The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses
Open accessAbstract
BACKGROUND: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasive GBS disease and the associated serotypes, updating previous estimates. METHODS: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data regarding invasive GBS disease in infants aged 0-89 days. We conducted random-effects meta-analyses of incidence, case fatality risk (CFR), and serotype prevalence. RESULTS: We identified 135 studies with data on incidence (n = 90), CFR (n = 64), or serotype (n = 45). The pooled incidence of invasive GBS disease in infants was 0.49 per 1000 live births (95% confidence interval [CI], .43-.56), and was highest in Africa (1.12) and lowest in Asia (0.30). Early-onset disease incidence was 0.41 (95% CI, .36-.47); late-onset disease incidence was 0.26 (95% CI, .21-.30). CFR was 8.4% (95% CI, 6.6%-10.2%). Serotype III (61.5%) dominated, with 97% of cases caused by serotypes Ia, Ib, II, III, and V. CONCLUSIONS: The incidence of infant GBS disease remains high in some regions, particularly Africa. We likely underestimated incidence in some contexts, due to limitations in case ascertainment and specimen collection and processing. Burden in Asia requires further investigation.
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Cites
Meta-analysis in clinical trials
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Self-citationEarly Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E. coli Disease Continues
Stoll, B. J., Hansen, N. I., Sánchez, P. J., Faix, R. G., Poindexter, B. B., Van Meurs, K. P., Bizzarro, M. J., Goldberg, R. N., Frantz, I. D., Hale, E. C., et al. (2011) · Pediatrics · doi:10.1542/peds.2010-2217 · Cited by 1,077
Self-citationHospital-acquired neonatal infections in developing countries
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Self-citationEdmond, K. M., Kortsalioudaki, C., Scott, S., Schrag, S. J., Zaidi, A. K., Cousens, S., & Heath, P. T. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61651-6 · Cited by 600
Self-citationRussell, N. J., Seale, A. C., O’Driscoll, M., O’Sullivan, C., Bianchi-Jassir, F., Gonzalez-Guarin, J., Lawn, J. E., Baker, C. J., Bartlett, L., Cutland, C., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix658 · Cited by 552
Self-citationSeale, A. C., Bianchi-Jassir, F., Russell, N. J., Kohli-Lynch, M., Tann, C. J., Hall, J., Madrid, L., Blencowe, H., Cousens, S., Baker, C. J., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix664 · Cited by 511
Self-citation(2016) · The Lancet Global Health · doi:10.1016/s2214-109x(16)30148-6 · Cited by 432
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Cited by
Seale, A. C., Bianchi-Jassir, F., Russell, N. J., Kohli-Lynch, M., Tann, C. J., Hall, J., Madrid, L., Blencowe, H., Cousens, S., Baker, C. J., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix664 · Cited by 511
Self-citationManagement of Infants at Risk for Group B Streptococcal Disease
Puopolo, K. M., Lynfield, R., Cummings, J. J., COMMITTEE ON FETUS AND NEWBORN, COMMITTEE ON INFECTIOUS DISEASES, Hand, I., Adams-Chapman, I., Poindexter, B., Stewart, D. L., Aucott, S. W., et al. (2019) · Pediatrics · doi:10.1542/peds.2019-1881 · Cited by 317
Temporal development of the infant gut microbiome
Moore, R. E., & Townsend, S. D. (2019) · Open Biology · doi:10.1098/rsob.190128 · Cited by 264
Megli, C. J., Carlin, S. M., Giacobe, E. J., Hillebrand, G. H., & Hooven, T. A. (2025) · Virulence · doi:10.1080/21505594.2025.2451173 · Cited by 24
(2025) · doi:10.1128/iai.00540-24 · Cited by 11
Metadata
- Authors
- Madrid, L., Seale, A. C., Kohli-Lynch, M., Edmond, K. M., Lawn, J. E., Heath, P. T., Madhi, S. A., Baker, C. J., Bartlett, L., Cutland, C., Gravett, M. G., Ip, M., Le Doare, K., Rubens, C. E., Saha, S. K., Sobanjo-ter Meulen, A., Vekemans, J., Schrag, S., for the Infant GBS Disease Investigator Group, Agarwal, R., da Silva, A. R. A., Bassat, Q., Berkley, J. A., Dangor, Z., Dhaded, S., Giannoni, E., Hammoud, M., Kobayahsi, M., O’Sullivan, C., Sakata, H., Sridhar, S., Sigaúque, B., Tyrrell, G., & Paul, V.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-11-06
- Volume
- 65
- Issue
- suppl_2
- Pages
- S160-S172
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2777601894
- Cited by
- 458
- References
- 85
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Madrid, L., Seale, A. C., Kohli-Lynch, M., Edmond, K. M., Lawn, J. E., Heath, P. T., Madhi, S. A., Baker, C. J., Bartlett, L., Cutland, C., Gravett, M. G., Ip, M., Le Doare, K., Rubens, C. E., Saha, S. K., Sobanjo-ter Meulen, A., Vekemans, J., Schrag, S., for the Infant GBS Disease Investigator Group, . . . Paul, V. (2017). Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses. Clinical Infectious Diseases. https://doi.org/10.1093/cid/cix656
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
