Multiple Omics Uncovers Host–Gut Microbial Mutualism During Prebiotic Fructooligosaccharide Supplementation
Open accessAbstract
Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remain(s) obscure. Traditional methods of profiling microbes and metabolites could barely show any significant features due to the existence of large interindividual differences, but our novel microbe-metabolite correlation approach, combined with faecal immunoglobulin A (IgA) measurements, has revealed that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific bacteria. Furthermore, the metabolic dynamics of butyrate, L-phenylalanine, L-lysine and tyramine were positively correlated with that of these bacteria and IgA production, whereas p-cresol was negatively correlated. Taken together, our focused intraindividual analysis with omics approaches is a powerful strategy for uncovering the gut molecular network and could provide a new vista for understanding the human gut ecosystem.
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Numerous studies have demonstrated the capability of prebiotics to promote bifidobacterial presence within the microbiota, correlating with other changes in the overall microbiota composition and metabolism.
“On the other hand, numerous studies have demonstrated the capability of prebiotics to promote bifidobacterial presence within the microbiota, correlating with other changes in the overall microbiota composition and metabolism.”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [61]
Dietary fibers contribute to intestinal microbiota modulation, especially acting on dominant species, and a diversified microbiota could be favorable for the host.
“furthermore, diverse papers highlight that dietary fibers contribute to the intestinal microbiota modulation, especially acting on the dominant species, indicating that a diversified microbiota could be favorable for the host [10,17].”
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- Authors
- Kato, T., Fukuda, S., Fujiwara, A., Suda, W., Hattori, M., Kikuchi, J., & Ohno, H.
- Affiliations
- RIKEN Center for Integrative Medical Sciences (JP)
- The University of Tokyo (JP)
- RIKEN Center for Sustainable Resource Science (JP)
- Corresponding author
- Ohno, Hiroshi
- Venue
- DNA Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-19
- Volume
- 21
- Issue
- 5
- Pages
- 469-480
- ISSN
- 1340-2838 (ISSN-L)
- 1756-1663
- PMC
- PMC4195493
- OpenAlex
- W2097460814
- Cited by
- 88
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 5 · 2015: 9
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- DNA Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (20113003, 24380072, 21390155, 25513012)
- RIKEN
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- fructooligosaccharides, prebiotic supplementation, gut microbiota, mucosal IgA, butyrate, L-phenylalanine, L-lysine, tyramine, p-cresol, microbial metabolites, interindividual variability
- MeSH terms
- Adult, Butyrates, Cresols, Feces, Female, Humans, Immunoglobulin A, Lysine, Male, Oligosaccharides, Phenylalanine, Tyramine, Dietary Supplements, Gastrointestinal Tract, Young Adult, Prebiotics
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