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Cited by 34Menopause: Health Impacts and TreatmentsThermoregulation and physiological responsesThermal Regulation in Medicine

Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women

Brooks-Asplund, E. M., Cannon, J. G., Kenney, W. L.·2000·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.2000.279.3.r839
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Abstract

Postmenopausal women receiving estrogen-replacement therapy (ERT) regulate body temperature (T b) at a lower level than women not receiving hormone replacement therapy (untreated) and women using estrogen plus progesterone therapy (E + P), but it is not clear if reproductive hormones alter T b by directly acting on central thermoregulatory centers or indirectly via a secondary mediator(s). The purpose of the present investigation was to examine the possible involvement of pyrogenic cytokines and cyclooxygenase (COX) products (e.g., prostaglandins) in the regulation of T b in three groups of postmenopausal women (8 ERT, 7 E + P, and 8 untreated). We measured ex vivo secretion of cytokine agonists [tumor necrosis factor (TNF)-α and interleukin (IL)-1β and -6] and modifiers (IL-2 soluble receptor, IL-1 receptor antagonist, soluble TNF receptor type I, soluble TNF receptor type II, soluble IL-6 receptor, and soluble glycoprotein 130) from peripheral blood mononuclear cells and thermoregulatory responses at rest and during 1 h of passive whole body heating in the postmenopausal women before and after 3 days of placebo or aspirin (50 mg · day−1· kg−1). With and without aspirin, the ERT group had a lower baseline rectal temperature (T re; 0.44°C, P < 0.004) and a reduced T b threshold for cutaneous vasodilation (0.29°C and 0.38°C, P < 0.01) compared with the untreated and E + P groups, respectively. In the placebo condition, waking morning oral temperature (T or) correlated with ex vivo secretion of the proteins associated with IL-6 bioactivity. Aspirin caused significant reductions in waking T or in the E + P group and in baseline T re in the untreated group. However, the difference in thermoregulation brought about by steroid hormone treatment could not be explained by these relatively modest apparent influences by cytokines and COX products. Therefore, the altered thermoregulation induced by reproductive steroid therapy appears to occur via a mechanism distinct from a classic infection-induced fever.

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Crossref · 10.1152/ajpregu.2000.279.3.r839

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  • Aspirin has only minor effects on oral body temperature in postmenopausal women taking hormone therapy (estrogen or combined estrogen/progesterone).

    “Brooks-Asplund et al. [164] found only minor effects of an antipyretic (aspirin) on oral body temperature and cytokine levels in postmenopausal women taking hormone therapy (estrogen or combined estrogen/progesterone), and no effect of aspirin on rectal temperature in the estrogen/progesterone group.”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [164]

  • Aspirin has no effect on rectal temperature in the estrogen/progesterone group of postmenopausal women taking hormone therapy.

    “Brooks-Asplund et al. [164] found only minor effects of an antipyretic (aspirin) on oral body temperature and cytokine levels in postmenopausal women taking hormone therapy (estrogen or combined estrogen/progesterone), and no effect of aspirin on rectal temperature in the estrogen/progesterone group.”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [164]

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Authors
Brooks-Asplund, E. M., Cannon, J. G., & Kenney, W. L.
Affiliations
Pennsylvania State University (US)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2000-09-01
Volume
279
Issue
3
Pages
R839-R848
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.2000.279.3.r839
OpenAlex
W1933584925
Cited by
34
References
37
Citations by year
2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 3 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
3.15
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01 AG-07004-09, R01AG007004)
  • National Center for Research Resources (MO1 RR10732, M01RR010732)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords
hormone replacement therapy, estrogen replacement therapy, aspirin, thermoregulation, postmenopausal women, pyrogenic cytokines, interleukin-6, TNF-α, interleukin-1, cyclooxygenase, prostaglandins, cutaneous vasodilation, rectal temperature, oral temperature, soluble cytokine receptors
MeSH terms
Aged, Arginine Vasopressin, Aspirin, Body Temperature Regulation, Cells, Cultured, Estrogens, Female, Hot Temperature, Humans, Interleukin-1, Lipopolysaccharides, Membrane Glycoproteins, Middle Aged, Osmolar Concentration, Progesterone, Sialoglycoproteins, Skin, Tumor Necrosis Factor-alpha, Vasodilation, Receptors, Interleukin-2, Antigens, CD, Interleukin-6, Cyclooxygenase Inhibitors, Postmenopause, Receptors, Tumor Necrosis Factor, Receptors, Interleukin-6, Hormone Replacement Therapy, Cytokine Receptor gp130, Interleukin 1 Receptor Antagonist Protein

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