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The Mucosa-associated Microbiota of PSC Patients is Characterized by Low Diversity and Low Abundance of Uncultured Clostridiales II
Open accessAbstract
BACKGROUND: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease that is strongly associated with a particular phenotype of inflammatory bowel disease (IBD) with right-sided colonic involvement. In IBD, several studies demonstrated significant aberrancies in the intestinal microbiota in comparison with healthy controls. We aimed to explore the link between IBD and PSC by studying the intestinal mucosa-adherent microbiota in PSC and ulcerative colitis (UC) patients and noninflammatory controls. METHODS: We included 12 PSC patients, 11 UC patients, and nine noninflammatory controls. The microbiota composition was determined in ileocecal biopsies from each patient by 16S rRNA-based analyses using the human intestinal tract chip. RESULTS: Profiling of the mucosa-adherent microbiota of PSC patients, UC patients, and noninflammatory controls revealed that these groups did not cluster separately based on microbiota composition. At the genus-like level, the relative abundance of uncultured Clostridiales II was significantly lower (almost 2-fold) in PSC (0.26 ± 0.10%) compared with UC (0.41 ± 0.29%) and controls (0.49 ± 0.25%) (p = 0.02). Diversity and richness in the microbiota composition differed across the groups and were significantly lower in PSC patients compared with noninflammatory controls (p = 0.04 and p = 0.02, respectively). No significant differences were found in evenness. CONCLUSIONS: Reduced amounts of uncultured Clostridiales II in PSC biopsies in comparison with UC and healthy controls can be considered a signature of a compromised gut, as we have recently observed that this group of as yet uncultured Firmicutes correlates significantly with health.
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“Analysis of colon biopsy microbiota revealed that patients with PSC-IBD and IBD showed reduced abundance of Prevotella and Roseburia (a butyrate-producer) compared with controls.48 49”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [49]
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“Recently it was shown that patients with PSC have distinct gut microbiota.”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [49]
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Metadata
- Authors
- Rossen, N. G., Fuentes, S., Boonstra, K., D’Haens, G. R., Heilig, H. G., Zoetendal, E. G., de Vos, W. M., & Ponsioen, C. Y.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Wageningen University & Research (NL)
- Corresponding author
- Ponsioen, Cyriel Y.
- ORCID
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-12-29
- Volume
- 9
- Issue
- 4
- Pages
- 342-348
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- OpenAlex
- W2040286034
- Cited by
- 129
- References
- 32
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 18 · 2021: 16 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 18 · 2016: 11 · 2015: 5
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- primary sclerosing cholangitis, ulcerative colitis
- MeSH terms
- Eubacteriales, Adult, Aged, Biopsy, Colitis, Ulcerative, Colonoscopy, Cross-Sectional Studies, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Retrospective Studies, RNA, Bacterial, Cholangitis, Sclerosing, Gram-Positive Bacterial Infections, Young Adult, Microbiota
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