The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on ‘coronary microvascular dysfunction in cardiovascular disease’
Open accessAbstract
Although myocardial ischaemia usually manifests as a consequence of atherosclerosis-dependent obstructive epicardial coronary artery disease, a significant percentage of patients suffer ischaemic events in the absence of epicardial coronary artery obstruction. Experimental and clinical evidence highlight the abnormalities of the coronary microcirculation as a main cause of myocardial ischaemia in patients with ‘normal or near normal’ coronary arteries on angiography. Coronary microvascular disturbances have been associated with early stages of atherosclerosis even prior to any angiographic evidence of epicardial coronary stenosis, as well as to other cardiac pathologies such as myocardial hypertrophy and heart failure. The main objectives of the manuscript are (i) to provide updated evidence in our current understanding of the pathophysiological consequences of microvascular dysfunction in the heart; (ii) to report on the current knowledge on the relevance of cardiovascular risk factors and comorbid conditions for microcirculatory dysfunction; and (iii) to evidence the relevance of the clinical consequences of microvascular dysfunction. Highlighting the clinical importance of coronary microvascular dysfunction will open the field for research and the development of novel strategies for intervention will encourage early detection of subclinical disease and will help in the stratification of cardiovascular risk in agreement with the new concept of precision medicine.
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Cites
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Self-citation2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz425 · Cited by 7,166
Self-citationFourth universal definition of myocardial infarction (2018)
Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., ESC Scientific Document Group, Thygesen, K., Alpert, J. S., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy462 · Cited by 5,880
Self-citationFourth Universal Definition of Myocardial Infarction (2018)
Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., & The Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction (2018) · Circulation · doi:10.1161/cir.0000000000000617 · Cited by 3,799
Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction
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Human epicardial adipose tissue is a source of inflammatory mediators
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“obesity, perivascular and epicardial adipose tissue accumulate around the coronary vasculature and heart and become inflamed.(53)”
BackgroundTIMI Frame Count: A Quantitative Method of Assessing Coronary Artery Flow
Gibson, C. M., Cannon, C. P., Daley, W. L., Dodge, J. T., Alexander, B., Marble, S. J., McCabe, C. H., Raymond, L., Fortin, T., Poole, W. K., et al. (1996) · Circulation · doi:10.1161/01.cir.93.5.879 · Cited by 1,866
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519
Prognostic Value of Coronary Vascular Endothelial Dysfunction
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“Thus, endothelial dysfunction is significantly associated with diffuse epicardial vasoconstrictor response following intracoronary infusion of acetylcholine with adverse cardiovascular events.(66) Assessment of endothelial function may identify early changes in vasoactive functions relevant in the development of ather…”
BackgroundWu, K. C., Zerhouni, E. A., Judd, R. M., Lugo-Olivieri, C. H., Barouch, L. A., Schulman, S. P., Blumenthal, R. S., & Lima, J. A. C. (1998) · Circulation · doi:10.1161/01.cir.97.8.765 · Cited by 1,357
Cited by
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Loffredo, G., Rinaldi, L., Catalini, C., Gjeloshi, K., Albanese, G., Di Martino, A., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092274 · Cited by 98
Sucato, V., Corrado, E., Manno, G., Amata, F., Testa, G., Novo, G., & Galassi, A. R. (2022) · Angiology · doi:10.1177/00033197211034267 · Cited by 21
Metadata
- Authors
- Padro, T., Manfrini, O., Bugiardini, R., Canty, J., Cenko, E., De Luca, G., Duncker, D. J., Eringa, E. C., Koller, A., Tousoulis, D., Trifunovic, D., Vavlukis, M., de Wit, C., & Badimon, L.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-02-08
- Volume
- 116
- Issue
- 4
- Pages
- 741-755
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W3005427274
- Cited by
- 294
- References
- 120
- FWCI
- 17.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Padro, T., Manfrini, O., Bugiardini, R., Canty, J., Cenko, E., De Luca, G., Duncker, D. J., Eringa, E. C., Koller, A., Tousoulis, D., Trifunovic, D., Vavlukis, M., de Wit, C., & Badimon, L. (2020). ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on ‘coronary microvascular dysfunction in cardiovascular disease’. Cardiovascular Research. https://doi.org/10.1093/cvr/cvaa003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
