The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
New Concepts on the Pathogenesis of Fever
Abstract
For more than 50 years, experimental studies on fever have focused on a substance from leukocytes called leukocytic or endogenous pyrogen. Various investigators concluded that changes associated with infection--such as numbers of circulating leukocytes; levels of trace metals, amino acids, and hepatic proteins; and altered lymphocyte function--were also caused by endogenous leukocyte mediators. There was reasonable evidence that fever and these other changes were brought about through the action of a single endogenous pyrogen, now known as interleukin 1 (IL-1). Two forms of IL-1 have been cloned (IL-1 beta and IL-1 alpha), and studies of recombinant IL-1 preparations have confirmed that fever and the broad spectrum of host responses to infection and injury are indeed mediated by this substance. However, IL-1 is not the only leukocyte product that induces fever: tumor necrosis factor (cachectin) and interferon produce fever in humans and animals. Accordingly, the concept of a single endogenous pyrogen now requires modification. Nature has conferred the ability to produce fever on no fewer than three structurally distinct molecules. Investigators trying to determine what triggers the hypothalamus to initiate fever in a particular disease must now consider these three endogenous pyrogens, either alone or together, as mediators of fever.
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Cites
Interleukin 1 of the central nervous system is produced by ameboid microglia.
Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B. (1986) · The Journal of experimental medicine · doi:10.1084/jem.164.2.594 · Cited by 859
FLOWER, R. J., & VANE, J. R. (1972) · Nature · doi:10.1038/240410a0 · Cited by 779
Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs
Blatteis, C. M., Bealer, S. L., Hunter, W. S., Llanos, J.-Q., Ahokas, R. A., & Mashburn, T. A. (1983) · Brain Research Bulletin · doi:10.1016/0361-9230(83)90124-7 · Cited by 213
Feldberg, W., Gupta, K. P., Milton, A. S., & Wendlandt, S. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010346 · Cited by 165
Cited by
Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1996) · Brain Research · doi:10.1016/0006-8993(96)00575-6 · Cited by 308
Tilders, F. J. H., DeRuk, R. H., Van Dam, A.-M., Vincent, V. A. M., Schotanus, K., & Persoons, J. H. A. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90010-8 · Cited by 277
Matsumura, K., Cao, C., Ozaki, M., Morii, H., Nakadate, K., & Watanabe, Y. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06279.1998 · Cited by 247
Niven, D. J., Gaudet, J. E., Laupland, K. B., Mrklas, K. J., Roberts, D. J., & Stelfox, H. T. (2015) · Annals of Internal Medicine · doi:10.7326/m15-1150 · Cited by 240
The metabolic effects of thermal injury
Tredget, E. E., & Yu, Y. M. (1992) · World Journal of Surgery · doi:10.1007/bf02067117 · Cited by 149
Lenczowski, M. J. P., Van Dam, A.-M., Poole, S., Larrick, J. W., & Tilders, F. J. H. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.6.r1870 · Cited by 115
Brooks-Asplund, E. M., Cannon, J. G., & Kenney, W. L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.3.r839 · Cited by 34
Self-citationHermus, A. R., Sweep, C. G., Demacker, P. N., van der Meer, M. J., Kloppenborg, P. W., & van der Meer, J. W. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.9.1036 · Cited by 12
Metadata
- Authors
- Dinarello, C. A., Cannon, J. G., & Wolff, S. M.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-01-01
- Volume
- 10
- Issue
- 1
- Pages
- 168-189
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2063041173
- Cited by
- 367
- References
- 4
- FWCI
- 27.14
- Type
- journal article
- Language
- en
- Open access
- closed
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