The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation
Abstract
Smooth muscle cells (SMCs) are the main cell type in intimal thickenings and some stages of human atherosclerosis. Like monocyte-derived macrophages, SMCs accumulate excess lipids and contribute to the total intimal foam cell population. In contrast, apolipoprotein (Apo)E-deficient and LDL receptor-deficient mice develop atherosclerotic lesions that are macrophage- as opposed to SMC-rich. The lesser contribution of SMCs to lesion development in these mouse models has distracted attention away from the importance of SMC cholesterol homeostasis in the artery wall. Intimal SMCs accumulate excess amounts of cholesteryl esters when compared with medial layer SMCs, possibly explained by reduced ATP-binding cassette transporter A1 expression and ApoA-I binding to intimal-type SMCs. The aim of this review is to compare the relative contribution of monocyte-derived macrophages and SMCs to human vs. mouse atherosclerosis, and describe what is known about lipid uptake and removal mechanisms contributing to arterial macrophage and SMC foam cell formation. An increased understanding of the contribution of these cell types to lesion development will help to delineate their relative importance in atherogenesis and as potential therapeutic targets.
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Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
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Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase
Ouimet, M., Franklin, V., Mak, E., Liao, X., Tabas, I., & Marcel, Y. L. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.023 · Cited by 774
Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake
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Singaraja, R. R., Bocher, V., James, E. R., Clee, S. M., Zhang, L.-H., Leavitt, B. R., Tan, B., Brooks-Wilson, A., Kwok, A., Bissada, N., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102503200 · Cited by 194
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“Modified lipoproteins recognized by scavenger receptors include oxLDL,(39) acetylated LDL,(40) enzymatically altered (by trypsin, cholesterol esterase and neuraminidase) LDL,(41) and glycolaldehyde (an advanced glycation end product)-modified LDL.(42) Aggregated LDL, another lipoprotein ligand involved in foam cell fo…”
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Cited by
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
Kapellos, T. S., Bonaguro, L., Gemünd, I., Reusch, N., Saglam, A., Hinkley, E. R., & Schultze, J. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02035 · Cited by 890
Smooth muscle cell fate and plasticity in atherosclerosis
Allahverdian, S., Chaabane, C., Boukais, K., Francis, G. A., & Bochaton-Piallat, M.-L. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy022 · Cited by 507
Self-citationSmooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Frismantiene, A., Philippova, M., Erne, P., & Resink, T. J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.08.019 · Cited by 406
Vengrenyuk, Y., Nishi, H., Long, X., Ouimet, M., Savji, N., Martinez, F. O., Cassella, C. P., Moore, K. J., Ramsey, S. A., Miano, J. M., et al. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304029 · Cited by 358
Wang, Y., Li, L., Zhao, W., Dou, Y., An, H., Tao, H., Xu, X., Jia, Y., Lu, S., Zhang, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02037 · Cited by 361
Metadata
- Authors
- Allahverdian, S., Pannu, P. S., & Francis, G. A.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-15
- Volume
- 95
- Issue
- 2
- Pages
- 165-172
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2160451772
- Cited by
- 158
- References
- 9
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
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