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Cited by 30Cardiovascular and exercise physiologyLipoproteins and Cardiovascular HealthPhysical Activity and Health

High-density lipoprotein particle pattern and overall lipid responses to a short-term moderate-intensity aerobic exercise training intervention in patients with chronic kidney disease

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Miele, Emily M., Headley, Samuel A.E., Germain, Michael, Joubert, Jyovani, Herrick, Sarah, Milch, Charles, Evans, Elizabeth, Cornelius, Allen +3 more·2017·Clinical Kidney Journal
DOI 10.1093/ckj/sfx006PMC PMC5570090
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Abstract

Chronic kidney disease (CKD) is associated with abnormal lipid profiles and altered high-density lipoprotein (HDL) particle size patterns. Lower levels of the larger, cardioprotective HDL particles found in CKD may play a role in the increased risk for cardiovascular disease in these patients. The current study was designed to assess the effects of short-term moderate-intensity aerobic exercise training on the HDL particle pattern and overall lipid profiles in stage 3 CKD patients. Forty-six men and women with stage 3 CKD were randomized to either exercise (EX, n = 25) or control (CON, n = 21). Those in the EX group completed 16 weeks of supervised moderate-intensity aerobic exercise three times per week. Serum total cholesterol, HDL cholesterol (HDL-C), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), HDL particle size, estimated glomerular filtration rate (eGFR), body composition and peak oxygen uptake (VO2peak) were assessed at baseline and week 16. The rate of compliance in the EX group was 97 ± 7.2%. No change was observed in eGFR over time in either group. There was an 8.2% improvement in VO2peak in the EX group (P = 0.05), while VO2peak decreased in the CON group. HDL-C, TGs, HDL particle size and body composition remained unchanged in both groups. A trend was found for lower total cholesterol (TC) (P = 0.051) and LDL-C (P = 0.07) in the CON group. Our findings indicate that a short-term aerobic exercise training intervention in stage 3 CKD patients does not induce changes in HDL particle size or favorable lipid profile modifications.

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Authors
Miele, E. M., Headley, S. A. E., Germain, M., Joubert, J., Herrick, S., Milch, C., Evans, E., Cornelius, A., Brewer, B., Taylor, B., & Wood, R. J.
Affiliations
  • Springfield College (US)
  • University of the Rockies (US)
  • University of Connecticut (US)
Corresponding author
Wood, Richard J.
ORCID
Venue
Clinical Kidney Journal
Publisher
Oxford University Press (OUP)
Published
2017-03-27
Volume
10
Issue
4
Pages
524-531
ISSN
  • 2048-8505 (ISSN-L)
  • 2048-8513
DOI
10.1093/ckj/sfx006
PMC
PMC5570090
OpenAlex
W2597971971
Cited by
30
References
6
Citations by year
2026: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 2
FWCI
2.84
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Clinical Kidney Journal (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (1R15HL096097-01)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
chronic kidney disease, aerobic exercise training, HDL particle size, HDL cholesterol, lipid profile, cardiovascular risk, peak oxygen uptake, body composition, triglycerides, LDL cholesterol, total cholesterol, exercise intervention

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