The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4
Open accessAbstract
AIMS: The aims of the present study are to determine the miRNA expression signature in rat hearts after ischaemic preconditioning (IP) and to identify an IP-regulated miRNA, miR-21, in IP-mediated cardiac protection, and the potential cellular and molecular mechanisms involved. METHODS AND RESULTS: The miRNA expression signature was investigated in rat hearts. Among the 341 arrayed miRNAs, 40 miRNAs were differentially expressed (21 up and 19 down) in rat hearts with IP, compared with their controls. Some of these differentially expressed miRNAs were further verified by quantitative reverse transcriptase-polymerase chain reaction. Remarkably, miR-21 was one of most upregulated miRNAs in hearts after IP. In vivo, IP-mediated cardiac protection against ischaemia/reperfusion injury was inhibited by knockdown of cardiac miR-21. In cultured cardiac myocytes, we identified that miR-21 also had a protective effect on hypoxia/reoxygenation-induced cell apoptosis that was associated with its target gene, programmed cell death 4. The protective effect of miR-21 on cardiac cell apoptosis was further confirmed in rat hearts after ischaemia/reperfusion injury in vivo. CONCLUSION: The results suggest that miRNAs are involved in IP-mediated cardiac protection. Identifying the roles of IP-regulated miRNAs in cardiac protection may provide novel therapeutic and preventive targets for ischaemic heart disease.
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Self-citationAltered microRNA expression in human heart disease
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Cited by
Baggish, A. L., Hale, A., Weiner, R. B., Lewis, G. D., Systrom, D., Wang, F., Wang, T. J., & Chan, S. Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.213363 · Cited by 431
Hypoxia-regulated microRNAs in human cancer
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Anti-Apoptotic Effect of MicroRNA-21 after Contusion Spinal Cord Injury in Rats
Hu, J.-Z., Huang, J.-H., Zeng, L., Wang, G., Cao, M., & Lu, H.-B. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2748 · Cited by 153
Potential Clinical Implications of miR-1 and miR-21 in Heart Disease and Cardioprotection
Kura, B., Kalocayova, B., Devaux, Y., & Bartekova, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030700 · Cited by 106
Nie, Y., Han, B.-M., Liu, X.-B., Yang, J.-J., Wang, F., Cong, X.-F., & Chen, X. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.762 · Cited by 104
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Metadata
- Authors
- Cheng, Y., Zhu, P., Yang, J., Liu, X., Dong, S., Wang, X., Chun, B., Zhuang, J., & Zhang, C.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-10
- Volume
- 87
- Issue
- 3
- Pages
- 431-439
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2121236121
- Cited by
- 331
- References
- 21
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cheng, Y., Zhu, P., Yang, J., Liu, X., Dong, S., Wang, X., Chun, B., Zhuang, J., & Zhang, C. (2010). Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovascular Research. https://doi.org/10.1093/cvr/cvq082
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