the intestine-on-chip model as a platform for functional studies on microbial communication and host-microbe interaction in vitro .”
BackgroundResultInfluentialNormal Oral Flora and the Oral Ecosystem
Samaranayake, L. P., & Matsubara, V. H. (2017) · Dental Clinics of North America · doi:10.1016/j.cden.2016.11.002 · Cited by 191
Early gut mycobiota and mother-offspring transfer
Schei, K., Avershina, E., Øien, T., Rudi, K., Follestad, T., Salamati, S., & Ødegård, R. A. (2017) · Microbiome · doi:10.1186/s40168-017-0319-x · Cited by 179
The role of probiotic bacteria in managing periodontal disease: a systematic review
Matsubara, V. H., Bandara, N., Ishikawa, K., Mayer, M. P. A., & Samaranayake, L. P. (2016) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2016.1194198 · Cited by 147
“Consequently, there has been an increasing interest in the use of probiotics for oral infections [39], including periodontal diseases.”
BackgroundWang, S., Wang, Q., Yang, E., Yan, L., Li, T., & Zhuang, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00564 · Cited by 152
Biofilms and vulvovaginal candidiasis
Rodríguez‐Cerdeira, C., Carnero-Gregorio, M., Molares-Vila, A., López-Bárcenas, A., Fabbrocini, G., Bardhi, B., Sinani, A., Sánchez-Blanco, E., Arenas, R., & Hernández‐Castro, R. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.011 · Cited by 159
Probiotics: A Promising Role in Dental Health
Mahasneh, S. A., & Mahasneh, S. A. (2017) · Dentistry Journal · doi:10.3390/dj5040026 · Cited by 112
“Significant differences in growth inhibition and co-aggregation were observed, especially against Candida pathogenic species [11,85,88].”
Bio-functional properties of probiotic Lactobacillus: current applications and research perspectives
Minj, J., Chandra, P., Paul, C., & Sharma, R. K. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1774496 · Cited by 110
“Anti-candidal effects of probiotic L. acidophilus have been reported earlier that could be a good choice for the treatment of candidal infections (Matsubara et al. 2016).”
BackgroundThe role of Lactobacillus species in the control of Candida via biotrophic interactions
Zangl, I., Pap, I.-J., Aspöck, C., & Schüller, C. (2020) · Microbial Cell · doi:10.15698/mic2020.01.702 · Cited by 113
“are commensals of the human microbiome [4].”
BackgroundProbiotic Lactobacillus reuteri has antifungal effects on oral Candida species in vitro
Jørgensen, M. R., Kragelund, C., Jensen, P. Ø., Keller, M. K., & Twetman, S. (2017) · Journal of Oral Microbiology · doi:10.1080/20002297.2016.1274582 · Cited by 107
Alonso‐Román, R., Last, A., Mirhakkak, M. H., Sprague, J. L., Möller, L., Großmann, P., Graf, K., Gratz, R., Mogavero, S., Vylkova, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30661-5 · Cited by 110
de Carvalho, F. G., Magalhães, T. C., Teixeira, N. M., Gondim, B. L. C., Carlo, H. L., dos Santos, R. L., de Oliveira, A. R., & Denadai, Â. M. L. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109885 · Cited by 111
Fungal interactions with the human host: exploring the spectrum of symbiosis
Hall, R. A., & Noverr, M. C. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.10.020 · Cited by 110
“In agreement with this, lactobacilli have been proposed to reduce Candida colonisation [37 ], and have been explored as a potential probiotics [38].”
The Postbiotic Activity of Lactobacillus paracasei 28.4 Against Candida auris
Rossoni, R. D., de Barros, P. P., Mendonça, I. D. C., Medina, R. P., Silva, D. H. S., Fuchs, B. B., Junqueira, J. C., & Mylonakis, E. E. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00397 · Cited by 118
“In this context, the use of probiotics has been considered a promising strategy for prevention and control of several fungal infections (Mailander-Sanchez et al., 2012; Matsubara et al., 2016a; Hu et al., 2017; Rodrigues C. F. et al., 2019).”
BackgroundRossoni, R. D., de Barros, P. P., de Alvarenga, J. A., Ribeiro, F. D. C., Velloso, M. D. S., Fuchs, B. B., Mylonakis, E. E., Jorge, A. O. C., & Junqueira, J. C. (2018) · Biofouling · doi:10.1080/08927014.2018.1425402 · Cited by 103
“In addition, the supernatant can inhibit C albicans due to the high levels of organic acid produced by Lactobacillus metabolism and consequently reduce the final pH of the environment (Simark-Mattsson et al. 2009; Matsubara et al. 2016; Ribeiro et al. 2017).”
BackgroundInfluentialThe Benefits of Probiotics on Oral Health: Systematic Review of the Literature
Inchingolo, F., Inchingolo, A. M., Malcangi, G., Leonardis, N. D., Sardano, R., Pezzolla, C., de Ruvo, E., Venere, D. D., Palermo, A., Inchingolo, A. D., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16091313 · Cited by 99
“Studies largely show their ability to compete with pathogens for adhesion surfaces [24], possibly enhancing oral health indirectly through immunological means rather than directly attacking periodontopathogens.”
BackgroundRusso, R., Superti, F., Karadja, E., & De Seta, F. (2019) · Mycoses · doi:10.1111/myc.12883 · Cited by 94
Swidsinski, A., Guschin, A. E., Tang, Q.-L., Dörffel, Y., Verstraelen, H., Tertychnyy, A. S., Khayrullina, G., Luo, X., Sobel, J. D., & Jiang, X. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.10.023 · Cited by 88
Graf, K., Last, A., Gratz, R., Allert, S., Linde, S., Westermann, M., Gröger, M., Mosig, A. S., Gresnigt, M. S., & Hube, B. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039719 · Cited by 83
“Furthermore, lactobacilli can produce compounds such as hydrogen peroxide, lactic acid, bacteriocins and biosurfactants, which inhibit the growth of potential pathogens (reviewed by Förster et al., 2016 and Matsubara et al., 2016b).”
BackgroundLacticaseibacillus rhamnosus GR-1, a.k.a. Lactobacillus rhamnosus GR-1: Past and Future Perspectives
Petrova, M., Reid, G., & ter Haar, J. A. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.03.010 · Cited by 80
Role of probiotics and prebiotics in mitigation of different diseases
Manzoor, S., Wani, S. M., Mir, S. A., & Rizwan, D. (2022) · Nutrition · doi:10.1016/j.nut.2022.111602 · Cited by 79
Candidemia in children: Epidemiology, prevention and management
Mantadakis, E., Pana, Z. D., & Zaoutis, T. E. (2018) · Mycoses · doi:10.1111/myc.12792 · Cited by 73
Alternative and complementary therapies for vulvovaginal candidiasis
Felix, T. C., Röder, D. V. D. D. B., & Pedroso, R. D. S. (2018) · Folia Microbiologica · doi:10.1007/s12223-018-0652-x · Cited by 69
Immunomodulation as Therapy for Fungal Infection: Are We Closer?
Sam, Q. H., Yew, W. S., Seneviratne, C. J., Chang, M. W., & Chai, L. Y. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01612 · Cited by 68
Action mechanisms of probiotics on Candida spp. and candidiasis prevention: an update
Ribeiro, F. D. C., Rossoni, R. D., de Barros, P. P., dos Santos, J. D., Fugisaki, L. R. D. O., Leão, M. V. P., & Junqueira, J. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14511 · Cited by 65
“…individuals, being able to become a pathogen when the balance between the fungus, mucosa and host defence mechanisms is interrupted, which leads to the appearance of candidiasis (Thompson et al. 2010; Cassone and Cauda 2012; Hebecker et al. 2014; Matsubara et al. 2016; Salvatori et al. 2016).”
BackgroundBandara, N., & Samaranayake, L. P. (2019) · Periodontology 2000 · doi:10.1111/prd.12273 · Cited by 64
Probiotics and their postbiotics for the control of opportunistic fungal pathogens: A review
Divyashree, S., Shruthi, B., Vanitha, P. R., & Sreenivasa, M. Y. (2023) · Biotechnology Reports · doi:10.1016/j.btre.2023.e00800 · Cited by 58
“Hence, for these concerns, the need of biocontrol agent such as probiotic bacteria and its postbiotics has been anticipated as an substitute approach of treatment against opportunistic human fungal infections [11].”
BackgroundSalazar, S. B., Simões, R., Pedro, N. A., Pinheiro, M. J. F., Carvalho, M. F. N. N., & Mira, N. P. (2020) · Journal of Fungi · doi:10.3390/jof6010023 · Cited by 58
“In this sense, a few products are currently available in the market mostly based on the use of lactobacilli, considering the well-known track record of these species as probiotics [165].”
BackgroundChe, J., Shi, J., Fang, C., Zeng, X., Wu, Z., Du, Q., Tu, M., & Pan, D. (2024) · Microorganisms · doi:10.3390/microorganisms12040704 · Cited by 52
“Postbiotics from LAB have been observed to hinder the biofilm formation of pathogens through the presence of multiple key constituents, such as short-chain fatty acids, EPS, bacteriocin, lipid wall phosphate, glycolipids, and glycoproteins [64].”
BackgroundFungal infections in dentistry: Clinical presentations, diagnosis, and treatment alternatives
Lombardi, A. M., & Ouanounou, A. (2020) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2020.08.011 · Cited by 47
El Barnossi, A., Moussaid, F., & Iraqi Housseini, A. (2020) · E3S Web of Conferences · doi:10.1051/e3sconf/202015002003 · Cited by 43
Poon, Y., & Hui, M. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1105949 · Cited by 45
“In view of the emergence of antifungal resistance, the use of probiotic Lactobacillus species has been suggested as an alternative therapeutic option against Candida infection (Matsubara et al., 2016a).”
BackgroundMatsubara, V. H., Ishikawa, K., Ando‐Suguimoto, E. S., Bueno‐Silva, B., Nakamae, A. É. M., & Mayer, M. P. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02280 · Cited by 44
Application of probiotics in candidiasis management
Andrade, J. C., Kumar, S., Kumar, A., Černáková, L., & Rodrigues, C. F. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1926905 · Cited by 43
“Earlier, Matsubara et al. (2016) have also shown that probiotic lactobacilli cells, namely Lactobacillus rhamnosus LR32, inhibit the early stages of C. albicans biofilm development by reducing their growth, cell adhesion, and filamentation.”
BackgroundMethodAggregation and adhesion ability of various probiotic strains and Candida species: An in vitro study
Chantanawilas, P., Pahumunto, N., & Teanpaisan, R. (2024) · Journal of Dental Sciences · doi:10.1016/j.jds.2024.03.016 · Cited by 46
Emerging and future strategies in the management of recalcitrant Candida auris
Bandara, N., & Samaranayake, L. P. (2022) · Medical Mycology · doi:10.1093/mmy/myac008 · Cited by 42
Ribeiro, F. D. C., Junqueira, J. C., dos Santos, J. D., de Barros, P. P., Rossoni, R. D., Shukla, S., Fuchs, B. B., Shukla, A., & Mylonakis, E. E. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02323-19 · Cited by 41
Promising Alternative Therapeutics for Oral Candidiasis
Rodrigues, C. F., Rodrigues, M. E., & Henriques, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180601102333 · Cited by 40
Kim, H., & Kang, S. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.01.006 · Cited by 40
Poupet, C., Saraoui, T., Veisseire, P., Bonnet, M., Dausset, C., Gachinat, M., Camarès, O., Chassard, C., Nivoliez, A., & Bornes, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216184 · Cited by 42
Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis
Morse, D. J., Smith, A., Wilson, M. J., Marsh, L. L., White, L. P., Posso, R. B., Bradshaw, D. J., Wei, X., Lewis, M. A. O., & Williams, D. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-46494-0 · Cited by 41
Probiotics—A complete oral healthcare package
Mishra, S., Rath, S., & Mohanty, N. (2020) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2020.08.005 · Cited by 37
Takano, T., Kudo, H., Eguchi, S., Matsumoto, A., Oka, K., Yamasaki, Y., Takahashi, M., Koshikawa, T., Takemura, H., Yamagishi, Y., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1113401 · Cited by 40
“However, as with bacterial infections, the use of antifungal drugs is strongly implicated in the occurrence of pathogenic fungi, and thus new methods of prevention or treatment of RVVC that are not dependent on antifungal use are required (Matsubara et al., 2016).”
BackgroundMethodPathophysiological microenvironments in oral candidiasis
Jørgensen, M. R. (2024) · Apmis · doi:10.1111/apm.13412 · Cited by 42
“Controlling the healthy oral microbiota with pre-, pro-, or synbiotics is a noninvasive and preventive approach to prevent mucosal candidiasis [173 – 175].”
Intestinal fungal-host interactions in promoting and maintaining health
Hill, J. H., & Round, J. L. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.09.010 · Cited by 38
Probiotics as antifungal agents: Experimental confirmation and future prospects
Kosgey, J. C., Jia, L., Fang, Y., Yang, J., Gao, L., Wang, J., Nyamao, R. M., Cheteu, M., Tong, D., Wekesa, V. W., et al. (2019) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2019.05.001 · Cited by 36
Ai, R., Wei, J., Ma, D., Jiang, L., Dan, H., Zhou, Y. J., Ji, N., Zeng, X. Y., & Chen, Q. (2017) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.04.030 · Cited by 33
“There are also no studies showing side effects, which may not have been considered in clinical trials (Matsubara et al., 2016).”
Rossoni, R. D., Velloso, M. D. S., Figueiredo-Godoi, L. M. A., Martins, C. P., Jorge, A. O. C., & Junqueira, J. C. (2017) · Folia Microbiologica · doi:10.1007/s12223-017-0569-9 · Cited by 33
Donders, G. G. G., Ruban, K., Bellen, G., & Grinceviciene, S. (2018) · Wiley eBooks · doi:10.1002/9781119380924.ch15 · Cited by 35
Novel Therapies for Biofilm-Based Candida spp. Infections
Černáková, L., Light, C. J., Salehi, B., Rogel-Castillo, C., Victoriano, M., Martorell, M., Sharifi‐Rad, J., Martins, N. A., & Rodrigues, C. F. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_400 · Cited by 32
Lordello, V. B., Meneguin, A. B., de Annunzio, S. R., Taranto, M. P., Chorilli, M., Fontana, C. R., & Cavallini, D. C. U. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070998 · Cited by 35
Paniágua, A. L., Correia, A. F., Pereira, L. C., de Alencar, B. M., Brandão, F., Almeida, R. M., & Nóbrega, Y. K. D. M. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03405-z · Cited by 32
“Anti-Candida properties, such as the suppression of inflammatory genes [10] and the reduction in adherence and biofilm formation [11, 12], have been attributed to Lactobacillus strains.”
BackgroundLactobacillus is able to alter the virulence and the sensitivity profile of Candida albicans
Oliveira, V. M. C., dos Santos, S. S. F., Silva, C. R. G., Jorge, A. O. C., & Leão, M. V. P. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13289 · Cited by 31
“Studies reveal that lactobacilli, suppress Candida growth and biofilm development, and also diminish the symptoms and invasive fungal infection (Matsubara et al. 2016).”
BackgroundVaginal microbiota: Potential targets for vulvovaginal candidiasis infection
Wang, Y., Liu, Z., & Chen, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27239 · Cited by 36
“Most Lactobacillus strains (particularly L. crispatus , L. fermentum , and L. rhamnosus ) exhibited great auto-aggregation and anti-Candida activity, suggesting their role in the treatment of VVC [54,55].”
BackgroundCandidiasis vulvovaginal: una antigua enfermedad con nuevos desafíos
Miró, M. S., Rodríguez, E., Vigezzi, C., Icely, P. A., Araújo, M. G. D. F., Riera, F. O., Vargas, L., Abiega, C. D., Caeiro, J. P., & Sotomayor, C. E. (2017) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2016.11.006 · Cited by 34
Tomičić, R., Tomičić, Z., & Raspor, P. (2022) · Folia Microbiologica · doi:10.1007/s12223-022-00956-7 · Cited by 29
“2020), while among yeasts, only Saccharomyces boulardii is widely used and represents an effective biotherapeutic agents against Candida infections (Krasowska et al. 2009; Matsubara et al. 2016; Mundula et al. 2019).”
BackgroundMucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis
García-Carnero, L. C., & Mora-Montes, H. M. (2022) · Journal of Fungi · doi:10.3390/jof8050445 · Cited by 29
Future therapies targeted towards eliminatingCandidabiofilms and associated infections
Bandara, N., Matsubara, V. H., & Samaranayake, L. P. (2016) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2017.1268530 · Cited by 29
Potential of probiotics for use as functional foods in patients with non-infectious gastric ulcer
Yang, R., Zhao, X., Wu, W., & Shi, J. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.02.070 · Cited by 27
COVID-19 associated mucormycosis: evolving technologies for early and rapid diagnosis
Samson, R., & Dharne, M. S. (2021) · 3 Biotech · doi:10.1007/s13205-021-03080-4 · Cited by 26
“Several other studies have also shown in-vivo efficacy and safety of probiotics in treatment of candidiasis and other fungal infections (Brzozowski et al. 2005; Vicariotto et al. 2012; Demirel et al. 2013; Matsubara et al. 2016; Silva et al. 2016).”
Candida albicans: the current status regarding vaginal infections
Faustino, M., Ferreira, C., Pereira, A. M., & CARVALHO, A. P. F. D. (2025) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-025-13478-2 · Cited by 33
“Indeed, different Lactobacillus and Bifido-bacterium genera species have been widely used for many decades as probiotics, as they provide a health benefit to the host by inhibiting Candida spp. growth (Chew et al. 2015; Matsubara et al. 2016; Hernãndez-Bautista et al. 2020).”
de Alvarenga, J. A., de Barros, P. P., Ribeiro, F. D. C., Rossoni, R. D., Garcia, M. T., Velloso, M. D. S., Shukla, S., Fuchs, B. B., Shukla, A., Mylonakis, E. E., et al. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09712-0 · Cited by 25
Precision Postbiotics and Mental Health: the Management of Post-COVID-19 Complications
Pandey, M., Bhati, A., Priya, K. G. G. L. S., Sharma, K. K., & Singhal, B. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09875-4 · Cited by 24
“parasiticus has been done by the supplementation of various probiotics majorly including Lactobacillus strains [133].”
BackgroundJakab, Á., Kovács, F., Balla, N., Tóth, Z., Ragyák, Á. Z., Sajtos, Z., Csillag, K., Nagy-Köteles, C., Nemes, D., Bácskay, I., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113220 · Cited by 26
Authier, H., Salon, M., Rahabi, M. C., Bertrand, B., Blondeau, C., Kuylle, S., Holowacz, S., & Coste, A. (2021) · Journal of Fungi · doi:10.3390/jof7010057 · Cited by 22
“albicans growth and biofilm formation [17].”
BackgroundDemin, K. A., Refeld, A. G., Bogdanova, A. A., Prazdnova, E. V., Popov, I. V., Kutsevalova, O. Y., Ermakov, A. M., Bren, A. B., Rudoy, D. V., Chistyakov, V. A., et al. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09776-6 · Cited by 24
Probiotics for Oral Candidiasis: Critical Appraisal of the Evidence and a Path Forward
Archambault, L. S., & Dongari‐Bagtzoglou, A. I. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.880746 · Cited by 20
Saccharomyces cerevisiae CNCM I-3856 as a New Therapeutic Agent Against Oropharyngeal Candidiasis
Roselletti, E., Sabbatini, S., Ballet, N., Perito, S., Pericolini, E., Blasi, E., Mosci, P., Decherf, A. C., Monari, C., & Vecchiarelli, A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01469 · Cited by 20
Jia, L., Kosgey, J. C., Wang, J., Yang, J., Nyamao, R. M., Zhao, Y., Teng, X., Gao, L., Wabo, M. C., Vasilyeva, N. V., et al. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1770 · Cited by 24
Shan, Q., Liu, N., Wang, X., Zhu, Y., Yin, J., & Wang, J. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00752-w · Cited by 22
“Further studies have shown that LGR-1 inhibits biofilm formation on Candida albicans strains on abiotic surfaces and Salmonella enterica serovar Typhimurium [35, 36].”
BackgroundHu, L., Zhou, P., Zhao, W., Hua, H., & Yan, Z. (2020) · Oral Diseases · doi:10.1111/odi.13293 · Cited by 19
Unveiling The Therapeutic Potential of Probiotics: A Review
Tukaram, K. S., Sopanrao, S. R., & Kacharu, L. O. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.09.011 · Cited by 19
The Potential Value of Probiotics after Dental Implant Placement
Xu, J., Chen, C., Gan, S., Liao, Y., Fu, R., Hou, C., Yang, S., Zheng, Z., & Chen, W. (2023) · Microorganisms · doi:10.3390/microorganisms11071845 · Cited by 20
Balakrishna, K., Naveena, G., & Kingston, J. J. (2026) · Archives of Microbiology · doi:10.1007/s00203-025-04701-9 · Cited by 21
“Supporting this, studies have shown that administration of heat-killed Lactobacillus species in mice conferred partial protection against Candida infection by suppressing colonization of viable Candida cells in the gastrointestinal tract (Matsubara et al. 2016).”
Vij, R., Hube, B., & Brunke, S. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.02.003 · Cited by 15
“can decrease mucosal Candida infections (reviewed in [146]).”
BackgroundLi, G., Li, Q., Zhang, C., Yu, Q., Li, Q., Zhou, X., Yang, R., Yang, X., Liu, H., & Yang, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1242711 · Cited by 15
“In severe hepatic insufficiency, both natural and acquired immunity are severely impaired, resulting in decreased immunity, and often accompanied by intestinal dysfunction, intestinal mucosal edema, increased permeability, impaired intestinal barrier leading to flora translocation, intestinal microorganisms can enter…”
BackgroundElsayes, S. A., EL-Attar, M. S., Elhadary, A., Aboulela, A., Essawy, M. M., & Soliman, I. S. (2024) · Journal of Prosthetic Dentistry · doi:10.1016/j.prosdent.2024.05.018 · Cited by 14
Probiotics in the management of radiation-induced oral mucositis
Li, Y., Li, Z., Zheng, S., & Xu, X. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1477143 · Cited by 17
Lactobacillus rhamnosus strains of oral and vaginal origin show strong antifungal activity in vitro
Jørgensen, M. R., Rikvold, P. D., Lichtenberg, M., Jensen, P. Ø., Kragelund, C., & Twetman, S. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1832832 · Cited by 15
“The most investigated probiotics for anti-Candida activity belong to the genera Lactobacillus and Bifidobacterium, but also Streptococcus has been proposed [12].”
BackgroundCatanoze, I. A., Cunha, B. G., Costa, G. Q., da Silva, E. V. F., Duque, C., & Guiotti, A. M. (2020) · Journal of Prosthetic Dentistry · doi:10.1016/j.prosdent.2020.10.005 · Cited by 11
Dai, P., Yang, M., Du, J., Wang, K., Chen, R., Feng, X., Chen, C., & Zhang, X. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1418101 · Cited by 10
Rajasekharan, S. K., Angelini, L. L., Kroupitski, Y., Mwangi, E. W., Chai, Y., & Shemesh, M. (2024) · Biofilm · doi:10.1016/j.bioflm.2024.100244 · Cited by 10
A Prerequisite for Health: Probiotics
Rossoni, R. D., Ribeiro, F. D. C., de Barros, P. P., Mylonakis, E. E., & Junqueira, J. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816664-2.00011-6 · Cited by 9
Short-Term Probiotic Administration Increases Fecal-Anti Candida Activity in Healthy Subjects
Angelis, M. D., Scagnolari, C., Oliva, A., Cavallari, E. N., Celani, L., Santinelli, L., Innocenti, G. P., Borrazzo, C., Ceccarelli, G., Vullo, V., et al. (2019) · Microorganisms · doi:10.3390/microorganisms7060162 · Cited by 8
“In conclusion a number of preliminary clinical studies suggested that probiotics might play a role in the reduction of Candida colonization on human mucosal surfaces, potentially reducing the risk of not only oral, vaginal and intestinal colonization, but also the incidence of invasive fungal infections [30].”
BackgroundWu, Y., Chen, J., Chen, L.-C., Chen, L., Huang, Y., & Liao, C. (2025) · Pathogens · doi:10.3390/pathogens14040308 · Cited by 7
“In a disseminated infection model in mice, yeast cells dispersed within mature biofilms have been shown to display higher virulence [2–5].”
The pathogenicity and future treatment strategies of Candida albicans
Wu, J., Jiang, C., Wang, H., Chen, T., Chen, X., & Da, W. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1752304 · Cited by 7
Rebai, Y., Wagner, L., Gnaien, M., Hammer, M. L., Kapitan, M., Niemiec, M. J., Mami, W., Mosbah, A., Messadi, E., Mardassi, H., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11081929 · Cited by 8
“Several studies have focused on the antimicrobial potential of probiotic bacteria, particularly via the natural secretion of metabolites with antifungal properties [14].”
BackgroundAbramov, V. M., Kosarev, I. V., Валериевич, М. А., Priputnevich, T. V., Deryusheva, E. I., Панин, А. Н., Chikileva, I. O., Abashina, T. N., Melnikov, V. G., Сузина, Н. Е., et al. (2023) · Biomolecules · doi:10.3390/biom13121740 · Cited by 8
“Several studies have reported the anti-pathogenic potential of probiotic bacteria for the prevention and/or the treatment of OPC [32,37–41] and IC [42–49].”
BackgroundIn Vitro Inhibitory Effects and Co-Aggregation Activity of Lactobacilli on Candida albicans
Yocheva, L. D., Tserovska, L., Danguleva, A., Todorova, T., Zhelezova, G., Karaivanova, E., & Georgieva, R. (2024) · Microbiology Research · doi:10.3390/microbiolres15030104 · Cited by 6
“The obtained results in both model systems confirm the hypothesis that only elevated levels of lactic acid efficiently inhibit fungal growth [6,30,31].”
BackgroundResultChauhan, V., Kumar, A., Tripathi, S., Jha, M., Kumar, N., Poluri, K. M., & Gupta, P. (2024) · Discover Public Health · doi:10.1186/s12982-024-00274-y · Cited by 7
Seyyedi, Z. S., Kashani, H. H., Parchebafi, A., Ghayoumi, R., Lari, M. M. H., & Hosseini, E. S. (2025) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2025.100340 · Cited by 6
Gümrü, B., & Akkitap, M. P. (2021) · Black Sea Journal of Health Science · doi:10.19127/bshealthscience.943993 · Cited by 7
Evaluation of the antifungal activity of Lactobacillus reuteri against Candida species
bakhshi, M., Salari, S., Almani, P. G. N., & Afshari, S. A. K. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101369 · Cited by 6
Lyasota, V., Bakhur, T. I., & Утеченко, М. В. (2020) · Ukrainian Journal of Ecology · doi:10.15421/2020_250 · Cited by 5
“, 2011), haemolytic Staphylococcus (Sikorska and Smoragiewicz, 2013), and fungi of Candida genus (Matsubara et al., 2016).”
BackgroundMicrobiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy
Zhou, Q., Liu, P., Chen, M., He, H., Xu, M., Xu, Q., Yu, J., Deng, Y., Yan, J., & Wen, Y. (2025) · Frontiers in Oral Health · doi:10.3389/froh.2025.1485028 · Cited by 5
“LrGG bacteria have the ability to adhere to epithelial cells, promote type 1 immune response, and through inhibiting the activation of macrophages to effectively reduce the in fl ammatory response, and promote the production of innate immune cells such as IL-10, IL-12, and TNF-α (67, 68).”
Pariano, M., Puccetti, M., Fabi, C., Nunzi, E., Balucchi, S., Perioli, L., Ricci, M., Giovagnoli, S., Garaci, E., & Romani, L. R. (2025) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2025.2569831 · Cited by 6
“Lactobacillus strains, such as Lactobacillus rhamnosus GG , have been shown to restore microbial balance and inhibit fungal overgrowth, making them a valuable tool in preventing recurrent infections [184].”
Harnessing Probiotics to Combat Candidiasis: Mechanisms, Evidence, and Future Directions
Wright, E., Valand, N., & Girija, U. V. (2025) · Journal of Fungi · doi:10.3390/jof11110779 · Cited by 5
“Research indicates that certain probiotic strains such as Lactobacillus can suppress Candida growth and biofilm formation [77].”
The Hygienic Significance of Microbiota and Probiotics for Human Wellbeing
Todorov, S. D., Tagg, J. R., Algburi, A., Tiwari, S. K., Popov, I. V., Weeks, R. M., Mitrokhin, O. V., Kudryashov, I. A., Александрович, К. Д., & Chikindas, M. L. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10419-9 · Cited by 5
“Each strain, when used together, complements each other's action, and preparations containing all three types of lactobacilli better mimic the normal microbiota of the vagina [179].”
InfluentialAshouritoustani, R., Pinho, C., Oliveira, A. I., Barros, P., & Cruz, A. (2025) · Microorganisms · doi:10.3390/microorganisms13122883 · Cited by 4
“While conventional antifungal therapies such as nystatin and azoles remain the standard of care [14,15], their efficacy is often limited by side effects [16,17], and the emergence of drug-resistant Candida strains [18].”
Metadata
- Authors
- Matsubara, V. H., Bandara, H. M. H. N., Mayer, M. P. A., & Samaranayake, L. P.
- Affiliations
- The University of Queensland (AU)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01-29
- Volume
- 62
- Issue
- 9
- Pages
- 1143-1153
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2325976755
- Cited by
- 151
- References
- 40
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 16 · 2023: 13 · 2022: 18 · 2021: 15 · 2020: 20 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 6
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (acceptedVersion, other-oa)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- probiotics, antifungal activity, mucosal candidiasis, Candida, lactobacilli, candidal colonization, biofilm formation, oral candidiasis, vaginal candidiasis, invasive fungal infections, critically ill patients, antifungal resistance, candidiasis prophylaxis
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Candidiasis, Female, Humans, Infant, Infant, Newborn, Lactobacillus, Middle Aged, Probiotics, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
