N‐Acetylcysteine an Allium Plant Compound Improves High‐Sucrose Diet‐Induced Obesity and Related Effects
Open accessAbstract
This study was designed to determine whether N‐acetylcysteine (NAC, C 5 H 9–NO 3 S), a compound from Allium species may be used as a complementary therapeutic agent, to inhibit high‐sucrose induced‐obesity and its effects on glucose tolerance, in vivo low‐density lipoprotein (LDL)‐oxidation and serum oxidative stress in rats. Initially, 24 male Wistar rats were divided into two groups: controls receiving standard chow (C, n = 6) and those receiving high‐sucrose diet (HS, n = 18). After 22 days, (HS) group was divided into three groups (n = 6/group); (HS‐HS) continued to eat high‐sucrose diet and water; (HS‐N) continued to eat high‐sucrose diet and received 2 mg l−1‐NAC in its drinking water; (HS‐CN) changing high‐sucrose to standard chow and receiving 2 mg l1‐NAC in its drinking water. After 22 days of the HS‐group division (44 days of experimental period) body weight, body mass index and surface area were enhanced in HS‐HS rats (P < .001). HS‐HS rats had glucose intolerance, increased serum triacylglycerol (TG), very low‐density lipoprotein (VLDL), oxidized‐LDL (ox‐LDL) and lipid‐hydroperoxide (LH) than the others (P < .01). NAC in HS‐N and HS‐CN rats reduced the obesity markers, feed efficiency, LH and ox‐LDL, as well normalized glucose response, TG and VLDL (P < .01) in these groups compared with HS‐HS. Total antioxidant substances, GSH/GSSG ratio and glutathione‐reductase, were higher in HS‐N than in HS‐HS (P < .01). In conclusion, NAC improved high‐sucrose diet‐induced obesity and its effects on glucose tolerance, lipid profile, in vivo LDL‐oxidation and serum oxidative stress, enhancing antioxidant defences. The application of this agent may be feasible and beneficial for high‐sucrose diet‐induced obesity, which certainly would bring new insights on obesity‐related adverse effects control.
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S-alk(en)yl-l-cysteine sulfoxides are secondary metabolites obtained from cysteine that accumulate in plants of the Allium genus.
“S-alk(en)yl-l-cysteine sulfoxides are the secondary metabolites obtained from cysteine which accumulate in the plants of Allium genus [32].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [32]
Garlic has been used in traditional medicine to treat indigestion, respiratory and urinary tract infections and cardiac disorders, and it showed carminative, antipyretic, sedative, aphrodisiac, and diuretic effects.
“Moreover, garlic has been used in traditional medicine to treat indigestion, respiratory and urinary tract infections and cardiac disorders and it showed carminative, antipyretic, sedative, aphrodisiac, and diuretic effects [32].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [32]
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
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<i>N</i>-acetylcysteine for therapy-resistant tobacco use disorder: a pilot study
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- Authors
- Souza, G. A., Ebaid, G. X., Seiva, F. R. F., Rocha, K. H. R., Galhardi, C. M., Mani, F., & Novelli, E. L. B.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Corresponding author
- Novelli, Ethel L. B.
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 2011
- Issue
- 1
- Pages
- 643269-643269
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC3136759
- OpenAlex
- W2039070064
- Cited by
- 49
- References
- 31
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- N-acetylcysteine, Allium, high-sucrose diet, diet-induced obesity, glucose tolerance, LDL oxidation, oxidative stress, lipid peroxidation, triglycerides, VLDL, glutathione, antioxidant defense, obesity treatment
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