Cited by 89Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

Multiple Omics Uncovers Host–Gut Microbial Mutualism During Prebiotic Fructooligosaccharide Supplementation

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Kato, Tamotsu, Fukuda, Shinji, Fujiwara, Akemi, Suda, Wataru, Hattori, Masahira, Kikuchi, Jun, Ohno, Hiroshi·2014·DNA Research

Abstract

Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remain(s) obscure. Traditional methods of profiling microbes and metabolites could barely show any significant features due to the existence of large interindividual differences, but our novel microbe-metabolite correlation approach, combined with faecal immunoglobulin A (IgA) measurements, has revealed that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific bacteria. Furthermore, the metabolic dynamics of butyrate, L-phenylalanine, L-lysine and tyramine were positively correlated with that of these bacteria and IgA production, whereas p-cresol was negatively correlated. Taken together, our focused intraindividual analysis with omics approaches is a powerful strategy for uncovering the gut molecular network and could provide a new vista for understanding the human gut ecosystem.

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Authors
Kato, T., Fukuda, S., Fujiwara, A., Suda, W., Hattori, M., Kikuchi, J., & Ohno, H.
Affiliations
  • RIKEN Center for Integrative Medical Sciences (JP)
  • The University of Tokyo (JP)
  • RIKEN Center for Sustainable Resource Science (JP)
Corresponding author
Ohno, Hiroshi
Venue
DNA Research
Published
2014-05-19
Volume
21
Issue
5
Pages
469-480
ISSN
  • 1340-2838 (ISSN-L)
  • 1756-1663
OpenAlex
W2097460814
Cited by
88
References
57
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 5 · 2015: 9
FWCI
3.55
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • DNA Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science (20113003, 24380072, 21390155, 25513012)
  • RIKEN
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
fructooligosaccharides, prebiotic supplementation, gut microbiota, mucosal IgA, butyrate, L-phenylalanine, L-lysine, tyramine, p-cresol, microbial metabolites, interindividual variability
MeSH terms
Adult, Butyrates, Cresols, Feces, Female, Humans, Immunoglobulin A, Lysine, Male, Oligosaccharides, Phenylalanine, Tyramine, Dietary Supplements, Gastrointestinal Tract, Young Adult, Prebiotics

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