The Effect of Regular Aerobic Exercise on Reverse Cholesterol Transport A1 and Apo Lipoprotein A-I Gene Expression in Inactive Women
Open accessAbstract
BACKGROUND: Atherosclerotic cardiovascular disease is currently a cause of mortality in some parts of the world. The ATP-Binding Cassette Transporter (ABCA1) gene prepares instructions to produce the ATP-binding cassette transporter protein whose operation is for export of phospholipids and cholesterol, outside cells where they are limited to Apolipoprotein A1 (apoA1). Increased ABCA1 activity could inhibit atherosclerosis. OBJECTIVES: In the present study, the effect of aerobic exercise was investigated on gene expression and biochemical parameters. PATIENTS AND METHODS: The participants included 36 inactive women, which were randomly assigned to control (CON) and experimental (EX) groups. The EX group performed 12 weeks of aerobic exercise and the CON group remained inactive. Fasting blood samples were collected 24 hours before the first session and 48 hours after completion of the course. The ABCA1 and APOA1 gene expressions were measured using semi-quantitative-RT-PCR. Data were analyzed by the SPSS software (version 18). RESULTS: A significant increase in blood ABCA1 (EX group P < 0.002, t = - 9.876) and Apo A-I (EX group P < 0.05, t = 2.76) gene expression was shown following the 12 weeks of training. Plasma high-density lipoprotein-cholesterol (HDL-C) concentration increased (P < 0.001, t = 4.90 respectively) while plasma low-density lipoprotein-cholesterol (LDL-C) concentration decreased (P < 0.001, t = 4.27) in the EX group compared with the CON group. CONCLUSIONS: Aerobic exercises can increase ABCA1 and APO-A1 gene expression. Induction of these genes can effectively prevent cardiovascular disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ABCA1 mRNA expression increases regardless of the intensity of exercise.
“Ghanbari-Niaki et al. [70] also found that ABCA1 mRNA expression increased regardless of the intensity of exercise.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Importance of Different Pathways of Cellular Cholesterol Efflux
Yancey, P. G., Bortnick, A. E., Kellner-Weibel, G., de la Llera-Moya, M., Phillips, M. C., & Rothblat, G. H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000057572.97137.dd · Cited by 506 · see citing works
Langmann, T., Klucken, J., Reil, M., Liebisch, G., Luciani, M., Chimini, G., Kaminski, W. E., & Schmitz, G. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0406 · Cited by 492 · see citing works
Timmins, J. M., Lee, J.-Y., Boudyguina, E., Kluckman, K. D., Brunham, L. R., Mulya, A., Gebre, A. K., Coutinho, J. M., Colvin, P. L., Smith, T. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23915 · Cited by 447 · see citing works
ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease
Oram, J. F., & Vaughan, A. M. (2006) · Circulation Research · doi:10.1161/01.res.0000250171.54048.5c · Cited by 411 · see citing works
Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages
Aiello, R. J., Brees, D., Bourassa, P.-A., Royer, L., Lindsey, S., Coskran, T., Haghpassand, M., & Francone, O. L. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000014804.35824.da · Cited by 390 · see citing works
Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels
Haghpassand, M., Bourassa, P.-A. K., Francone, O. L., & Aiello, R. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112810 · Cited by 257 · see citing works
Increased ABCA1 activity protects against atherosclerosis
Singaraja, R. R., Fievet, C., Castro, G., James, E. R., Hennuyer, N., Clee, S. M., Bissada, N., Choy, J. C., Fruchart, J.-C., McManus, B. M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15748 · Cited by 250 · see citing works
Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1
Cavelier, C., Lorenzi, I., Rohrer, L., & von Eckardstein, A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.012 · Cited by 232 · see citing works
Effects of exercise on gene expression in human peripheral blood mononuclear cells
Connolly, P. H., Caiozzo, V. J., Zaldivar, F. P., Nemet, D., Larson, J. K., Hung, S., Heck, J. D., Hatfield, G. W., & Cooper, D. M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00316.2004 · Cited by 198 · see citing works
Low-Intensity Exercise Exerts Beneficial Effects on Plasma Lipids via PPARγ
BUTCHER, L. R., THOMAS, A., BACKX, K., ROBERTS, A., WEBB, R., & MORRIS, K. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816c091d · Cited by 128 · see citing works
Exercise, Lipids, and Lipoproteins in Older Adults: A Meta‐Analysis
Kelley, G. A., Kelley, K. S., & Tran, Z. V. (2005) · Preventive Cardiology · doi:10.1111/j.0197-3118.2005.03769.x · Cited by 118 · see citing works
Exercise affects the gene expression profiles of human white blood cells
Buttner, P. G., Mosig, S., Lechtermann, A., Funke, H., & Mooren, F. C. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00066.2006 · Cited by 115 · see citing works
Physical Fitness and Reverse Cholesterol Transport
Olchawa, B., Kingwell, B. A., Hoang, A., Schneider, L., Miyazaki, O., Nestel, P. J., & Sviridov, D. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000128124.72935.0f · Cited by 106 · see citing works
Treadmill exercise enhances ABCA1 expression in rat liver
Ghanbari-Niaki, A., Khabazian, B. M., Hossaini-Kakhak, S. A., Rahbarizadeh, F., & Hedayati, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.100 · Cited by 94 · see citing works
Sahoo, D., Trischuk, T. C., Chan, T., Drover, V. A. B., Ho, S. B., Chimini, G., Agellon, L. B., Agnihotri, R., Francis, G. A., & Lehner, R. S. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300529-jlr200 · Cited by 88 · see citing works
Singaraja, R. R., Eck, M. V., Bissada, N., Zimetti, F., Collins, H. L., Hildebrand, R. B., Hayden, A., Brunham, L. R., Kang, M. H., Fruchart, J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.621433 · Cited by 84 · see citing works
High-density lipoprotein subfractions and risk of coronary artery disease
Morgan, J., Carey, C., Lincoff, A., & Capuzzi, D. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0047-0 · Cited by 75 · cited 1× · see citing works
“This protective effect of HDL-C against atherosclerosis (2) is due to the role of HDL-C in Reverse Cholesterol Transport (RCT).”
BackgroundZieker, D., Fehrenbach, E., Dietzsch, J., Fliegner, J., Waidmann, M., Nieselt, K., Gebicke‐Haerter, P. J., Spanagel, R., Simon, P. D., Niess, A. M., et al. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00096.2005 · Cited by 74 · see citing works
ABCA1 expression in humans is associated with physical activity and alcohol consumption
Hoang, A., Tefft, C., Duffy, S. J., Formosa, M. F., Henstridge, D. C., Kingwell, B. A., & Sviridov, D. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.03.017 · Cited by 52 · see citing works
Endurance training enhances ABCA1 expression in rat small intestine
Khabazian, B. M., Ghanbari–Niaki, A., Safarzade, A., Ebrahimi, M., Rahbarizadeh, F., & Abednazari, H. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1133-3 · Cited by 50 · see citing works
Harmful Effects of Increased LDLR Expression in Mice With Human APOE*4 But Not APOE*3
Malloy, S. I., Altenburg, M. K., Knouff, C. W., Lanningham‐Foster, L., Parks, J. S., & Maeda, N. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000094963.07902.fb · Cited by 46 · see citing works
Ghanbari–Niaki, A., Saghebjoo, M., & Hedayati, M. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.08.001 · Cited by 44 · see citing works
Sgouraki, E., Tsopanakis, A., & Tsopanakis, C. (2001) · PubMed · Cited by 41 · see citing works
Gordon, P. M., Fowler, S., WARTY, V. S., Danduran, M., Visich, P. S., & Keteyian, S. J. (1998) · British Journal of Sports Medicine · doi:10.1136/bjsm.32.1.63 · Cited by 30 · see citing works
Angelopoulos, T. J., Robertson, R. M., Goss, F. L., Metz, K. F., & LaPorte, R. E. (1993) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021163 · Cited by 30 · see citing works
Effects of exercise with varying energy expenditure on high-density lipoprotein-cholesterol
Visich, P. S., Goss, F. L., Gordon, P. M., Robertson, R. J., WARTY, V. S., Denys, B. G., & Metz, K. F. (1996) · European Journal of Applied Physiology · doi:10.1007/bf00838646 · Cited by 26 · see citing works
Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1
Singaraja, R. R., James, E. R., Crim, J. L., Visscher, H., Chatterjee, A., & Hayden, M. R. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500133-jlr200 · Cited by 22 · see citing works
Effect of TNFα on activities of different promoters of human apolipoprotein A-I gene
Orlov, S., Mogilenko, D. A., Shavva, V. S., Dizhe, E. B., Ignatovich, I. A., & Ap, P. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.064 · Cited by 20 · see citing works
Rashidlamir, A., نیاکی, ع. ق., & Saadatnia, A. (2011) · Cited by 8 · see citing works
Study of Lipid Profile in Obese Individuals and the Effect of Cholesterol Lowering Agents on Them
Mukhopadhyay, S. K. (2012) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 6 · see citing works
Brundel, B. J. J. M., Oi, X., Yeh, Y., Shiroshita-Takeshita, A., Chartier, D., Henning, R. H., Kampinga, H. H., & Nattel, S. (2006) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 3 · see citing works
Optimizing Bicycle Fit for Performance
Marr, D. S. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000321398.21862.6f · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Effects of aerobic exercise on lipids and lipoproteins
Wang, Y., & Xu, D. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0515-5 · Cited by 436 · see citing works
Morton, A. B., Huertas, A. M., Hinkley, J. M., Ichinoseki‐Sekine, N., Christou, D. D., & Smuder, A. J. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.02.005 · Cited by 70 · see citing works
Exercise, Physical Activity, and Cardiometabolic Health
Belanger, M. J., Rao, P., & Robbins, J. (2021) · Cardiology in Review · doi:10.1097/crd.0000000000000417 · Cited by 60 · see citing works
Cancer therapy's impact on lipid metabolism: Mechanisms and future avenues
Bhatnagar, R., Dixit, N. M., Yang, E. H., & Sallam, T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.925816 · Cited by 47 · see citing works
Miele, E. M., Headley, S. A. E., Germain, M., Joubert, J., Herrick, S., Milch, C., Evans, E., Cornelius, A., Brewer, B., Taylor, B., et al. (2017) · Clinical Kidney Journal · doi:10.1093/ckj/sfx006 · Cited by 30 · see citing works
Rahmati-Ahmadabad, S., Azarbayjani, M. A., Farzanegi, P., & Moradi, L. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319887828 · Cited by 28 · see citing works
Rahmati-Ahmadabad, S., Shirvani, H., Ghanbari–Niaki, A., & Rostamkhani, F. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.036 · Cited by 27 · see citing works
Park, J., Choi, J., Kim, J.-E., Lee, M., Shin, A., Lee, J., Kang, D., & Choi, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-92312-x · Cited by 9 · see citing works
Expression of ABC transporter and scavenger receptor mRNAs in PBMCs in 100‐km ultramarathon runners
Juan, C., Li, L., Hou, S., Liu, P., Kao, W., Chiu, Y., & How, C. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13365 · Cited by 6 · see citing works
Bayat, G., Javan, M., Safari, F., Khalili, A., Shokri, S., Goudarzvand, M., Salimi, M., & Hajizadeh, S. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0040 · Cited by 4 · see citing works
Bagheri, R., Darroudi, S., Hosseini, S. M., Nikkar, H., Khodadadi, F., kasraee, S., sazegar, M., & Rashidlamir, A. (2020) · Medical Laboratory Journal · doi:10.29252/mlj.14.3.40 · Cited by 3 · see citing works
Wang, D., Zhang, P., & Li, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1190109 · Cited by 3 · see citing works
Sakr, H. I., Amen, M. A., Rashed, L. A., Khowailed, A. A., Sayed, H. A., Motawee, M. E. E., Sakr, H., & Khalifa, M. M. (2020) · Archives of Medical Science · doi:10.5114/aoms.2020.99023 · Cited by 3 · see citing works
Obi, P. O., Turner-Brannen, E., West, A. R., Labouta, H. I., Gordon, J. W., & Saleem, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.25.481852 · Cited by 2 · see citing works
Wang, Y., Xu, J., Yang, L., Zhang, N., Zhang, L., & Han, B. (2024) · Toxics · doi:10.3390/toxics12100748 · Cited by 1 · see citing works
Parsa, H., Alvar, Y. M., & آداب, ف. ع. (2021) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Hasanvand, B., Karami, K., & Mehrialvar, Y. (2019) · journal of ilam university of medical sciences · doi:10.29252/sjimu.27.2.30 · Cited by 1 · see citing works
Abadi, P. N. N., Etemad, Z., Hoseini, R., & Moradi, F. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Efectos del consumo moderado de cerveza sobre la salud cardiovascular
Sedano, S., & José, P. G. S. (2015)
Hajhosseini, M., Rashidlamir, A., Moazzami, M., & Moazenzadeh, M. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.22062/jkmu.2020.90638
Mulyawan, R., Sumaryanti, S., Nugroho, S., & Dev, R. D. O. (2023) · doi:10.56984/8zg07b425
Unraveling the Role of Physical Activity on Cardiovascular Health
Gupta, P., Ahuja, K. K., Das, B., Munjal, P., Shaik, T. A., & Jain, R. (2025) · Turkish Journal of Internal Medicine · doi:10.46310/tjim.1592426
- Authors
- Tofighi, A., Rahmani, F., Jamali Qarakhanlou, B., & Babaei, S.
- Affiliations
- Urmia University (IR)
- Corresponding author
- Babaei, Solmaz
- Venue
- Iranian Red Crescent Medical Journal
- Publisher
- DoNotEdit
- Published
- 2015-04-25
- Volume
- 17
- Issue
- 4
- Pages
- e26321-e26321
- ISSN
- 2074-1804 (ISSN-L)
- 2074-1812
- PMC
- PMC4443300
- OpenAlex
- W2136654917
- Cited by
- 22
- References
- 32
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2 · 2015: 2
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Iranian Red Crescent Medical Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- aerobic exercise, apolipoprotein A-I, reverse cholesterol transport, HDL cholesterol, LDL cholesterol, atherosclerosis prevention, sedentary women, cardiovascular risk
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
