Garlic increases antioxidant levels in diabetic and hypertensive rats determined by a modified peroxidase method
Open accessAbstract
Oxidative damage by free radicals has been implicated in the pathogenesis of vascular disease in diabetes and hypertension. In the present study, the total antioxidant status in diabetic and hypertensive rats before and after treatment with garlic (Allium sativum) was determined. The total serum antioxidants were measured by a modified method reported earlier by Miller and coworkers. The reproducibility of the assay was confirmed by determining standard curves for the known antioxidants: trolox (a stable analog of vitamin E), glutathione and vitamin C with interassay correlation coefficients (R 2, n = 10 in triplicate) of 0.9984, 0.9768 and 0.987, respectively, confirming the reliability and reproducibility of the assay. This assay was then used to determine total serum antioxidant levels of streptozotocin‐induced diabetic rats and two‐kidney one‐clip hypertensive rats both before and after 3 weeks of treatment with an aqueous extract of garlic (500 mg/kg IP daily). The serum antioxidant levels of rats after 3 weeks of treatment were significantly higher (P < .001) than the pretreatment levels in both diabetic and hypertensive rats. The increased serum antioxidant levels were paralleled by a decrease in serum glucose in the garlic‐treated diabetic rats and lowered systolic blood pressure in the garlic‐treated hypertensive rats. We conclude from our study that (i) total antioxidants can be measured by a simple, reproducible, reliable assay and (ii) the total antioxidant status can be significantly improved by treatment with garlic.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Garlic formulations have been broadly used to inhibit and relieve cardiovascular disorders such as hypertension, arrhythmia, thrombosis, hyperlipidemia, and atherosclerosis.
“Garlic formulations have been broadly used to inhibit and relieve cardiovascular disorders such as hypertension, arrhythmia, thrombosis, hyperlipidemia, and atherosclerosis [19,120].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [120]
Garlic administration at a dose of 100 mg/kg for 5 days resulted in complete prevention of acute hypoxic pulmonary vasoconstriction caused by endothelin-1 in isolated rat pulmonary arteries, acting by reducing endothelin 1 and angiotensin II production.
“Garlic administration at a dose of 100 mg/kg for 5 days resulted in complete prevention of acute hypoxic pulmonary vasoconstriction caused by endothelin-1 in isolated rat pulmonary arteries and they found that garlic acts by reducing endothelin 1 and angiotensin II production [120].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [120]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,298 · see citing works
Colowick, S. P., Joshi, M. D., Jagannathan, & KAPLAN, N. O. (1966) · Cited by 26,137 · see citing works
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
The Chemistry behind Antioxidant Capacity Assays
Huang, D., Ou, B., & Prior, R. L. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030723c · Cited by 6,162 · see citing works
Free Radicals in Biology and Medicine
Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works
Miller, N. J., Rice-Evans, C. A., Davies, M. J., Gopinathan, V., & Milner, A. D. (1993) · Clinical Science · doi:10.1042/cs0840407 · Cited by 3,108 · see citing works
Guide for the care and use of laboratory animals
(1997) · Choice Reviews Online · doi:10.5860/choice.34-3310 · Cited by 2,930 · see citing works
Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?
Halliwell, B. B. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92211-x · Cited by 2,926 · see citing works
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works
Biomarkers of Oxidative Damage in Human Disease
Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani, A. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.061408 · Cited by 1,703 · see citing works
The Role of Oxidative Stress in Carcinogenesis
Klaunig, J. E., & Kamendulis, L. M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121851 · Cited by 1,537 · see citing works
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works
Oxidative Stress: Oxidants and Antioxidants.
Haddock, P. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.8.816a · Cited by 1,190 · see citing works
Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications
Sheetz, M. J. (2002) · JAMA · doi:10.1001/jama.288.20.2579 · Cited by 1,003 · see citing works
[241 Total antioxidant status in plasma and body fluids
Rice-Evans, C. A., & Miller, N. J. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)34095-1 · Cited by 991 · see citing works
Comparison of different analytical methods for assessing total antioxidant capacity of human serum
Cao, G., & Prior, R. L. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.6.1309 · Cited by 904 · see citing works
Wayner, D. D. M., Burton, G. W., Ingold, K. U., Barclay, L. R. C., & Locke, S. J. (1987) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(87)90155-3 · Cited by 871 · see citing works
Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension
Touyz, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000138070.47616.9d · Cited by 866 · see citing works
van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A. (1999) · Food Chemistry · doi:10.1016/s0308-8146(99)00089-8 · Cited by 765 · see citing works
Ceriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734 · see citing works
Effect of garlic on cardiovascular disorders: a review
Banerjee, S., & Maulik, S. K. (2002) · Nutrition Journal · doi:10.1186/1475-2891-1-4 · Cited by 628 · see citing works
Endothelial dysfunction in diabetes mellitus.
Hadi, H. A. R., & Suwaidi, J. M. S. A. (2007) · Europe PMC (PubMed Central) · Cited by 568 · see citing works
Endothelial Function and Oxidative Stress in Renovascular Hypertension
Higashi, Y., Sasaki, S., Nakagawa, K., Matsuura, H., Oshima, T., & Chayama, K. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013591 · Cited by 542 · see citing works
Glucose and diabetic vascular disease 1
Ruderman, N. B., Williamson, J. R., & Brownlee, M. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.11.1644256 · Cited by 375 · see citing works
Diabetes mellitus, hypertension, and cardiovascular disease: Which role for oxidative stress?
Giugliano, D., Ceriello, A., & Paolisso, G. (1995) · Metabolism · doi:10.1016/0026-0495(95)90167-1 · Cited by 369 · see citing works
Garlic for Treating Hypercholesterolemia
Stevinson, C. D., Pittler, M. H., & Ernst, E. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00009 · Cited by 365 · see citing works
Spectrophotometric determination of antioxidant activity
Miller, N. J., & Rice-Evans, C. A. (1996) · Redox Report · doi:10.1080/13510002.1996.11747044 · Cited by 362 · see citing works
Inhibitory effect of garlic extract on oral bacteria
Bakri, I. M., & Douglas, C. W. I. (2005) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2004.12.002 · Cited by 323 · see citing works
Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin
Anwar, M. M., & Meki, A. M. A. (2003) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(03)00114-4 · Cited by 312 · see citing works
Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn.
Sheela, C. G., & Augusti, K. T. (1992) · PubMed · Cited by 306 · see citing works
Relationship of Microvascular Disease in Diabetes to Metabolic Control
Engerman, R. L., Bloodworth, J. M. B., & Nelson, S. C. (1977) · Diabetes · doi:10.2337/diab.26.8.760 · Cited by 295 · see citing works
Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.).
Augusti, K. T. (1996) · PubMed · Cited by 284 · see citing works
Oxidative Stress and Diabetes-Associated Complications
Ceriello, A. (2006) · Endocrine Practice · doi:10.4158/ep.12.s1.60 · Cited by 254 · see citing works
Calcium, mitochondria and oxidative stress in neuronal pathology
Chinopoulos, C., & Ádám‐Vizi, V. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05103.x · Cited by 239 · see citing works
Anti-Diabetic Effects of Onion and Garlic Sulfoxide Amino Acids in Rats
Sheela, C. G., Kumud, K., & Augusti, K. T. (1995) · Planta Medica · doi:10.1055/s-2006-958099 · Cited by 192 · see citing works
Rodríguez‐Iturbe, B., Zhan, C.-D., Quiroz, Y., Sindhu, R. K., & Vaziri, N. D. (2003) · Hypertension · doi:10.1161/01.hyp.0000052833.20759.64 · Cited by 191 · see citing works
Ali, M., Al‐Qattan, K. K., Alenezi, F., Khanafer, R. M. A., & Mustafa, T. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0152 · Cited by 188 · see citing works
Self-citationSteiner, M., & Li, W. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.980s · Cited by 178 · see citing works
Reactive oxygen species in vascular biology: role in arterial hypertension
Touyz, R. M. (2003) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.1.1.91 · Cited by 171 · see citing works
A quantitative assessment of the antimicrobial activity of garlic (Allium sativum)
Rees, L. P., Minney, S. F., Plummer, N. T., Slater, J. H., & Skyrme, D. A. (1993) · World Journal of Microbiology & Biotechnology · doi:10.1007/bf00383068 · Cited by 168 · see citing works
Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats
Liu, C., Hse, H., Lii, C., Chen, P.-S., & Sheen, L. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.04.031 · Cited by 151 · see citing works
Jelodar, G., Maleki, M., Motadayen, M., & Sirus, S. (2005) · Indian Journal of Medical Sciences · doi:10.4103/0019-5359.13905 · Cited by 145 · see citing works
Relationship of microvascular disease in diabetes to metabolic control
Engerman, R. L., Bloodworth, J. M. B., & Nelson, S. (1977) · Diabetes · doi:10.2337/diabetes.26.8.760 · Cited by 123 · see citing works
Consumption of a garlic clove a day could be beneficial in preventing thrombosis
Ali, M., & Thomson, M. (1995) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(95)90118-3 · Cited by 108 · see citing works
Self-citationEffect of garlic on thrombocyte aggregation, microcirculation, and other risk factors.
Kiesewetter, H., Jung, F., Pindur, G., Jung, E. M., Mrowietz, C., & Wenzel, E. (1991) · PubMed · Cited by 106 · see citing works
An evaluation of garlic and onion as antithrombotic agents
Bordia, T., Mohammed, N. A.-Q., Thomson, M., & Ali, M. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90014-9 · Cited by 100 · see citing works
Self-citationFree radicals, diabetes and endothelial dysfunction
Bayraktutan, U. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00184.x · Cited by 96 · see citing works
Peltz, G. (2002) · Nutrition Journal · doi:10.1186/1475-2891-1-1 · Cited by 87 · see citing works
Al‐Qattan, K. K., Thomson, M., Al-Mutawa'a, S., Alhajeri, D. M., Drobiova, H., & Ali, M. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.774s · Cited by 85 · see citing works
Self-citationAntimicrobial Activity of a Compound Isolated from an Oil-Macerated Garlic Extract
YOSHIDA, H., Iwata, N., Katsuzaki, H., Naganawa, R., Ishikawa, K., Fukuda, H., Fujino, T., & SUZUKI, A. (1998) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.62.1014 · Cited by 79 · see citing works
Modulation of oxidative stress-induced changes in hypertension and atherosclerosis by antioxidants.
Vasdev, S., Gill, V. D., & Singal, P. K. (2006) · PubMed Central · Cited by 78 · see citing works
Oxidant Stress, Immune Dysregulation, and Vascular Function in Type I Diabetes
Nicolls, M. R., HASKINS, K. M., & Flores, S. C. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1631 · Cited by 75 · see citing works
Effect of aged garlic extract(AGE) on hyperglycemia induced by immobilization stress in mice.
Kasuga, S., USHIJIMA, M., Morihara, N., Itakura, Y., & Nakata, Y. (1999) · Folia Pharmacologica Japonica · doi:10.1254/fpj.114.191 · Cited by 72 · see citing works
Al‐Qattan, K. K., Khan, I., Alnaqeeb, M. A., & Ali, M. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(03)00087-5 · Cited by 56 · see citing works
Self-citationEffects of Garlic Consumption on Plasma and Erythrocyte Antioxidant Parameters in Elderly Subjects
Avcı, A., Atlı, T., Ergüder, B. İ., Varlı, M., Devrím, E., Aras, S., & Durak, İ. (2008) · Gerontology · doi:10.1159/000130426 · Cited by 55 · see citing works
Souza, G. A., Ebaid, G. X., Seiva, F. R. F., Rocha, K. H. R., Galhardi, C. M., Mani, F., & Novelli, E. L. B. (2011) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nen070 · Cited by 49 · see citing works
Ali, M., Thomson, M., Alnaqeeb, M. A., Al‐Hassan, J. M., Khater, S. H., & Gomes, S. A. (1990) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(90)90060-x · Cited by 49 · see citing works
Self-citationOxidative stress: The special case of diabetes
Wiernsperger, N. F. (2003) · BioFactors · doi:10.1002/biof.5520190103 · Cited by 43 · see citing works
S-allyl cysteine attenuated CCl4-induced oxidative stress and pulmonary fibrosis in rats
Mizuguchi, S., Takemura, S., Minamiyama, Y., Kodai, S., Tsukioka, T., Inoue, K., Okada, S., & Suehiro, S. (2006) · BioFactors · doi:10.1002/biof.5520260108 · Cited by 41 · see citing works
Thomson, M., Mustafa, T., & Ali, M. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0212 · Cited by 38 · see citing works
Self-citationDetermination of the antioxidant status of plasma from type 2 diabetic patients
Medina, L. O., Veloso, C. A., Borges, E. A., Isoni, C. A., Calsolari, M. R., Chaves, M. M., & Nogueira‐Machado, J. A. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.12.008 · Cited by 31 · see citing works
Enumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction
Eisenbarth, G. S., & Kotzin, B. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17621 · Cited by 26 · see citing works
Zimmerman, M. A., & Flores, S. C. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.04.026 · Cited by 22 · see citing works
Prospects for the use of antioxidant therapy in hypertension.
Digiesi, V., Lenuzza, M., & Digiesi, G. (2002) · PubMed · Cited by 18 · see citing works
Zalejska–Fiolka, J., Kasperczyk, A., Kasperczyk, S., Błaszczyk, U., & Birkner, E. (2007) · Biological Trace Element Research · doi:10.1007/s12011-007-0068-y · Cited by 17 · see citing works
Antioxidant studies need a change of direction.
Shishehbor, M. H., & Hazen, S. L. (2004) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.71.4.285 · Cited by 16 · see citing works
Al‐Qattan, K. K. (2001) · Kidney & Blood Pressure Research · doi:10.1159/000054205 · Cited by 5 · see citing works
Self-citationKhan, I. U., Al‐Qattan, K. K., Alnaqeeb, M. A., & Ali, M. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000063308 · Cited by 4 · see citing works
Self-citationEnumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction
Eisenbarth, G. S., & Kotzin, B. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317621 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works
Mikaili, P., Maadirad, S., Moloudizargari, M., Aghajanshakeri, S., & Sarahroodi, S. (2013) · Europe PMC (PubMed Central) · Cited by 241 · see citing works
Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus
Lee, Y. M., Gweon, O.-C., Seo, Y.-J., Im, J., Kang, M., Kim, M.-J., & Kim, J.-I. (2009) · Nutrition Research and Practice · doi:10.4162/nrp.2009.3.2.156 · Cited by 183 · see citing works
Traditional Indian Medicines Used for the Management of Diabetes Mellitus
Rizvi, S. I., & Mishra, N. (2013) · Journal of Diabetes Research · doi:10.1155/2013/712092 · Cited by 179 · see citing works
Anti-hypertensive Herbs and their Mechanisms of Action: Part I
Disi, S. S. A., Anwar, M. A., & Eid, A. H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00323 · Cited by 163 · see citing works
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
Anwar, M. A., Disi, S. S. A., & Eid, A. H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00050 · Cited by 140 · see citing works
Chukwuma, C. I., Matsabisa, M. G., Ibrahim, M. A., Erukainure, O. L., Chabalala, M., & Islam, M. S. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.02.024 · Cited by 139 · see citing works
Plants Used as Antihypertensive
Verma, T., Sinha, M. D., Bansal, N., Yadav, S. R., Shah, K., & Chauhan, N. S. (2020) · Natural Products and Bioprospecting · doi:10.1007/s13659-020-00281-x · Cited by 124 · see citing works
Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
Zhai, B., Zhang, C., Sheng, Y., Zhao, C., He, X., Xu, W., Huang, K., & Luo, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-21421-x · Cited by 123 · see citing works
Thomson, M., Al‐Qattan, K. K., Divya, J. S., & Ali, M. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-0992-5 · Cited by 110 · see citing works
Self-citationAl-Waili, N., Al-Waili, H., Al-Waili, T. N., & Salom, K. (2017) · Redox Report · doi:10.1080/13510002.2017.1297885 · Cited by 110 · see citing works
Ezeorba, T., Chukwudozie, K., Ezema, C. A., Anaduaka, E., Nweze, E., & Okeke, E. (2022) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2022.100075 · Cited by 69 · see citing works
Onion anthocyanins: Extraction, stability, bioavailability, dietary effect, and health implications
Samota, M. K., Sharma, M., Kaur, K., Sarita, Yadav, D. K., Pandey, A. K., Tak, Y., Rawat, M., Thakur, J., & Rani, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.917617 · Cited by 66 · see citing works
Thiagarajan, K., Chandrasekaran, R., Suthindhiran, K., & Mathew, L. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neq060 · Cited by 63 · see citing works
Ozma, M. A., Abbasi, A., Rezaee, M. A., Hosseini, H., Hosseinzadeh, N., Sabahi, S., Noori, S. M. A., Sepordeh, S., Khodadadi, E., Lahouty, M., et al. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2100417 · Cited by 64 · see citing works
Asdaq, S. M. B., & Inamdar, M. N. (2011) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/neq076 · Cited by 57 · see citing works
Onion (Allium cepa L.) is potentially a good source of important antioxidants
Sidhu, J. S., Ali, M., Al-Rashdan, A., & Ahmed, N. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-03625-9 · Cited by 57 · see citing works
Self-citationRahmani, G., Farajdokht, F., Mohaddes, G., Babri, S., Ebrahimi, V., & Ebrahimi, H. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1494746 · Cited by 52 · see citing works
Mohebbi, A., Nematollahi, A., Ebrahimi, E., & Asad, F. G. (2011) · Aquaculture Research · doi:10.1111/j.1365-2109.2011.02922.x · Cited by 49 · see citing works
Adefegha, S. A. (2013) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajppx12.014 · Cited by 49 · see citing works
Adineh, H., Harsij, M., Jafaryan, H., & Asadi, M. (2020) · Journal of Applied Animal Research · doi:10.1080/09712119.2020.1808473 · Cited by 46 · see citing works
Age-dependent alteration of antioxidant defense system in hypertensive and type-2 diabetes patients
Okoduwa, S. I. R., Umar, I. A., Ibrahim, S., Bello, F., & Habila, N. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0164-z · Cited by 45 · see citing works
George, J., Singh, M., Srivastava, A. K., Bhui, K., & Shukla, Y. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.03.040 · Cited by 43 · see citing works
RetractedFaroughi, F., Mohammad-Alizadeh Charandabi, S., Javadzadeh, Y., & Mirghafourvand, M. (2018) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.60675 · Cited by 37 · see citing works
Bakhshaeshi, M., Khaki, A., Fathiazad, F., Khaki, A. A., & Ghadamkheir, E. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60090-2 · Cited by 36 · see citing works
Naderi, R., Mohaddes, G., Mohammadi, M., Alihemmati, A., Badalzadeh, R., Ghaznavi, R., Ghiasi, R., & Mohammadi, S. (2015) · Acta Physiologica Hungarica · doi:10.1556/036.102.2015.4.5 · Cited by 36 · see citing works
Bioactives from culinary spices and herbs: a review
Embuscado, M. E. (2019) · Journal of Food Bioactives · doi:10.31665/jfb.2019.6186 · Cited by 35 · see citing works
Effect of Cinnamomum zeylanicumon on Spermatogenesis
Khaki, A. (2015) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.18668 · Cited by 34 · see citing works
Gong, X., Su, X., & Liu, H. (2021) · Molecules · doi:10.3390/molecules26237186 · Cited by 33 · see citing works
Xu, S., Liao, Y., Wang, Q., Liu, L., & Yang, W. F. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2049691 · Cited by 33 · see citing works
Alkreathy, H. M., Damanhouri, Z. A., Ahmed, N., SLEVIN, M. A., & Osman, A. M. (2011) · Integrative Cancer Therapies · doi:10.1177/1534735411426726 · Cited by 32 · see citing works
Mansour, M. H., Al‐Qattan, K. K., Thomson, M., & Ali, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-012-0139-3 · Cited by 30 · see citing works
Self-citationNasim, S. A., Dhir, B., Kapoor, R., Fatima, S., Mahmooduzzafar, M., & Mujib, A. (2011) · Pharmaceutical Biology · doi:10.3109/13880209.2010.521163 · Cited by 27 · see citing works
Anaeigoudari, A., Safari, H., & Khazdair, M. R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762182 · Cited by 26 · see citing works
Antioxidative Effects of Allium Cepa Essential Oil in Streptozotocin Induced Diabetic Rats
El-Soud, N. H. A., & Khalil, M. (2010) · Macedonian Journal of Medical Sciences · doi:10.3889/mjms.1857-5773.2010.0118 · Cited by 26 · see citing works
Salimi, Z., Eskandary, A., Headari, R., Nejati, Moradi, M., & Kalhori, Z. (2015) · PubMed · Cited by 26 · see citing works
Huang, Y., Lu, K., Lin, Y., Panyod, S., Wu, H., Chang, W.-T., & Sheen, L. (2019) · Food & Function · doi:10.1039/c9fo00601j · Cited by 25 · see citing works
Al‐Qattan, K. K., Mansour, M. H., Thomson, M., & Ali, M. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.02.003 · Cited by 24 · see citing works
Self-citationJangam, G. B., & Badole, S. L. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00046-3 · Cited by 24 · see citing works
Bai, X., Batallé, G., & Pol, O. (2021) · Antioxidants · doi:10.3390/antiox10071074 · Cited by 19 · see citing works
Allicin, a SUR2 opener: possible mechanism for the treatment of diabetic hypertension in rats
Dubey, H., Singh, A., Patole, A. M., Tenpe, C. R., & Ghule, B. (2012) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2012005000046 · Cited by 19 · see citing works
Zhang, H.-M., Liang, F.-X., & Chen, R. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/747982 · Cited by 19 · see citing works
Khan, M. S., Qureshi, N. A., Jabeen, F., Wajid, M., Sabri, S., & Shakir, M. S. (2020) · Fisheries Science · doi:10.1007/s12562-020-01403-7 · Cited by 19 · see citing works
Kohda, K., Goda, H., Itoh, K., Samejima, K., & Fukuuchi, T. (2013) · Pharmacology & Pharmacy · doi:10.4236/pp.2013.41004 · Cited by 18 · see citing works
Evaluation effects of quercetin on liver apoptosis in streptozotocin-induced diabetic rat.
Khaki, A., Nouri, M., Reza, A. A. H., Rastgar, H., Rezazadeh, S., Azad, F. F., & Ghanbari, M. (2009) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 18 · see citing works
Lu, M., Pan, J., Hu, Y., Ding, L., Li, Y., Cui, X., Zhang, M., Zhang, M., & Li, C. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109531 · Cited by 17 · see citing works
Zadhoush, R., Naeini, A. A., Feizi, A., Naghshineh, E., & Ghazvini, M. R. A. (2021) · Phytotherapy Research · doi:10.1002/ptr.7282 · Cited by 17 · see citing works
Effect of Cinnamon Zeylanicum on serum Testosterone and anti-oxidants levels in Rats
Fathiazad, F., Khaki, A., Nouri, M., & Khaki, A. A. (2013) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2013.05 · Cited by 16 · see citing works
Al‐Qattan, K. K., Thomson, M., Jayasree, D., & Ali, M. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/8142394 · Cited by 16 · see citing works
Self-citationJiang, Y., Yue, R., Liu, G., Liu, J., Peng, B., Yang, M., Zhao, L., & Li, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2153793 · Cited by 19 · see citing works
Balamash, K. S., Al-Bar, O. A. M., Wang, Q., & Ahmed, N. (2012) · journal of Diabetes Research and Clinical Metabolism · doi:10.7243/2050-0866-1-18 · Cited by 15 · see citing works
Thomson, M., Al‐Qattan, K. K., Mansour, M. H., & Ali, M. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/409047 · Cited by 14 · see citing works
Self-citationBioactive Compounds and Biological Activities of Allium sativum L.
Abbasi, A., Sanej, K. D., Moradi, S., Bazzaz, S., Esmaeili, A., Ghafourian, K., Sabahi, S., Lahouty, M., Akrami, S., Aslani, R., et al. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-29006-0_11-1 · Cited by 12 · see citing works
Lotf, F., Ziamajidi, N., Abbasalipourkabir, R., Goodarzi, M. T., & Asl, S. S. (2021) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v19i10.9825 · Cited by 10 · see citing works
Esfandiari, E., Dorali, A., Ghanadian, M., Rashidi, B., & Mostafavi, F. S. (2020) · Comparative Clinical Pathology · doi:10.1007/s00580-020-03121-z · Cited by 10 · see citing works
Bioactives from Culinary Spices and Herbs: A Review
Embuscado, M. E. (2019) · Journal of Food Bioactives · doi:10.31665/jfb.2019.5185 · Cited by 9 · see citing works
Effect of substitution of wheat flour with chickpea flour on their physico-chemical characteristics
Sidhu, J. S., Zafar, T. A., Almusallam, A., Ali, M., & Al-Othman, A. R. (2023) · Arab Gulf Journal of Scientific Research · doi:10.1108/agjsr-09-2022-0178 · Cited by 8 · see citing works
Self-citationA Comprehensive Review of Moroccan Medicinal Plants for Diabetes Management
Boutaj, H. (2024) · Diseases · doi:10.3390/diseases12100246 · Cited by 7 · see citing works
Kamal, Z., Ebnalwaled, A. A., Al‐Amgad, Z., Saied, A. A., Metwally, A. A., & Said, A. H. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26264-2 · Cited by 7 · see citing works
Antidiabetic and Anti-Inflammatory Effect of Cinnamomum cassia Oil in Alloxan-Induced Diabetic Rats
Cordero‐Pérez, P., Hernández-Cruz, F. E., Garza-Guzmán, D., Moreno-Pena, D. P., Sánchez‐Martínez, C., Torres-González, L., Muñoz-Espinosa, L. E., Zapata-Chavira, H. A., Cura–Esquivel, I., Serrano-Sandoval, M. I., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17091135 · Cited by 7 · see citing works
Safiriyu, A. A., Semuyaba, I., Lawal, S. K., Buhari, M. O., Ayikobua, E. T., Kalange, M., Okpanachi, A. O., & Nansunga, M. (2018) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2018.119021 · Cited by 6 · see citing works
Mansour, M. H., Al‐Qattan, K. K., Thomson, M., & Ali, M. (2011) · Advances in Biological Chemistry · doi:10.4236/abc.2011.13011 · Cited by 5 · see citing works
Self-citationHajhosieni, L., Fatemeh, F. R., & Khaki, A. (2014) · Cited by 5 · see citing works
Pande, S., & Srinivasan, K. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0082 · Cited by 5 · see citing works
Habtemariam, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102922-0.00019-5 · Cited by 4 · see citing works
Lim, T. K. (2014) · Springer eBooks · doi:10.1007/978-94-017-9511-1_6 · Cited by 3 · see citing works
Dewi, M., Wijaya, I., & Wijayahadi, N. (2011) · MEDIA MEDIKA INDONESIANA · Cited by 3 · see citing works
EFFECT OF REGULAR GARLIC INGESTION ON BODY WEIGHT AND BLOOD GLUCOSE: A CASE STUDY IN MICE
Osonuga, A., Ekpale, J., & Otoo, P. (2012) · Cited by 3 · see citing works
Nureye, D., Tadege, G., Dubale, S., Kebebe, D., Suleman, S., & Nguelefack‐Mbuyo, E. P. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1514911 · Cited by 2 · see citing works
TOTUM-854 Human Circulating Bioactives Preserve Endothelial Cell Function
Wauquier, F., Ripoche, D., Boutin-Wittrant, L., Otero, Y. F., Krisa, S., Valls, J., Maura, M., Joubioux, F. L., Maugard, T., Boléa, G., et al. (2025) · Nutrients · doi:10.3390/nu17081331 · Cited by 2 · see citing works
Klassa, B., Grosseli, M. M., Kiyomura, A. K., & Alves, M. J. Q. F. (2013) · Revista Brasileira de Plantas Medicinais · doi:10.1590/s1516-05722013000400012 · Cited by 2 · see citing works
Role of dietary spices in modulating inflammation and oxidative stress
Oh, E. S., Petersen, K. H., Kris‐Etherton, P. M., & Rogers, C. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823482-2.00005-4 · Cited by 2 · see citing works
Bioactive Compounds and Biological Activities of Allium sativum L.
Abbasi, A., Sanej, K. D., Moradi, S., Bazzaz, S., Esmaeili, A., Ghafourian, K., Sabahi, S., Lahouty, M., Akrami, S., Aslani, R., et al. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-44746-4_11 · Cited by 2 · see citing works
Reduction in Serum Glucose with Garlic Extracts
Nasim, S. A., & Dhir, B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397153-1.00010-x · Cited by 1 · see citing works
QUERCETIN CAUSES TO DECREASE PROXIMAL TUBULES APOPTOTIC CELLS IN STREPTOZOTOCIN-INDUCED DIABETIC RAT
Zahedi, A., Ahmadnezhad, B., & Khaki, A. (2012) · Gadjah Mada University Library (Gadjah Mada University) · Cited by 1 · see citing works
Bakhshaeshi, M. (2012) · Journal of Cell and Animal Biology · doi:10.5897/jcab11.084 · Cited by 1 · see citing works
The most common Indian antidiabetic plants
Hilles, A. R., Waly, M. I., & Mahmood, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95719-9.00011-2 · Cited by 1 · see citing works
Kinetics of bioactive compounds in aged Brazilian garlic
Maldonade, I. R., & Resende, F. V. (2015) · Acta Horticulturae · doi:10.17660/actahortic.2015.1106.28 · Cited by 1 · see citing works
Phytomedicines as Sources of Natural Antioxidants
Abdullah, S. M., & Mazumder, P. M. (2022) · Wiley eBooks · doi:10.1002/9781119811794.ch2 · Cited by 1 · see citing works
The Emerging Role of 8- Isoprostane and ADMA in the Diagnosis of Diabetic Nephropathy
(2015) · Egyptian Journal of Pure and Applied Science · doi:10.21608/ejaps.2015.184785
Paese, M. C. D. S., Magnabosco, P., de Godoy, S., & Marchi-Alves, L. M. (2023) · Revista da Associação Brasileira de Nutrição - RASBRAN · doi:10.47320/rasbran.2023.2620
Imaga, N., Babalola, O. M., Ashiru, M. A., Taiwo, O., Abiru, O., & Awodele, O. (2022) · University of Lagos Journal of Basic Medical Sciences · doi:10.52968/23688765
Ani, P. N., Umeakuka, O. P., & Obi, J. (2023) · Journal of Dietitians Association of Nigeria · doi:10.4314/jdan.v13i2.1
CHANDA, S., & Dikshit, N. (2023) · Journal of Medicinal and Aromatic Plant Sciences · doi:10.62029/jmaps.v45i3.chanda
Al‐Hassan, J. M., Renno, W. M., Oommen, S., Nair, D., Paul, B. M., Mathew, B., Kumar, J., Ummerkutty, A., & Pace-Asciak, C. R. (2025) · Biomolecules · doi:10.3390/biom15070929
Igbinoba, S. I., Onyeji, C. O., Adegbola, A. J., Ademisoye, A. A., & Soyinka, J. O. (2025) · Drug Metabolism and Bioanalysis · doi:10.2174/0118723128380660250717140750
Singh, A., Pandey, R., Sarvottam, K., & Tripathi, A. (2026) · International Journal of Applied and Basic Medical Research · doi:10.4103/ijabmr.ijabmr_318_25
Saadat, M., Mirzaei, G., Morvaridi, M., & Hallajzadeh, J. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503419
Sant'Anna, B. K. C. (2010) · Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)
- Authors
- Drobiova, H., Thomson, M., Al-Qattan, K., Peltonen-Shalaby, R., Al-Amin, Z., & Ali, M.
- Affiliations
- Kuwait University (KW)
- Corresponding author
- Thomson, Martha
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2010-10-20
- Volume
- 2011
- Issue
- 1
- Pages
- 703049-703049
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC3137236
- OpenAlex
- W2006528374
- Cited by
- 91
- References
- 72
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 2 · 2013: 8 · 2012: 10
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- College of Graduate Studies, Kuwait University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- garlic, total antioxidant status, oxidative stress, diabetes mellitus, hypertension, streptozotocin-induced diabetes, two-kidney one-clip hypertension, serum antioxidants, serum glucose, blood pressure, vascular disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
