Nitrite regulation of shock

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503 · see citing works

The epidemiology of sepsis in the United States from 1979 through 2000

Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841 · see citing works

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works

Hydrogen sulphide and its therapeutic potential

Szabó, C. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2425 · Cited by 2,039 · see citing works

The Journal of Laboratory and Clinical Medicine

(2003) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(03)00127-6 · Cited by 1,767 · see citing works

Association between mitochondrial dysfunction and severity and outcome of septic shock

Brealey, D. A., Brand, M. P., Hargreaves, I. P., Heales, S., Land, J. M., Smolenski, R. T., Davies, N. A., Cooper, C. E., & Singer, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09459-x · Cited by 1,505 · see citing works

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

Ong, S.-B., Subrayan, S., Lim, S. Y., Yellon, D. M., Davidson, S. M., & Hausenloy, D. J. (2010) · Circulation · doi:10.1161/circulationaha.109.906610 · Cited by 986 · see citing works

Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock*

López, A., Lorente, J. A., Steingrub, J. S., Bakker, J., McLuckie, A., Willatts, S. M., Brockway, M., Anzueto, A., Holzapfel, L., Breen, D. P., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000105581.01815.c6 · Cited by 917 · see citing works

Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms

Kim, Y.-M., Talanian, R. V., & Billiar, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.31138 · Cited by 887 · see citing works

Persistent inhibition of cell respiration by nitric oxide: Crucial role of <i>S</i> -nitrosylation of mitochondrial complex I and protective action of glutathione

Clementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7631 · Cited by 863 · see citing works

The microcirculation is the motor of sepsis.

İnce, C. (2005) · Critical Care · doi:10.1186/cc3753 · Cited by 786 · see citing works

Novel strategies for the treatment of sepsis

Riedemann, N. C., Guo, R., & Ward, P. A. (2003) · Nature Medicine · doi:10.1038/nm0503-517 · Cited by 774 · see citing works

Hypoxia and mitochondrial oxidative metabolism

Solaini, G., Baracca, A., Lenaz, G., & Sgarbi, G. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.011 · Cited by 608 · see citing works

Protective and pathological roles of nitric oxide in endotoxin shock

Wright, C. E., Rees, D. D., & Moncada, S. S. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.1.48 · Cited by 596 · see citing works

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works

Nitroglycerin in septic shock after intravascular volume resuscitation

Spronk, P. E., İnce, C., Gardien, M., Mathura, K. R., Straaten, H. M. O., & Zandstra, D. F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11393-6 · Cited by 541 · see citing works

Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals

Nisoli, E., Falcone, S., Tonello, C., Cozzi, V., Palomba, L., Fiorani, M., Pisconti, A., Brunelli, S., Cardile, A., Francolini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405432101 · Cited by 495 · see citing works

The inflammasomes: mechanisms of activation and function

Latz, E. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.12.004 · Cited by 455 · see citing works

Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology

van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works

Mechanisms of the Antioxidant Effects of Nitric Oxide

Wink, D. A., Miranda, K. M., Espey, M. G., Pluta, R. M., Hewett, S. J., Colton, C. A., Vitek, M. P., Feelisch, M., & Grisham, M. B. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601300185179 · Cited by 400 · see citing works

Effects of Nitric Oxide in Septic Shock

Vincent, J., Zhang, H., Szabó, C., & Preiser, J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.6.9812004 · Cited by 351 · see citing works

Nitric Oxide and Mitochondrial Signaling: From Physiology to Pathophysiology

Erusalimsky, J. D., & Moncada, S. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.151167 · Cited by 336 · see citing works

Redox Signaling, Vascular Function, and Hypertension

Lee, M. Y., & Griendling, K. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1986 · Cited by 241 · see citing works

Resuscitating the Microcirculation in Sepsis: The Central Role of Nitric Oxide, Emerging Concepts for Novel Therapies, and Challenges for Clinical Trials

Trzeciak, S. W., Cinel, İ., Dellinger, R. P., Shapiro, N. I., Arnold, R. C., Parrillo, J. E., Hollenberg, S. M., & on behalf of the Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators (2008) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2008.00109.x · Cited by 224 · see citing works

Caspase inhibition causes hyperacute tumor necrosis factor–induced shock via oxidative stress and phospholipase A2

Cauwels, A., Janssen, B. J., Waeytens, A., Cuvelier, C. A., & Brouckaert, P. (2003) · Nature Immunology · doi:10.1038/ni914 · Cited by 217 · see citing works

Review article: bacterial translocation in the critically ill – evidence and methods of prevention

Gatt, M., REDDY, B. S., & Macfie, J. M. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03174.x · Cited by 201 · see citing works

Cytokines and the immunomodulatory function of the vagus nerve

Johnston, G. R., & Webster, N. R. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aep037 · Cited by 201 · see citing works

Changing pattern of organ dysfunction in early human sepsis is related to mortality

Russell, J. A., Singer, J., Bernard, G. R., Wheeler, A. P., Fulkerson, W., Hudson, L. D., Schein, R. M. H., Summer, W. R., Wright, P. E., & Walley, K. R. (2000) · Critical Care Medicine · doi:10.1097/00003246-200010000-00005 · Cited by 181 · see citing works

Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation

Allen, B. W., Stamler, J. S., & Piantadosi, C. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.08.002 · Cited by 165 · see citing works

Understanding immunity requires more than immunology

Tracey, K. J. (2010) · Nature Immunology · doi:10.1038/ni0710-561 · Cited by 160 · see citing works

Oxidative Stress and Mitochondrial Dysfunction in Atherosclerosis: Mitochondria-Targeted Antioxidants as Potential Therapy

Víctor, V. M., Apostolova, N., Herance, J. R., Hernández‐Mijares, A., & Rocha, M. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709789878265 · Cited by 159 · see citing works

Nitric oxide in shock

Cauwels, A. (2007) · Kidney International · doi:10.1038/sj.ki.5002340 · Cited by 156 · see citing works

Is nitric oxide overproduction the target of choice for the management of septic shock?

Feihl, F., Waeber, B., & Liaudet, L. (2001) · Pharmacology &amp; Therapeutics · doi:10.1016/s0163-7258(01)00155-3 · Cited by 151 · see citing works

cGMP signalling in pre- and post-conditioning: the role of mitochondria

Costa, A. D. T., Pierre, S. V., Cohen, M. V., Downey, J. M., & Garlid, K. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm050 · Cited by 141 · see citing works

Nitric oxide and mitochondrial biogenesis: A key to long-term regulation of cellular metabolism

Clementi, E., & Nisoli, E. (2005) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2005.04.022 · Cited by 136 · see citing works

Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase*

Boulos, M., Astiz, M. E., Barua, R. S., & Osman, M. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050074.82486.b2 · Cited by 130 · see citing works

Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat

Boughton-Smith, N. K., Hutcheson, I. R., Deakin, A. M., Whittle, B. J. R., & Moncada, S. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)94185-z · Cited by 127 · see citing works

Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury

Bloomfield, G. L., Holloway, S., Ridings, P. C., Fisher, B. J., Blocher, C. R., Sholley, M. M., Bunch, T. J., Sugerman, H. J., & Fowler, A. A. (1997) · Critical Care Medicine · doi:10.1097/00003246-199704000-00006 · Cited by 123 · see citing works

Nutritional epidemiology in the context of nitric oxide biology: A risk-benefit evaluation for dietary nitrite and nitrate

Milkowski, A., Garg, H. K., Coughlin, J. R., & Bryan, N. S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.08.004 · Cited by 123 · see citing works

Nitric oxide‐sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition

Dangel, O., Mergia, E., Karlisch, K., Groneberg, D., Koesling, D., & Friebe, A. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03806.x · Cited by 118 · see citing works

Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation

Palma, C. D., Falcone, S., Pisoni, S., Cipolat, S., Panzeri, C., Pambianco, S., Pisconti, A., Allevi, R., Bassi, M. T., Cossu, G., et al. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.48 · Cited by 117 · see citing works

Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall

Alzawahra, W. F., Talukder, M. A. H., Liu, X., Samouilov, A., & Zweier, J. L. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00374.2008 · Cited by 111 · see citing works

Antioxidant treatment reverses mitochondrial dysfunction in a sepsis animal model

Zapelini, P. H., Rezin, G. T., Cardoso, M. R., Ritter, C., Klamt, F., Moreira, J. C. F., STRECK, E. L., & Dal‐Pizzol, F. (2008) · Mitochondrion · doi:10.1016/j.mito.2008.03.002 · Cited by 105 · see citing works

Brief Periods of Nitric Oxide Inhalation Protect against Myocardial Ischemia–Reperfusion Injury

Nagasaka, Y., Fernandez, B. O., Garcia-Saura, M. F., Petersen, B., Ichinose, F., Bloch, K. D., Feelisch, M., & Zapol, W. M. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318186316e · Cited by 101 · see citing works

Mitochondrial dysfunction in patients with severe sepsis: An EPR interrogation of individual respiratory chain components

Svistunenko, D. A., Davies, N. A., Brealey, D. A., Singer, M., & Cooper, C. E. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.007 · Cited by 95 · see citing works

Smooth Muscle–Specific Deletion of Nitric Oxide–Sensitive Guanylyl Cyclase Is Sufficient to Induce Hypertension in Mice

Groneberg, D., König, P., Wirth, A., Offermanns, S., Koesling, D., & Friebe, A. (2010) · Circulation · doi:10.1161/circulationaha.109.890962 · Cited by 93 · see citing works

Mitochondria as metabolizers and targets of nitrite

Shiva, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.09.002 · Cited by 87 · see citing works

Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner

Cauwels, A., Buys, E. S., Thoonen, R., Geary, L., Delanghe, J., Shiva, S., & Brouckaert, P. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091236 · Cited by 80 · see citing works

Effects of nitrite on modulating ROS generation following ischemia and reperfusion

Raat, N. J. H., Shiva, S., & Gladwin, M. T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.02.002 · Cited by 79 · see citing works

Plasma-induced endothelial oxidative stress is related to the severity of septic shock*

Huet, O., Obata, R., Aubron, C., Spraul, A., Charpentier, J., Laplace, C., Nguyen‐Khoa, T., Conti, M., Vicaut, É., Mira, J. P., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000257464.79067.af · Cited by 78 · see citing works

Role of inducible nitric oxide synthase in the regulation of leucocyte recruitment

Hickey, M. J. (2001) · Clinical Science · doi:10.1042/cs20000135 · Cited by 77 · see citing works

Cellular Dysfunction in Sepsis

Singer, M. (2008) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2008.06.003 · Cited by 77 · see citing works

INCREASED NITRIC OXIDE SYNTHESIS DURING THE DEVELOPMENT OF ENDOTOXIN TOLERANCE

Zingarelli, B., Halushka, P. V., Caputi, A. P., & Cook, J. A. (1995) · Shock · doi:10.1097/00024382-199502000-00004 · Cited by 76 · see citing works

Nitrite directly vasodilates hypoxic vasculature via nitric oxide‐dependent and ‐independent pathways

Pinder, A. G., Pittaway, E., Morris, K., & James, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00340.x · Cited by 66 · see citing works

Inhaled Nitric Oxide Primes Lung Macrophages to Produce Reactive Oxygen and Nitrogen Intermediates

Weinberger, B. I., Fakhrzadeh, L., Heck, D. E., Laskin, J. D., Gardner, C. R., & Laskin, D. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.3.9708014 · Cited by 59 · see citing works

Exogenous nitric oxide prevents endotoxin-induced glomerular thrombosis in rats

Westberg, G., Shultz, P. J., & Raij, L. R. (1994) · Kidney International · doi:10.1038/ki.1994.325 · Cited by 54 · see citing works

Effects of nitric oxide on blood flow distribution and O2extraction capabilities during endotoxic shock

Zhang, H., Rogiers, P., Smaïl, N., Cabral, A., Preiser, J., Peny, M.-O., & Vincent, J. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.4.1164 · Cited by 54 · see citing works

Effects of Nitric Oxide Donor SIN-1 on Oxygen Availability and Regional Blood Flow During Endotoxic Shock

Zhang, H. (1996) · Archives of Surgery · doi:10.1001/archsurg.1996.01430190089022 · Cited by 52 · see citing works

Nitric oxide donor prevents hepatic and systemic perfusion decrease induced by endotoxin in anesthetized rabbits

Pastor, C. M., Losser, M.-R., & Payen, D. M. (1995) · Hepatology · doi:10.1002/hep.1840220530 · Cited by 52 · see citing works

Myocardial cytochrome oxidase activity is decreased following carbon monoxide exposure

Iheagwara, K. N., Thom, S. R., Deutschman, C. S., & Levy, R. J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.06.002 · Cited by 52 · see citing works

Is MOF an outcome parameter or a transient, adaptive state in critical illness?

Mongardon, N., Dyson, A., & Singer, M. (2009) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e3283307a3b · Cited by 49 · see citing works

sGCα₁β₁attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Buys, E. S., Cauwels, A., Raher, M. J., Passeri, J. J., Hobai, I., Cawley, S. M., Rauwerdink, K. M., Thibault, H., Sips, P. Y., Thoonen, R., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00367.2009 · Cited by 49 · see citing works

The nitric oxide donor sodium nitroprusside protects against hepatic microcirculatory dysfunction in early endotoxaemia

Gundersen, Y., Corso, C. O., Leiderer, R., Dörger, M., Lilleaasen, P., Aasen, A. O., & Meßmer, K. (1998) · Intensive Care Medicine · doi:10.1007/s001340050759 · Cited by 46 · see citing works

EFFECT OF MODIFYING NITRIC OXIDE PATHWAY ON LIVER CIRCULATION IN A RABBIT ENDOTOXIN SHOCK MODEL

Pastor, C. M., & Payen, D. M. (1994) · Shock · doi:10.1097/00024382-199409000-00007 · Cited by 42 · see citing works

The NO donor SIN‐1 improves intestinal–arterial Pco2 gap in experimental endotoxemia: an animal study

Siegemund, M., van Bommel, J., Sinaasappel, M., Schwarte, L. A., Studer, W., Girard, T., Vollebregt, K. C., & İnce, C. (2007) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2007.01334.x · Cited by 41 · see citing works

Treatment of septic shock in rats with nitric oxide synthase inhibitors and inhaled nitric oxide

Pedoto, A. C., Tassiopoulos, A. K., Oler, A., McGraw, D. J., Hoffmann, S. P., Camporesi, E. M., & HAKIM, T. S. (1998) · Critical Care Medicine · doi:10.1097/00003246-199812000-00034 · Cited by 40 · see citing works

Systemic and Gut O2 Extraction during Endotoxemia. Role of Nitric Oxide Synthesis

Schumacker, P. T., Kazaglis, J., Connolly, H., Samsel, R. W., O’Connor, M. F., & Umans, J. G. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.1.7812539 · Cited by 38 · see citing works

Controversies in the Treatment of Sepsis

Sandrock, C., & Albertson, T. E. (2010) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0029-1246290 · Cited by 37 · see citing works

Mediator modulation therapy of severe sepsis and septic shock: Does it work? *

Dellinger, R. P., & Parrillo, J. E. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000105423.06091.8e · Cited by 37 · see citing works

Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats

Nevière, R., Guery, B. P., Mordon, S. R., Zerimech, F., Charré, S., Wattel, F., & Chopin, C. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.6.h1783 · Cited by 31 · see citing works

S-nitroso human serum albumin given after LPS challenge reduces acute lung injury and prolongs survival in a rat model of endotoxemia

Jakubowski, A., Максимович, Н. Е., Olszanecki, R., Gębska, A., Gasser, H., Podesser, B. K., Hallström, S., & Chłopicki, S. (2008) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-008-0351-2 · Cited by 28 · see citing works

Delayed Administration of Inhaled Nitric Oxide Preserves Alveolar-Capillary Membrane Integrity in Porcine Gram-negative Sepsis

Bloomfield, G. L. (1997) · Archives of Surgery · doi:10.1001/archsurg.1997.01430250067016 · Cited by 28 · see citing works

Attenuation by nitrosothiol NO donors of acute intestinal microvascular dysfunction in the rat

László, F. A., Whittle, B. J. R., & Moncada, S. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16361.x · Cited by 28 · see citing works

Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock

Cauwels, A., Rogge, E., Janssen, B. J., & Brouckaert, P. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0633-2 · Cited by 25 · see citing works

Inhaled nitric oxide modulates leukocyte kinetics in the mesenteric venules of endotoxemic rats

Nevière, R., Mordon, S. R., Maréchal, X., Buys, B., Guery, B. P., Mathieu, D., Wattel, F., & Chopin, C. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004000-00027 · Cited by 23 · see citing works

MOLSIDOMINE INCREASES ENDOTOXIC SURVIVAL AND DECREASES CYTOKINE PRODUCTION

Kumins, N. H., Hunt, J., Gamelli, R. L., & Filkins, J. P. (1997) · Shock · doi:10.1097/00024382-199703000-00008 · Cited by 23 · see citing works

Effects of sodium nitroprusside on splanchnic microcirculation in a resuscitated porcine model of septic shock

Assadi, A., Desebbe, O., Kaminski, C., Rimmele, T. R., Benatir, F., Goudable, J., CHASSARD, D., & Allaouchiche, B. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem278 · Cited by 23 · see citing works

EFFECTS OF 1400W AND/OR NITROGLYCERIN ON RENAL OXYGENATION AND KIDNEY FUNCTION DURING ENDOTOXAEMIA IN ANAESTHETIZED RATS

Johannes, T., Mik, E. G., Klingel, K., Goedhart, P. T., Zanke, C., Nohé, B., Dieterich, H. ‐., Unertl, K. E., & İnce, C. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05204.x · Cited by 21 · see citing works

The Nitric Oxide Donor Molsidomine Improves Survival and Reduces Hepatocyte Apoptosis in Cholestasis and Endotoxemia

Brown, K. M., Brems, J. J., Moazzam, F. N., Hartman, G., Gamelli, R. L., & Ding, J. W. (2003) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(03)00386-7 · Cited by 21 · see citing works

Nitric Oxide Administration Restores the Hepatic Artery Buffer Response During Porcine Endotoxemia

Tamandl, D., Jørgensen, P. F., Gundersen, Y., Fuegger, R., Sautner, T., Aasen, A. O., & Goetzinger, P. (2008) · Journal of Investigative Surgery · doi:10.1080/08941930802130131 · Cited by 14 · see citing works

ENDOTOXIN‐INDUCED ACUTE LUNG INJURY IS ENHANCED IN RATS WITH SPONTANEOUS HYPERTENSION

Liu, D. D., Hsu, Y. H., & Chen, H. I. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04526.x · Cited by 12 · see citing works

Effect of sepsis therapies on health-related quality of life

Erickson, S. E., & Martin, G. S. (2008) · Critical Care · doi:10.1186/cc6215 · Cited by 10 · see citing works

Effect of nitric oxide donors and nitric oxide synthase inhibitors in neonatal rat endotoxic shock

Cochran, J. B., Genovese, F., Ogura, S., Teti, G., & Cook, J. A. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00128-8 · Cited by 8 · see citing works

Modulators of Nitric Oxide in Porcine Endotoxemia: Effects on Hepatic Oxygen Delivery and Consumption

Gundersen, Y., tre, T. S. A., Carlsen, H. S., Scholz, T., Lilleaasen, P., & Aasen, A. O. (2008) · European Surgical Research · doi:10.1159/000129529 · Cited by 7 · see citing works

Diltiazem treatment of endotoxic shock in suckling rats.

Gotō, M., Zeller, W. P., Rc, L., & Rm, H. (1992) · PubMed · Cited by 5 · see citing works

Nitric oxide donor prevents hepatic and systemic perfusion decrease induced by endotoxin in anesthetized rabbits*1

Pastor, C. M. (1995) · Hepatology · doi:10.1016/0270-9139(95)90163-9 · Cited by 3 · see citing works

The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology

Graves, D. B. (2012) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,512 · see citing works

Genetic association studies of angiogenesis- and vasoconstriction-related genes in women with recurrent pregnancy loss: a systematic review and meta-analysis

Su, M., Lin, S., & Chen, Y. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr027 · Cited by 154 · see citing works

Inorganic nitrite therapy: historical perspective and future directions

Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works

Vasoplegia in patients with sepsis and septic shock: pathways and mechanisms

Burgdorff, A.-M., Bucher, M., & Schumann, J. E. (2018) · Journal of International Medical Research · doi:10.1177/0300060517743836 · Cited by 107 · see citing works

Circulating microparticles from septic shock patients exert differential tissue expression of enzymes related to inflammation and oxidative stress*

Mastronardi, M. L., Mostefai, H. A., Meziani, F., Martínez, M. C., Asfar, P., & Andriantsitohaina, R. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182190b4b · Cited by 90 · see citing works

New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsis

Huttunen, R., & Aittoniemi, J. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.08.004 · Cited by 70 · see citing works

Inorganic nitrite supplementation for healthy arterial aging

Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works

Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review

Blot, S. (2021) · Intensive Care Medicine · doi:10.1007/s00134-020-06276-z · Cited by 73 · see citing works

Nitrate/Nitrite as Critical Mediators to Limit Oxidative Injury and Inflammation

Waltz, P., Escobar, D., Botero, A. M., & Zuckerbraun, B. S. (2015) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2015.6256 · Cited by 70 · see citing works

Nitrite in organ protection

Rassaf, T., Ferdinandy, P., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12291 · Cited by 62 · see citing works

Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis

Fletcher, A. L., Elman, J. S., Astarita, J. L., Murray, R. M., Saeidi, N., D’Rozario, J., Knoblich, K., Brown, F. D., Schildberg, F. A., Nieves-Bonilla, J. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009377 · Cited by 50 · see citing works

Induction of mitochondrial dysfunction and oxidative stress in human fibroblast cultures exposed to serum from septic patients

Raffaella, T., Fiore, F., Massaro, F., Francesco, P. D., Arcangela, I., Scacco, S., Santacroce, L., & Brienza, N. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.06.041 · Cited by 37 · see citing works

Gaseous Mediators in Temperature Regulation

Branco, L. G. S., Soriano, R. N., & Steiner, A. A. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130053 · Cited by 38 · see citing works

Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis

Fang, H., Jiang, W., Jin, C. S., Lu, Y., Liu, A., Kan, L., & Dahmen, U. (2015) · Journal of Immunology Research · doi:10.1155/2015/187048 · Cited by 36 · see citing works

Extending the translational potential of targeting NO/ cGMP ‐regulated pathways in the CVS

Papapetropoulos, A., Hobbs, A. J., & Topouzis, S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12980 · Cited by 34 · see citing works

Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model

Murata, I., Nozaki, R., Ooi, K., Ohtake, K., Kimura, S., Ueda, H., Nakano, G., Sonoda, K., Inoue, Y., Uchida, H., et al. (2012) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0b013e31824a76b5 · Cited by 33 · see citing works

Asymmetric dimethylarginine and critical illness

Brinkmann, S. J. H., de Boer, M. C., Buijs, N., & van Leeuwen, P. A. M. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000020 · Cited by 33 · see citing works

Review focus on inorganic nitrite and nitrate in cardiovascular health and disease

Kevil, C. G., & Lefer, D. J. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq409 · Cited by 32 · see citing works

Betulinic acid negates oxidative lung injury in surgical sepsis model

Lingaraju, M. C., Pathak, N. N., Begum, J., Balaganur, V., Bhat, R. A., Ram, M., Kumar, D., Kumar, D., & Tandan, S. K. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.09.008 · Cited by 24 · see citing works

Electro-Acupuncture at ‘neiguan— (Pc6) Attenuates Liver Injury in Endotoxaemic Rats

Liu, H.-W., Liu, M.-C., Tsao, C., Liao, M., & Wu, C. (2011) · Acupuncture in Medicine · doi:10.1136/aim.2010.003525 · Cited by 18 · see citing works

Ailanthoidol suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

Kim, J., & Jun, J. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23312 · Cited by 17 · see citing works

Overexpression of GTP Cyclohydrolase 1 Feedback Regulatory Protein Is Protective in a Murine Model of Septic Shock

Starr, A., Sand, C. A., Heikal, L., Kelly, P. D., Spina, D., Crabtree, M. J., Channon, K. M., LEIPER, J. M., & Nandi, M. (2014) · Shock · doi:10.1097/shk.0000000000000235 · Cited by 13 · see citing works

Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

Kaur, M., Kaur, R., Chhabra, K., & Khetarpal, P. (2023) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14701 · Cited by 12 · see citing works

Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction

Singer, G., Stokes, K. Y., & Granger, D. N. (2012) · Inflammation Research · doi:10.1007/s00011-012-0562-3 · Cited by 11 · see citing works

TLR2 activation causes no morbidity or cardiovascular failure, despite excessive systemic nitric oxide production

Cauwels, A., Vandendriessche, B., Bultinck, J., Descamps, B., Rogge, E., Nieuwenhuysen, T. V., Sips, M., Vanhove, C., & Brouckaert, P. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt168 · Cited by 11 · see citing works

Estradiol to Androstenedione Ratios Moderate the Relationship between Neurological Injury Severity and Mortality Risk after Severe Traumatic Brain Injury

Ranganathan, P. R., Kumar, R. G., Oh, B., Rakholia, M. V., Berga, S. L., & Wagner, A. K. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5677 · Cited by 8 · see citing works

Nitric Oxide Therapeutics: New Hopes for More Effective Tuberculosis Treatment Combine with Targeted and Controlled Nanotechnology

Jin, X., Wang, J., Ruan, Y., Li, J., Kong, X., Xia, J., Yang, J., Zhang, Q., Liu, J., & Pi, J. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s531255 · Cited by 7 · see citing works

High‐Volume Hemofiltration Reduces the Expression of Myocardial Tumor Necrosis Factor‐Alpha in Septic Shock Pigs

Li, C., Zhang, P., Cheng, X., & Chen, J. (2012) · Artificial Organs · doi:10.1111/j.1525-1594.2012.01536.x · Cited by 6 · see citing works

Nitrite and Nitric Oxide as Potential Diagnostic Markers in Acute Vascular Diseases

Silver, J. H. (2011) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.s1-005 · Cited by 6 · see citing works

Nitrate and Nitrite in Aging and Age-Related Disease

Johnson, L. C., DeVan, A. E., Justice, J. N., & Seals, D. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_18 · Cited by 5 · see citing works

Immunomodulation by Vasoactive Intestinal Polypeptide (VIP)

Hooper, K. M., Kong, W., & Ganea, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-28609-9_5 · Cited by 3 · see citing works

Gaseous Mediators in Temperature Regulation

Branco, L. G. S., Soriano, R. N., & Steiner, A. A. (2014) · Comprehensive physiology · doi:10.1002/j.2040-4603.2014.tb00586.x · Cited by 2 · see citing works

Low-dose plasmid DNA treatment increases plasma vasopressin and regulates blood pressure in experimental endotoxemia

Malardo, T., Batalhão, M. E., Panunto-Castelo, A., de Almeida, L. P., Padilha, É., Fontoura, I. C., Silva, C. L., Cárnio, E. C., & Coelho‐Castelo, A. A. M. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-59 · Cited by 2 · see citing works

Pathways to Reduce Late Mortality of Hemorrhagic Shock

Bonanno, F. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1004934 · Cited by 2 · see citing works

ANESTEZJOLOGIA I INTENSYWNA TERAPIA Inhaled nitric oxide effects outside the lungs – experimental and clinical evidence

Goździk, W., & Goździk, A. (2012) · Polish Journal of Cardio-Thoracic Surgery · doi:10.5114/kitp.2012.32684 · Cited by 1 · see citing works

JAK/STAT Signalling in the Induction of the L-Arginine-Nitric Oxide Pathway in Macrophages and Vascular Smooth Muscle Cells

Garr, E. (2014) · University of Hertfordshire Research Archive (University of Hertfordshire) · doi:10.18745/th.13825 · Cited by 1 · see citing works

Y a-t-il une place pour les dérivés nitrés dans le traitement du choc septique ?

Favory, R., Poissy, J., Vanbaelinghem, C., & Mathieu, D. (2012) · Réanimation · doi:10.1007/s13546-012-0446-4

Efeito da ghrelina sobre o eixo GH/IGF-1 em animais submetidos à endotoxemia

Faim, F. D. L. (2018) · doi:10.11606/t.17.2018.tde-13092018-142102

Contemporary Approach to Trauma and Emergency Surgery

Karcioglu, O., & Akman, C. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1001692

News updates

(2010) · Lab Animal · doi:10.1038/laban0210-29 · Cited by 1 · see citing works

[Septic shock and nitric oxide].

Lorente, J. A., Delgado, M. A., & Landín, L. (1997) · PubMed · Cited by 5 · see citing works

Nitric oxide in septic shock: directions for future therapy?

Hon, W., Khoo, H. E., & Moochhala, S. (1998) · PubMed · Cited by 6 · see citing works

Hypoxic NO-donor nitrite protects sGC-dependently against morbidity and mortality associated with sterile inflammatory shock in mice

Cauwels, A., Vandendriessche, B., Rogge, E., Shiva, S., & Brouckaert, P. (2011) · Critical Care · doi:10.1186/cc9677

The role of nitric oxide in sepsis – an overview

Kirkebøen, K. A., & Strand, Ø. A. (1999) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.1999.430307.x · Cited by 278 · see citing works