Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation
Open accessAbstract
The protected transport of nitric oxide (NO) by hemoglobin (Hb) links the metabolic activity of working tissue to the regulation of its local blood supply through hypoxic vasodilation. This physiologic mechanism is allosterically coupled to the O(2) saturation of Hb and involves the covalent binding of NO to a cysteine residue in the beta-chain of Hb (Cys beta93) to form S-nitrosohemoglobin (SNO-Hb). Subsequent S-transnitrosation, the transfer of NO groups to thiols on the RBC membrane and then in the plasma, preserves NO vasodilator activity for delivery to the vascular endothelium. This SNO-Hb paradigm provides insight into the respiratory cycle and a new therapeutic focus for diseases involving abnormal microcirculatory perfusion. In addition, the formation of S-nitrosothiols in other proteins may regulate an array of physiological functions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Evidence for nitrite reactions with erythrocytic hemoglobin and stimulation of hypoxic blood flow remains more limited and is the subject of much debate.
“The evidence for nitrite reactions with erythrocytic hemoglobin and stimulation of hypoxic blood flow remains more limited and is the subject of much debate [16, 61].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744 · see citing works
Self-citationNitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
Bolotina, V. M., Najibi, S., Palacino, J. J., Pagano, P. J., & Cohen, R. A. (1994) · Nature · doi:10.1038/368850a0 · Cited by 1,676 · see citing works
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,586 · see citing works
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine · doi:10.1038/nm1202-799 · Cited by 1,330 · see citing works
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261 · see citing works
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., et al. (2002) · Nature Medicine · doi:10.1038/nm799 · Cited by 1,097 · see citing works
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092 · see citing works
Blood Flow Regulation by <i>S</i> -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050 · see citing works
Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973 · see citing works
The human protein disulphide isomerase family: substrate interactions and functional properties
Ellgaard, L., & Ruddock, L. W. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400311 · Cited by 757 · see citing works
Protein S-nitrosylation in health and disease: a current perspective
Foster, M. W., Hess, D. T., & Stamler, J. S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.007 · Cited by 752 · see citing works
Evolution of adverse changes in stored RBCs
Bennett‐Guerrero, E., Veldman, T. H., Doctor, A., Telen, M. J., Ortel, T. L., Reid, T. S., Mulherin, M. A., Zhu, H., Buck, R. D., Califf, R. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708160104 · Cited by 614 · see citing works
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586 · see citing works
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585 · see citing works
Export by red blood cells of nitric oxide bioactivity
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2001) · Nature · doi:10.1038/35054560 · Cited by 579 · see citing works
Self-citationEssential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock
Liu, L., Yan, Y., Zeng, M., Zhang, J., Hanes, M. A., Ahearn, G. S., McMahon, T., Dickfeld, T. L., Marshall, H. E., Que, L. G., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00131-x · Cited by 546 · see citing works
Regulation of Blood Flow in the Microcirculation
Segal, S. S. (2005) · Microcirculation · doi:10.1080/10739680590895028 · Cited by 537 · see citing works
The erythrocyte as a regulator of vascular tone
Ellsworth, M. L., Forrester, T., Ellis, C. G., & Dietrich, H. H. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.6.h2155 · Cited by 508 · see citing works
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
Crawford, J. H. (2006) · Blood · doi:10.1182/blood-2005-07-2668 · Cited by 497 · see citing works
Singel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481 · see citing works
Self-citationThe mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels
Weir, E. K., & Archer, S. L. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781921 · Cited by 466 · see citing works
Nitric oxide in the human respiratory cycle
McMahon, T., Moon, R. E., Luschinger, B. P., Carraway, M. S., Stone, A. E., Stolp, B. W., Gow, A. J., Pawloski, J. R., Watke, P., Singel, D. J., et al. (2002) · Nature Medicine · doi:10.1038/nm718 · Cited by 462 · see citing works
Gladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441 · see citing works
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin
Gibson, Q. H., & Roughton, F. J. W. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005777 · Cited by 396 · see citing works
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
Nitrite‐derived nitric oxide: a possible mediator of ‘acidic–metabolic’ vasodilation
Modin, A., Björne, H., Herulf, M., Alving, K., Weitzberg, E., & Lundberg, J. O. N. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00771.x · Cited by 346 · see citing works
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341 · see citing works
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334 · see citing works
Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334 · see citing works
Erythrocyte and the Regulation of Human Skeletal Muscle Blood Flow and Oxygen Delivery
González‐Alonso, J., Olsen, D. B., & Saltin, B. (2002) · Circulation Research · doi:10.1161/01.res.0000044939.73286.e2 · Cited by 331 · see citing works
Ignarro, L. J., & Gruetter, C. S. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90297-4 · Cited by 317 · see citing works
Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease-Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112761 · Cited by 298 · see citing works
Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease‐Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12761 · Cited by 289 · see citing works
S -nitrosohemoglobin deficiency: A mechanism for loss of physiological activity in banked blood
Reynolds, J. D. H., Ahearn, G. S., Angelo, M., Zhang, J., Cobb, F. R., & Stamler, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707958104 · Cited by 282 · see citing works
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281 · see citing works
Gladwin, M. T., Ognibene, F. P., Pannell, L. K., Nichols, J. S., Pease‐Fye, M. E., Shelhamer, J. H., & Schechter, A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180155397 · Cited by 274 · see citing works
Martinez‐Lemus, L. A., Hill, M. A., & Meininger, G. A. (2009) · Physiology · doi:10.1152/physiol.00029.2008 · Cited by 254 · see citing works
An <i>S</i> -nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate
Angelo, M., Singel, D. J., & Stamler, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600942103 · Cited by 233 · see citing works
Self-citationPotential Oxidative Stress of Gold Nanoparticles by Induced-NO Releasing in Serum
Jia, H., Liu, Y., Zhang, X. J., Han, L., Du, L. B., Tian, Q., & Xu, Y. C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja808033w · Cited by 228 · see citing works
Endogenous S -nitrosothiols protect against myocardial injury
Lima, B., Lam, G. K. W., Xie, L., Diesen, D. L., Villamizar, N. R., Nienaber, J. J., Messina, E., Bowles, D. E., Kontos, C. D., Hare, J. M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901043106 · Cited by 223 · see citing works
Joshi, M. S., Ferguson, T. B., Han, T. H., Hyduke, D. R., Liao, J. C., Rassaf, T., Bryan, N., Feelisch, M., & Lancaster, J. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152149699 · Cited by 216 · see citing works
Wiley, K. E., & Davenport, A. P. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704815 · Cited by 213 · see citing works
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans
Maher, A. R., Milsom, A. B., Gunaruwan, P., Abozguia, K., Ahmed, I., Weaver, R. A., Thomas, P., Ashrafian, H., Born, G. V. R., James, P. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.719591 · Cited by 210 · see citing works
Hemoglobin conformation couples erythrocyte S -nitrosothiol content to O 2 gradients
Doctor, A., Platt, R., Sheram, M. L., Eischeid, A. C., McMahon, T., Maxey, T., Doherty, J., Axelrod, M. J., Kline, J. M., Gurka, M. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407490102 · Cited by 205 · see citing works
Webb, A. J., Milsom, A. B., Rathod, K. S., Chu, W. L., Qureshi, S., Lovell, M. J., Lecomte, F. M. J., Perrett, D., Raimondo, C., Khoshbin, E., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.175810 · Cited by 203 · see citing works
Luchsinger, B. P., Rich, E. N., Gow, A. J., Williams, E. M., Stamler, J. S., & Singel, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0233287100 · Cited by 202 · see citing works
Capillary recruitment in exercise: rate, extent, uniformity, and relation to blood flow
Honig, C. R., Odoroff, C. L., & Frierson, J. L. (1980) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1980.238.1.h31 · Cited by 191 · see citing works
Roach, R. C., Koskolou, M. D., Calbet, J. A. L., & Saltin, B. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.2.h438 · Cited by 177 · see citing works
CARLSEN, E. N., & Comroe, J. H. (1958) · The Journal of General Physiology · doi:10.1085/jgp.42.1.83 · Cited by 177 · see citing works
<i>S</i> -Nitrosothiols in the Blood: Roles, Amounts, and Methods of Analysis
Stamler, J. S. (2004) · Circulation Research · doi:10.1161/01.res.0000122071.55721.bc · Cited by 170 · see citing works
S-Nitrosothiols signal hypoxia-mimetic vascular pathology
Palmer, L. A., Doctor, A., Chhabra, P., Sheram, M. L., Laubach, V. E., Karlinsey, M. Z., Forbes, M. S., Macdonald, T. L., & Gaston, B. M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29444 · Cited by 161 · see citing works
SNO-hemoglobin is not essential for red blood cell–dependent hypoxic vasodilation
Isbell, T. S., Sun, C.-W., Wu, L.-C., Teng, X., Vitturi, D. A., Branch, B. G., Kevil, C. G., Peng, N., Wyss, J. M., Ambalavanan, N., et al. (2008) · Nature Medicine · doi:10.1038/nm1771 · Cited by 157 · see citing works
Hypoxic Vasodilation by Red Blood Cells
Diesen, D. L., Hess, D. T., & Stamler, J. S. (2008) · Circulation Research · doi:10.1161/circresaha.108.176867 · Cited by 145 · see citing works
Functional Coupling of Oxygen Binding and Vasoactivity inS-Nitrosohemoglobin
McMahon, T., Stone, A. E., Bonaventura, J., Singel, D. J., & Stamler, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000532200 · Cited by 140 · see citing works
Impaired vasodilation by red blood cells in sickle cell disease
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409876102 · Cited by 137 · see citing works
Liu, Z., Rudd, M. A., Freedman, J. E., & Loscalzo, J. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37255-6 · Cited by 131 · see citing works
Gladwin, M. T., Schechter, A. N., Shelhamer, J. H., Pannell, L. K., Conway, D. A., Hrinczenko, B. W., Nichols, J. S., Pease‐Fye, M. E., Noguchi, C. T., Rodgers, G. P., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7637 · Cited by 131 · see citing works
McMahon, T., Ahearn, G. S., Moya, M. M., Gow, A. J., Huang, Y.-C. T., Luchsinger, B. P., Nudelman, R., Yan, Y., Krichman, A. D., Bashore, T. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506957102 · Cited by 130 · see citing works
Vasorelaxation by Red Blood Cells and Impairment in Diabetes
James, P. E., Lang, D., Tufnell-Barret, T., Milsom, A. B., & Frenneaux, M. P. (2004) · Circulation Research · doi:10.1161/01.res.0000122044.21787.01 · Cited by 125 · see citing works
Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn
Moya, M. P., Gow, A. J., Califf, R. M., Goldberg, R. N., & Stamler, J. S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09385-6 · Cited by 123 · see citing works
S-Nitrosothiol measurements in biological systems
Gow, A. J., Doctor, A., Mannick, J. B., & Gaston, B. M. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.01.052 · Cited by 122 · see citing works
Bioactivation of Nitroglycerin by the Mitochondrial Aldehyde Dehydrogenase
Chen, Z., & Stamler, J. S. (2006) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2006.05.001 · Cited by 117 · see citing works
Autoregulation of blood flow by oxygen lack
Ross, J. M., Fairchild, H. M., Weldy, J., & Guyton, A. C. (1962) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1962.202.1.21 · Cited by 113 · see citing works
A Genetic Analysis of Nitrosative Stress
Foster, M. W., Liu, L., Zeng, M., Hess, D. T., & Stamler, J. S. (2009) · Biochemistry · doi:10.1021/bi801813n · Cited by 112 · see citing works
Crawford, J. H., Chacko, B. K., Pruitt, H. M., Piknova, B., Hogg, N., & Patel, R. P. (2004) · Blood · doi:10.1182/blood-2004-03-0880 · Cited by 111 · see citing works
Dalsgaard, T., Simonsen, U., & Fago, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01298.2006 · Cited by 110 · see citing works
Köck, K., Grube, M., Jedlitschky, G., Oevermann, L., Siegmund, W., Ritter, C. A., & Kroemer, H. K. (2007) · Clinical Pharmacokinetics · doi:10.2165/00003088-200746060-00001 · Cited by 105 · see citing works
Red Blood Cell Nitric Oxide as an Endocrine Vasoregulator
Datta, B. N., Tufnell-Barret, T., Bleasdale, R. A., Jones, C. J. H., Beeton, I., Paul, V., Frenneaux, M. P., & James, P. E. (2004) · Circulation · doi:10.1161/01.cir.0000124450.07016.1d · Cited by 102 · see citing works
Assessment of nitric oxide signals by triiodide chemiluminescence
Hausladen, A., Rafikov, R., Angelo, M., Singel, D. J., Nudler, E., & Stamler, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611191104 · Cited by 99 · see citing works
Enhanced <i>S</i> -Nitroso-Albumin Formation From Inhaled NO During Ischemia/Reperfusion
Ng, E. S. M., Jourd’heuil, D., McCord, J. M., Hernandez, D., Yasui, M., Knight, D., & Kubes, P. (2004) · Circulation Research · doi:10.1161/01.res.0000117771.63140.d6 · Cited by 97 · see citing works
How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm
Allen, B. W., & Piantadosi, C. A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00310.2006 · Cited by 90 · see citing works
Gladwin, M. T., & Schechter, A. N. (2004) · Circulation Research · doi:10.1161/01.res.0000126697.64381.37 · Cited by 85 · see citing works
Isbell, T. S., Gladwin, M. T., & Patel, R. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00759.2007 · Cited by 82 · see citing works
Identification of Stereoselective Transporters for S-Nitroso-L-cysteine
Li, S., & Whorton, A. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413164200 · Cited by 81 · see citing works
Xu, X., Cho, M., Spencer, N. Y., Patel, N. K., Huang, Z., Shields, H. W., King, S. B., Gladwin, M. T., Hogg, N., & Kim‐Shapiro, D. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2033883100 · Cited by 77 · see citing works
Inhaled Ethyl Nitrite Prevents Hyperoxia-impaired Postnatal Alveolar Development in Newborn Rats
Auten, R. L., Mason, S. N., Whorton, M. H., Lampe, W. R., Foster, W. M., Goldberg, R. N., Li, B., Stamler, J. S., & Auten, K. M. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200605-662oc · Cited by 70 · see citing works
Tsikas, D., Sandmann, J., Rossa, S., Gutzki, F., & Frölich, J. C. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4084 · Cited by 69 · see citing works
S -Nitrosoalbumin–Mediated Relaxation Is Enhanced by Ascorbate and Copper
Gandley, R. E., Tyurin, V. A., Huang, W., Arroyo, A., Daftary, A. R., Harger, G. F., Jiang, J., Pitt, B. R., Taylor, R. N., Hubel, C. A., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000150158.42620.3e · Cited by 66 · see citing works
Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models
Tsoukias, N. M. (2008) · Microcirculation · doi:10.1080/10739680802010070 · Cited by 65 · see citing works
Indexes of NO Bioavailability in Human Blood
Lauer, T., Kleinbongard, P., & Kelm, M. (2002) · Physiology · doi:10.1152/nips.01405.2002 · Cited by 64 · see citing works
Oxygen lack as a possible cause of reactive hyperemia
Crawford, D. G., Fairchild, H. M., & Guyton, A. C. (1959) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1959.197.3.613 · Cited by 62 · see citing works
Nitric oxide release from S-nitrosoglutathione (GSNO)
Noble, D. R., Swift, H. R., & Williams, D. L. H. (1999) · Chemical Communications · doi:10.1039/a907891f · Cited by 59 · see citing works
Purinergic 2X1 Receptors Mediate Endothelial Dependent Vasodilation to ATP
Mackenzie, L. S., Evans, R. J., Wray, J., Norling, L. V., Swales, K. E., Vial, C., Ali, F., CARRIER, M. J., & Mitchell, J. A. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.037325 · Cited by 52 · see citing works
Reduced number of CFTR molecules in erythrocyte plasma membrane of cystic fibrosis patients
Lange, T. J., Jungmann, P. M., Häberle, J., Falk, S., Dübbers, A., Bruns, R., Ebner, A., Hinterdorfer, P., Oberleithner, H., & Schillers, H. (2006) · Molecular Membrane Biology · doi:10.1080/09687860600738304 · Cited by 42 · see citing works
Shah, C. M., Bell, S. E., Locke, I. C., Chowdrey, H. S., & Gordge, M. P. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.08.001 · Cited by 39 · see citing works
SNO-hemoglobin and hypoxic vasodilation
Stamler, J. S., Singel, D. J., & Piantadosi, C. A. (2008) · Nature Medicine · doi:10.1038/nm1008-1008 · Cited by 37 · see citing works
Evidence Mounts That Nitrite Contributes to Hypoxic Vasodilation in the Human Circulation
Gladwin, M. T. (2008) · Circulation · doi:10.1161/circulationaha.107.753897 · Cited by 36 · see citing works
Heme Redox Properties of S-Nitrosated Hemoglobin A0 and Hemoglobin S
Bonaventura, C., Taboy, C. H., Low, P. S., Stevens, R. D., Lafon, C., & Crumbliss, A. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107658200 · Cited by 34 · see citing works
Contrasting effects of thiol-modulating agents on endothelial NO bioactivity
Huang, A., Xiao, H. Q., Samii, J. M., Vita, J. A., & Keaney, J. F. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.2.c719 · Cited by 32 · see citing works
Walsh, S. B., Borgèse, F., Gabillat, N., Unwin, R. J., & Guizouarn, H. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00587.2007 · Cited by 32 · see citing works
Amperometric S-nitrosothiol sensor with enhanced sensitivity based on organoselenium catalysts
Cha, W., Anderson, M. R., Zhang, F., & Meyerhoff, M. E. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2008.12.022 · Cited by 29 · see citing works
Sandmann, J., Schwedhelm, K. S., & Tsikas, D. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.06.040 · Cited by 26 · see citing works
Bramanti, E., JACOVOZZI, K., D’Ulivo, L., Vecoli, C., Zamboni, R., Mester, Z., & D’Ulivo, A. (2008) · Talanta · doi:10.1016/j.talanta.2008.07.020 · Cited by 24 · see citing works
Pulmonary vascular effects of red blood cells containing S-nitrosated hemoglobin
Deem, S. A., Kim, S. S., Min, J.-H., Eveland, R. L., Moulding, J., Martyr, S. E., Wang, X., Swenson, E. R., & Gladwin, M. T. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00310.2004 · Cited by 24 · see citing works
Reactions of nitrite with hemoglobin measured by membrane inlet mass spectrometry
Tu, C., Mikulski, R., Swenson, E. R., & Silverman, D. N. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.016 · Cited by 21 · see citing works
Nitric Oxide, Invertebrates and Hemoglobin1
Bonaventura, J., & Lance, V. P. (2001) · American Zoologist · doi:10.1668/0003-1569(2001)041[0346:noiah]2.0.co;2 · Cited by 10 · see citing works
How Do Red Blood Cells Dilate Blood Vessels?
Allen, B. W., & Piantadosi, C. A. (2004) · Circulation Research · doi:10.1161/res.94.12.e105 · Cited by 5 · see citing works
Mechanism of systemic hemodynamic response during limb reactive hyperemia
ZELIS, R. F., & Mason, D. T. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.217.6.1742 · Cited by 4 · see citing works
Tsikas, D. (2009) · Talanta · doi:10.1016/j.talanta.2009.03.030 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Vascular nitric oxide: Beyond eNOS
Zhao, Y., Vanhoutte, P. M., & Leung, S. W. S. (2015) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2015.09.002 · Cited by 823 · see citing works
<i>S</i> -Nitrosylation in Cardiovascular Signaling
Lima, B., Forrester, M. T., Hess, D. T., & Stamler, J. S. (2010) · Circulation Research · doi:10.1161/circresaha.109.207381 · Cited by 490 · see citing works
Vascular nitric oxide: formation and function
Loscalzo, J., & Jin (2010) · Journal of Blood Medicine · doi:10.2147/jbm.s7000 · Cited by 228 · see citing works
Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
Totzeck, M., Hendgen-Cotta, U. B., Luedike, P., Berenbrink, M., Klare, J. P., Steinhoff, H.-J., Semmler, D., Shiva, S., Williams, D., Kipar, A., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.087155 · Cited by 202 · see citing works
Terpolilli, N. A., Kim, S.-W., Thal, S. C., Kataoka, H., Zeisig, V., Nitzsche, B., Klaesner, B., Zhu, C., Schwarzmaier, S. M., Meissner, L., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.253419 · Cited by 199 · see citing works
Nitric Oxide: A Guardian for Vascular Grafts?
de Mel, A., Murad, F., & Seifalian, A. M. (2011) · Chemical Reviews · doi:10.1021/cr200008n · Cited by 187 · see citing works
Redox regulation of mitochondrial biogenesis
Piantadosi, C. A., & Suliman, H. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.014 · Cited by 178 · see citing works
Hemoglobin-mediated nitric oxide signaling
Helms, C., & Kim-Shapiro, D. B. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.028 · Cited by 146 · see citing works
Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System
Nagpure, B. V., & Bian, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6904327 · Cited by 145 · see citing works
Regulation of mitochondrial processes by protein S-nitrosylation
Piantadosi, C. A. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.008 · Cited by 144 · see citing works
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin
Miyamoto, T., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2011) · Nature Communications · doi:10.1038/ncomms1371 · Cited by 141 · see citing works
Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology
Premont, R. T., Reynolds, J. D. H., Zhang, R., & Stamler, J. S. (2019) · Circulation Research · doi:10.1161/circresaha.119.315626 · Cited by 142 · see citing works
Reactive Oxygen Species: Physiological Roles in the Regulation of Vascular Cells
Vara, D. S., & Pula, G. (2014) · Current Molecular Medicine · doi:10.2174/1566524014666140603114010 · Cited by 130 · see citing works
Cui, H., Zhu, W., Huang, Y., Liu, C., Yu, Z., Nowicki, M. A., Miao, S., Cheng, Y., Zhou, X., Lee, S.-J., et al. (2019) · Biofabrication · doi:10.1088/1758-5090/ab402c · Cited by 121 · see citing works
Duration of red cell storage before transfusion and in-hospital mortality
Eikelboom, J. W., Cook, R. J., Liu, Y., & Heddle, N. M. (2010) · American Heart Journal · doi:10.1016/j.ahj.2009.12.045 · Cited by 106 · see citing works
Thiol Signalling Network with an Eye to Diabetes
Matteucci, E., & Giampietro, O. (2010) · Molecules · doi:10.3390/molecules15128890 · Cited by 106 · see citing works
Cell-free hemoglobin: a novel mediator of acute lung injury
Shaver, C. M., Upchurch, C. P., Janz, D. R., Grove, B. S., Putz, N. D., Wickersham, N. E., Dikalov, S., Ware, L. B., & Bastarache, J. A. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00155.2015 · Cited by 95 · see citing works
An association between vasomotion and oxygen extraction
Thorn, C. E., Kyte, H., Slaff, D. W., & Shore, A. C. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01316.2010 · Cited by 78 · see citing works
Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport
Storz, J. F. (2016) · Physiology · doi:10.1152/physiol.00060.2015 · Cited by 76 · see citing works
Chatzinikolaou, P. N., Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Vrabas, I. S., Kyparos, A., D’Alessandro, A., & Nikolaidis, M. G. (2024) · Acta Physiologica · doi:10.1111/apha.14081 · Cited by 74 · see citing works
An Update on the Appropriate Role for Hyperbaric Oxygen: Indications and Evidence
Fife, C. E., Eckert, K. A., & Carter, M. J. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000002714 · Cited by 67 · see citing works
S. Rocha, B., Gago, B., Pereira, C., M. Barbosa, R., Bartesaghi, S., O. Lundberg, J., Radi, R., & Laranjinha, J. (2011) · Current Drug Targets · doi:10.2174/138945011796150334 · Cited by 64 · see citing works
Kurhaluk, N., & Tkaczenko, H. (2025) · Nutrients · doi:10.3390/nu17040665 · Cited by 62 · see citing works
Vitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59 · see citing works
Regulation of oxygen delivery to the body via hypoxic vasodilation
Kulandavelu, S., Balkan, W., & Hare, J. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506523112 · Cited by 55 · see citing works
Gaston, B. M., May, W. J., Sullivan, S., Yemen, S., Marozkina, N. V., Palmer, L. A., Bates, J. N., & Lewis, S. J. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01050.2013 · Cited by 54 · see citing works
Modulation of Vascular Sarco/Endoplasmic Reticulum Calcium ATPase in Cardiovascular Pathophysiology
Adachi, T. K. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)59006-9 · Cited by 51 · see citing works
Scicinski, J. J., Oronsky, B. T., Taylor, M., Luo, G., Musick, T. J., Marini, J., Adams, C. M., & Fitch, W. L. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.046755 · Cited by 50 · see citing works
Wagner, P. D. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1955-7 · Cited by 46 · see citing works
Belcastro, E., Gaucher, C., Corti, A., Leroy, P., Lartaud, I., & Alfonso Pompella, C. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0150 · Cited by 46 · see citing works
Hypoxia: Turning vessels into vassals of cancer immunotolerance
Schito, L., & Rey, S. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.05.015 · Cited by 47 · see citing works
Koller, Á., Laughlin, M. H., Cenko, E., de Wit, C., Tóth, K., Bugiardini, R., Trifunović, D., Vavlukis, M., Manfrini, O., Lelbach, A., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab246 · Cited by 46 · see citing works
S-nitrosylation therapy to improve oxygen delivery of banked blood
Reynolds, J. D. H., Bennett, K. M., Cina, A. J., Diesen, D. L., Henderson, M. B., Matto, F., Plante, A., Williamson, R. A., Zandinejad, K., It, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306489110 · Cited by 41 · see citing works
Ishikawa, N., Ohlmeier, S., Salmenkivi, K., Myllärniemi, M., Rahman, I., Mazur, W., & Kinnula, V. L. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-123 · Cited by 40 · see citing works
Cauwels, A., & Brouckaert, P. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq317 · Cited by 39 · see citing works
The transfusion problem: role of aberrant S‐nitrosylation
Reynolds, J. D. H., Hess, D. T., & Stamler, J. S. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03097.x · Cited by 37 · see citing works
Coll-Satue, C., Bishnoi, S., Chen, J., & Hosta‐Rigau, L. (2020) · Biomaterials Science · doi:10.1039/d0bm01767a · Cited by 38 · see citing works
Endothelial alpha globin is a nitrite reductase
Keller, T. C. S., Lechauve, C., Keller, A., Broseghini-Filho, G. B., Butcher, J. T., Page, H. R. A., Islam, A., Tan, Z. Y., DeLalio, L. J., Brooks, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34154-3 · Cited by 36 · see citing works
Sheng, H., Reynolds, J. D. H., Auten, R. L., It, D., Piantadosi, C. A., Stamler, J. S., & Warner, D. S. (2010) · Stroke · doi:10.1161/strokeaha.110.600569 · Cited by 36 · see citing works
Gaseous Signaling Molecules in Cardiovascular Function: From Mechanisms to Clinical Translation
Lee, S. R., Nilius, B., & Han, J. (2018) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2017_7 · Cited by 35 · see citing works
Palmer, L. A., May, W. J., deRonde, K. A., Brown-Steinke, K., Bates, J. N., Gaston, B. M., & Lewis, S. J. (2012) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.11.009 · Cited by 32 · see citing works
Liu, T., Schroeder, H. J., Power, G. G., & Blood, A. B. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102327 · Cited by 30 · see citing works
Generating S-Nitrosothiols from Hemoglobin
Roche, C. J., Cassera, M. B., Dantsker, D., Hirsch, R. E., & Friedman, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482679 · Cited by 30 · see citing works
Seckler, J. M., Grossfield, A. M., May, W. J., Getsy, P. M., & Lewis, S. J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112571 · Cited by 30 · see citing works
A Contemporary Review of Blood Transfusion in Critically Ill Patients
Yadav, S. K., Hussein, G., Liu, B., Vojjala, N., Warsame, M., Labban, M. E., Rauf, I., Hassan, M. S., Zareen, T., Usama, S. M., et al. (2024) · Medicina · doi:10.3390/medicina60081247 · Cited by 29 · see citing works
Further studies on the photoreactivities of ruthenium–nitrosyl complexes with terpyridyl ligands
Sasaki, I., Amabilino, S., Mallet‐Ladeira, S., Tassé, M., Sournia‐Saquet, A., Lacroix, P. G., & Malfant, I. (2019) · New Journal of Chemistry · doi:10.1039/c9nj02398d · Cited by 28 · see citing works
Determination of S-nitrosoglutathione in plasma: Comparison of two methods
Bramanti, E., Angeli, V. W., Mester, Z., Alfonso Pompella, C., Paolicchi, A., & D’Ulivo, A. (2010) · Talanta · doi:10.1016/j.talanta.2010.02.024 · Cited by 28 · see citing works
Almac, E., Bezemer, R., Hilarius, P. M., Goedhart, P. T., de Korte, D., Verhoeven, A. J., & İnce, C. (2014) · Transfusion · doi:10.1111/trf.12738 · Cited by 26 · see citing works
NITRIC OXIDE: ROLE IN HUMAN BIOLOGY
Omer, N., Rohilla, A., Rohilla, S., & Kushnoor, A. (2012) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2012.040203 · Cited by 25 · see citing works
Gambaryan, S. P., Subramanian, H., Kehrer, L., Викторович, М. И., Sudnitsyna, J. S., Reiß, C., Rukoyatkina, N., Friebe, A., Sharina, I. G., Martin, E., et al. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0139-9 · Cited by 25 · see citing works
Mitochondrial oxygen sensing of acute hypoxia in specialized cells - Is there a unifying mechanism?
Pak, O., Nolte, A., Knoepp, F., Giordano, L., Pecina, P., Hüttemann, M., Grossman, L. I., Weißmann, N., & Sommer, N. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2022.148911 · Cited by 25 · see citing works
Structural and Functional Studies Indicating Altered Redox Properties of Hemoglobin E
Roche, C. J., Malashkevich, V. N., Balazs, T. C., Dantsker, D., Chen, Q., Moreira, J. C., Almo, S. C., Friedman, J. M., & Hirsch, R. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183186 · Cited by 23 · see citing works
Nitrite potentiates the vasodilatory signaling of S-nitrosothiols
Liu, T., Zhang, M., Terry, M. H., Schroeder, H. J., Wilson, S. M., Power, G. G., Li, Q., Tipple, T. E., Borchardt, D., & Blood, A. B. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.01.011 · Cited by 23 · see citing works
Recent insights into nitrite signaling processes in blood
Helms, C. C., Liu, X., & Kim‐Shapiro, D. B. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0263 · Cited by 23 · see citing works
Khokhlova, O. N., Borozdina, N. A., Sadovnikova, E. S., Pakhomova, I. A., Rudenko, P. A., Korolkova, Y. V., Kozlov, S. A., & Dyachenko, I. A. (2022) · Biomedicines · doi:10.3390/biomedicines10020512 · Cited by 22 · see citing works
Dzik, S. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03114.x · Cited by 22 · see citing works
Tracing the path of inhaled nitric oxide: Biological consequences of protein nitrosylation
Bhatia, V., Elnagary, L., & Dakshinamurti, S. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.25201 · Cited by 23 · see citing works
Lewis Acid Coordination Redirects S‐Nitrosothiol Signaling Output
Hosseininasab, V., McQuilken, A. C., Bakhoda, A. G., Bertke, J. A., Timerghazin, Q. K., & Warren, T. H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202001450 · Cited by 20 · see citing works
S-Nitrosoglutathione Acts as a Small Molecule Modulator of Human Fibrin Clot Architecture
Bateman, R. M., Ellis, C. G., Suematsu, M., & Walley, K. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043660 · Cited by 18 · see citing works
Perinajová, R., Álvarez-Cuevas, C. B., Juffermans, J. F., Westenberg, J. J. M., Lamb, H. J., & Kenjereš, S. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106925 · Cited by 18 · see citing works
Can Nitric Oxide–Based Therapy Prevent Bronchopulmonary Dysplasia?
Raffay, T. M., Martin, R. J., & Reynolds, J. D. H. (2012) · Clinics in Perinatology · doi:10.1016/j.clp.2012.06.011 · Cited by 18 · see citing works
Two-photon absorption-based delivery of nitric oxide from ruthenium nitrosyl complexes
Lacroix, P. G., Malfant, I., Labra‐Vázquez, P., Fárfan, N., & Ramos‐Ortíz, G. (2022) · Dalton Transactions · doi:10.1039/d2dt02553a · Cited by 17 · see citing works
EPR Spectroscopy of Nitrite Complexes of Methemoglobin
Schwab, D. E., Stamler, J. S., & Singel, D. J. (2010) · Inorganic Chemistry · doi:10.1021/ic902085s · Cited by 17 · see citing works
Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation
Reynolds, J. D. H., Jenkins, T. L., Matto, F., Nazemian, R., Farhan, O., Morris, N. J., Longphre, J., Hess, D. T., Moon, R. E., Piantadosi, C. A., et al. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.979 · Cited by 16 · see citing works
Anwar, A., Yameen, D., Masood, M., Parvez, S., & Haque, M. M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148589 · Cited by 16 · see citing works
On-chip electrocatalytic NO sensing using ruthenium oxide nanorods
Tanumihardja, E., Rodríguez, A. P., Loessberg-Zahl, J., Mei, B., Olthuis, W., & van den Berg, A. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.129631 · Cited by 16 · see citing works
Hemoglobin Variants as Targets for Stabilizing Drugs
Žoldáková, M., Novotný, M., Khakurel, K. P., & Žoldák, G. (2025) · Molecules · doi:10.3390/molecules30020385 · Cited by 14 · see citing works
A new physiologic-based integrated algorithm in the management of neonatal hemodynamic instability
Elsayed, Y. N., & Wahab, M. G. A. (2021) · European Journal of Pediatrics · doi:10.1007/s00431-021-04307-5 · Cited by 14 · see citing works
Sierra, J. A., Pazarín–Villaseñor, L., Yanowsky-Escatell, F. G., la Cruz, E. N. D.-D., García-Sánchez, A., Cardona-Muñóz, E. G., Munguía-Galaviz, F. J., Alba-Razo, A. D., & Miranda‐Díaz, A. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911196 · Cited by 14 · see citing works
Pathological Impact of the Interaction of NO and CO with Mitochondria in Critical Care Diseases
Duvigneau, J. C., & Kozlov, A. V. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00223 · Cited by 14 · see citing works
Muller, M. A., Belcik, T. A., Hodovan, J., Ozawa, K., Brown, E., Powers, J., Sheeran, P. S., & Lindner, J. R. (2021) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2021.02.018 · Cited by 14 · see citing works
Yurcisin, B. M., Davison, T. E., Bibbs, S. M., Collins, B. H., Stamler, J. S., & Reynolds, J. D. H. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182822c52 · Cited by 14 · see citing works
Grote, K., Schaefer, A.-C., Soufi, M., Ruppert, V., Linne, U., Bhagwat, A. M., Szymanski, W. G., Graumann, J., Gercke, Y., Aldudak, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084522 · Cited by 13 · see citing works
Otto, C. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-53045-3.00016-7 · Cited by 12 · see citing works
Getu, A. A., Ilardo, M. A., Tremblay, J. C., Carr, J. M. J. R., Faoro, V., & Ainslie, P. N. (2025) · Experimental Physiology · doi:10.1113/ep092811 · Cited by 16 · see citing works
Cytoplasmic Protein Serine/Threonine Kinases
Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_5 · Cited by 11 · see citing works
Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxation.
Liu, Y., Sun, C., Honavar, J., Townes, T. M., & Patel, R. P. (2013) · Europe PMC (PubMed Central) · Cited by 12 · see citing works
Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_2 · Cited by 9 · see citing works
Cytoplasmic Protein Tyrosine Kinases
Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_4 · Cited by 8 · see citing works
A moonlighting job for α-globin in blood vessels
Abbineni, P. S., Baid, S., & Weiss, M. J. (2024) · Blood · doi:10.1182/blood.2023022192 · Cited by 9 · see citing works
Impact of nitric oxide-mediated vasodilation on outer medullary NaCl transport and oxygenation
Edwards, A., & Layton, A. T. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00055.2012 · Cited by 9 · see citing works
Detection of Reactive Metabolites of Oxygen and Nitrogen
Grisham, M. B. (2011) · doi:10.1002/9781444345988.ch24 · Cited by 9 · see citing works
Guanosine Triphosphatases and Their Regulators
Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_9 · Cited by 7 · see citing works
Macionis, V. (2023) · Current Pain and Headache Reports · doi:10.1007/s11916-023-01174-7 · Cited by 8 · see citing works
Lewis Acid Coordination Redirects S‐Nitrosothiol Signaling Output
Hosseininasab, V., McQuilken, A. C., Bakhoda, A. G., Bertke, J. A., Timerghazin, Q. K., & Warren, T. H. (2020) · Angewandte Chemie · doi:10.1002/ange.202001450 · Cited by 8 · see citing works
Mendoza, J. P., Passafaro, R. J., Baby, S. M., Young, A. P., Bates, J. N., Gaston, B. M., & Lewis, S. J. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00842.2013 · Cited by 8 · see citing works
Lacroix, P. G., Tassé, M., de, D., & Malfant, I. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216417 · Cited by 7 · see citing works
Wu, P.-P., Shanminna, Liang, K., Yue, H., Qian, L., & Sun, B. (2016) · Acta Paediatrica · doi:10.1111/apa.13331 · Cited by 7 · see citing works
Паршукова, О. И., Геннадьевна, В. Н., Потолицына, Н. Н., Lyudinina, A. Y., & Bojko, E. R. (2021) · Cells · doi:10.3390/cells11010039 · Cited by 8 · see citing works
Anemia contributes to cardiovascular disease through reductions in nitric oxide
Andreotti, F., Coluzzi, G., Pafundi, T., Rio, T., Navarese, E. P., Crea, F., Pistolesi, M., Maseri, A., & Hennekens, C. H. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00995.2015 · Cited by 7 · see citing works
S‐Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery
Matto, F., Kouretas, P. C., Smith, R., Ostrowsky, J., Cina, A. J., Hess, D. T., Stamler, J. S., & Reynolds, J. D. H. (2017) · Clinical and Translational Science · doi:10.1111/cts.12530 · Cited by 7 · see citing works
Endocrine Nitric Oxide Bioactivity and Hypoxic Vasodilation by Inhaled Nitric Oxide
Stamler, J. S., Reynolds, J. D. H., & Hess, D. T. (2012) · Circulation Research · doi:10.1161/circresaha.111.263996 · Cited by 7 · see citing works
Red Blood Cell Storage in Transfusion-Related Acute Gut Injury
Gamma, E. F. L., Feldman, A., Mintzer, J. P., Lakshminrusimha, S., & Alpan, G. (2015) · NeoReviews · doi:10.1542/neo.16-7-e420 · Cited by 6 · see citing works
RRx-001 Increases Erythrocyte Preferential Adhesion to the Tumor Vasculature
Jani, V. P., Asaro, R. J., Oronsky, B. T., & Cabrales, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094713 · Cited by 6 · see citing works
Strategies of Pathogens to Escape from NO-Based Host Defense
Simone, G. D., di Masi, A., & Ascenzi, P. (2022) · Antioxidants · doi:10.3390/antiox11112176 · Cited by 6 · see citing works
Erythropoietin reduces storage lesions and decreases apoptosis indices in blood bank red blood cells
Peñuela, O., Palomino, F., & Gómez, L. A. (2015) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.1016/j.bjhh.2015.10.003 · Cited by 6 · see citing works
Nitric Oxide Signaling in Health and Disease
Bryan, N. S., & Lancaster, J. R. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_11 · Cited by 7 · see citing works
Cardioprotective role of S-nitrosylated hemoglobin from rbc
Piantadosi, C. A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci91303 · Cited by 6 · see citing works
Foley, T. D., Koval, K. S., Gallagher, A. G., & Olsen, S. H. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0340-1 · Cited by 6 · see citing works
Nitric Oxide Signaling in Health and Disease
Bryan, N. S., & Lancaster, J. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_13 · Cited by 5 · see citing works
- Authors
- Allen, B. W., Stamler, J. S., & Piantadosi, C. A.
- Affiliations
- Duke University (US)
- Corresponding author
- Allen, Barry W.
- ORCID
- Stamler, Jonathan S.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 15
- Issue
- 10
- Pages
- 452-460
- ISSN
- 1471-4914 (ISSN-L)
- PMC
- PMC2785508
- OpenAlex
- W2033703576
- Cited by
- 165
- References
- 100
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 9 · 2012: 23
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL091876)
- Office of Naval Research
- National Institute of Allergy and Infectious Diseases (R01AI064789)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- nitric oxide, hemoglobin, hypoxic vasodilation, S-nitrosohemoglobin, S-nitrosothiols, oxygen saturation, erythrocyte membrane, microvascular blood flow, respiratory cycle, endothelium
- MeSH terms
- Animals, Endothelium, Vascular, Hemoglobins, Humans, Nitric Oxide, Oxygen, Vasodilation, Nitrosation, Cell Hypoxia, S-Nitrosothiols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
